Phenominer Database Results (22 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Time Value Experiment Notes Record ID Study ID
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 60.83 % 3.75 15.89 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54840 522
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 53.2 % 4.62 10.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62653 528
BN/NHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 20 -6.87 null 0.08 0.37 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56976 522
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 16 serial mean 118.6 mmHg 3.4 13.6 vascular indwelling catheter method left femoral artery 120.0 0 69543 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 17 serial mean 144.9 mmHg 3.1 12.78 vascular indwelling catheter method left femoral artery 120.0 0 69549 151
BN/NHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 18 1.35 E-7mole 0.19 0.79 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55957 522
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 66.75 % 4.42 12.5 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62651 528
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 61.94 % 3.77 16.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57286 522
BN/NHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 2.06 E-7mole 0.37 1.57 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55956 522
BN/NHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 20 1.89 E-7mole 0.46 2.07 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56581 522
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 138.6 mmHg 3.8 17.41 vascular indwelling catheter method left femoral artery 120.0 0 69547 151
BN/NHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 -6.8 null 0.07 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55687 522
BN/NHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 -6.67 null 0.11 0.48 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56975 522
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 20 66.8 % 3.88 17.34 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54841 522
BN/NHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 -6.98 null 0.1 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62874 528
BN/NHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 -6.71 null 0.05 0.1 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62876 528
BN/NHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 2.01 E-7mole 0.22 0.48 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63053 528
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 18 62.67 % 3.92 16.65 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57287 522
BN/NHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 3.1 E-7mole 0.51 2.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56580 522
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 111.3 mmHg 4.6 21.08 vascular indwelling catheter method left femoral artery 120.0 0 69541 151
BN/NHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 1.23 E-7mole 0.27 0.76 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63051 528
BN/NHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 18 -6.94 null 0.06 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55688 522