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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased tumor necrosis factor secretion
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Accession:MP:0008560 term browser browse the term
Definition:increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
Synonyms:exact_synonym: increased TNF secretion;   increased TNFA secretion;   increased cachectin secretion;   increased tumor necrosis factor alpha secretion;   increased tumour necrosis factor alpha secretion;   increased tumour necrosis factor secretion


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increased tumor necrosis factor secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S SS-Chr 2BN/Mcwi IAGP compared to SS/Hsd; RGD PMID:20044442 RGD:4890416
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  mammalian phenotype 5420
    immune system phenotype 502
      abnormal immune system physiology 384
        abnormal immune serum protein physiology 92
          abnormal cytokine secretion 24
            abnormal tumor necrosis factor secretion 5
              increased tumor necrosis factor secretion 1
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