| ACI/SegHsd |
mammary tumor number |
17 beta-estradiol (27.5 mg) (between 193 and 199 days) |
Schaffer BS, et al., Cancer Res. 2006 Aug 1;66(15):7793-800 |
mammary gland integrity trait |
female |
143.0 days-259.0 days |
22 |
|
8.8 |
null |
1.4 |
6.57 |
manual palpation method |
|
0.0 |
crystalline implant |
|
|
|
11382 |
81 |
| ACI/SegHsd |
post-insult time to mammary tumor formation |
17 beta-estradiol (27.5 mg) (between 99 and 197 days) |
Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 |
mammary gland integrity trait |
female |
160.0 days-260.0 days |
21 |
serial mean |
145.0 |
d |
|
|
manual palpation method |
mammary gland |
0.0 |
|
|
|
|
66104 |
76 |
| ACI/SegHsd |
post-insult time to mammary tumor formation |
17 beta-estradiol (27.5 mg) (between 99 and 197 days) |
Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 |
mammary gland integrity trait |
female |
160.0 days-260.0 days |
21 |
median |
143.0 |
d |
|
|
manual palpation method |
mammary gland |
0.0 |
|
|
|
|
66111 |
76 |
| ACI/SegHsd |
mammary tumor number |
17 beta-estradiol (27.5 mg) (for 196 days) |
Kurz SG, et al., Endocrinology. 2008 Apr 17 |
mammary gland integrity trait |
female |
259.0 days
| 21 |
|
7.0 |
null |
1.16 |
5.3 |
necropsy |
|
|
|
|
|
|
11368 |
75 |
| ACI/SegHsd |
post-insult time to mammary tumor formation |
17 beta-estradiol (27.5 mg) (for 196 days) |
Kurz SG, et al., Endocrinology. 2008 Apr 17 |
mammary gland integrity trait |
female |
days-259.0 days |
21 |
|
145.0 |
d |
|
|
manual palpation method |
|
0 |
|
|
|
median |
11375 |
75 |
| ACI/SegHsd |
post-insult time to mammary tumor formation |
17 beta-estradiol (27.5 mg) (between 147 and 195 days) |
Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 |
mammary gland integrity trait |
female |
206.0 days-264.0 days |
31 |
|
141.0 |
d |
4.85 |
27.0 |
manual palpation method |
|
|
|
|
|
mean |
11748 |
144 |
| ACI/SegHsd |
post-insult time to mammary tumor formation |
17 beta-estradiol (27.5 mg) (between 193 and 199 days) |
Schaffer BS, et al., Cancer Res. 2006 Aug 1;66(15):7793-800 |
mammary gland integrity trait |
female |
143.0 days-259.0 days |
22 |
median |
133.0 |
d |
|
|
manual palpation method |
|
0 |
crystalline implant |
|
|
|
65763 |
81 |
| ACI/SegHsd |
binary logarithm of pituitary gland wet weight |
surgical implantation then 17 beta-estradiol (27.5 mg) (between 193 and 199 days) |
Shull JD, et al., Mamm Genome. 2007 Sep 18;. |
pituitary gland mass |
female |
252.0 days-266.0 days |
9 |
|
7.15 |
null |
0.12 |
0.36 |
post excision weight measurement |
pituitary gland |
0 |
|
|
|
logarithm of pituitary wet weight |
65770 |
331 |
| ACI/SegHsd |
percentage of study population developing pituitary tumors during a period of time |
17 beta-estradiol (27.5 mg) (between 146 and 202 days) |
Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 |
pituitary gland integrity trait |
female |
207.0 days-265.0 days |
21 |
|
100.0 |
% |
|
|
ex vivo visual assessment |
|
0 |
|
|
|
|
65551 |
76 |
| ACI/SegHsd |
percentage of study population developing mammary tumors during a period of time |
bilateral ovariectomy then 17 beta-estradiol (27.5 mg) (for 140 days) |
Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 |
mammary gland integrity trait |
female |
201.0 days-203.0 days |
11 |
|
0.0 |
% |
|
|
manual palpation method |
mammary gland |
0 |
|
|
|
|
11379 |
76 |
| ACI/SegHsd |
percentage of study population developing mammary tumors during a period of time |
17 beta-estradiol (27.5 mg) (between 147 and 195 days) |
Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 |
mammary gland integrity trait |
female |
206.0 days-264.0 days |
31 |
|
100.0 |
% |
|
|
manual palpation method |
|
0 |
|
|
|
mean |
66112 |
144 |
| ACI/SegHsd |
percentage of study population developing mammary tumors during a period of time |
17 beta-estradiol (27.5 mg) (for 197 days) |
Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 |
mammary gland integrity trait |
female |
160.0 days-260.0 days |
21 |
|
100.0 |
% |
|
|
manual palpation method |
mammary gland |
0 |
|
|
|
|
65549 |
76 |
| ACI/SegHsd |
pituitary gland wet weight |
surgical implantation then 17 beta-estradiol (27.5 mg) (between 193 and 199 days) |
Shull JD, et al., Mamm Genome. 2007 Sep 18;. |
pituitary gland mass |
female |
252.0 days-266.0 days |
9 |
|
0.15 |
g |
0.01 |
0.04 |
post excision weight measurement |
pituitary gland |
0 |
|
|
|
|
13093 |
331 |
| ACI/SegHsd |
percentage of study population developing mammary tumors during a period of time |
17 beta-estradiol (27.5 mg) (between 193 and 199 days) |
Schaffer BS, et al., Cancer Res. 2006 Aug 1;66(15):7793-800 |
mammary gland integrity trait |
female |
143.0 days-259.0 days |
22 |
|
94.0 |
% |
|
|
manual palpation method |
|
0 |
crystalline implant |
|
|
|
65764 |
81 |
| ACI/SegHsd |
percentage of study population developing pituitary tumors during a period of time |
bilateral ovariectomy then 17 beta-estradiol (27.5 mg) (for 140 days) |
Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 |
pituitary gland integrity trait |
female |
201.0 days-203.0 days |
11 |
|
100.0 |
% |
|
|
ex vivo visual assessment |
|
0 |
|
|
|
|
65561 |
76 |
| ACI/SegHsd |
mammary tumor number |
17 beta-estradiol (27.5 mg) (between 99 and 197 days) |
Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 |
mammary gland integrity trait |
female |
160.0 days-260.0 days |
20 |
|
5.6 |
null |
|
|
necropsy |
|
0.0 |
|
|
tumor size reach 1-1.5 cm |
|
11377 |
76 |
| ACI/SegHsd |
post-insult time to mammary tumor formation |
17 beta-estradiol (27.5 mg) (between 193 and 199 days) |
Schaffer BS, et al., Cancer Res. 2006 Aug 1;66(15):7793-800 |
mammary gland integrity trait |
female |
143.0 days-259.0 days |
22 |
|
136.0 |
d |
6.0 |
28.14 |
manual palpation method |
|
0.0 |
crystalline implant |
|
|
|
11383 |
81 |
| ACI/SegHsd |
post-insult time to mammary tumor formation |
17 beta-estradiol (27.5 mg) (between 147 and 195 days) |
Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 |
mammary gland integrity trait |
female |
206.0 days-264.0 days |
31 |
median |
140.0 |
d |
|
|
manual palpation method |
|
|
|
|
|
median |
11750 |
144 |
| ACI/SegHsd |
mammary tumor number |
17 beta-estradiol (27.5 mg) (between 144 and 195 days) |
Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 |
mammary gland integrity trait |
female |
203.0 days-264.0 days |
34 |
|
3.9 |
null |
0.6 |
3.5 |
manual palpation method |
|
0 |
|
|
|
|
11752 |
144 |