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The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

Term:Mode of inheritance
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Accession:HP:0000005 term browser browse the term
Definition:The pattern in which a particular genetic trait or disorder is passed from one generation to the next.
Comment:While there is a close conceptual relationship between allelic requirement and inheritance, they serve different purposes; allelic requirement is necessary for variant annotation pipelines and to determine if a given variant in a specific context is relevant to the phenotype of the patient e.g. a heterozygous variant (in the absence of compound heterozygosity) is relevant for dominant but not for recessive disease; while inheritance is used for describing the mode of inheritance of a phenotype and is particularly applicable in the clinical setting for communicating recurrence risk, to guide family screening, and to guide reproductive advice.
Synonyms:exact_synonym: Inheritance
 alt_id: HP:0001425;   HP:0001453;   HP:0001461;   HP:0010985
 xref: UMLS:C1708511

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Term Annotations click to browse term
  Human phenotype 0
    Mode of inheritance 0
      Inheritance qualifier + 0
      Mendelian inheritance + 0
      Non-Mendelian inheritance + 0
      Sporadic 0
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