Phenominer Database Results (129 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Record ID Study ID
BN/NHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 20 serial mean 25.0 mmHg 3.0 13.42 vascular indwelling catheter method left femoral artery 0.0 67303 151
SS/JrHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 9 serial mean 24.0 mmHg 4.0 12.0 vascular indwelling catheter method left femoral artery 0.0 67304 151
LEW/Cub both kidneys wet weight to body weight ratio losartan (10 mg/kg) (for 0.2 hours) then pentolinium (5 mg/kg) (for 0.1 hours) then NG-nitroarginine methyl ester (30 mg/kg) (for 0.3 hours) Ueno T, et al., Physiol Res 2003;52(6):689-700. kidney mass not specified  days 9 serial mean 6.84 g/kg post excision weight measurement 0 65427 568
SS.BN-(D13Hmgc41-D13Hmgc23)/Mcwi resting tone of middle cerebral artery controlled calcium ion content physiological salt solution perfusate (0 %) then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 7 [(Dmax - Drest) /Dmax] x 100 49.0 % 2.4 6.35 ex vivo videomicroscopy 0.0 69557 732
SS/Jr logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) then NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98.0 days 12 -7.92 null 0.36 1.25 tissue force analysis utilizing a force transducer 0.0 isometric force transducer 69071 1096
SS.MNS-(D2Mit6-D2Rat303)/Ayd receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then phenylephrine (1-100 mmol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98.0 days 13 143.03 % 6.62 23.87 tissue force analysis utilizing a force transducer 0.0 isometric force transducer 69057 1096
SS/JrHsdMcwi middle cerebral artery inner diameter angiotensin II (3 ng/kg/min) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 5 246.0 um 3.7 8.27 ex vivo videomicroscopy 0.0 69577 732
SS/JrHsdMcwi resting tone of middle cerebral artery angiotensin II (3 ng/kg/min) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 5 [(Dmax - Drest) /Dmax] x 100 54.0 % 2.2 4.92 ex vivo videomicroscopy 0.0 69578 732
SS/JrHsdMcwi resting tone of middle cerebral artery controlled tempol content drinking water (15 mg/kg/d) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 6 [(Dmax - Drest) /Dmax] x 100 44.0 % 3.3 8.08 ex vivo videomicroscopy 0.0 69587 732
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 138.6 mmHg 3.8 17.41 vascular indwelling catheter method left femoral artery 120.0 69547 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 9 serial mean 159.1 mmHg 6.4 19.2 vascular indwelling catheter method left femoral artery 120.0 69550 151
ACI/Eur body weight right nephrectomy then NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 body mass male 168.0 days-175.0 days 12 314.0 g 6.0 20.78 body weighing method 0.0 67704 62
ACI.FHH-(D1Rat475-D1Rat90)(D3Rat84-D3Rat59)/Eur body weight NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 body mass male 168.0 days-175.0 days 12 296.0 g 6.0 20.78 body weighing method 0.0 67703 62
ACI.FHH-(D1Rat298-D1Rat90)/Eur body weight right nephrectomy then NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 body mass male 168.0 days-175.0 days 12 319.0 g 6.0 20.78 body weighing method 0.0 67706 62
ACI.FHH-(D3Wox2-D3Rat59)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 kidney glomerulus integrity trait male 168.0 days-175.0 days 12 18.0 % 2.0 6.93 ex vivo light microscopy 0.0 67714 62
ACI.FHH-(D1Rat298-D1Rat90)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio right nephrectomy then NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 kidney glomerulus integrity trait male 168.0 days-175.0 days 12 37.0 % 4.0 13.86 ex vivo light microscopy 0.0 67724 62
ACI.FHH-(D1Rat475-D1Rat90)(D3Rat84-D3Rat59)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio right nephrectomy then NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 kidney glomerulus integrity trait male 168.0 days-175.0 days 5 64.0 % 11.0 24.6 ex vivo light microscopy 0.0 67725 62
ACI/Eur creatinine clearance to body weight ratio NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 glomerular filtration trait male 168.0 days-175.0 days 12 0.5 ml/min/100g 0.02 0.07 blood creatinine analysis 0.0 67730 62
ACI.FHH-(D1Rat384-D1Rat452)(D17Rat61-D1Arb5)(D17Rat51)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then NG-nitroarginine methyl ester (10-21 mg/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. kidney glomerulus integrity trait not specified 168.0 days-175.0 days 9 29.0 % 4.0 12.0 ex vivo light microscopy 0.0 unilateral nephrectomy 126 days Original CMO_ID, CMO:0001176, was merged into current ID and field automatically updated. 4-26-2013 68885 832
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112.0 days 5 logEC50 -6.7 null 0.2 0.45 wire myography mesenteric artery 0.0 84647 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112.0 days 7 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 -12.94 % 4.38 11.59 wire myography aorta 0.0 84658 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112.0 days 10 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 -29.33 % 4.38 13.85 wire myography aorta 0.0 84657 735
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112.0 days 7 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 756.89 % 61.56 162.87 wire myography mesenteric artery 0.0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84676 735
Crlj:WI mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16.0 days 6 undefined 120.0 mmHg 7.0 17.15 vascular transducer tipped catheter 0.0 103031 2784
Crlj:WI heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16.0 days 7 287.0 beats/min 7.0 18.52 vascular transducer tipped catheter 0.0 103048 2784
Crlj:WI heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16.0 days 6 275.0 beats/min 8.0 19.6 vascular transducer tipped catheter 0.0 103051 2784
ACI/EurMcwi urine total protein excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. total urine protein amount male 91.0 days 9 68.52 mg/d 7.28 21.84 urine protein analysis 0.0 unx 56 days rf-1-1 100051 2400
ACI.FHH-(rs105487995-rs106411696)/Mcwi urine total protein excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. total urine protein amount male 91.0 days 8 81.88 mg/d 16.62 47.01 urine protein analysis 0.0 unx 56 days rf-1-2 100053 2400
ACI/EurMcwi urine albumin excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. urine albumin amount male 91.0 days 9 19.16 mg/d 5.53 16.59 urine albumin analysis 0.0 unx 56 days 100059 2400
ACI.FHH-(rs105373896-rgdv253272372)/Mcwi urine total protein excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. total urine protein amount male 91.0 days 6 41.34 mg/d 4.81 11.78 urine protein analysis 0.0 unx 56 days rf-1-6 100057 2400
ACI.FHH-(rgdv393055223-rs107095981)/Mcwi urine albumin excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. urine albumin amount male 91.0 days 5 93.07 mg/d 13.96 31.22 urine albumin analysis 0.0 unx 56 days rf-1-3 100062 2400
ACI.FHH-(rs105373896-rgdv253272372)/Mcwi urine albumin excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. urine albumin amount male 91.0 days 6 16.35 mg/d 3.01 7.37 urine albumin analysis 0.0 unx 56 days rf-1-6 100065 2400
LEW mean arterial blood pressure losartan (10 mg/kg) (for 0.2 hours) then pentolinium (5 mg/kg) (for 0.1 hours) then NG-nitroarginine methyl ester (30 mg/kg) (for 0.3 hours) Ueno T, et al., J Mol Med 2003 Jan;81(1):51-60. Epub 2002 Nov 21. arterial blood pressure trait both 151.0 days-181.0 days 21 continuous mean 123.0 mmHg 5.0 22.91 vascular indwelling catheter method carotid artery, jugular vein 1800 64706 249
LEW/Cub systolic blood pressure losartan (10 mg/kg) (for 0.2 hours) then pentolinium (5 mg/kg) (for 0.1 hours) then NG-nitroarginine methyl ester (30 mg/kg) (for 0.3 hours) Ueno T, et al., Physiol Res 2003;52(6):689-700. arterial blood pressure trait not specified  days 9 continuous mean 128.5 mmHg vascular indwelling catheter method 65383 568
HTG heart weight to body weight ratio losartan (10 mg/kg) (for 0.2 hours) then pentolinium (5 mg/kg) (for 0.1 hours) then NG-nitroarginine methyl ester (30 mg/kg) (for 0.3 hours) Ueno T, et al., Physiol Res 2003;52(6):689-700. heart mass not specified  days 10 2.67 g/kg post excision weight measurement 0 65404 568
HTG body weight losartan (10 mg/kg) (for 0.2 hours) then pentolinium (5 mg/kg) (for 0.1 hours) then NG-nitroarginine methyl ester (30 mg/kg) (for 0.3 hours) Ueno T, et al., Physiol Res 2003;52(6):689-700. body mass not specified  days 10 serial mean 309.3 g body weighing method 0 65438 568
LEW/Cub body weight losartan (10 mg/kg) (for 0.2 hours) then pentolinium (5 mg/kg) (for 0.1 hours) then NG-nitroarginine methyl ester (30 mg/kg) (for 0.3 hours) Ueno T, et al., Physiol Res 2003;52(6):689-700. body mass not specified  days 9 serial mean 300.2 g body weighing method 0 65439 568
SS.MNS-(D2Mit6-D2Rat303)/Ayd logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98.0 days 13 -7.2 null 0.31 1.12 tissue force analysis utilizing a force transducer 0.0 isometric force transducer 69072 1096
SS/Jr receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then phenylephrine (1-100 mmol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98.0 days 12 141.72 % 7.73 26.78 tissue force analysis utilizing a force transducer 0.0 isometric force transducer 69056 1096
SS/JrHsdMcwi middle cerebral artery inner diameter angiotensin II (3 ng/kg/min) (for 3 days) then physiological salt solution perfusate then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 5 113.0 um 4.2 9.39 ex vivo videomicroscopy 0.0 69576 732
SS/JrHsdMcwi middle cerebral artery inner diameter controlled tempol content drinking water (15 mg/kg/d) (for 3 days) then physiological salt solution perfusate then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 6 138.0 um 10.1 24.74 ex vivo videomicroscopy 0.0 69585 732
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 9 serial mean 160.0 mmHg 6.7 20.1 vascular indwelling catheter method left femoral artery 120.0 69548 151
ACI.FHH-(D1Rat384-D1Rat156)/Eur body weight unilateral nephrectomy then NG-nitroarginine methyl ester (10-21 ml/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. body mass not specified 168.0 days-175.0 days 11 267.0 g 11.0 36.48 body weighing method 0.0 unilateral nephrectomy 126 days 67908 832
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112.0 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 91.96 % 2.76 6.76 wire myography mesenteric artery 0.0 69622 735
ACI.FHH-(D3Wox2-D3Rat59)/Eur body weight NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 body mass male 168.0 days-175.0 days 12 321.0 g 4.0 13.86 body weighing method 0.0 67701 62
ACI.FHH-(D3Wox2-D3Rat59)/Eur body weight right nephrectomy then NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 body mass male 168.0 days-175.0 days 11 301.0 g 6.0 19.9 body weighing method 0.0 67705 62
ACI.FHH-(D1Rat298-D1Rat90)/Eur body weight NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 body mass male 168.0 days-175.0 days 12 328.0 g 3.0 10.39 body weighing method 0.0 67702 62
ACI/Eur kidney sclerotic glomeruli count to total glomeruli count ratio NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 kidney glomerulus integrity trait male 168.0 days-175.0 days 12 11.0 % 1.0 3.46 ex vivo light microscopy 0.0 67712 62
ACI.FHH-(D1Mit18-D1Mit8)(D14Mit11-D14Hmgc14b)(D14Rat65-D14Rat90)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then NG-nitroarginine methyl ester (10-21 mg/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. kidney glomerulus integrity trait not specified 168.0 days-175.0 days 2 59.0 % 11.0 15.56 ex vivo light microscopy 0.0 unilateral nephrectomy 126 days Original CMO_ID, CMO:0001176, was merged into current ID and field automatically updated. 4-26-2013 68884 832
ACI/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then NG-nitroarginine methyl ester (10-21 mg/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. kidney glomerulus integrity trait not specified 168.0 days-175.0 days 12 20.0 % 3.0 10.39 ex vivo light microscopy 0.0 unilateral nephrectomy 126 days Original CMO_ID, CMO:0001176, was merged into current ID and field automatically updated. 4-26-2013 68882 832
ACI.FHH-(D1Rat384-D1Rat156)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio NG-nitroarginine methyl ester (9-16 mg/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. kidney glomerulus integrity trait not specified 168.0 days-175.0 days 12 20.0 % 3.0 10.39 ex vivo light microscopy 0.0 Original CMO_ID, CMO:0001176, was merged into current ID and field automatically updated. 4-26-2013 68887 832
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112.0 days 9 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 626.89 % 61.39 184.17 wire myography mesenteric artery 0.0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84677 735
Crlj:WI mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16.0 days 7 undefined 136.0 mmHg 13.0 34.39 vascular transducer tipped catheter 0.0 103028 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16.0 days 7 undefined 102.0 mmHg 11.0 29.1 vascular transducer tipped catheter 0.0 103032 2784
GK mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16.0 days 5 undefined 137.0 mmHg 3.0 6.71 vascular transducer tipped catheter 0.0 103033 2784
Crlj:WI heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) then meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16.0 days 6 288.0 beats/min 11.0 26.94 vascular transducer tipped catheter 0.0 103047 2784
Crlj:WI heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16.0 days 7 264.0 beats/min 9.0 23.81 vascular transducer tipped catheter 0.0 103052 2784
ACI.FHH-(rs105487995-rs106411696)/Mcwi urine albumin excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. urine albumin amount male 91.0 days 8 33.72 mg/d 6.92 19.57 urine albumin analysis 0.0 unx 56 days rf-1-2 100061 2400
BN/NHsdMcwi ratio of change in renal blood flow rate to kidney weight controlled sodium content diet (0.4 %) (for 16 hours) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renal blood flow trait female 97.0 days-101.0 days 20 -1.2 ml/min/g 0.7 3.13 electromagnetic flowmetry 0.0 electromagnetic flowmetry 67309 151
HTG systolic blood pressure losartan (10 mg/kg) (for 0.2 hours) then pentolinium (5 mg/kg) (for 0.1 hours) then NG-nitroarginine methyl ester (30 mg/kg) (for 0.3 hours) Ueno T, et al., Physiol Res 2003;52(6):689-700. arterial blood pressure trait not specified  days 10 continuous mean 163.4 mmHg vascular indwelling catheter method 65381 568
HTG diastolic blood pressure losartan (10 mg/kg) (for 0.2 hours) then pentolinium (5 mg/kg) (for 0.1 hours) then NG-nitroarginine methyl ester (30 mg/kg) (for 0.3 hours) Ueno T, et al., Physiol Res 2003;52(6):689-700. arterial blood pressure trait not specified  days 10 continuous mean 108.8 mmHg vascular indwelling catheter method 65387 568
LEW/Cub heart weight to body weight ratio losartan (10 mg/kg) (for 0.2 hours) then pentolinium (5 mg/kg) (for 0.1 hours) then NG-nitroarginine methyl ester (30 mg/kg) (for 0.3 hours) Ueno T, et al., Physiol Res 2003;52(6):689-700. heart mass not specified  days 9 2.5 g/kg post excision weight measurement 0 65413 568
HTG both kidneys wet weight to body weight ratio losartan (10 mg/kg) (for 0.2 hours) then pentolinium (5 mg/kg) (for 0.1 hours) then NG-nitroarginine methyl ester (30 mg/kg) (for 0.3 hours) Ueno T, et al., Physiol Res 2003;52(6):689-700. kidney mass not specified  days 10 continuous mean 5.92 g/kg post excision weight measurement 0 65418 568
ACI/Eur body weight NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 body mass male 168.0 days-175.0 days 12 319.0 g 5.0 17.32 body weighing method 0.0 67700 62
SS.MNS-(D2Mit6-D2Rat303)/Ayd blood vessel contractile force measurement Kreb's solution perfusate then potassium chloride solution (40 mmol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98.0 days 13 1.6 g 0.12 0.43 tissue force analysis utilizing a force transducer 0.0 isometric force transducer 69051 1096
SS/Jr logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then phenylephrine (1-100 mmol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98.0 days 12 -7.6 null 0.05 0.17 tissue force analysis utilizing a force transducer 0.0 isometric force transducer EC50 value is probably moles/liter 69058 1096
ACI.FHH-(D1Rat384-D1Rat452)(D17Rat61-D1Arb5)(D17Rat51)/Eur body weight NG-nitroarginine methyl ester (9-16 mg/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. body mass not specified 168.0 days-175.0 days 12 296.0 g 5.0 17.32 body weighing method 0.0 67938 832
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 17 serial mean 144.9 mmHg 3.1 12.78 vascular indwelling catheter method left femoral artery 120.0 69549 151
ACI.FHH-(D1Mit18-D1Mit8)(D14Mit11-D14Hmgc14b)(D14Rat65-D14Rat90)/Eur body weight unilateral nephrectomy then NG-nitroarginine methyl ester (10-21 ml/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. body mass not specified 168.0 days-175.0 days 2 286.0 g 1.0 1.41 body weighing method 0.0 unilateral nephrectomy 126 days 67909 832
ACI.FHH-(D1Rat384-D1Rat452)(D17Rat61-D1Arb5)(D17Rat51)/Eur body weight unilateral nephrectomy then NG-nitroarginine methyl ester (10-21 ml/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. body mass not specified 168.0 days-175.0 days 9 277.0 g 6.0 18.0 body weighing method 0.0 unilateral nephrectomy 126 days 67910 832
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112.0 days 10 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 64.5 % 15.34 48.51 wire myography mesenteric artery 0.0 69621 735
ACI.FHH-(D3Wox2-D3Rat59)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio right nephrectomy then NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 kidney glomerulus integrity trait male 168.0 days-175.0 days 11 39.0 % 5.0 16.58 ex vivo light microscopy 0.0 67723 62
ACI/Eur kidney sclerotic glomeruli count to total glomeruli count ratio right nephrectomy then NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 kidney glomerulus integrity trait male 168.0 days-175.0 days 12 15.0 % 1.0 3.46 ex vivo light microscopy 0.0 67722 62
ACI.FHH-(D3Wox2-D3Rat59)/Eur creatinine clearance to body weight ratio NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 glomerular filtration trait male 168.0 days-175.0 days 12 0.78 ml/min/100g 0.04 0.14 blood creatinine analysis 0.0 67732 62
ACI.FHH-(D1Rat475-D1Rat90)(D3Rat84-D3Rat59)/Eur creatinine clearance to body weight ratio NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 glomerular filtration trait male 168.0 days-175.0 days 12 0.52 ml/min/100g 0.04 0.14 blood creatinine analysis 0.0 67734 62
ACI.FHH-(D1Rat298-D1Rat90)/Eur creatinine clearance to body weight ratio right nephrectomy then NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 glomerular filtration trait male 168.0 days-175.0 days 12 0.4 ml/min/100g 0.03 0.1 blood creatinine analysis 0.0 67742 62
ACI.FHH-(D1Rat475-D1Rat90)(D3Rat84-D3Rat59)/Eur creatinine clearance to body weight ratio right nephrectomy then NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 glomerular filtration trait male 168.0 days-175.0 days 5 0.31 ml/min/100g 0.06 0.13 blood creatinine analysis 0.0 67743 62
ACI.FHH-(D1Rat384-D1Rat452)(D17Rat61-D1Arb5)(D17Rat51)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio NG-nitroarginine methyl ester (9-16 mg/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. kidney glomerulus integrity trait not specified 168.0 days-175.0 days 12 14.0 % 7.0 24.25 ex vivo light microscopy 0.0 Original CMO_ID, CMO:0001176, was merged into current ID and field automatically updated. 4-26-2013 68889 832
ACI.FHH-(D1Mit18-D1Mit8)(D14Mit11-D14Hmgc14b)(D14Rat65-D14Rat90)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio NG-nitroarginine methyl ester (9-16 mg/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. kidney glomerulus integrity trait not specified 168.0 days-175.0 days 12 33.0 % 3.0 10.39 ex vivo light microscopy 0.0 Original CMO_ID, CMO:0001176, was merged into current ID and field automatically updated. 4-26-2013 68888 832
ACI/Eur kidney sclerotic glomeruli count to total glomeruli count ratio NG-nitroarginine methyl ester (9-16 mg/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. kidney glomerulus integrity trait not specified 168.0 days-175.0 days 12 11.0 % 1.0 3.46 ex vivo light microscopy 0.0 Original CMO_ID, CMO:0001176, was merged into current ID and field automatically updated. 4-26-2013 68886 832
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112.0 days 5 logEC50 -6.2 null 0.1 0.22 wire myography mesenteric artery 0.0 BCA assay 84644 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112.0 days 6 logEC50 -6.6 null 0.1 0.24 wire myography mesenteric artery 0.0 84646 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112.0 days 8 logEC50 -6.3 null 0.2 0.57 wire myography mesenteric artery 0.0 84645 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112.0 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 -19.03 % 4.01 9.82 wire myography aorta 0.0 BCA assay 84656 735
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112.0 days 6 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 564.27 % 57.82 141.63 wire myography mesenteric artery 0.0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84678 735
Crlj:WI mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) then meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16.0 days 6 undefined 155.0 mmHg 10.0 24.49 vascular transducer tipped catheter 0.0 103027 2784
GK mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16.0 days 5 undefined 151.0 mmHg 1.0 2.24 vascular transducer tipped catheter 0.0 103029 2784
GK heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16.0 days 5 301.0 beats/min 21.0 46.96 vascular transducer tipped catheter 0.0 103049 2784
ACI.FHH-(rs105487995-rs105373896)/Mcwi urine total protein excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. total urine protein amount male 91.0 days 8 62.94 mg/d 7.34 20.76 urine protein analysis 0.0 unx 56 days rf-1-1 100052 2400
ACI.FHH-(rgdv393055223-rs198922144)/Mcwi urine total protein excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. total urine protein amount male 91.0 days 7 173.13 mg/d 18.71 49.5 urine protein analysis 0.0 unx 56 days rf-1-4 100055 2400
ACI.FHH-(rgdv393055223-rs198076037)/Mcwi urine albumin excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. urine albumin amount male 91.0 days 7 27.46 mg/d 3.8 10.05 urine albumin analysis 0.0 unx 56 days rf-1-5 100064 2400
HTG mean arterial blood pressure losartan (10 mg/kg) (for 0.2 hours) then pentolinium (5 mg/kg) (for 0.1 hours) then NG-nitroarginine methyl ester (30 mg/kg) (for 0.3 hours) Ueno T, et al., J Mol Med 2003 Jan;81(1):51-60. Epub 2002 Nov 21. arterial blood pressure trait both 151.0 days-181.0 days 19 continuous mean 139.0 mmHg 5.0 21.79 vascular indwelling catheter method carotid artery, jugular vein 1800 64705 249
SS.BN-(D13Hmgc41-D13Hmgc23)/Mcwi middle cerebral artery inner diameter controlled calcium ion content physiological salt solution perfusate (0 %) then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 7 255.0 um 5.2 13.76 ex vivo videomicroscopy 0.0 69556 732
SS.BN-(D13Hmgc41-D13Hmgc23)/Mcwi middle cerebral artery inner diameter physiological salt solution perfusate then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 7 131.0 um 5.7 15.08 ex vivo videomicroscopy 0.0 69555 732
SS/Jr receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98.0 days 12 50.61 % 5.29 18.33 tissue force analysis utilizing a force transducer 0.0 isometric force transducer 69069 1096
SS/JrHsdMcwi middle cerebral artery inner diameter controlled tempol content drinking water (15 mg/kg/d) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 6 246.0 um 8.9 21.8 ex vivo videomicroscopy 0.0 69586 732
ACI/Eur body weight NG-nitroarginine methyl ester (9-16 mg/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. body mass not specified 168.0 days-175.0 days 12 314.0 g 6.0 20.78 body weighing method 0.0 67935 832
ACI.FHH-(D1Mit18-D1Mit8)(D14Mit11-D14Hmgc14b)(D14Rat65-D14Rat90)/Eur body weight NG-nitroarginine methyl ester (9-16 mg/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. body mass not specified 168.0 days-175.0 days 12 285.0 g 8.0 27.71 body weighing method 0.0 67937 832
ACI/Eur body weight unilateral nephrectomy then NG-nitroarginine methyl ester (10-21 ml/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. body mass not specified 168.0 days-175.0 days 12 314.0 g 5.0 17.32 body weighing method 0.0 unilateral nephrectomy 126 days 67907 832
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112.0 days 5 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 94.99 % 0.39 0.87 wire myography mesenteric artery 0.0 BCA assay 69620 735
ACI.FHH-(D3Wox2-D3Rat59)/Eur creatinine clearance to body weight ratio right nephrectomy then NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 glomerular filtration trait male 168.0 days-175.0 days 11 0.63 ml/min/100g 0.04 0.13 blood creatinine analysis 0.0 67741 62
ACI/Eur creatinine clearance to body weight ratio right nephrectomy then NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 glomerular filtration trait male 168.0 days-175.0 days 12 0.46 ml/min/100g 0.05 0.17 blood creatinine analysis 0.0 67740 62
ACI.FHH-(D1Rat384-D1Rat156)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then NG-nitroarginine methyl ester (10-21 mg/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. kidney glomerulus integrity trait not specified 168.0 days-175.0 days 11 42.0 % 6.0 19.9 ex vivo light microscopy 0.0 unilateral nephrectomy 126 days Original CMO_ID, CMO:0001176, was merged into current ID and field automatically updated. 4-26-2013 68883 832
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112.0 days 5 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 665.33 % 79.91 178.68 wire myography mesenteric artery 0.0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84679 735
GK mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16.0 days 7 undefined 143.0 mmHg 3.0 7.94 vascular transducer tipped catheter 0.0 103034 2784
GK heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16.0 days 7 344.0 beats/min 11.0 29.1 vascular transducer tipped catheter 0.0 103050 2784
GK heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16.0 days 7 279.0 beats/min 17.0 44.98 vascular transducer tipped catheter 0.0 103054 2784
ACI.FHH-(rgdv393055223-rs107095981)/Mcwi urine total protein excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. total urine protein amount male 91.0 days 5 188.71 mg/d 20.03 44.79 urine protein analysis 0.0 unx 56 days rf-1-3 100054 2400
ACI.FHH-(rs198076037-rs105278863)/Mcwi urine total protein excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. total urine protein amount male 91.0 days 5 154.55 mg/d 13.31 29.76 urine protein analysis 0.0 unx 56 days rf-1-7 100058 2400
SS/JrHsdMcwi ratio of change in renal blood flow rate to kidney weight controlled sodium content diet (0.4 %) (for 16 hours) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renal blood flow trait female 97.0 days-101.0 days 9 1.9 ml/min/g 0.5 1.5 electromagnetic flowmetry 0.0 electromagnetic flowmetry 67310 151
LEW/Cub diastolic blood pressure losartan (10 mg/kg) (for 0.2 hours) then pentolinium (5 mg/kg) (for 0.1 hours) then NG-nitroarginine methyl ester (30 mg/kg) (for 0.3 hours) Ueno T, et al., Physiol Res 2003;52(6):689-700. arterial blood pressure trait not specified  days 9 continuous mean 82.5 mmHg vascular indwelling catheter method 65392 568
SS.MNS-(D2Mit6-D2Rat303)/Ayd receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98.0 days 13 26.63 % 4.0 14.42 tissue force analysis utilizing a force transducer 0.0 isometric force transducer 69070 1096
SS/Jr blood vessel contractile force measurement Kreb's solution perfusate then potassium chloride solution (40 mmol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98.0 days 12 1.39 g 0.06 0.21 tissue force analysis utilizing a force transducer 0.0 isometric force transducer 69050 1096
SS.MNS-(D2Mit6-D2Rat303)/Ayd logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then phenylephrine (1-100 mmol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98.0 days 13 -7.41 null 0.16 0.58 tissue force analysis utilizing a force transducer 0.0 isometric force transducer EC50 value is probably moles/liter 69059 1096
ACI.FHH-(D1Rat384-D1Rat156)/Eur body weight NG-nitroarginine methyl ester (9-16 mg/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. body mass not specified 168.0 days-175.0 days 12 292.0 g 5.0 17.32 body weighing method 0.0 67936 832
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 137.4 mmHg 4.0 18.33 vascular indwelling catheter method left femoral artery 120.0 69545 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 9 serial mean 159.0 mmHg 7.1 21.3 vascular indwelling catheter method left femoral artery 120.0 69546 151
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112.0 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 92.95 % 1.46 3.58 wire myography mesenteric artery 0.0 69623 735
ACI.FHH-(D1Rat475-D1Rat90)(D3Rat84-D3Rat59)/Eur body weight right nephrectomy then NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 body mass male 168.0 days-175.0 days 5 263.0 g 12.0 26.83 body weighing method 0.0 67707 62
ACI.FHH-(D1Rat298-D1Rat90)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 kidney glomerulus integrity trait male 168.0 days-175.0 days 12 23.0 % 2.0 6.93 ex vivo light microscopy 0.0 67715 62
ACI.FHH-(D1Rat475-D1Rat90)(D3Rat84-D3Rat59)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 kidney glomerulus integrity trait male 168.0 days-175.0 days 12 31.0 % 6.0 20.78 ex vivo light microscopy 0.0 67716 62
ACI.FHH-(D1Rat298-D1Rat90)/Eur creatinine clearance to body weight ratio NG-nitroarginine methyl ester (50-150 mg/l) Van Dijk SJ, et al., Kidney Int. 2006 glomerular filtration trait male 168.0 days-175.0 days 12 0.49 ml/min/100g 0.01 0.03 blood creatinine analysis 0.0 67733 62
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112.0 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 -16.62 % 7.27 17.81 wire myography aorta 0.0 84659 735
GK mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16.0 days 7 undefined 140.0 mmHg 8.0 21.17 vascular transducer tipped catheter 0.0 103030 2784
GK heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16.0 days 5 252.0 beats/min 25.0 55.9 vascular transducer tipped catheter 0.0 103053 2784
ACI.FHH-(rgdv393055223-rs198076037)/Mcwi urine total protein excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. total urine protein amount male 91.0 days 7 67.24 mg/d 4.02 10.64 urine protein analysis 0.0 unx 56 days rf-1-5 100056 2400
ACI.FHH-(rs105487995-rs105373896)/Mcwi urine albumin excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. urine albumin amount male 91.0 days 8 18.95 mg/d 2.93 8.29 urine albumin analysis 0.0 unx 56 days rf-1-1 100060 2400
ACI.FHH-(rgdv393055223-rs198922144)/Mcwi urine albumin excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. urine albumin amount male 91.0 days 7 74.0 mg/d 8.91 23.57 urine albumin analysis 0.0 unx 56 days rf-1-4 100063 2400
ACI.FHH-(rs198076037-rs105278863)/Mcwi urine albumin excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. urine albumin amount male 91.0 days 5 69.44 mg/d 7.49 16.75 urine albumin analysis 0.0 unx 56 days rf-1-7 100066 2400