| ACI/SegHsd |
prostate tumorous lesion number |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
prostate integrity trait |
male |
900.0 days
| 12 |
|
|
5.3 |
null |
|
|
ex vivo light microscopy |
|
0 |
|
|
|
|
|
|
65822 |
341 |
| ACI/SegHsd |
prostate gland wet weight |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
prostate mass |
male |
900.0 days
| 12 |
|
|
1.54 |
g |
|
|
post excision weight measurement |
|
0 |
|
|
|
|
|
|
65828 |
341 |
| ACI/SegHsd |
mammary tumor number |
17 beta-estradiol (27.5 mg) (between 193 and 199 days) |
Schaffer BS, et al., Cancer Res. 2006 Aug 1;66(15):7793-800 |
mammary gland integrity trait |
female |
143.0 days-259.0 days |
22 |
|
|
8.8 |
null |
1.4 |
6.57 |
manual palpation method |
|
0.0 |
crystalline implant |
|
|
|
|
|
11382 |
81 |
| ACI/SegHsd |
post-insult time to mammary tumor formation |
17 beta-estradiol (27.5 mg) (between 99 and 197 days) |
Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 |
mammary gland integrity trait |
female |
160.0 days-260.0 days |
21 |
|
serial mean |
145.0 |
d |
|
|
manual palpation method |
mammary gland |
0.0 |
|
|
|
|
|
|
66104 |
76 |
| ACI/SegHsd |
well differentiated malignant colorectal tumor surface area measurement |
1,2-dimethylhydrazine (20 mg/kg/week) (for 182 days) |
De Miglio MR, et al., Carcinogenesis. 2007 May 17;. |
colorectal integrity trait |
not specified |
days
| 20 |
|
|
43.9 |
mm2 |
1.52 |
6.8 |
ex vivo caliper method |
|
0.0 |
|
|
|
caliper |
|
|
70390 |
1378 |
| ACI/SegHsd |
area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
prostate integrity trait |
male |
900.0 days
| 12 |
|
|
1.61 |
% |
|
|
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
|
|
|
|
|
67946 |
341 |
| ACI/SegHsd |
area of ventral prostate occupied by tumorous lesions with solid structure to total ventral prostate area ratio |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
prostate integrity trait |
male |
900.0 days
| 12 |
|
|
1.09 |
% |
0.38 |
1.31 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
|
|
|
|
|
109891 |
341 |
| ACI/SegHsd |
percentage of study population developing experimental autoimmune neuritis during a period of time |
peripheral myelin protein 2 peptide 58-81 (100 ug) and Freund's complete adjuvant (100 ul) |
de Graaf KL, et al., J Neuroimmunol. 2004 Oct;155(1-2):73-84. |
peripheral nervous system integrity trait |
male |
98.0 days-200.0 days |
4 |
|
|
0.0 |
% |
|
|
ex vivo visual assessment |
|
0.0 |
|
|
|
|
|
peripheral nervous system integrity trait |
84524 |
1178 |
| ACI/SegHsd |
hematocrit |
arterial catheter implantation (for 1 days) then controlled hemorrhage (for 0.4 hours) |
Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. |
erythrocyte quantity |
male |
89.0 days-95.0 days |
9 |
|
|
30.6 |
% |
1.1 |
3.3 |
microhematocrit tube assay with visual assessment |
|
0.0 |
|
|
|
|
|
initial hematocrit, final hematocrit, change in hematocrit |
107249 |
3077 |
| ACI/SegHsd |
mean arterial blood pressure |
arterial catheter implantation (for 1 days) |
Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. |
arterial blood pressure trait |
male |
89.0 days-95.0 days |
9 |
|
|
116.0 |
mmHg |
5.0 |
15.0 |
vascular fluid filled catheter |
|
300.0 |
|
|
|
5-second intervals |
|
Initial MAP |
107329 |
3077 |
| ACI/SegHsd |
post-insult time to mammary tumor formation |
17 beta-estradiol (27.5 mg) (between 99 and 197 days) |
Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 |
mammary gland integrity trait |
female |
160.0 days-260.0 days |
21 |
|
median |
143.0 |
d |
|
|
manual palpation method |
mammary gland |
0.0 |
|
|
|
|
|
|
66111 |
76 |
| ACI/SegHsd |
mammary tumor number |
17 beta-estradiol (27.5 mg) (for 196 days) |
Kurz SG, et al., Endocrinology. 2008 Apr 17 |
mammary gland integrity trait |
female |
259.0 days
| 21 |
|
|
7.0 |
null |
1.16 |
5.3 |
necropsy |
|
|
|
|
|
|
|
|
11368 |
75 |
| ACI/SegHsd |
post-insult time to mammary tumor formation |
17 beta-estradiol (27.5 mg) (for 196 days) |
Kurz SG, et al., Endocrinology. 2008 Apr 17 |
mammary gland integrity trait |
female |
days-259.0 days |
21 |
|
|
145.0 |
d |
|
|
manual palpation method |
|
0 |
|
|
|
|
median |
|
11375 |
75 |
| ACI/SegHsd |
percentage of study population developing mammary tumors during a period of time |
control condition |
Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 |
mammary gland integrity trait |
female |
201.0 days-518.0 days |
3 |
|
|
0.0 |
% |
|
|
manual palpation method |
mammary gland |
0 |
|
|
|
|
|
|
11378 |
76 |
| ACI/SegHsd |
post-insult time to mammary tumor formation |
17 beta-estradiol (27.5 mg) (between 147 and 195 days) |
Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 |
mammary gland integrity trait |
female |
206.0 days-264.0 days |
31 |
|
|
141.0 |
d |
4.85 |
27.0 |
manual palpation method |
|
|
|
|
|
|
mean |
|
11748 |
144 |
| ACI/SegHsd |
pituitary gland wet weight |
sham surgical control condition (between 193 and 199 days) |
Shull JD, et al., Mamm Genome. 2007 Sep 18;. |
pituitary gland mass |
female |
252.0 days-266.0 days |
10 |
|
|
0.01 |
g |
0.0 |
0.0 |
post excision weight measurement |
pituitary gland |
0 |
|
|
|
|
|
|
13090 |
331 |
| ACI/SegHsd |
body weight |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
body mass |
male |
900.0 days
| 12 |
|
null |
419.6 |
g |
|
|
body weighing method |
|
|
|
|
|
method not specified, assumed to be digital scale |
|
|
13301 |
341 |
| ACI/SegHsd |
benign colorectal tumor surface area measurement |
1,2-dimethylhydrazine (20 mg/kg/week) (for 182 days) |
De Miglio MR, et al., Carcinogenesis. 2007 May 17;. |
colorectal integrity trait |
not specified |
days
| 20 |
|
|
8.2 |
mm2 |
1.03 |
4.6 |
ex vivo caliper method |
|
0.0 |
|
|
|
caliper |
|
|
70388 |
1378 |
| ACI/SegHsd |
pituitary gland wet weight |
diethylstilbestrol (5 mg) (for 84 days) and surgical implantation |
Strecker TE, et al., Genetics 2005 Jan 31;. |
pituitary gland mass |
male |
147.0 days
| 14 |
|
|
0.08 |
g |
0.0 |
0.01 |
post excision weight measurement |
|
0.0 |
subcutaneous implant |
84 |
days |
diethylstilbestrol |
|
|
69101 |
1122 |
| ACI/SegHsd |
pituitary gland wet weight |
sham surgical control condition |
Strecker TE, et al., Genetics 2005 Jan 31;. |
pituitary gland mass |
male |
147.0 days
| 7 |
|
|
0.01 |
g |
0.0 |
0.0 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
|
69104 |
1122 |
| ACI/SegHsd |
percentage of study population developing benign colorectal tumors during a period of time |
1,2-dimethylhydrazine (20 mg/kg/week) (for 182 days) |
De Miglio MR, et al., Carcinogenesis. 2007 May 17;. |
colorectal integrity trait |
not specified |
days
| 20 |
|
|
75.0 |
% |
|
|
ex vivo light microscopy |
|
0.0 |
|
|
|
|
|
|
70376 |
1378 |
| ACI/SegHsd |
benign colorectal tumor number |
1,2-dimethylhydrazine (20 mg/kg/week) (for 182 days) |
De Miglio MR, et al., Carcinogenesis. 2007 May 17;. |
colorectal integrity trait |
not specified |
days
| 20 |
|
|
1.5 |
null |
0.31 |
1.4 |
ex vivo light microscopy |
|
0.0 |
|
|
|
|
|
|
70378 |
1378 |
| ACI/SegHsd |
thymus wet weight |
control condition |
Gould KA, et al., Mamm Genome. 2006 May;17(5):451-64. |
thymus mass |
male |
147.0 days
| 9 |
|
|
150.0 |
mg |
15.33 |
46.0 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
|
69097 |
1121 |
| ACI/SegHsd |
thymus wet weight |
diethylstilbestrol (5 mg) (for 84 days) and surgical implantation |
Gould KA, et al., Mamm Genome. 2006 May;17(5):451-64. |
thymus mass |
male |
147.0 days
| 13 |
|
|
166.0 |
mg |
6.1 |
22.0 |
post excision weight measurement |
|
0.0 |
subcutaneous implant |
84 |
days |
diethylstilbestrol |
|
|
69099 |
1121 |
| ACI/SegHsd |
percentage of study population developing experimental autoimmune neuritis during a period of time |
peripheral nerve myelin (2 mg) and Freund's complete adjuvant (100 ul) |
de Graaf KL, et al., J Neuroimmunol. 2004 Oct;155(1-2):73-84. |
peripheral nervous system integrity trait |
male |
98.0 days-200.0 days |
4 |
|
|
0.0 |
% |
|
|
ex vivo visual assessment |
|
0.0 |
|
|
|
|
|
peripheral nervous system integrity trait |
84474 |
1178 |
| ACI/SegHsd |
percentage of study population developing subcutaneous tumors during a period of time |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
hypodermis integrity trait |
male |
900.0 days
| 12 |
|
|
0.0 |
% |
|
|
necropsy |
|
0.0 |
|
|
|
|
CMO:0003387 percentage of study population developing subcutaneous tumors during a period of time |
|
106887 |
341 |
| ACI/SegHsd |
percentage of study population developing ventral prostate tumorous lesions with a solid structure during a period of time |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
prostate integrity trait |
male |
900.0 days
| 12 |
|
|
92.0 |
% |
|
|
ex vivo light microscopy |
|
0.0 |
|
|
|
|
|
|
109885 |
341 |
| ACI/SegHsd |
number of ventral prostate tumorous lesions with solid structure |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
prostate integrity trait |
male |
900.0 days
| 12 |
|
|
3.0 |
null |
0.75 |
2.6 |
ex vivo light microscopy |
|
0.0 |
|
|
|
|
|
|
109887 |
341 |
| ACI/SegHsd |
percentage of study population developing ventral prostate tumorous lesions with round, irregular size nuclei during a period of time |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
prostate integrity trait |
male |
900.0 days
| 12 |
|
|
100.0 |
% |
|
|
ex vivo light microscopy |
|
0.0 |
|
|
|
|
|
|
109957 |
341 |
| ACI/SegHsd |
post-insult time to mammary tumor formation |
17 beta-estradiol (27.5 mg) (between 193 and 199 days) |
Schaffer BS, et al., Cancer Res. 2006 Aug 1;66(15):7793-800 |
mammary gland integrity trait |
female |
143.0 days-259.0 days |
22 |
|
median |
133.0 |
d |
|
|
manual palpation method |
|
0 |
crystalline implant |
|
|
|
|
|
65763 |
81 |
| ACI/SegHsd |
binary logarithm of pituitary gland wet weight |
surgical implantation then 17 beta-estradiol (27.5 mg) (between 193 and 199 days) |
Shull JD, et al., Mamm Genome. 2007 Sep 18;. |
pituitary gland mass |
female |
252.0 days-266.0 days |
9 |
|
|
7.15 |
null |
0.12 |
0.36 |
post excision weight measurement |
pituitary gland |
0 |
|
|
|
|
logarithm of pituitary wet weight |
|
65770 |
331 |
| ACI/SegHsd |
percentage of study population developing ventral prostate tumorous lesions during a period of time |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
prostate integrity trait |
male |
900.0 days
| 12 |
|
|
100.0 |
% |
|
|
ex vivo light microscopy |
|
0 |
|
|
|
|
|
|
65825 |
341 |
| ACI/SegHsd |
ventral prostate gland wet weight |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
ventral prostate mass |
male |
900.0 days
| 12 |
|
|
0.32 |
g |
|
|
post excision weight measurement |
|
0.0 |
|
|
|
|
|
|
65826 |
341 |
| ACI/SegHsd |
percentage of study population developing pituitary tumors during a period of time |
17 beta-estradiol (27.5 mg) (between 146 and 202 days) |
Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 |
pituitary gland integrity trait |
female |
207.0 days-265.0 days |
21 |
|
|
100.0 |
% |
|
|
ex vivo visual assessment |
|
0 |
|
|
|
|
|
|
65551 |
76 |
| ACI/SegHsd |
percentage of study population developing mammary tumors during a period of time |
bilateral ovariectomy then 17 beta-estradiol (27.5 mg) (for 140 days) |
Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 |
mammary gland integrity trait |
female |
201.0 days-203.0 days |
11 |
|
|
0.0 |
% |
|
|
manual palpation method |
mammary gland |
0 |
|
|
|
|
|
|
11379 |
76 |
| ACI/SegHsd |
percentage of study population developing leukemia during a period of time |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
leukocyte integrity trait |
male |
900.0 days
| 12 |
|
|
0.0 |
% |
|
|
ex vivo light microscopy |
|
0 |
|
|
|
|
leukemia incidence |
|
66143 |
341 |
| ACI/SegHsd |
percentage of study population developing poorly differentiated malignant colorectal tumors during a period of time |
1,2-dimethylhydrazine (20 mg/kg/week) (for 182 days) |
De Miglio MR, et al., Carcinogenesis. 2007 May 17;. |
colorectal integrity trait |
not specified |
days
| 20 |
|
|
15.0 |
% |
|
|
ex vivo light microscopy |
|
0.0 |
|
|
|
|
|
|
70384 |
1378 |
| ACI/SegHsd |
poorly differentiated malignant colorectal tumor surface area measurement |
1,2-dimethylhydrazine (20 mg/kg/week) (for 182 days) |
De Miglio MR, et al., Carcinogenesis. 2007 May 17;. |
colorectal integrity trait |
not specified |
days
| 20 |
|
|
38.7 |
mm2 |
1.81 |
8.1 |
ex vivo caliper method |
|
0.0 |
|
|
|
caliper |
|
|
70392 |
1378 |
| ACI/SegHsd |
pituitary gland wet weight |
diethylstilbestrol (5 mg) (for 84 days) and surgical implantation |
Strecker TE, et al., Genetics 2005 Jan 31;. |
pituitary gland mass |
male |
147.0 days
| 28 |
|
|
0.07 |
g |
0.0 |
0.01 |
post excision weight measurement |
|
0.0 |
subcutaneous implant |
84 |
days |
diethylstilbestrol |
|
|
69105 |
1122 |
| ACI/SegHsd |
percentage of study population developing experimental autoimmune encephalomyelitis during a period of time |
myelin oligodendrocyte glycoprotein (0.25 mg/ml) and Freund's incomplete adjuvant (50 %) |
Dahlman I, et al., Hum Mol Genet 1999 Nov;8(12):2183-90. |
central nervous system integrity trait |
not specified |
70.0 days-145.0 days |
21 |
|
|
5.0 |
% |
|
|
in vivo visual assessment |
|
0.0 |
|
|
|
|
|
|
69970 |
1279 |
| ACI/SegHsd |
percentage of study population developing bilateral testis tumors during a period of time |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
testis integrity trait |
male |
900.0 days
| 12 |
|
|
25.0 |
% |
|
|
ex vivo light microscopy |
|
0.0 |
|
|
|
necropsy |
bilateral testis tumor incidence |
|
67948 |
341 |
| ACI/SegHsd |
absolute change in thymus weight |
control condition |
Gould KA, et al., Mamm Genome. 2006 May;17(5):451-64. |
thymus mass |
male |
147.0 days
| 9 |
|
|
268.0 |
mg |
|
|
post excision weight measurement |
|
0.0 |
|
|
|
|
|
|
69098 |
1121 |
| ACI/SegHsd |
volume of blood removed to total prehemorrhagic blood volume ratio |
arterial catheter implantation (between 1 and 1.2 days) then controlled hemorrhage (for 0.4 hours) |
Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. |
blood amount |
male |
89.0 days-95.0 days |
9 |
5.83 mL/100 g of body weight |
|
56.9 |
% |
0.5 |
1.5 |
body weighing method |
|
0.0 |
|
|
|
|
volume of blood removed to total prehemorrhagic blood volume ratio (CMO:0003663) |
|
109123 |
3077 |
| ACI/SegHsd |
area of ventral prostate occupied by tumorous lesions with round, irregular size nuclei to total ventral prostate area ratio |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
prostate integrity trait |
male |
900.0 days
| 12 |
|
|
1.57 |
% |
0.38 |
1.31 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
|
|
|
|
|
109963 |
341 |
| ACI/SegHsd |
percentage of study population developing mammary tumors during a period of time |
17 beta-estradiol (27.5 mg) (between 147 and 195 days) |
Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 |
mammary gland integrity trait |
female |
206.0 days-264.0 days |
31 |
|
|
100.0 |
% |
|
|
manual palpation method |
|
0 |
|
|
|
|
mean |
|
66112 |
144 |
| ACI/SegHsd |
binary logarithm of pituitary gland wet weight |
sham surgical control condition (between 193 and 199 days) |
Shull JD, et al., Mamm Genome. 2007 Sep 18;. |
pituitary gland mass |
female |
252.0 days-266.0 days |
10 |
|
|
3.13 |
null |
0.06 |
0.19 |
post excision weight measurement |
pituitary gland |
0 |
|
|
|
|
logarithm of pituitary wet weight |
|
65771 |
331 |
| ACI/SegHsd |
both testes wet weight |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
testis mass |
male |
900.0 days
| 12 |
|
|
2.81 |
g |
|
|
post excision weight measurement |
|
0 |
|
|
|
|
|
|
65820 |
341 |
| ACI/SegHsd |
area of individual prostate tumorous lesion |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
prostate integrity trait |
male |
900.0 days
| 12 |
|
|
1.78 |
mm2 |
|
|
ex vivo light microscopy with digital image analysis |
|
0 |
|
|
|
|
|
|
65838 |
341 |
| ACI/SegHsd |
percentage of study population developing mammary tumors during a period of time |
17 beta-estradiol (27.5 mg) (for 197 days) |
Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 |
mammary gland integrity trait |
female |
160.0 days-260.0 days |
21 |
|
|
100.0 |
% |
|
|
manual palpation method |
mammary gland |
0 |
|
|
|
|
|
|
65549 |
76 |
| ACI/SegHsd |
pituitary gland wet weight |
surgical implantation then 17 beta-estradiol (27.5 mg) (between 193 and 199 days) |
Shull JD, et al., Mamm Genome. 2007 Sep 18;. |
pituitary gland mass |
female |
252.0 days-266.0 days |
9 |
|
|
0.15 |
g |
0.01 |
0.04 |
post excision weight measurement |
pituitary gland |
0 |
|
|
|
|
|
|
13093 |
331 |
| ACI/SegHsd |
percentage of study population developing well differentiated malignant colorectal tumors during a period of time |
1,2-dimethylhydrazine (20 mg/kg/week) (for 182 days) |
De Miglio MR, et al., Carcinogenesis. 2007 May 17;. |
colorectal integrity trait |
not specified |
days
| 20 |
|
|
20.0 |
% |
|
|
ex vivo light microscopy |
|
0.0 |
|
|
|
|
|
|
70380 |
1378 |
| ACI/SegHsd |
thymus wet weight |
control condition |
Gould KA, et al., Mamm Genome. 2006 May;17(5):451-64. |
thymus mass |
male |
63.0 days
| 9 |
|
|
419.0 |
mg |
13.33 |
40.0 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
|
69096 |
1121 |
| ACI/SegHsd |
water intake drink rate to body weight ratio |
arterial catheter implantation (for 1 days) |
Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. |
drinking behavior trait |
male |
89.0 days-95.0 days |
9 |
|
|
0.36 |
ml/d/kg |
0.08 |
0.24 |
drink intake measuring method |
|
0.0 |
arterial catheter implantation |
1 |
days |
|
water intake/body weight ratio |
Water consumed
(g) postsurgery
per 100 g BW |
107154 |
3077 |
| ACI/SegHsd |
hematocrit |
arterial catheter implantation (for 1 days) then controlled hemorrhage (for 0 hours) |
Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. |
erythrocyte quantity |
male |
89.0 days-95.0 days |
9 |
|
|
35.1 |
% |
2.1 |
6.3 |
microhematocrit tube assay with visual assessment |
|
0.0 |
|
|
|
|
|
initial hematocrit, final hematocrit, change in hematocrit |
107231 |
3077 |
| ACI/SegHsd |
absolute change in hematocrit |
arterial catheter implantation (for 1 days) then controlled hemorrhage (between 0 and 0.4 hours) |
Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. |
erythrocyte quantity |
male |
89.0 days-95.0 days |
9 |
|
|
4.5 |
% |
2.5 |
7.5 |
microhematocrit tube assay with visual assessment |
|
0.0 |
|
|
|
|
start vs end of hemorrhage |
initial hematocrit, final hematocrit, change in hematocrit |
107265 |
3077 |
| ACI/SegHsd |
percentage of study population developing unilateral renal agenesis during a period of time |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
kidney integrity trait |
male |
900.0 days
| 12 |
|
|
24.0 |
% |
|
|
necropsy |
|
0.0 |
|
|
|
|
|
|
106885 |
341 |
| ACI/SegHsd |
area of individual ventral prostate tumorous lesion with a solid structure |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
prostate integrity trait |
male |
900.0 days
| 12 |
|
|
1.17 |
mm2 |
0.36 |
1.25 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
|
|
|
|
|
109889 |
341 |
| ACI/SegHsd |
number of ventral prostate tumorous lesions with round, irregular size nuclei |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
prostate integrity trait |
male |
900.0 days
| 12 |
|
|
5.1 |
null |
0.69 |
2.4 |
ex vivo light microscopy |
|
0.0 |
|
|
|
|
|
|
109959 |
341 |
| ACI/SegHsd |
area of individual ventral prostate tumorous lesion with round, irregular size nuclei |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
prostate integrity trait |
male |
900.0 days
| 12 |
|
|
1.73 |
mm2 |
0.36 |
1.24 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
|
|
|
|
|
109961 |
341 |
| ACI/SegHsd |
percentage of study population developing mammary tumors during a period of time |
17 beta-estradiol (27.5 mg) (between 193 and 199 days) |
Schaffer BS, et al., Cancer Res. 2006 Aug 1;66(15):7793-800 |
mammary gland integrity trait |
female |
143.0 days-259.0 days |
22 |
|
|
94.0 |
% |
|
|
manual palpation method |
|
0 |
crystalline implant |
|
|
|
|
|
65764 |
81 |
| ACI/SegHsd |
percentage of study population developing testis tumors during a period of time |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
testis integrity trait |
male |
900.0 days
| 12 |
|
|
92.0 |
% |
|
|
ex vivo light microscopy |
|
0.0 |
|
|
|
|
testis tumor incidence |
|
65840 |
341 |
| ACI/SegHsd |
percentage of study population developing pituitary tumors during a period of time |
bilateral ovariectomy then 17 beta-estradiol (27.5 mg) (for 140 days) |
Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 |
pituitary gland integrity trait |
female |
201.0 days-203.0 days |
11 |
|
|
100.0 |
% |
|
|
ex vivo visual assessment |
|
0 |
|
|
|
|
|
|
65561 |
76 |
| ACI/SegHsd |
mammary tumor number |
control condition |
Kurz SG, et al., Endocrinology. 2008 Apr 17 |
mammary gland integrity trait |
female |
259.0 days
| 4 |
|
|
0.0 |
null |
|
|
necropsy |
|
|
|
|
|
|
|
|
11367 |
75 |
| ACI/SegHsd |
mammary tumor number |
17 beta-estradiol (27.5 mg) (between 99 and 197 days) |
Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 |
mammary gland integrity trait |
female |
160.0 days-260.0 days |
20 |
|
|
5.6 |
null |
|
|
necropsy |
|
0.0 |
|
|
|
tumor size reach 1-1.5 cm |
|
|
11377 |
76 |
| ACI/SegHsd |
post-insult time to mammary tumor formation |
17 beta-estradiol (27.5 mg) (between 193 and 199 days) |
Schaffer BS, et al., Cancer Res. 2006 Aug 1;66(15):7793-800 |
mammary gland integrity trait |
female |
143.0 days-259.0 days |
22 |
|
|
136.0 |
d |
6.0 |
28.14 |
manual palpation method |
|
0.0 |
crystalline implant |
|
|
|
|
|
11383 |
81 |
| ACI/SegHsd |
post-insult time to mammary tumor formation |
17 beta-estradiol (27.5 mg) (between 147 and 195 days) |
Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 |
mammary gland integrity trait |
female |
206.0 days-264.0 days |
31 |
|
median |
140.0 |
d |
|
|
manual palpation method |
|
|
|
|
|
|
median |
|
11750 |
144 |
| ACI/SegHsd |
mammary tumor number |
17 beta-estradiol (27.5 mg) (between 144 and 195 days) |
Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 |
mammary gland integrity trait |
female |
203.0 days-264.0 days |
34 |
|
|
3.9 |
null |
0.6 |
3.5 |
manual palpation method |
|
0 |
|
|
|
|
|
|
11752 |
144 |
| ACI/SegHsd |
liver wet weight |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
liver mass |
male |
900.0 days
| 12 |
|
null |
11.3 |
g |
|
|
post excision weight measurement |
|
|
|
|
|
method not specified, assumed to be digital scale |
|
|
13303 |
341 |
| ACI/SegHsd |
spleen wet weight |
control condition |
Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. |
spleen mass |
male |
900.0 days
| 12 |
|
null |
0.8 |
g |
|
|
post excision weight measurement |
|
|
|
|
|
method not specified, assumed to be digital scale |
|
|
13305 |
341 |
| ACI/SegHsd |
pituitary gland wet weight |
sham surgical control condition |
Strecker TE, et al., Genetics 2005 Jan 31;. |
pituitary gland mass |
male |
147.0 days
| 6 |
|
|
0.01 |
g |
0.0 |
0.0 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
|
69100 |
1122 |
| ACI/SegHsd |
percentage of study population developing unilateral renal agenesis during a period of time |
control condition |
Shull JD, et al., Mamm Genome. 2006 Jul;17(7):751-9. Epub 2006 Jul 14. |
kidney integrity trait |
female |
days
| 96 |
|
|
13.5 |
% |
|
|
necropsy |
|
0.0 |
|
|
|
|
|
|
69372 |
1157 |
| ACI/SegHsd |
percentage of study population developing unilateral renal agenesis during a period of time |
control condition |
Shull JD, et al., Mamm Genome. 2006 Jul;17(7):751-9. Epub 2006 Jul 14. |
kidney integrity trait |
male |
days
| 87 |
|
|
5.7 |
% |
|
|
necropsy |
|
0.0 |
|
|
|
|
|
|
69374 |
1157 |
| ACI/SegHsd |
well differentiated malignant colorectal tumor number |
1,2-dimethylhydrazine (20 mg/kg/week) (for 182 days) |
De Miglio MR, et al., Carcinogenesis. 2007 May 17;. |
colorectal integrity trait |
not specified |
days
| 20 |
|
|
0.28 |
null |
0.04 |
0.16 |
ex vivo light microscopy |
|
0.0 |
|
|
|
|
|
|
70381 |
1378 |
| ACI/SegHsd |
food intake weight to body weight ratio |
arterial catheter implantation (for 1 days) |
Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. |
eating behavior trait |
male |
89.0 days-95.0 days |
9 |
|
|
4.5 |
g/d/100g |
0.5 |
1.5 |
food intake measuring method |
|
0.0 |
arterial catheter implantation |
1 |
days |
|
|
Food consumed
(g) postsurgery
per 100 g BW |
107119 |
3077 |