F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
8 |
-8.21 |
null |
0.1 |
0.29 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
63086 |
528 |
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
4 |
0.01 |
umol/l |
0.0 |
0.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62765 |
528 |
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
4 |
56.5 |
% |
17.75 |
35.49 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62620 |
528 |
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
8 |
2.55 |
E-7mole |
0.6 |
1.69 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
63018 |
528 |
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
4 |
-8.21 |
null |
0.15 |
0.3 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
63088 |
528 |
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
8 |
44.88 |
% |
7.5 |
21.22 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62618 |
528 |
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
4 |
0.83 |
g/mg |
0.22 |
0.44 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
63157 |
528 |
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
8 |
1.15 |
g/mg |
0.15 |
0.41 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
63155 |
528 |
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
8 |
0.01 |
umol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62763 |
528 |
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
4 |
-6.88 |
null |
0.05 |
0.1 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62843 |
528 |
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
8 |
-6.68 |
null |
0.1 |
0.29 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62841 |
528 |
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
4 |
1.34 |
E-7mole |
0.15 |
0.29 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
63020 |
528 |