| FHH/EurMcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70.0 days-84.0 days |
8 |
0.01 |
umol/l |
0.0 |
0.01 |
Download Values
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Teklad |
54688 |
522 |
| FHH/EurMcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70.0 days-84.0 days |
50 |
0.02 |
umol/l |
0.0 |
0.01 |
Download Values
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Teklad |
54707 |
522 |
| FHH/EurMcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70.0 days-84.0 days |
10 |
0.05 |
umol/l |
0.01 |
0.03 |
Download Values
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Dyets |
54987 |
522 |
| FHH/EurMcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70.0 days-84.0 days |
6 |
0.05 |
umol/l |
0.02 |
0.04 |
Download Values
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Dyets |
54993 |
522 |
| FHH/EurMcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70.0 days-84.0 days |
8 |
0.74 |
umol/l |
0.12 |
0.34 |
Download Values
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Dyets |
56876 |
522 |
| FHH/EurMcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70.0 days-84.0 days |
5 |
0.04 |
umol/l |
0.01 |
0.02 |
Download Values
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
55124 |
522 |
| FHH/EurMcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70.0 days-84.0 days |
6 |
0.01 |
umol/l |
0.0 |
0.01 |
Download Values
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
62774 |
528 |
| FHH/EurMcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70.0 days-84.0 days |
119 |
0.01 |
umol/l |
0.0 |
0.02 |
Download Values
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
62785 |
528 |
| FHH/EurMcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70.0 days-84.0 days |
10 |
0.02 |
umol/l |
0.01 |
0.02 |
Download Values
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Teklad |
54920 |
522 |
| FHH/EurMcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70.0 days-84.0 days |
5 |
0.03 |
umol/l |
0.01 |
0.02 |
Download Values
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
55127 |
522 |
| FHH/EurMcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70.0 days-84.0 days |
8 |
0.63 |
umol/l |
0.15 |
0.42 |
Download Values
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Dyets |
56882 |
522 |
| FHH/EurMcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70.0 days-84.0 days |
54 |
0.05 |
umol/l |
0.02 |
0.18 |
Download Values
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Teklad |
54939 |
522 |