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Term:
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long-chain fatty acid-CoA ligase activity +   
Catalysis of the reaction: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
medium-chain fatty acid-CoA ligase activity +   
short-chain fatty acid-CoA ligase activity +   
very long-chain fatty acid-CoA ligase activity  

Synonyms
Narrow Synonyms: pristanoyl-CoA synthetase ;   stearoyl-CoA synthetase
Broad Synonyms: acyl-activating enzyme activity
Related Synonyms: LCFA synthetase activity ;   acyl-CoA ligase activity ;   acyl-CoA synthetase activity ;   fatty acid thiokinase (long chain) activity ;   lignoceroyl-CoA synthase activity ;   long chain fatty acyl-CoA synthetase activity ;   long-chain acyl CoA synthetase activity ;   long-chain acyl-coenzyme A synthetase activity ;   long-chain fatty acid activation ;   long-chain fatty acyl coenzyme A synthetase activity
Alternate IDs: GO:0003996
Xrefs: EC:6.2.1.3 ;   MetaCyc:RXN-7904 ;   RHEA:15421 ;   Reactome:R-HSA-5696004 "ACSF2 ligates CoA-SH to MCFA" ;   Reactome:R-HSA-9734535 "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA" ;   reactome:R-HSA-159425 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)" ;   reactome:R-HSA-192137 "THCA is conjugated with Coenzyme A (SLC27A5 BACS)" ;   reactome:R-HSA-193401 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)" ;   reactome:R-HSA-193407 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)" ;   reactome:R-HSA-193424 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)"
Definition Sources: RHEA:15421

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