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EXPERIMENTAL CONDITION - ANNOTATIONS

The Clinical Measurement Ontology (CMO), Measurement Methods Ontology (MMO), and Experimental Condition Ontology (XCO) are currently being developed at the Rat Genome Database. For more information about these vocabularies please see Shimoyama et al. Three ontologies to define phenotype measurement data. Front Genet. 2012;3:87. Epub 2012 May 28 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:controlled N-methyl-N'-nitro-N-nitrosoguanidine content drinking water
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Accession:XCO:0000355 term browser browse the term
Definition:A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of water and a specified amount of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), and consumed by an organism as part of an experiment. Water is the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). MNNG is a guanidine derivative with a nitro group (-NO2) on the nitrogen at position 3 and a methyl group (-CH3) and nitroso group (-NO) on the nitrogen at position 1. MNNG acts by adding alkyl groups to the O6 of guanine and O4 of thymine of DNA, giving it potent mutagenic and carcinogenic properties.
Synonyms:exact_synonym: controlled 1-methyl-3-nitro-1-nitrosoguanidine content drinking water;   controlled methylnitronitrosoguanidine content drinking water
 related_synonym: controlled MNNG content drinking water
 xref: CHEBI:21759


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controlled N-methyl-N'-nitro-N-nitrosoguanidine content drinking water term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
Q Gcr1 Gastric cancer resistance QTL 1 IDA RGD PMID:10706129 RGD:69698 NCBI chr 4:120,260,281...147,278,687 JBrowse link
Q Gcr2 Gastric cancer resistance QTL 2 IDA RGD PMID:10706129 RGD:69698 NCBI chr 3:8,658,162...27,494,778 JBrowse link
Q Gcr3 Gastric cancer resistance QTL 3 IDA RGD PMID:10706129 RGD:69698 NCBI chr16:17,696,791...82,635,055 JBrowse link
Q Gcs1 Gastric cancer susceptibility QTL1 IDA RGD PMID:10706129 RGD:69698 NCBI chr15:76,306,099...101,769,107 JBrowse link

Related Phenotype Data for Term "controlled N-methyl-N'-nitro-N-nitrosoguanidine content drinking water" (XCO:0000355)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:
Term paths to the root
Path 1
Term Annotations click to browse term
  experimental condition 2376
    chemical 712
      chemical with specified structure 560
        water 92
          controlled content drinking water 92
            controlled N-methyl-N'-nitro-N-nitrosoguanidine content drinking water 4
Path 2
Term Annotations click to browse term
  experimental condition 2376
    consumption 1027
      diet 1027
        drink 92
          water 92
            controlled content drinking water 92
              controlled N-methyl-N'-nitro-N-nitrosoguanidine content drinking water 4
paths to the root