Phenominer Database Results (45 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Average Type Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 12BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80.0 days-99.0 days 6 0.3 mg/dl 0.02 0.06 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52229 482
SS-Chr 12BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80.0 days-99.0 days 8 19.17 mEq/d 2.94 8.3 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52775 482
SS-Chr 12BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 0.56 g/mg 0.07 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57385 522
SS-Chr 12BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 10 281.1 g 6.6 21.0 whole body digital scale Moms and pups used in studies were fed Teklad 55230 522
SS-Chr 12BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 -7.27 null 0.06 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56156 522
SS-Chr 12BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 9 -7.52 null 0.07 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56164 522
SS-Chr 12BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 83.0 % 4.55 14.38 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54839 522
SS-Chr 12BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 1.16 E-7mole 0.16 0.45 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56571 522
SS-Chr 12BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 -6.81 null 0.06 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56974 522
SS-Chr 12BN/Mcwi mean arterial blood pressure controlled sodium content diet (0.3 %) Prisco SZ, et al., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22. arterial blood pressure trait male 66.0 days-73.0 days 11 serial mean 111.0 mmHg 1.0 3.32 intra-aortic abdominal radiotelemetry 14400.0 abdominal aorta 4 hrs for 3 consecutive days 96870 1719
SS-Chr 12BN/Mcwi artery wall thickness to artery inner diameter ratio controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (140 mmHg) Prisco SZ, et al., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22. mesenteric artery morphology trait male 63.0 days-70.0 days 7 7.8 % 0.4 1.06 unspecified method 0.0 mesenteric artery morphology trait 96879 1719
SS-Chr 12BN/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (between 42 and 49 days) Prisco SZ, et al., Hypertension. 2014 Jul 7. pii: HYPERTENSIONAHA.114.03550. arterial blood pressure trait male 71.0 days-77.0 days 25 109.0 mmHg 1.0 5.0 intra-aortic abdominal radiotelemetry 0.0 96802 1698
SS-Chr 12BN/Mcwi artery wall thickness to artery inner diameter ratio controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (160 mmHg) Prisco SZ, et al., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22. mesenteric artery morphology trait male 63.0 days-70.0 days 7 7.6 % 0.4 1.06 unspecified method 0.0 mesenteric artery morphology trait 96880 1719
SS-Chr 12BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80.0 days-99.0 days 7 162.57 mmHg 8.34 22.07 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52868 482
SS-Chr 12BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80.0 days-99.0 days 6 143.57 mmHg 5.12 12.54 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52873 482
SS-Chr 12BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80.0 days-99.0 days 5 0.88 ng/ml/h 0.15 0.33 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52479 482
SS-Chr 12BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80.0 days-99.0 days 9 347.55 mg/d 54.69 164.06 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52719 482
SS-Chr 12BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80.0 days-99.0 days 9 24.35 mEq/d 2.98 8.95 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52770 482
SS-Chr 12BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 1.01 g/mg 0.13 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57393 522
SS-Chr 12BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 95.75 % 3.71 10.5 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54831 522
SS-Chr 12BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 9 0.03 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54965 522
SS-Chr 12BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 1.72 E-7mole 0.28 0.89 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56579 522
SS-Chr 12BN/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (between 42 and 49 days) then controlled sodium content diet (8 %) (for 21 days) Prisco SZ, et al., Hypertension. 2014 Jul 7. pii: HYPERTENSIONAHA.114.03550. arterial blood pressure trait male 92.0 days-98.0 days 25 148.0 mmHg 2.0 10.0 intra-aortic abdominal radiotelemetry 0.0 96803 1698
SS-Chr 12BN/Mcwi artery wall thickness to artery inner diameter ratio controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (40 mmHg) Prisco SZ, et al., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22. mesenteric artery morphology trait male 63.0 days-70.0 days 7 17.2 % 0.6 1.59 unspecified method 0.0 mesenteric artery morphology trait 96874 1719
SS-Chr 12BN/Mcwi artery wall thickness to artery inner diameter ratio controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (80 mmHg) Prisco SZ, et al., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22. mesenteric artery morphology trait male 63.0 days-70.0 days 7 10.8 % 0.6 1.59 unspecified method 0.0 mesenteric artery morphology trait 96876 1719
SS-Chr 12BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80.0 days-99.0 days 9 1.61 mEq/d 0.08 0.24 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52966 482
SS-Chr 12BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80.0 days-99.0 days 9 160.7 mg/d 27.11 81.32 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52619 482
SS-Chr 12BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80.0 days-99.0 days 8 34.37 mg/d 6.33 17.9 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52624 482
SS-Chr 12BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 -6.96 null 0.06 0.16 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56966 522
SS-Chr 12BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80.0 days-99.0 days 8 1.31 mEq/d 0.06 0.16 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52971 482
SS-Chr 12BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80.0 days-99.0 days 7 358.72 beats/min 9.8 25.93 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52670 482
SS-Chr 12BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80.0 days-99.0 days 6 379.27 beats/min 8.81 21.58 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52675 482
SS-Chr 12BN/Mcwi artery wall thickness to artery inner diameter ratio controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (20 mmHg) Prisco SZ, et al., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22. mesenteric artery morphology trait male 63.0 days-70.0 days 7 22.7 % 0.4 1.06 unspecified method 0.0 mesenteric artery morphology trait 96873 1719
SS-Chr 12BN/Mcwi artery wall thickness to artery inner diameter ratio controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (60 mmHg) Prisco SZ, et al., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22. mesenteric artery morphology trait male 63.0 days-70.0 days 7 13.8 % 0.8 2.12 unspecified method 0.0 mesenteric artery morphology trait 96875 1719
SS-Chr 12BN/Mcwi artery wall thickness to artery inner diameter ratio controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (100 mmHg) Prisco SZ, et al., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22. mesenteric artery morphology trait male 63.0 days-70.0 days 7 9.4 % 0.5 1.32 unspecified method 0.0 mesenteric artery morphology trait 96877 1719
SS-Chr 12BN/Mcwi artery wall thickness to artery inner diameter ratio controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (120 mmHg) Prisco SZ, et al., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22. mesenteric artery morphology trait male 63.0 days-70.0 days 7 8.7 % 0.4 1.06 unspecified method 0.0 mesenteric artery morphology trait 96878 1719
SS-Chr 12BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80.0 days-99.0 days 5 2.85 ml/min 0.21 0.48 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52180 482
SS-Chr 12BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80.0 days-99.0 days 3 2.21 ml/min 0.03 0.06 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52185 482
SS-Chr 12BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80.0 days-99.0 days 3 0.27 mg/dl 0.02 0.04 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52234 482
SS-Chr 12BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80.0 days-99.0 days 7 0.29 ng/ml/h 0.05 0.14 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52474 482
SS-Chr 12BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80.0 days-99.0 days 8 119.08 mg/d 24.74 69.97 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52724 482
SS-Chr 12BN/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (for 77 days) Flister MJ, et al., Hypertension. 2012 Oct;60(4):942-8. doi: 10.1161/HYPERTENSIONAHA.112.198200. Epub 2012 Aug 6. arterial blood pressure trait male 67.0 days-77.0 days 10 serial mean 127.0 mmHg 1.0 3.16 intra-aortic abdominal radiotelemetry 14400.0 abdominal aorta 4 hrs for 3 consecutive days 96862 1718
SS-Chr 12BN/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (for 77 days) then controlled sodium content diet (8 %) (for 7 days) Flister MJ, et al., Hypertension. 2012 Oct;60(4):942-8. doi: 10.1161/HYPERTENSIONAHA.112.198200. Epub 2012 Aug 6. arterial blood pressure trait male 74.0 days-84.0 days 10 serial mean 144.0 mmHg 6.0 18.97 intra-aortic abdominal radiotelemetry 14400.0 abdominal aorta 4 hrs for 3 consecutive days 96863 1718
SS-Chr 12BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 10 188.5 g 3.3 10.3 whole body digital scale Moms and pups used in studies were fed Teklad 55238 522
SS-Chr 12BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 0.06 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54957 522