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| Strain |
Phenotype |
Conditions |
Study |
Experiment Name |
Sex |
Age |
# of Animals |
Value |
Units |
SEM |
SD |
Method |
Method Duration |
Post Insult Time Value |
Clinical Measurement Notes |
Record ID |
Study ID |
| Crl:CD(SD) |
plasma AMG-8718 maximum concentration |
AMG-8718 (100 mg/kg) (for 4 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
blood enzyme inhibitor amount |
male |
59.0 days-66.0 days |
5 |
21500.0 |
ng/ml |
1784.38 |
3990.0 |
liquid chromatography-mass spectrometry |
0.0 |
|
max conc |
105423 |
3016 |
| Crl:CD(SD) |
plasma AMG-8718 maximum concentration |
AMG-8718 (100 mg/kg) (for 4 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
blood enzyme inhibitor amount |
male |
81.0 days-88.0 days |
5 |
22500.0 |
ng/ml |
1533.94 |
3430.0 |
liquid chromatography-mass spectrometry |
0.0 |
|
max conc |
105429 |
3016 |
| Crl:CD(SD) |
plasma AMG-8718 maximum concentration |
AMG-8718 (600 mg/kg) (for 4 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
blood enzyme inhibitor amount |
male |
59.0 days-66.0 days |
5 |
39900.0 |
ng/ml |
2575.95 |
5760.0 |
liquid chromatography-mass spectrometry |
0.0 |
|
max conc |
105424 |
3016 |
| Crl:CD(SD) |
plasma AMG-8718 maximum concentration |
AMG-8718 (10 mg/kg) (for 4 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
blood enzyme inhibitor amount |
male |
59.0 days-66.0 days |
5 |
2730.0 |
ng/ml |
287.11 |
642.0 |
liquid chromatography-mass spectrometry |
0.0 |
|
max conc |
105422 |
3016 |
| Crl:CD(SD) |
plasma AMG-8718 maximum concentration |
AMG-8718 (600 mg/kg) (for 4 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
blood enzyme inhibitor amount |
male |
59.0 days-66.0 days |
5 |
50300.0 |
ng/ml |
5321.84 |
11900.0 |
liquid chromatography-mass spectrometry |
0.0 |
|
max conc |
105430 |
3016 |
| Crl:CD(SD) |
plasma AMG-8718 maximum concentration |
AMG-8718 (10 mg/kg) (for 4 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
blood enzyme inhibitor amount |
male |
81.0 days-88.0 days |
5 |
4450.0 |
ng/ml |
496.41 |
1110.0 |
liquid chromatography-mass spectrometry |
0.0 |
|
max conc |
105428 |
3016 |
|