| SD |
blood total cholesterol level |
acetaminophen (1000 mg/kg) (for 28 days) |
Venkatesan PS, et al., Biol Pharm Bull. 2014 Apr 5. |
blood cholesterol amount |
female |
71.0 days-85.0 days |
6 |
96.5 |
mg/dl |
6.17 |
15.11 |
automated blood analysis |
0.0 |
|
Siemens biochemical analyzer |
|
85176 |
1602 |
| SD |
blood total cholesterol level |
control condition |
Venkatesan PS, et al., Biol Pharm Bull. 2014 Apr 5. |
blood cholesterol amount |
female |
85.0 days-99.0 days |
6 |
112.17 |
mg/dl |
3.51 |
8.59 |
automated blood analysis |
0.0 |
|
Siemens biochemical analyzer |
|
85177 |
1602 |
| SD |
blood total cholesterol level |
acetaminophen (500 mg/kg) (for 28 days) |
Venkatesan PS, et al., Biol Pharm Bull. 2014 Apr 5. |
blood cholesterol amount |
male |
71.0 days-85.0 days |
6 |
87.8 |
mg/dl |
3.31 |
8.11 |
automated blood analysis |
0.0 |
|
Siemens biochemical analyzer |
|
85169 |
1602 |
| PXO8-1/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127.0 days
| 10 |
62.0 |
mg/dl |
1.3 |
4.11 |
enzymatic cholesterol assay |
0.0 |
|
|
|
97224 |
1858 |
| PXO2/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127.0 days
| 11 |
74.1 |
mg/dl |
1.8 |
5.97 |
enzymatic cholesterol assay |
0.0 |
|
|
|
97226 |
1858 |
| BXH2/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127.0 days
| 18 |
48.7 |
mg/dl |
1.6 |
6.79 |
enzymatic cholesterol assay |
0.0 |
|
|
|
97211 |
1858 |
| PXO3-2/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127.0 days
| 9 |
58.5 |
mg/dl |
2.7 |
8.1 |
enzymatic cholesterol assay |
0.0 |
|
|
|
97219 |
1858 |
| OLETF |
blood total cholesterol level |
control condition (for 84 days) |
Koga K, et al., Mol Med. 2002 Oct;8(10):591-9. |
blood cholesterol amount |
male |
364.0 days
| 12 |
168.73 |
mg/dl |
8.88 |
30.76 |
blood cholesterol analysis |
0.0 |
|
|
|
99431 |
2298 |
| OLETF |
blood total cholesterol level |
temocapril (3.9 mg/kg/d) (for 84 days) |
Koga K, et al., Mol Med. 2002 Oct;8(10):591-9. |
blood cholesterol amount |
male |
364.0 days
| 11 |
78.38 |
mg/dl |
2.7 |
8.96 |
blood cholesterol analysis |
0.0 |
|
|
|
99434 |
2298 |
| SD |
blood total cholesterol level |
control condition |
Venkatesan PS, et al., Biol Pharm Bull. 2014 Apr 5. |
blood cholesterol amount |
male |
71.0 days-85.0 days |
6 |
78.0 |
mg/dl |
2.9 |
7.1 |
automated blood analysis |
0.0 |
|
Siemens biochemical analyzer |
|
85167 |
1602 |
| SD |
blood total cholesterol level |
acetaminophen (250 mg/kg) (for 28 days) |
Venkatesan PS, et al., Biol Pharm Bull. 2014 Apr 5. |
blood cholesterol amount |
female |
71.0 days-85.0 days |
6 |
92.2 |
mg/dl |
5.71 |
13.98 |
automated blood analysis |
0.0 |
|
Siemens biochemical analyzer |
|
85174 |
1602 |
| Jcl:WI |
blood total cholesterol level |
Omacor (400 mg/kg/d) (for 56 days) |
Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. |
blood cholesterol amount |
male |
84.0 days
| 8 |
60.62 |
mg/dl |
3.0 |
8.49 |
blood cholesterol analysis |
0.0 |
|
|
|
103080 |
2785 |
| GK/Jcl |
blood total cholesterol level |
standard diet |
Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. |
blood cholesterol amount |
male |
84.0 days
| 8 |
83.01 |
mg/dl |
0.96 |
2.7 |
blood cholesterol analysis |
0.0 |
|
|
|
103081 |
2785 |
| GK/Jcl |
blood total cholesterol level |
Omacor (400 mg/kg/d) (for 56 days) |
Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. |
blood cholesterol amount |
male |
84.0 days
| 8 |
76.83 |
mg/dl |
2.18 |
6.18 |
blood cholesterol analysis |
0.0 |
|
|
|
103082 |
2785 |
| SD |
blood total cholesterol level |
acetaminophen (1000 mg/kg) (for 28 days) |
Venkatesan PS, et al., Biol Pharm Bull. 2014 Apr 5. |
blood cholesterol amount |
male |
85.0 days-99.0 days |
6 |
60.1 |
mg/dl |
12.24 |
29.99 |
automated blood analysis |
0.0 |
|
Siemens biochemical analyzer |
|
85172 |
1602 |
| PXO6-2/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127.0 days
| 8 |
61.7 |
mg/dl |
2.6 |
7.35 |
enzymatic cholesterol assay |
0.0 |
|
|
|
97223 |
1858 |
| Slc:W |
blood total cholesterol level |
vehicle control condition (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood cholesterol amount |
male |
105.0 days
| |
67.0 |
mg/dl |
3.5 |
|
blood cholesterol analysis |
0.0 |
|
|
n=4-6 |
102890 |
2781 |
| SD |
blood total cholesterol level |
acetaminophen (250 mg/kg) (for 28 days) |
Venkatesan PS, et al., Biol Pharm Bull. 2014 Apr 5. |
blood cholesterol amount |
male |
71.0 days-85.0 days |
6 |
92.8 |
mg/dl |
6.06 |
14.84 |
automated blood analysis |
0.0 |
|
Siemens biochemical analyzer |
|
85168 |
1602 |
| SD |
blood total cholesterol level |
acetaminophen (1000 mg/kg) (for 28 days) |
Venkatesan PS, et al., Biol Pharm Bull. 2014 Apr 5. |
blood cholesterol amount |
male |
71.0 days-85.0 days |
6 |
86.8 |
mg/dl |
5.76 |
14.12 |
automated blood analysis |
0.0 |
|
Siemens biochemical analyzer |
|
85170 |
1602 |
| SD |
blood total cholesterol level |
control condition |
Venkatesan PS, et al., Biol Pharm Bull. 2014 Apr 5. |
blood cholesterol amount |
male |
85.0 days-99.0 days |
6 |
73.99 |
mg/dl |
12.53 |
30.68 |
automated blood analysis |
0.0 |
|
Siemens biochemical analyzer |
|
85171 |
1602 |
| PXO6-1/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127.0 days
| 10 |
42.9 |
mg/dl |
1.7 |
5.38 |
enzymatic cholesterol assay |
0.0 |
|
|
|
97210 |
1858 |
| PXO5-1/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127.0 days
| 11 |
53.3 |
mg/dl |
2.4 |
7.96 |
enzymatic cholesterol assay |
0.0 |
|
|
|
97214 |
1858 |
| PXO7-1/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127.0 days
| 8 |
51.7 |
mg/dl |
1.0 |
2.83 |
enzymatic cholesterol assay |
0.0 |
|
|
|
97213 |
1858 |
| PXO3-1/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127.0 days
| 10 |
53.7 |
mg/dl |
1.3 |
4.11 |
enzymatic cholesterol assay |
0.0 |
|
|
|
97215 |
1858 |
| PXO6-3/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127.0 days
| 10 |
56.0 |
mg/dl |
1.6 |
5.06 |
enzymatic cholesterol assay |
0.0 |
|
|
|
97217 |
1858 |
| PXO1/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127.0 days
| 11 |
57.4 |
mg/dl |
1.4 |
4.64 |
enzymatic cholesterol assay |
0.0 |
|
|
|
97218 |
1858 |
| PXO5-2/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127.0 days
| 10 |
60.6 |
mg/dl |
1.4 |
4.43 |
enzymatic cholesterol assay |
0.0 |
|
|
|
97220 |
1858 |
| Slc:W |
blood total cholesterol level |
controlled ipragliflozin content diet (0.008 %) (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood cholesterol amount |
male |
105.0 days
| |
58.2 |
mg/dl |
3.0 |
|
blood cholesterol analysis |
0.0 |
|
|
n=4-6 |
102891 |
2781 |
| GK/Slc |
blood total cholesterol level |
vehicle control condition (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood cholesterol amount |
male |
105.0 days
| |
77.8 |
mg/dl |
5.2 |
|
blood cholesterol analysis |
0.0 |
|
|
n=4-6 |
102892 |
2781 |
| SD |
blood total cholesterol level |
acetaminophen (1000 mg/kg) (for 28 days) |
Venkatesan PS, et al., Biol Pharm Bull. 2014 Apr 5. |
blood cholesterol amount |
female |
85.0 days-99.0 days |
6 |
109.17 |
mg/dl |
4.94 |
12.09 |
automated blood analysis |
0.0 |
|
Siemens biochemical analyzer |
|
85178 |
1602 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127.0 days
| 13 |
53.7 |
mg/dl |
1.2 |
4.33 |
enzymatic cholesterol assay |
0.0 |
|
|
|
97216 |
1858 |
| PXO8-2/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127.0 days
| 13 |
61.0 |
mg/dl |
1.3 |
4.69 |
enzymatic cholesterol assay |
0.0 |
|
|
|
97222 |
1858 |
| GK/Slc |
blood total cholesterol level |
controlled ipragliflozin content diet (0.008 %) (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood cholesterol amount |
male |
105.0 days
| |
78.8 |
mg/dl |
3.8 |
|
blood cholesterol analysis |
0.0 |
|
|
n=4-6 |
102893 |
2781 |
| OLETF |
blood total cholesterol level |
olmesartan medoxomil (3.8 mg/kg/d) (for 84 days) |
Koga K, et al., Mol Med. 2002 Oct;8(10):591-9. |
blood cholesterol amount |
male |
364.0 days
| 12 |
93.44 |
mg/dl |
5.02 |
17.39 |
blood cholesterol analysis |
0.0 |
|
|
|
99433 |
2298 |
| OLETF |
blood total cholesterol level |
olmesartan medoxomil (0.35 mg/kg/d) (for 84 days) |
Koga K, et al., Mol Med. 2002 Oct;8(10):591-9. |
blood cholesterol amount |
male |
364.0 days
| 11 |
153.28 |
mg/dl |
7.72 |
25.61 |
blood cholesterol analysis |
0.0 |
|
|
|
99432 |
2298 |
| LETO |
blood total cholesterol level |
control condition (for 84 days) |
Koga K, et al., Mol Med. 2002 Oct;8(10):591-9. |
blood cholesterol amount |
male |
364.0 days
| 11 |
67.95 |
mg/dl |
1.54 |
5.12 |
blood cholesterol analysis |
0.0 |
|
|
|
99435 |
2298 |
| SS.ZUC-Leprfa+/+/Slc |
blood total cholesterol level |
everolimus (0.83 mg/kg/d) (for 28 days) |
Uchinaka A, et al., Pharmacol Res Perspect. 2017 Aug;5(4). doi: 10.1002/prp2.331. |
blood cholesterol amount |
male |
91.0 days
| 10 |
11.83 |
mg/dl |
8.11 |
25.65 |
blood cholesterol analysis |
0.0 |
|
|
|
101838 |
2641 |
| SS.ZUC-Leprfa-/-/Slc |
blood total cholesterol level |
control condition |
Uchinaka A, et al., Pharmacol Res Perspect. 2017 Aug;5(4). doi: 10.1002/prp2.331. |
blood cholesterol amount |
male |
91.0 days
| 7 |
329.25 |
mg/dl |
52.32 |
138.43 |
blood cholesterol analysis |
0.0 |
|
|
|
101839 |
2641 |
| SS.ZUC-Leprfa-/-/Slc |
blood total cholesterol level |
everolimus (0.83 mg/kg/d) (for 28 days) |
Uchinaka A, et al., Pharmacol Res Perspect. 2017 Aug;5(4). doi: 10.1002/prp2.331. |
blood cholesterol amount |
male |
91.0 days
| 12 |
297.67 |
mg/dl |
35.78 |
123.95 |
blood cholesterol analysis |
0.0 |
|
|
|
101840 |
2641 |
| SD |
blood total cholesterol level |
control condition |
Venkatesan PS, et al., Biol Pharm Bull. 2014 Apr 5. |
blood cholesterol amount |
female |
71.0 days-85.0 days |
6 |
102.5 |
mg/dl |
1.84 |
4.51 |
automated blood analysis |
0.0 |
|
Siemens biochemical analyzer |
|
85173 |
1602 |
| SD |
blood total cholesterol level |
acetaminophen (500 mg/kg) (for 28 days) |
Venkatesan PS, et al., Biol Pharm Bull. 2014 Apr 5. |
blood cholesterol amount |
female |
71.0 days-85.0 days |
6 |
102.3 |
mg/dl |
3.01 |
7.37 |
automated blood analysis |
0.0 |
|
Siemens biochemical analyzer |
|
85175 |
1602 |
| PXO4/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127.0 days
| 9 |
66.5 |
mg/dl |
1.3 |
3.9 |
enzymatic cholesterol assay |
0.0 |
|
|
|
97225 |
1858 |
| PXO10/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127.0 days
| 12 |
49.4 |
mg/dl |
2.0 |
6.93 |
enzymatic cholesterol assay |
0.0 |
|
|
|
97212 |
1858 |
| PXO9/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127.0 days
| 9 |
60.9 |
mg/dl |
2.0 |
6.0 |
enzymatic cholesterol assay |
0.0 |
|
|
|
97221 |
1858 |
| Jcl:WI |
blood total cholesterol level |
standard diet |
Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. |
blood cholesterol amount |
male |
84.0 days
| 8 |
51.74 |
mg/dl |
2.59 |
7.34 |
blood cholesterol analysis |
0.0 |
|
|
|
103079 |
2785 |
| SS.ZUC-Leprfa+/+/Slc |
blood total cholesterol level |
control condition |
Uchinaka A, et al., Pharmacol Res Perspect. 2017 Aug;5(4). doi: 10.1002/prp2.331. |
blood cholesterol amount |
male |
91.0 days
| 8 |
68.0 |
mg/dl |
2.0 |
5.66 |
blood cholesterol analysis |
0.0 |
|
|
|
101837 |
2641 |