Phenominer Database Results (246 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Site Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 11 124.5 mmHg 2.7 8.97 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15123 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 4 450.69 beats/min 12.38 24.77 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15197 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 9 14.18 mmHg 1.52 4.55 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15535 381
SS/JrHsdMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 7 381.66 beats/min 15.84 41.9 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15588 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 1 47.76 mmHg vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15757 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 9 122.02 mmHg 7.52 22.57 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14670 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 4 126.47 mmHg 4.99 9.97 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16023 381
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 17 -45.26 beats/min 9.09 37.49 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51691 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 129.64 mmHg 6.29 12.58 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51742 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 -28.65 beats/min 9.43 39.99 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52049 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80.0 days-99.0 days 9 159.75 mmHg 6.83 20.5 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52865 482
SS/JrHsdMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80.0 days-99.0 days 59 400.39 beats/min 4.05 31.09 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52661 482
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 -37.31 beats/min 13.25 51.33 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50582 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 10 148.46 mmHg 3.82 12.09 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50646 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 3 118.36 mmHg 3.5 6.07 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50673 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 13 17.49 beats/min 12.18 43.9 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50680 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 -40.21 beats/min 9.65 40.92 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50718 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 5 126.48 mmHg 5.04 11.27 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50794 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 5 8.29 beats/min 21.22 47.46 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50905 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 10.04 mmHg 1.85 7.15 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50913 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 1.89 mmHg 2.65 9.18 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51026 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 8.89 mmHg 2.26 9.57 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51101 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 5.27 mmHg 1.01 3.5 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51106 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 10 407.56 beats/min 6.03 19.06 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51250 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 5 117.49 mmHg 2.54 5.67 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51324 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 17 30.86 mmHg 2.26 9.32 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51421 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 3 9.52 mmHg 0.72 1.24 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51495 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -46.0 beats/min 14.52 50.29 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51509 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 157.55 mmHg 5.0 21.21 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51628 481
SS/JrHsdMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 411.25 beats/min 8.66 27.37 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14728 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 122.71 mmHg 2.46 7.78 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14361 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 127.72 mmHg 7.58 20.05 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 13774 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 9 522.7 beats/min 7.28 21.83 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13805 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 108.33 mmHg 5.29 9.16 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13906 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 9 130.99 mmHg 4.35 13.06 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19704 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 38 11.35 mmHg 1.07 6.58 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20729 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 62 413.02 beats/min 4.88 38.45 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20947 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 10 419.73 beats/min 8.86 28.02 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20971 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 517.01 beats/min 6.36 16.81 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19963 381
SS/JrHsdMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 473.71 beats/min 17.29 29.95 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17668 381
SS/JrHsdMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 8 448.96 beats/min 12.9 36.5 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17748 381
SS/JrHsdMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 48 409.84 beats/min 3.74 25.89 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17743 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 130.87 mmHg 6.42 16.99 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17772 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 9 120.65 mmHg 4.0 11.99 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18949 381
SS/JrHsdMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 9 415.16 beats/min 9.54 28.61 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18194 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 4 21.82 mmHg 3.62 7.24 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16251 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 11 411.41 beats/min 9.43 31.29 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 16351 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 9 447.76 beats/min 12.54 37.63 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 16360 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 10 5.44 mmHg 2.1 6.63 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 16775 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 5.11 mmHg 2.88 7.61 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 16784 381
SS/JrHsdMcwi mean arterial blood pressure controlled sodium chloride content diet (0.4 %) (for 70 days) Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. arterial blood pressure trait not specified 70.0 days 6 15sec/min for 3 hrs/day for 7days 127.5 mmHg 1.5 3.67 vascular fluid filled catheter 0.0 n=6-8 106520 3031
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 22 21.73 mmHg 1.57 7.35 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15145 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 6 20.79 mmHg 3.5 8.56 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15154 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 10 126.99 mmHg 3.33 10.55 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15199 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 7.27 mmHg 10.91 18.9 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15763 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 11 131.52 mmHg 2.55 8.47 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14661 381
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 16 -24.39 beats/min 8.55 34.19 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51718 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 3 23.81 mmHg 5.74 9.95 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51813 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 135.0 mmHg 5.04 21.4 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51821 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 17 -5.13 beats/min 7.08 29.2 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51848 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 16.35 mmHg 2.77 9.58 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51869 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -26.95 beats/min 8.55 29.62 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52054 481
SS/JrHsdMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80.0 days-99.0 days 9 416.02 beats/min 6.59 19.78 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52667 482
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 17 406.36 beats/min 7.25 29.89 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50523 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -30.56 beats/min 50.56 101.11 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50593 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 2.06 mmHg 2.57 10.89 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50600 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 157.81 mmHg 6.04 25.64 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50640 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 16 6.61 mmHg 2.25 8.99 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50695 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 144.0 mmHg 3.04 12.89 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50734 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 5.95 mmHg 2.39 9.25 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50774 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 3 49.33 mmHg 4.56 7.91 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50785 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 3 21.03 mmHg 14.54 25.18 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50841 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 16 139.76 mmHg 3.93 15.73 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50939 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 3.44 beats/min 4.53 17.54 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50977 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 3 15.0 beats/min 17.09 29.6 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51070 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 -17.17 beats/min 7.62 32.34 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51088 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 405.69 beats/min 11.75 49.86 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51114 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 432.92 beats/min 10.44 36.17 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51119 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 16 15.97 mmHg 2.94 11.75 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51184 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -13.26 beats/min 12.39 24.79 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51212 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 383.68 beats/min 7.38 31.32 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51245 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 393.77 beats/min 10.28 43.62 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51280 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 16 -26.39 beats/min 10.75 42.99 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51349 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 10 401.83 beats/min 4.13 13.07 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51583 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 17 3.92 mmHg 3.22 13.28 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51591 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 3 -12.6 beats/min 13.02 22.55 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51608 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 -21.75 beats/min 16.71 64.71 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50355 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -47.58 beats/min 14.04 48.64 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50424 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 -9.03 beats/min 7.32 31.07 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50504 481
SS/JrHsdMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 51 370.19 beats/min 5.38 38.45 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14723 381
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait female 86.0 days-89.0 days 12 177.0 mmHg 5.0 17.32 vascular fluid filled catheter left femoral artery 14400 on 3 consecutive days 5405 15
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 8 heart rate during walking-heart rate during rest 72.73 beats/min 16.0 45.27 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13402 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 4 446.53 beats/min 77.6 155.19 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13826 381
SS/JrHsdMcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 11 134.71 mmHg 4.19 13.9 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 13887 381
SS/JrHsdMcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 8 132.8 mmHg 6.49 18.34 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 13896 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 4 104.65 mmHg 2.31 4.62 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13900 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 119.38 mmHg 3.99 12.63 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19896 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 436.5 beats/min 7.29 19.29 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20977 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 4 49.95 beats/min 66.91 133.82 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20990 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 22 136.46 mmHg 2.42 11.36 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17763 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 452.93 beats/min 8.97 28.36 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17534 381
SS/JrHsdMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 487.67 beats/min 8.92 23.59 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18203 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 11 409.67 beats/min 10.1 33.5 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20434 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 574.36 beats/min 4.48 11.85 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20535 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 152.73 beats/min 13.5 38.18 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19165 381
SS/JrHsdMcwi diastolic blood pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56.0 days 6 84.0 mmHg 4.05 9.92 vascular fluid filled catheter 0.0 106806 3032
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 6 427.49 beats/min 15.86 38.84 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15191 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 9 131.39 mmHg 4.31 12.92 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15556 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 4 122.43 mmHg 4.51 9.02 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14658 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 50 419.34 beats/min 5.77 40.82 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15953 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 27.49 mmHg 2.28 9.69 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51769 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 29.89 mmHg 2.83 9.8 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51774 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 14.65 beats/min 53.53 107.05 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51791 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 131.99 mmHg 3.79 14.69 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51997 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 451.75 beats/min 12.93 44.79 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50529 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 -22.81 mmHg 3.9 16.57 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50627 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -50.68 beats/min 14.96 51.82 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50723 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 3 43.55 mmHg 0.46 0.79 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50898 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 16 24.54 mmHg 2.93 11.72 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50961 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 16 -16.62 beats/min 6.53 26.13 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51154 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 10.55 beats/min 16.42 63.61 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51233 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 3 -0.13 beats/min 21.53 37.29 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51303 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 18.14 mmHg 3.11 10.77 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51342 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 5 393.13 beats/min 12.55 28.06 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51380 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 3 -20.8 beats/min 34.71 60.12 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51405 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 17 -43.12 beats/min 5.21 21.5 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51503 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -50.41 beats/min 16.19 32.37 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50336 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -71.27 beats/min 21.14 42.27 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50344 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 16 6.75 mmHg 1.79 7.15 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50366 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 -35.02 beats/min 11.98 50.83 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50419 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 -2.02 mmHg 7.38 14.75 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50431 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 3 356.33 beats/min 4.7 8.14 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50445 481
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 517.71 beats/min 27.96 48.43 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13832 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 1 145.33 beats/min vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14101 381
SS/JrHsdMcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 7 121.45 mmHg 3.1 8.21 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14120 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 133.2 mmHg 6.56 17.36 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19713 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 50 122.9 mmHg 2.03 14.37 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19891 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 11 451.63 beats/min 7.56 25.06 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20952 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 22 524.94 beats/min 8.14 38.2 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19954 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 48 117.4 mmHg 1.68 11.62 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20051 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 8 136.24 mmHg 5.73 16.22 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19523 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 22 113.5 beats/min 11.48 53.84 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18352 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 38 130.32 mmHg 2.26 13.93 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18944 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 61 412.19 beats/min 6.25 48.79 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17529 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 11 131.45 mmHg 3.35 11.1 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19514 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 122.6 mmHg 8.28 21.9 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20403 381
SS/JrHsdMcwi systolic blood pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56.0 days 6 115.0 mmHg 4.76 11.66 vascular fluid filled catheter 0.0 106802 3032
SS/JrHsdMcwi diastolic blood pressure monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56.0 days 8 85.9 mmHg 2.35 6.65 vascular fluid filled catheter 0.0 106808 3032
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 62 125.01 mmHg 1.69 13.31 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15118 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 10.6 mmHg 4.12 10.9 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15544 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 11 131.2 mmHg 2.53 8.39 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15547 381
SS/JrHsdMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 4 401.38 beats/min 19.18 38.37 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15594 381
SS/JrHsdMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 11 385.58 beats/min 9.77 32.41 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15336 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 132.16 mmHg 5.14 13.61 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14416 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 452.55 beats/min 9.34 29.53 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15958 381
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 16 -61.58 beats/min 12.05 48.19 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51704 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -16.0 beats/min 15.69 54.35 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51854 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 18.85 mmHg 1.94 8.25 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51864 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 -7.24 beats/min 8.54 33.06 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51920 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 3 1.67 beats/min 20.69 35.83 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51978 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 10 -17.53 mmHg 2.45 7.75 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50632 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 16 33.3 mmHg 3.27 13.09 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50653 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 28.78 mmHg 3.03 10.51 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50755 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 5 -8.98 mmHg 4.38 9.8 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50762 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 -2.59 mmHg 3.89 7.79 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50991 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 17 12.53 mmHg 2.38 9.83 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51020 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 -1.55 mmHg 1.88 3.77 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51081 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 10 5.72 beats/min 7.43 23.5 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51093 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 4.02 mmHg 2.34 9.04 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51129 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -63.27 beats/min 9.59 33.21 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51205 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 17 19.93 mmHg 2.55 10.53 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51336 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 -15.3 beats/min 12.74 54.04 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51368 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -14.77 beats/min 11.54 39.96 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51373 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 5 384.83 beats/min 13.09 29.27 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51482 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 21.74 mmHg 2.32 4.63 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51489 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 400.82 beats/min 9.27 39.31 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51577 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 -2.75 mmHg 3.49 12.1 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51597 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 144.43 mmHg 4.76 16.47 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51633 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 387.81 beats/min 8.14 31.52 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50323 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait male 86.0 days-89.0 days 12 181.0 mmHg 2.9 10.05 vascular fluid filled catheter left femoral artery 259200 5406 15
SS/JrHsdMcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 51 123.21 mmHg 1.69 12.1 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13510 381
SS/JrHsdMcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 121.8 mmHg 3.03 9.59 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13515 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 61 123.16 mmHg 2.06 16.07 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14356 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 10 122.92 mmHg 3.54 11.2 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 13765 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 26.99 beats/min 41.14 71.26 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14107 381
SS/JrHsdMcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 4 119.26 mmHg 4.6 9.21 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14126 381
SS/JrHsdMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 4 396.58 beats/min 15.33 30.67 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17662 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 9 430.66 beats/min 12.88 38.63 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18110 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 6 62.48 beats/min 17.33 42.44 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18361 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 413.33 beats/min 15.97 45.17 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18754 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 424.61 beats/min 10.82 28.62 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18760 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 1 152.36 mmHg vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19003 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 10 117.48 mmHg 3.71 11.72 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20394 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 9 82.61 beats/min 9.27 27.8 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20422 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 452.61 beats/min 5.11 16.16 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20443 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 1.8 mmHg 8.01 13.87 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16257 381
SS/JrHsdMcwi heart rate vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart pumping trait male 56.0 days 6 358.0 beats/min 7.95 19.47 vascular fluid filled catheter 0.0 106798 3032
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 126.83 mmHg 3.13 8.27 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15205 381
SS/JrHsdMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 9 418.52 beats/min 9.02 27.06 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15345 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 120.93 mmHg 6.37 18.01 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14410 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 6 122.15 mmHg 2.63 6.45 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14652 381
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -74.49 beats/min 13.87 48.04 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51697 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 14.83 mmHg 6.29 12.58 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51736 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 10 130.93 mmHg 4.07 12.88 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51826 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 21.26 mmHg 2.2 8.51 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51963 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 137.62 mmHg 4.07 15.75 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52084 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80.0 days-99.0 days 59 176.81 mmHg 2.61 20.06 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52859 482
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 3.46 mmHg 3.06 10.59 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50605 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 17 -9.14 beats/min 7.81 32.2 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50613 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -42.28 beats/min 12.66 43.87 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50619 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 411.76 beats/min 26.24 52.48 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50667 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 17 27.75 mmHg 2.45 10.1 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50749 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 -12.57 mmHg 1.76 6.83 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50801 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 386.98 beats/min 5.77 22.33 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50878 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 -5.4 mmHg 2.47 10.48 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50927 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 1.04 mmHg 1.37 4.76 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50932 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 17 157.61 mmHg 4.84 19.98 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51141 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 148.3 mmHg 5.49 19.02 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51147 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 17 -27.92 beats/min 8.05 33.2 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51199 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 16 -48.18 beats/min 8.64 34.54 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51218 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 31.81 mmHg 3.63 12.58 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51427 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 32.43 mmHg 3.05 11.82 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51659 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 16 386.28 beats/min 7.72 30.88 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50471 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -0.13 beats/min 12.28 42.54 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50509 481
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 37 heart rate during walking-heart rate during rest 82.39 beats/min 5.02 30.53 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13397 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 37 492.45 beats/min 5.9 35.89 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13800 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 9 497.77 beats/min 4.55 13.64 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14063 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 531.15 beats/min 5.18 13.7 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14072 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 8 8.82 mmHg 1.21 3.41 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20734 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 44.0 beats/min 18.08 31.32 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20996 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 1 502.35 beats/min vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19932 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 500.7 beats/min 32.3 55.95 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19938 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 8 113.83 mmHg 3.8 10.74 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20056 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 11 430.16 beats/min 6.98 23.14 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18101 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 115.6 mmHg 10.41 18.04 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19009 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 43.49 beats/min 12.01 31.77 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20431 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 565.64 beats/min 9.72 27.48 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20526 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 86.7 beats/min 12.11 32.05 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19174 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 110.14 mmHg 3.1 5.37 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16029 381
SS/JrHsdMcwi mean arterial blood pressure controlled sodium chloride content diet (0.4 %) (for 70 days) then controlled sodium chloride content diet (4 %) (for 21 days) Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. arterial blood pressure trait not specified 91.0 days 6 15sec/min for 3 hrs/day 175.5 mmHg 7.9 19.35 vascular fluid filled catheter 0.0 n=6-8 106522 3031
SS/JrHsdMcwi right ventricular end-systolic blood pressure monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricular blood pressure trait male 56.0 days 11 48.6 mmHg 1.8 5.97 vascular fluid filled catheter 0.0 106638 3032
SS/JrHsdMcwi right ventricular end-systolic blood pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricular blood pressure trait male 56.0 days 6 26.0 mmHg 0.99 2.42 vascular fluid filled catheter 0.0 106796 3032
SS/JrHsdMcwi heart rate monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart pumping trait male 56.0 days 8 340.0 beats/min 7.65 21.64 vascular fluid filled catheter 0.0 106800 3032
SS/JrHsdMcwi systolic blood pressure monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56.0 days 8 108.0 mmHg 2.62 7.41 vascular fluid filled catheter 0.0 106804 3032
SS/JrHsdMcwi mean aortic pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56.0 days 6 94.4 mmHg 4.27 10.46 vascular fluid filled catheter 0.0 Mean aortic pressure 106810 3032
SS/JrHsdMcwi mean aortic pressure monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56.0 days 8 93.2 mmHg 2.33 6.59 vascular fluid filled catheter 0.0 Mean aortic pressure 106812 3032