| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
78.0 days
| 19 |
35.0 |
U/l |
1.49 |
6.5 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85429 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
133.0 days
| 19 |
13.4 |
U/l |
0.3 |
1.3 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85453 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
4.37 |
g/d/100g |
0.23 |
0.66 |
unspecified method |
0.0 |
|
|
|
|
on days 74-77 |
85510 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (500 mg/kg) (for 1 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
71.0 days
| 8 |
375.0 |
g |
6.36 |
18.0 |
body weighing method |
0.0 |
|
|
|
|
|
85520 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 1 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
71.0 days
| 8 |
287.0 |
g |
5.3 |
15.0 |
body weighing method |
0.0 |
|
|
|
|
|
85523 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
168.0 days
| 8 |
447.0 |
g |
16.62 |
47.0 |
body weighing method |
0.0 |
|
|
|
|
|
85552 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 19 |
17.2 |
g/d |
0.6 |
2.6 |
unspecified method |
0.0 |
|
|
|
|
|
85293 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 19 |
20.1 |
g/d |
0.5 |
2.2 |
unspecified method |
0.0 |
|
|
|
|
|
85295 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 19 |
5.78 |
g/d/100g |
0.1 |
0.42 |
unspecified method |
0.0 |
|
|
|
|
|
85300 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
147.0 days
| 19 |
430.0 |
g |
5.96 |
26.0 |
body weighing method |
0.0 |
|
|
|
|
|
85319 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
78.0 days
| 19 |
130.0 |
mg/dl |
1.84 |
8.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85324 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
168.0 days
| 19 |
444.0 |
g |
6.65 |
29.0 |
body weighing method |
0.0 |
|
|
|
|
|
85321 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
70.0 days
| 19 |
0.54 |
mg/dl |
0.03 |
0.15 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85338 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
70.0 days
| 19 |
20.5 |
mg/dl |
1.81 |
7.9 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85354 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
133.0 days
| 19 |
30.2 |
mg/dl |
2.87 |
12.5 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85365 |
1604 |
| Crl:CD(SD) |
urine creatine excretion rate |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatine amount |
male |
70.0 days
| 19 |
1.67 |
umol/d |
0.05 |
0.22 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85378 |
1604 |
| Crl:CD(SD) |
urine creatine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatine amount |
male |
106.0 days
| 19 |
1.71 |
umol/d |
0.09 |
0.39 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85381 |
1604 |
| Crl:CD(SD) |
urine taurine excretion rate |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine taurine amount |
male |
106.0 days
| 19 |
137.6 |
umol/d |
8.44 |
36.8 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85396 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
70.0 days
| 19 |
60.7 |
U/l |
1.19 |
5.2 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85410 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
70.0 days
| 19 |
61.8 |
U/l |
1.26 |
5.5 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85411 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
78.0 days
| 19 |
61.0 |
U/l |
2.09 |
9.1 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85412 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
133.0 days
| 19 |
57.1 |
U/l |
2.18 |
9.5 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85420 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
78.0 days
| 19 |
13.7 |
U/l |
0.48 |
2.1 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85444 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
18.3 |
g/d |
1.98 |
5.6 |
unspecified method |
0.0 |
|
|
|
|
|
85486 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (300 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
4.05 |
g/d/100g |
0.08 |
0.24 |
unspecified method |
0.0 |
|
|
|
|
on days 95-98 |
85513 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 1 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
71.0 days
| 8 |
287.0 |
g |
6.72 |
19.0 |
body weighing method |
0.0 |
|
|
|
|
|
85522 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (500 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
168.0 days
| 8 |
564.0 |
g |
15.2 |
43.0 |
body weighing method |
0.0 |
|
|
|
|
|
85550 |
1604 |
| Crl:CD(SD) |
liver wet weight |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver mass |
male |
170.0 days
| 8 |
12.8 |
g |
0.22 |
0.61 |
unspecified method |
0.0 |
|
|
|
|
|
85559 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
22.1 |
g/d |
0.71 |
2.0 |
unspecified method |
0.0 |
|
|
|
|
|
85474 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
4.03 |
g/d/100g |
0.29 |
0.81 |
unspecified method |
0.0 |
|
|
|
|
on days 74-77 |
85511 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (300 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
105.0 days
| 8 |
477.0 |
g |
7.42 |
21.0 |
body weighing method |
0.0 |
|
|
|
|
|
85531 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level area under curve |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
500.6 |
(ug/ml) x h |
64.42 |
182.2 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
4-19 hr dosing |
4-19 hr dosing |
85589 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 19 |
6.11 |
g/d/100g |
0.1 |
0.45 |
unspecified method |
0.0 |
|
|
|
|
|
85301 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
84.0 days
| 19 |
419.0 |
g |
8.72 |
38.0 |
body weighing method |
0.0 |
|
|
|
|
|
85312 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
105.0 days
| 19 |
121.0 |
mg/dl |
1.61 |
7.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85329 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
105.0 days
| 19 |
0.49 |
mg/dl |
0.02 |
0.1 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85344 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
147.0 days
| 19 |
0.68 |
mg/dl |
0.1 |
0.42 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85351 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
147.0 days
| 19 |
0.47 |
mg/dl |
0.05 |
0.21 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85350 |
1604 |
| Crl:CD(SD) |
urine creatine excretion rate |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatine amount |
male |
169.0 days
| 19 |
2.11 |
umol/d |
0.11 |
0.48 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85384 |
1604 |
| Crl:CD(SD) |
urine creatinine excretion rate |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatinine amount |
male |
70.0 days
| 19 |
9.72 |
mg/d |
0.23 |
1.0 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85386 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
133.0 days
| 19 |
57.6 |
U/l |
1.58 |
6.9 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85421 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
78.0 days
| 19 |
33.9 |
U/l |
0.83 |
3.6 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85428 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
168.0 days
| 19 |
12.8 |
U/l |
0.69 |
3.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85457 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
16.7 |
g/d |
0.95 |
2.7 |
unspecified method |
0.0 |
|
|
|
|
|
85469 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
6.04 |
g/d/100g |
0.21 |
0.58 |
unspecified method |
0.0 |
|
|
|
|
on days 11-14 |
85492 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level area under curve |
standard diet then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
893.3 |
(ug/ml) x h |
44.55 |
126.0 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
4-19 hr dosing |
4-19 hr dosing |
85587 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
88.0 |
ug/ml |
3.89 |
11.0 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
240 |
min |
|
4 hr after dosing |
85578 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
147.0 days
| 19 |
16.1 |
U/l |
0.69 |
3.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85454 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
16.6 |
g/d |
0.95 |
2.7 |
unspecified method |
0.0 |
|
|
|
|
|
85487 |
1604 |
| Crl:CD(SD) |
liver wet weight |
standard diet then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver mass |
male |
170.0 days
| 8 |
20.3 |
g |
0.7 |
1.98 |
unspecified method |
0.0 |
|
|
|
|
liver weight not available |
85556 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 19 |
19.4 |
g/d |
0.87 |
3.8 |
unspecified method |
0.0 |
|
|
|
|
|
85297 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 19 |
4.74 |
g/d/100g |
0.11 |
0.5 |
unspecified method |
0.0 |
|
|
|
|
|
85304 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 19 |
4.62 |
g/d/100g |
0.13 |
0.56 |
unspecified method |
0.0 |
|
|
|
|
|
85305 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
147.0 days
| 19 |
129.0 |
mg/dl |
0.92 |
4.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85334 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
105.0 days
| 19 |
15.0 |
mg/dl |
0.48 |
2.1 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85360 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
91.0 days
| 19 |
18.8 |
mg/dl |
0.53 |
2.3 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85358 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
78.0 days
| 19 |
18.7 |
mg/dl |
1.28 |
5.6 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85357 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
78.0 days
| 19 |
21.1 |
mg/dl |
1.08 |
4.7 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85356 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
147.0 days
| 19 |
17.0 |
mg/dl |
1.24 |
5.4 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85366 |
1604 |
| Crl:CD(SD) |
urine creatinine excretion rate |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatinine amount |
male |
134.0 days
| 19 |
16.46 |
mg/d |
0.22 |
0.97 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85390 |
1604 |
| Crl:CD(SD) |
urine creatinine excretion rate |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatinine amount |
male |
169.0 days
| 19 |
14.95 |
mg/d |
0.54 |
2.38 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85392 |
1604 |
| Crl:CD(SD) |
liver reduced glutathione level to liver weight ratio |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 19 |
7.12 |
umol/g |
0.07 |
0.31 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
reduced liver glutathione level to liver weight ratio |
85406 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
105.0 days
| 19 |
34.0 |
U/l |
1.35 |
5.9 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85433 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (500 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
22.8 |
g/d |
0.71 |
2.0 |
unspecified method |
0.0 |
|
|
|
|
|
85484 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (500 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
5.12 |
g/d/100g |
0.15 |
0.42 |
unspecified method |
0.0 |
|
|
|
|
on days 32-35 |
85496 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
84.0 days
| 8 |
333.0 |
g |
8.13 |
23.0 |
body weighing method |
0.0 |
|
|
|
|
|
85528 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
105.0 days
| 8 |
375.0 |
g |
12.73 |
36.0 |
body weighing method |
0.0 |
|
|
|
|
|
85534 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
105.0 days
| 8 |
365.0 |
g |
6.36 |
18.0 |
body weighing method |
0.0 |
|
|
|
|
|
85535 |
1604 |
| Crl:CD(SD) |
liver reduced glutathione level to liver weight ratio |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
5.19 |
umol/g |
0.24 |
0.69 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
|
85571 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
70.0 days
| 19 |
143.0 |
mg/dl |
1.38 |
6.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85322 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
119.0 days
| 19 |
0.94 |
mg/dl |
0.09 |
0.39 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85347 |
1604 |
| Crl:CD(SD) |
urine creatinine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatinine amount |
male |
70.0 days
| 19 |
7.64 |
mg/d |
0.27 |
1.17 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85387 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 19 |
24.8 |
g/d |
0.53 |
2.3 |
unspecified method |
0.0 |
|
|
|
|
|
85294 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
78.0 days
| 19 |
126.0 |
mg/dl |
2.06 |
9.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85325 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
119.0 days
| 19 |
129.0 |
mg/dl |
2.29 |
10.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85330 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
168.0 days
| 19 |
0.56 |
mg/dl |
0.03 |
0.15 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85353 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
91.0 days
| 19 |
25.2 |
mg/dl |
2.09 |
9.1 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85359 |
1604 |
| Crl:CD(SD) |
plasma creatinine level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood creatinine amount |
male |
133.0 days
| 19 |
0.37 |
mg/dl |
0.0 |
0.02 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85374 |
1604 |
| Crl:CD(SD) |
urine taurine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine taurine amount |
male |
106.0 days
| 19 |
142.0 |
umol/d |
12.64 |
55.1 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85397 |
1604 |
| Crl:CD(SD) |
urine taurine excretion rate |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine taurine amount |
male |
134.0 days
| 19 |
141.5 |
umol/d |
12.76 |
55.6 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85398 |
1604 |
| Crl:CD(SD) |
urine taurine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine taurine amount |
male |
169.0 days
| 19 |
153.1 |
umol/d |
7.75 |
33.8 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85401 |
1604 |
| Crl:CD(SD) |
urine taurine excretion rate |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine taurine amount |
male |
169.0 days
| 19 |
129.3 |
umol/d |
8.3 |
36.2 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85400 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
91.0 days
| 19 |
33.3 |
U/l |
0.87 |
3.8 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85430 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
168.0 days
| 19 |
33.2 |
U/l |
1.1 |
4.8 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85441 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
70.0 days
| 19 |
14.3 |
U/l |
0.55 |
2.4 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85442 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
1.1 |
ug/ml |
0.32 |
0.9 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
|
19 hr after dosing |
85583 |
1604 |
| Crl:CD(SD) |
liver reduced glutathione level to liver weight ratio |
standard diet then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
9.16 |
umol/g |
0.18 |
0.5 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
reduced liver glutathione level to liver weight ratio |
85567 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (300 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
84.0 days
| 8 |
418.0 |
g |
6.72 |
19.0 |
body weighing method |
0.0 |
|
|
|
|
|
85525 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
147.0 days
| 8 |
432.0 |
g |
17.32 |
49.0 |
body weighing method |
0.0 |
|
|
|
|
|
85546 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
168.0 days
| 19 |
48.1 |
U/l |
0.69 |
3.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85425 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
3.96 |
g/d/100g |
0.35 |
0.98 |
unspecified method |
0.0 |
|
|
|
|
on days 95-98 |
85516 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 19 |
17.0 |
g/d |
0.73 |
3.2 |
unspecified method |
0.0 |
|
|
|
|
|
85292 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 19 |
5.36 |
g/d/100g |
0.15 |
0.65 |
unspecified method |
0.0 |
|
|
|
|
|
85303 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
126.0 days
| 19 |
526.0 |
g |
13.31 |
58.0 |
body weighing method |
0.0 |
|
|
|
|
|
85316 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
105.0 days
| 19 |
374.0 |
g |
5.28 |
23.0 |
body weighing method |
0.0 |
|
|
|
|
|
85315 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 19 |
4.44 |
g/d/100g |
0.06 |
0.28 |
unspecified method |
0.0 |
|
|
|
|
|
85306 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
133.0 days
| 19 |
134.0 |
mg/dl |
1.15 |
5.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85332 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
78.0 days
| 19 |
0.69 |
mg/dl |
0.15 |
0.64 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85341 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
133.0 days
| 19 |
17.4 |
mg/dl |
0.85 |
3.7 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85364 |
1604 |
| Crl:CD(SD) |
plasma creatinine level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood creatinine amount |
male |
105.0 days
| 19 |
0.38 |
mg/dl |
0.0 |
0.02 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85372 |
1604 |
| Crl:CD(SD) |
plasma creatinine level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood creatinine amount |
male |
105.0 days
| 19 |
0.41 |
mg/dl |
0.01 |
0.03 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85373 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
147.0 days
| 19 |
19.4 |
mg/dl |
0.78 |
3.4 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85367 |
1604 |
| Crl:CD(SD) |
urine taurine excretion rate |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine taurine amount |
male |
70.0 days
| 19 |
68.7 |
umol/d |
8.69 |
37.9 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85394 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
119.0 days
| 19 |
37.8 |
U/l |
0.87 |
3.8 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85434 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
20.3 |
g/d |
1.06 |
3.0 |
unspecified method |
0.0 |
|
|
|
|
|
85462 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (300 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
24.1 |
g/d |
0.53 |
1.5 |
unspecified method |
0.0 |
|
|
|
|
|
85459 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
18.8 |
g/d |
0.92 |
2.6 |
unspecified method |
0.0 |
|
|
|
|
|
85463 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (300 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
23.4 |
g/d |
0.42 |
1.2 |
unspecified method |
0.0 |
|
|
|
|
|
85483 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (300 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
5.74 |
g/d/100g |
0.1 |
0.29 |
unspecified method |
0.0 |
|
|
|
|
on days 11-14 |
85489 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (300 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
5.2 |
g/d/100g |
0.07 |
0.21 |
unspecified method |
0.0 |
|
|
|
|
on days 32-35 |
85495 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (500 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
4.53 |
g/d/100g |
0.13 |
0.36 |
unspecified method |
0.0 |
|
|
|
|
on days 53-56 |
85502 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
4.38 |
g/d/100g |
0.31 |
0.87 |
unspecified method |
0.0 |
|
|
|
|
on days 53-56 |
85504 |
1604 |
| Crl:CD(SD) |
liver wet weight |
standard diet then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver mass |
male |
170.0 days
| 8 |
20.1 |
g |
0.47 |
1.33 |
unspecified method |
0.0 |
|
|
|
|
liver weight not available |
85555 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level area under curve |
standard diet then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
662.2 |
(ug/ml) x h |
28.35 |
80.2 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
4-19 hr dosing |
4-19 hr dosing |
85586 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
2.4 |
ug/ml |
0.71 |
2.0 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
|
19 hr after dosing |
85585 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level area under curve |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
373.9 |
(ug/ml) x h |
38.93 |
110.1 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
4-19 hr dosing |
4-19 hr dosing |
85588 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
133.0 days
| 19 |
0.55 |
mg/dl |
0.03 |
0.12 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85348 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
119.0 days
| 19 |
0.61 |
mg/dl |
0.02 |
0.08 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85346 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 19 |
4.07 |
g/d/100g |
0.05 |
0.2 |
unspecified method |
0.0 |
|
|
|
|
|
85308 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
84.0 days
| 19 |
328.0 |
g |
4.82 |
21.0 |
body weighing method |
0.0 |
|
|
|
|
|
85313 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
168.0 days
| 19 |
131.0 |
mg/dl |
1.61 |
7.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85336 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
91.0 days
| 19 |
1.0 |
mg/dl |
0.08 |
0.35 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85343 |
1604 |
| Crl:CD(SD) |
urine creatine excretion rate |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatine amount |
male |
134.0 days
| 19 |
2.44 |
umol/d |
0.08 |
0.37 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85382 |
1604 |
| Crl:CD(SD) |
urine creatine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatine amount |
male |
169.0 days
| 19 |
2.06 |
umol/d |
0.12 |
0.51 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85385 |
1604 |
| Crl:CD(SD) |
urine taurine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine taurine amount |
male |
134.0 days
| 19 |
171.1 |
umol/d |
13.08 |
57.0 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85399 |
1604 |
| Crl:CD(SD) |
liver wet weight |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver mass |
male |
170.0 days
| 19 |
17.65 |
g |
0.54 |
2.35 |
unspecified method |
0.0 |
|
|
|
|
liver weight not available |
85402 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
168.0 days
| 19 |
37.3 |
U/l |
0.96 |
4.2 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85440 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (300 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
24.3 |
g/d |
0.32 |
0.9 |
unspecified method |
0.0 |
|
|
|
|
|
85477 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
4.9 |
g/d/100g |
0.18 |
0.5 |
unspecified method |
0.0 |
|
|
|
|
on days 32-35 |
85499 |
1604 |
| Crl:CD(SD) |
liver oxidized glutathione level to liver weight ratio |
standard diet then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
0.19 |
umol/g |
0.01 |
0.03 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
reduced liver glutathione level to liver weight ratio |
85574 |
1604 |
| Crl:CD(SD) |
liver wet weight |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver mass |
male |
170.0 days
| 8 |
12.2 |
g |
0.77 |
2.17 |
unspecified method |
0.0 |
|
|
|
|
|
85558 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
70.0 days
| 19 |
35.3 |
U/l |
1.03 |
4.5 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85427 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
105.0 days
| 19 |
13.5 |
U/l |
0.21 |
0.9 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85449 |
1604 |
| Crl:CD(SD) |
liver oxidized glutathione level to liver weight ratio |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
0.16 |
umol/g |
0.01 |
0.03 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
|
85576 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
105.0 days
| 19 |
14.7 |
U/l |
0.64 |
2.8 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85448 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (500 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
24.5 |
g/d |
0.32 |
0.9 |
unspecified method |
0.0 |
|
|
|
|
|
85478 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
6.04 |
g/d/100g |
0.23 |
0.66 |
unspecified method |
0.0 |
|
|
|
|
on days 11-14 |
85493 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (500 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
84.0 days
| 8 |
413.0 |
g |
6.01 |
17.0 |
body weighing method |
0.0 |
|
|
|
|
|
85526 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 19 |
17.2 |
g/d |
0.83 |
3.6 |
unspecified method |
0.0 |
|
|
|
|
|
85299 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 19 |
5.28 |
g/d/100g |
0.06 |
0.24 |
unspecified method |
0.0 |
|
|
|
|
|
85302 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
71.0 days
| 19 |
373.0 |
g |
4.59 |
20.0 |
body weighing method |
0.0 |
|
|
|
|
|
85310 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
105.0 days
| 19 |
481.0 |
g |
11.7 |
51.0 |
body weighing method |
0.0 |
|
|
|
|
|
85314 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
126.0 days
| 19 |
401.0 |
g |
4.82 |
21.0 |
body weighing method |
0.0 |
|
|
|
|
|
85317 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
70.0 days
| 19 |
0.57 |
mg/dl |
0.04 |
0.18 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85339 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
119.0 days
| 19 |
19.8 |
mg/dl |
0.87 |
3.8 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85362 |
1604 |
| Crl:CD(SD) |
urine creatine excretion rate |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatine amount |
male |
106.0 days
| 19 |
2.22 |
umol/d |
0.07 |
0.31 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85380 |
1604 |
| Crl:CD(SD) |
urine creatine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatine amount |
male |
70.0 days
| 19 |
1.05 |
umol/d |
0.04 |
0.19 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85379 |
1604 |
| Crl:CD(SD) |
urine creatinine excretion rate |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatinine amount |
male |
106.0 days
| 19 |
13.78 |
mg/d |
0.28 |
1.21 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85388 |
1604 |
| Crl:CD(SD) |
urine creatinine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatinine amount |
male |
134.0 days
| 19 |
12.5 |
mg/d |
0.25 |
1.11 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85391 |
1604 |
| Crl:CD(SD) |
urine creatinine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatinine amount |
male |
169.0 days
| 19 |
12.28 |
mg/d |
0.58 |
2.51 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85393 |
1604 |
| Crl:CD(SD) |
liver reduced glutathione level to liver weight ratio |
standard diet and restricted feeding (4 h) (for 114 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 19 |
6.1 |
umol/g |
0.15 |
0.67 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
|
85407 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
91.0 days
| 19 |
59.7 |
U/l |
0.8 |
3.5 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85415 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
105.0 days
| 19 |
58.0 |
U/l |
2.39 |
10.4 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85416 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
105.0 days
| 19 |
58.4 |
U/l |
1.06 |
4.6 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85417 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
91.0 days
| 19 |
35.4 |
U/l |
1.49 |
6.5 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85431 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
78.0 days
| 19 |
17.9 |
U/l |
1.61 |
7.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85445 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
91.0 days
| 19 |
14.4 |
U/l |
1.19 |
5.2 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85446 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
91.0 days
| 19 |
15.5 |
U/l |
0.62 |
2.7 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85447 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
119.0 days
| 19 |
15.0 |
U/l |
0.55 |
2.4 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85451 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
147.0 days
| 19 |
13.4 |
U/l |
0.41 |
1.8 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85455 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (500 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
24.7 |
g/d |
0.46 |
1.3 |
unspecified method |
0.0 |
|
|
|
|
|
85460 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
18.2 |
g/d |
1.13 |
3.2 |
unspecified method |
0.0 |
|
|
|
|
|
85468 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
5.09 |
g/d/100g |
0.24 |
0.67 |
unspecified method |
0.0 |
|
|
|
|
on days 32-35 |
85498 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (300 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
4.7 |
g/d/100g |
0.06 |
0.17 |
unspecified method |
0.0 |
|
|
|
|
on days 53-56 |
85501 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (300 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
4.09 |
g/d/100g |
0.45 |
1.28 |
unspecified method |
0.0 |
|
|
|
|
on days 74-77 |
85507 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (500 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
4.49 |
g/d/100g |
0.08 |
0.23 |
unspecified method |
0.0 |
|
|
|
|
on days 74-77 |
85508 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
4.23 |
g/d/100g |
0.27 |
0.77 |
unspecified method |
0.0 |
|
|
|
|
on days 53-56 |
85505 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (300 mg/kg) (for 1 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
71.0 days
| 8 |
371.0 |
g |
5.66 |
16.0 |
body weighing method |
0.0 |
|
|
|
|
|
85519 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
84.0 days
| 8 |
321.0 |
g |
7.78 |
22.0 |
body weighing method |
0.0 |
|
|
|
|
|
85529 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (300 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
126.0 days
| 8 |
522.0 |
g |
8.13 |
23.0 |
body weighing method |
0.0 |
|
|
|
|
|
85537 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (500 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
126.0 days
| 8 |
516.0 |
g |
12.73 |
36.0 |
body weighing method |
0.0 |
|
|
|
|
|
85538 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
126.0 days
| 8 |
404.0 |
g |
12.37 |
35.0 |
body weighing method |
0.0 |
|
|
|
|
|
85540 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (300 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
147.0 days
| 8 |
557.0 |
g |
8.13 |
23.0 |
body weighing method |
0.0 |
|
|
|
|
|
85543 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (300 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
168.0 days
| 8 |
581.0 |
g |
9.19 |
26.0 |
body weighing method |
0.0 |
|
|
|
|
|
85549 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
133.0 days
| 19 |
0.91 |
mg/dl |
0.1 |
0.43 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85349 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
168.0 days
| 19 |
15.1 |
mg/dl |
0.46 |
2.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85368 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 19 |
24.7 |
g/d |
0.48 |
2.1 |
unspecified method |
0.0 |
|
|
|
|
|
85290 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 19 |
4.01 |
g/d/100g |
0.27 |
1.17 |
unspecified method |
0.0 |
|
|
|
|
|
85309 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 19 |
4.18 |
g/d/100g |
0.19 |
0.84 |
unspecified method |
0.0 |
|
|
|
|
|
85307 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
168.0 days
| 19 |
588.0 |
g |
14.45 |
63.0 |
body weighing method |
0.0 |
|
|
|
|
|
85320 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
91.0 days
| 19 |
124.0 |
mg/dl |
2.29 |
10.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85327 |
1604 |
| Crl:CD(SD) |
plasma creatinine level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood creatinine amount |
male |
70.0 days
| 19 |
0.41 |
mg/dl |
0.0 |
0.02 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85370 |
1604 |
| Crl:CD(SD) |
plasma creatinine level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood creatinine amount |
male |
70.0 days
| 19 |
0.38 |
mg/dl |
0.0 |
0.02 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85371 |
1604 |
| Crl:CD(SD) |
plasma creatinine level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood creatinine amount |
male |
133.0 days
| 19 |
0.41 |
mg/dl |
0.01 |
0.04 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85375 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
91.0 days
| 19 |
56.3 |
U/l |
1.12 |
4.9 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85414 |
1604 |
| Crl:CD(SD) |
liver wet weight |
standard diet and restricted feeding (4 h) (for 114 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver mass |
male |
170.0 days
| 19 |
11.09 |
g |
0.16 |
0.71 |
unspecified method |
0.0 |
|
|
|
|
|
85403 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
119.0 days
| 19 |
36.8 |
U/l |
1.19 |
5.2 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85435 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
133.0 days
| 19 |
17.0 |
U/l |
0.71 |
3.1 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85452 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
118.1 |
ug/ml |
6.43 |
18.2 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
240 |
min |
|
4 hr after dosing |
85579 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
119.0 days
| 19 |
127.0 |
mg/dl |
1.84 |
8.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85331 |
1604 |
| Crl:CD(SD) |
liver reduced glutathione level to liver weight ratio |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
6.24 |
umol/g |
0.31 |
0.87 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
|
85570 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
147.0 days
| 19 |
54.3 |
U/l |
1.26 |
5.5 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85423 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (500 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
24.9 |
g/d |
0.85 |
2.4 |
unspecified method |
0.0 |
|
|
|
|
|
85472 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
18.7 |
g/d |
1.45 |
4.1 |
unspecified method |
0.0 |
|
|
|
|
|
85475 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
147.0 days
| 8 |
431.0 |
g |
8.49 |
24.0 |
body weighing method |
0.0 |
|
|
|
|
|
85547 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
133.0 days
| 19 |
35.9 |
U/l |
0.87 |
3.8 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85436 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
147.0 days
| 19 |
36.4 |
U/l |
0.62 |
2.7 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85438 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
133.0 days
| 19 |
32.4 |
U/l |
0.99 |
4.3 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85437 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
168.0 days
| 19 |
14.3 |
U/l |
0.8 |
3.5 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85456 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (500 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
25.7 |
g/d |
0.28 |
0.8 |
unspecified method |
0.0 |
|
|
|
|
|
85466 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (300 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
24.5 |
g/d |
0.57 |
1.6 |
unspecified method |
0.0 |
|
|
|
|
|
85465 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (300 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
24.6 |
g/d |
0.21 |
0.6 |
unspecified method |
0.0 |
|
|
|
|
|
85471 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
17.9 |
g/d |
1.77 |
5.0 |
unspecified method |
0.0 |
|
|
|
|
|
85480 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (500 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
105.0 days
| 8 |
472.0 |
g |
8.49 |
24.0 |
body weighing method |
0.0 |
|
|
|
|
|
85532 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (500 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
147.0 days
| 8 |
549.0 |
g |
12.73 |
36.0 |
body weighing method |
0.0 |
|
|
|
|
|
85544 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 19 |
23.7 |
g/d |
0.48 |
2.1 |
unspecified method |
0.0 |
|
|
|
|
|
85298 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
147.0 days
| 19 |
563.0 |
g |
13.54 |
59.0 |
body weighing method |
0.0 |
|
|
|
|
|
85318 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
70.0 days
| 19 |
14.7 |
mg/dl |
1.1 |
4.8 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85355 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
119.0 days
| 19 |
33.2 |
mg/dl |
3.4 |
14.8 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85363 |
1604 |
| Crl:CD(SD) |
plasma creatinine level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood creatinine amount |
male |
168.0 days
| 19 |
0.43 |
mg/dl |
0.0 |
0.01 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85376 |
1604 |
| Crl:CD(SD) |
plasma creatinine level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood creatinine amount |
male |
168.0 days
| 19 |
0.46 |
mg/dl |
0.0 |
0.02 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85377 |
1604 |
| Crl:CD(SD) |
urine creatinine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatinine amount |
male |
106.0 days
| 19 |
11.98 |
mg/d |
0.42 |
1.84 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85389 |
1604 |
| Crl:CD(SD) |
urine taurine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine taurine amount |
male |
70.0 days
| 19 |
58.1 |
umol/d |
5.41 |
23.6 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85395 |
1604 |
| Crl:CD(SD) |
liver oxidized glutathione level to liver weight ratio |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 19 |
0.21 |
umol/g |
0.01 |
0.03 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
oxidized liver glutathione level to liver weight ratio |
85408 |
1604 |
| Crl:CD(SD) |
liver oxidized glutathione level to liver weight ratio |
standard diet and restricted feeding (4 h) (for 114 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 19 |
0.17 |
umol/g |
0.0 |
0.02 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
|
85409 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
78.0 days
| 19 |
59.1 |
U/l |
1.28 |
5.6 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85413 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
70.0 days
| 19 |
32.5 |
U/l |
0.71 |
3.1 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85426 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
105.0 days
| 19 |
34.9 |
U/l |
1.1 |
4.8 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85432 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
17.7 |
g/d |
1.31 |
3.7 |
unspecified method |
0.0 |
|
|
|
|
|
85481 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (500 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
5.68 |
g/d/100g |
0.06 |
0.17 |
unspecified method |
0.0 |
|
|
|
|
on days 11-14 |
85490 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
126.0 days
| 8 |
400.0 |
g |
7.78 |
22.0 |
body weighing method |
0.0 |
|
|
|
|
|
85541 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
168.0 days
| 8 |
440.0 |
g |
9.19 |
26.0 |
body weighing method |
0.0 |
|
|
|
|
|
85553 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
0.6 |
ug/ml |
0.21 |
0.6 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
|
19 hr after dosing |
85584 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
168.0 days
| 19 |
128.0 |
mg/dl |
1.84 |
8.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85337 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
78.0 days
| 19 |
0.41 |
mg/dl |
0.03 |
0.11 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85340 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 19 |
24.5 |
g/d |
0.37 |
1.6 |
unspecified method |
0.0 |
|
|
|
|
|
85291 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 19 |
23.9 |
g/d |
0.39 |
1.7 |
unspecified method |
0.0 |
|
|
|
|
|
85296 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
71.0 days
| 19 |
288.0 |
g |
3.67 |
16.0 |
body weighing method |
0.0 |
|
|
|
|
|
85311 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
70.0 days
| 19 |
117.0 |
mg/dl |
1.84 |
8.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85323 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
105.0 days
| 19 |
129.0 |
mg/dl |
1.38 |
6.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85328 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
91.0 days
| 19 |
135.0 |
mg/dl |
1.15 |
5.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85326 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
133.0 days
| 19 |
124.0 |
mg/dl |
1.61 |
7.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85333 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
147.0 days
| 19 |
126.0 |
mg/dl |
1.84 |
8.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85335 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
91.0 days
| 19 |
0.62 |
mg/dl |
0.01 |
0.05 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85342 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
105.0 days
| 19 |
0.81 |
mg/dl |
0.06 |
0.27 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85345 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
168.0 days
| 19 |
0.44 |
mg/dl |
0.01 |
0.06 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85352 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
105.0 days
| 19 |
23.5 |
mg/dl |
2.29 |
10.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85361 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
168.0 days
| 19 |
18.9 |
mg/dl |
1.67 |
7.3 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85369 |
1604 |
| Crl:CD(SD) |
urine creatine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatine amount |
male |
134.0 days
| 19 |
2.0 |
umol/d |
0.13 |
0.57 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85383 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
119.0 days
| 19 |
56.4 |
U/l |
2.13 |
9.3 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85418 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
147.0 days
| 19 |
55.4 |
U/l |
2.25 |
9.8 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85422 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
119.0 days
| 19 |
58.8 |
U/l |
1.54 |
6.7 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85419 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
147.0 days
| 19 |
34.4 |
U/l |
1.31 |
5.7 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85439 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
119.0 days
| 19 |
14.8 |
U/l |
0.89 |
3.9 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85450 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
70.0 days
| 19 |
15.9 |
U/l |
1.17 |
5.1 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85443 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
4.34 |
g/d/100g |
0.34 |
0.96 |
unspecified method |
0.0 |
|
|
|
|
on days 95-98 |
85517 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (500 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
4.24 |
g/d/100g |
0.06 |
0.18 |
unspecified method |
0.0 |
|
|
|
|
on days 95-98 |
85514 |
1604 |
| Crl:CD(SD) |
liver reduced glutathione level to liver weight ratio |
standard diet then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
9.07 |
umol/g |
0.25 |
0.72 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
reduced liver glutathione level to liver weight ratio |
85568 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
0.3 |
ug/ml |
0.18 |
0.5 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
|
19 hr after dosing |
85582 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
64.3 |
ug/ml |
9.72 |
27.5 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
240 |
min |
|
4 hr after dosing |
85581 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
49.3 |
ug/ml |
5.62 |
15.9 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
240 |
min |
|
4 hr after dosing |
85580 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
168.0 days
| 19 |
52.7 |
U/l |
1.26 |
5.5 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85424 |
1604 |
| Crl:CD(SD) |
liver oxidized glutathione level to liver weight ratio |
standard diet then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
0.24 |
umol/g |
0.01 |
0.02 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
reduced liver glutathione level to liver weight ratio |
85573 |
1604 |
| Crl:CD(SD) |
liver oxidized glutathione level to liver weight ratio |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
0.14 |
umol/g |
0.0 |
0.01 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
|
85577 |
1604 |