controlled cilazapril content drinking water (0.16 mg/kg/d) (for 547.5 days)

 controlled cilazapril content drinking water (0.94 mg/kg/d) (for 547.5 days)

 controlled E4177 content drinking water (1.66 mg/kg/d) (for 547.5 days)

 controlled sodium content diet (8 %) (for 42 days) then candesartan (1 mg/kg/d) (for 42 days)

 controlled sodium content diet (8 %) (for 42 days) then cilazapril (10 mg/kg/d) (for 42 days)

 controlled sodium content diet (0.3 %) (for 91 days)

 controlled sodium content diet (8 %) (for 42 days) then 0.9% sodium chloride solution (0.3 ml) (for 42 days)

 vehicle control condition (for 547.5 days)