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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal podocyte motility
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Accession:MP:0011865 term browser browse the term
Definition:any anomaly in the ability of podocyte foot processes (FPs) to retract or elongate and hence move quickly along the glomerular basement membrane (GBM); motility refers to the dynamic reorganization of the interdigitating FP structure in vivo , and to the cell migration of cultured podocytes in vitro that is seen as surrogate for the former; alterations in podocyte motility are considered to underlie foot process effacement, with changes in the leading edge of the cell and its interactions with the GBM; a rather stationary podocyte phenotype is believed to reflect a stable FP structure with intact slit diaphragms, whereas hypermotility is believed to promote the development of FP effacement and proteinuria
Synonyms:exact_synonym: abnormal podocyte migration
 narrow_synonym: abnormal podocyte foot process motility


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  mammalian phenotype 5420
    renal/urinary system phenotype 649
      abnormal renal/urinary system physiology 478
        abnormal kidney physiology 142
          abnormal podocyte physiology 3
            abnormal podocyte motility 0
              decreased podocyte motility 0
              increased podocyte motility 0
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