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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal circulating C-peptide level
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Accession:MP:0031512 term browser browse the term
Definition:anomaly in the amount in the blood of the connecting (C) peptide that links the A and B chains in proinsulin
Comment:C-peptide provides a means to promote the efficient folding and assembly of the A and B chains of proinsulin in the endoplasmic reticulum during insulin biosynthesis; after cleavage of proinsulin, C-peptide is stored with insulin in the soluble phase of the secretory granules and is subsequently released in equimolar amounts with insulin, providing an independent indicator of insulin secretion.
Synonyms:exact_synonym: abnormal blood C-peptide level;   abnormal circulating connecting peptide level
 narrow_synonym: abnormal plasma C-peptide level;   abnormal serum C-peptide level


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  mammalian phenotype 5418
    homeostasis/metabolism phenotype 1423
      abnormal homeostasis 1324
        abnormal blood homeostasis 761
          abnormal circulating protein level 109
            abnormal circulating C-peptide level 0
              decreased circulating C-peptide level 0
              increased circulating C-peptide level 0
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