Phenominer Database Results (70 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Value Units SEM SD Method Method Duration Post Insult Type Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS.LEW-(D5Rat130-D5Rat31)/JrMcwi glomerular filtration rate to kidney weight ratio controlled in situ renal perfusion pressure (125-130 mmHg) (for 0.3 hours) then controlled in situ renal perfusion pressure (150 mmHg) (for 0.3 hours) then controlled in situ renal perfusion pressure (170-175 mmHg) (for 0.3 hours) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. glomerular filtration trait male 70.0 days 8 0.78 ml/min/g 0.07 0.2 liquid scintillation counting 0 64938 272
SS.LEW-(D5Rat130-D5Rat31)/JrMcwi glomerular filtration rate to kidney weight ratio controlled in situ renal perfusion pressure (125-130 mmHg) (for 0.3 hours) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. glomerular filtration trait male 70.0 days 8 0.56 ml/min/g 0.07 0.2 liquid scintillation counting 0 64943 272
SD retinal uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 35.0 days-49.0 days 3 180.0 % 12.0 20.78 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106116 3028
SD retinal uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and quinidine (10 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 35.0 days-49.0 days 3 187.0 % 22.0 38.11 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106115 3028
SD retinal uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 35.0 days-49.0 days 3 439.0 % 57.0 98.73 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106122 3028
SD-Abcb1aem1Sage-/- retinal uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and digoxin (0.01 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 42.0 days-56.0 days 3 18.8 % 3.1 5.37 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106127 3028
SD-Abcb1aem1Sage-/- retinal uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vinblastine (1 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 42.0 days-56.0 days 3 362.0 % 53.0 91.8 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106130 3028
SD aqueous humor uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 35.0 days-49.0 days 3 5.95 % 0.38 0.66 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index aqueous humor molecular composition trait 106132 3028
SD-Abcb1aem1Sage-/- aqueous humor uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 35.0 days-49.0 days 3 8.83 % 0.4 0.69 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index aqueous humor molecular composition trait 106143 3028
SD aqueous humor uptake index of digoxin tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 35.0 days-49.0 days 3 17.5 % 5.8 10.05 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index aqueous humor molecular composition trait 106135 3028
SD-Abcb1aem1Sage-/- aqueous humor uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and verapamil (1 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 35.0 days-49.0 days 3 13.4 % 0.5 0.87 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index aqueous humor molecular composition trait 106148 3028
SD brain uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 35.0 days-49.0 days 3 0.99 % 0.35 0.61 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106153 3028
SD-Abcb1aem1Sage-/- brain uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and digoxin (0.01 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 42.0 days-56.0 days 3 1.83 % 0.07 0.12 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106163 3028
SD-Abcb1aem1Sage-/- rapidly equilibrated distribution volume of verapamil in aqueous humor tritiated verapamil (10 uCi) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 42.0 days-56.0 days 3 0.13 ml/g 0.0 0.0 liquid scintillation counting 0.0 carotid injection 15 sec post excision aqueous humor molecular composition trait 106112 3028
SD-Abcb1aem1Sage-/- rapidly equilibrated distribution volume of verapamil in retina tritiated verapamil (10 uCi) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 42.0 days-56.0 days 3 6.25 ml/g 0.76 1.32 liquid scintillation counting 0.0 carotid injection 15 sec post excision 106111 3028
SD-Abcb1aem1Sage-/- aqueous humor uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 42.0 days-56.0 days 3 12.0 % 0.6 1.04 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index aqueous humor molecular composition trait 106141 3028
F344/NRrrc liver ornithine decarboxylase activity controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 140 days) Yan Y, et al., Carcinogenesis 2002 Jan;23(1):189-96. liver ornithine decarboxylase activity trait not specified 175.0 days 11 28.3 pmol/mg/h 3.29 10.9 liquid scintillation counting pmole/mg/hour 69940 890
SD retinal uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vinblastine (1 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 35.0 days-49.0 days 3 327.0 % 35.0 60.62 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106121 3028
SD-Abcb1aem1Sage-/- retinal uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 42.0 days-56.0 days 3 536.0 % 6.0 10.39 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106129 3028
SD brain uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 35.0 days-49.0 days 3 2.12 % 0.12 0.21 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106150 3028
SD brain uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 35.0 days-49.0 days 3 0.96 % 0.05 0.08 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106155 3028
SD brain uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vinblastine (1 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 35.0 days-49.0 days 3 42.5 % 4.8 8.31 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106157 3028
SD verapamil apparent influx permeability clearance in aqueous humor tritiated verapamil (10 uCi) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 35.0 days-49.0 days 3 0.0 ml/min/g 0.0 0.0 liquid scintillation counting 0.0 carotid injection 15 sec post excision ml/(min x g) aqueous humor molecular composition trait 106103 3028
SD rapidly equilibrated distribution volume of verapamil in retina tritiated verapamil (10 uCi) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 35.0 days-49.0 days 3 3.32 ml/g 0.2 0.34 liquid scintillation counting 0.0 carotid injection 15 sec post excision 106108 3028
SD retinal uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 35.0 days-49.0 days 3 24.0 % 5.8 10.05 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106117 3028
SD-Abcb1aem1Sage-/- retinal uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and quinidine (10 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 42.0 days-56.0 days 3 182.0 % 24.0 41.57 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106124 3028
SD aqueous humor uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 35.0 days-49.0 days 3 14.2 % 3.5 6.06 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index aqueous humor molecular composition trait 106134 3028
SD-Abcb1aem1Sage-/- aqueous humor uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and digoxin (0.01 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 42.0 days-56.0 days 3 11.0 % 0.5 0.87 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index aqueous humor molecular composition trait 106145 3028
SD brain uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 35.0 days-49.0 days 3 13.2 % 3.2 5.54 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106152 3028
SD-Abcb1aem1Sage-/- brain uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 42.0 days-56.0 days 3 26.1 % 2.4 4.16 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106159 3028
SD-Abcb1aem1Sage-/- brain uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 42.0 days-56.0 days 3 12.4 % 1.7 2.94 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106161 3028
SD-Abcb1aem1Sage-/- verapamil apparent influx permeability clearance in aqueous humor tritiated verapamil (10 uCi) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 42.0 days-56.0 days 3 0.01 ml/min/g 0.0 0.0 liquid scintillation counting 0.0 carotid injection 15 sec post excision ml/(min x g) aqueous humor molecular composition trait 106106 3028
SD rapidly equilibrated distribution volume of verapamil in brain tritiated verapamil (10 uCi) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 35.0 days-49.0 days 3 0.54 ml/g 0.01 0.02 liquid scintillation counting 0.0 carotid injection 15 sec post excision 106110 3028
SD aqueous humor uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vinblastine (1 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 35.0 days-49.0 days 3 15.7 % 1.0 1.73 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index aqueous humor molecular composition trait 106139 3028
SD aqueous humor uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 35.0 days-49.0 days 3 23.1 % 6.4 11.09 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index aqueous humor molecular composition trait 106140 3028
SD-Abcb1aem1Sage-/- aqueous humor uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and quinidine (10 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 35.0 days-49.0 days 3 12.5 % 0.7 1.21 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index aqueous humor molecular composition trait 106142 3028
SD retinal uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 35.0 days-49.0 days 3 212.0 % 13.0 22.52 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106114 3028
SD retinal uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 35.0 days-49.0 days 3 27.9 % 5.7 9.87 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106119 3028
SD retinal uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 35.0 days-49.0 days 3 336.0 % 7.0 12.12 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106120 3028
SD-Abcb1aem1Sage-/- retinal uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 42.0 days-56.0 days 3 142.0 % 5.0 8.66 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106125 3028
SD-Abcb1aem1Sage-/- retinal uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 42.0 days-56.0 days 3 227.0 % 25.0 43.3 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106123 3028
SD-Abcb1aem1Sage-/- retinal uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 42.0 days-56.0 days 3 27.0 % 3.2 5.54 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106128 3028
SD aqueous humor uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and quinidine (10 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 35.0 days-49.0 days 3 11.7 % 0.6 1.04 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index aqueous humor molecular composition trait 106133 3028
SD aqueous humor uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and digoxin (0.01 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 35.0 days-49.0 days 3 15.8 % 3.5 6.06 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index aqueous humor molecular composition trait 106136 3028
SD-Abcb1aem1Sage-/- aqueous humor uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 35.0 days-49.0 days 3 55.9 % 13.2 22.86 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index aqueous humor molecular composition trait 106144 3028
SD-Abcb1aem1Sage-/- aqueous humor uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 42.0 days-56.0 days 3 24.8 % 1.4 2.42 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index aqueous humor molecular composition trait 106147 3028
SD brain uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and quinidine (10 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 35.0 days-49.0 days 3 18.2 % 1.2 2.08 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106151 3028
SD brain uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and digoxin (0.01 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 35.0 days-49.0 days 3 1.18 % 0.2 0.35 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106154 3028
SD-Abcb1aem1Sage-/- brain uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 42.0 days-56.0 days 3 14.0 % 7.3 12.64 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106162 3028
SD-Abcb1aem1Sage-/- brain uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vinblastine (1 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 42.0 days-56.0 days 3 74.0 % 8.3 14.38 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106166 3028
SD-Abcb1aem1Sage-/- brain uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 42.0 days-56.0 days 3 75.5 % 6.3 10.91 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106167 3028
SD verapamil apparent influx permeability clearance in retina tritiated verapamil (10 uCi) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 35.0 days-49.0 days 3 0.82 ml/min/g 0.12 0.2 liquid scintillation counting 0.0 carotid injection 15 sec post excision 106102 3028
SD-Abcb1aem1Sage-/- verapamil apparent influx permeability clearance in retina tritiated verapamil (10 uCi) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 42.0 days-56.0 days 3 0.85 ml/min/g 0.57 0.98 liquid scintillation counting 0.0 carotid injection 15 sec post excision 106105 3028
SD rapidly equilibrated distribution volume of verapamil in aqueous humor tritiated verapamil (10 uCi) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 35.0 days-49.0 days 3 0.07 ml/g 0.0 0.0 liquid scintillation counting 0.0 carotid injection 15 sec post excision aqueous humor molecular composition trait 106109 3028
SD-Abcb1aem1Sage-/- rapidly equilibrated distribution volume of verapamil in brain tritiated verapamil (10 uCi) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 42.0 days-56.0 days 3 3.75 ml/g 0.08 0.13 liquid scintillation counting 0.0 carotid injection 15 sec post excision 106113 3028
SD aqueous humor uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 35.0 days-49.0 days 3 8.46 % 0.61 1.06 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index aqueous humor molecular composition trait 106138 3028
SS/JrHsdMcwi glomerular filtration rate to kidney weight ratio controlled in situ renal perfusion pressure (125-130 mmHg) (for 0.3 hours) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. glomerular filtration trait male 70.0 days 10 0.3 ml/min/g 0.02 0.06 liquid scintillation counting 0 64941 272
SS/JrHsdMcwi glomerular filtration rate to kidney weight ratio controlled in situ renal perfusion pressure (125-130 mmHg) (for 0.3 hours) then controlled in situ renal perfusion pressure (150 mmHg) (for 0.3 hours) then controlled in situ renal perfusion pressure (170-175 mmHg) (for 0.3 hours) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. glomerular filtration trait male 70.0 days 10 0.44 ml/min/g 0.04 0.13 liquid scintillation counting 0 64942 272
DRH/Seac liver ornithine decarboxylase activity controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 140 days) Yan Y, et al., Carcinogenesis 2002 Jan;23(1):189-96. liver ornithine decarboxylase activity trait not specified 175.0 days 5 18.3 pmol/mg/h 1.39 3.1 liquid scintillation counting 0.0 pmole/mg/hour 69941 890
SD retinal uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and digoxin (0.01 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 35.0 days-49.0 days 3 26.3 % 5.7 9.87 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106118 3028
SD-Abcb1aem1Sage-/- retinal uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 42.0 days-56.0 days 3 88.0 % 29.7 51.44 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106126 3028
SD-Abcb1aem1Sage-/- retinal uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 42.0 days-56.0 days 3 379.0 % 18.0 31.18 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106131 3028
SD-Abcb1aem1Sage-/- aqueous humor uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 42.0 days-56.0 days 3 21.0 % 2.4 4.16 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index aqueous humor molecular composition trait 106149 3028
SD-Abcb1aem1Sage-/- aqueous humor uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 42.0 days-56.0 days 3 10.3 % 1.1 1.91 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index aqueous humor molecular composition trait 106146 3028
SD brain uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 35.0 days-49.0 days 3 77.7 % 7.2 12.47 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106158 3028
SD brain uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 35.0 days-49.0 days 3 9.07 % 0.89 1.54 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106156 3028
SD-Abcb1aem1Sage-/- brain uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and quinidine (10 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 42.0 days-56.0 days 3 21.6 % 0.6 1.04 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106160 3028
SD-Abcb1aem1Sage-/- brain uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 42.0 days-56.0 days 3 1.68 % 0.07 0.12 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106164 3028
SD-Abcb1aem1Sage-/- brain uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 42.0 days-56.0 days 3 75.0 % 5.8 10.05 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106165 3028
SD aqueous humor uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 35.0 days-49.0 days 3 9.48 % 0.55 0.95 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index aqueous humor molecular composition trait 106137 3028