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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Decreased CSF N-acetyl-aspartyl-glutamate concentration
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Accession:HP:6000765 term browser browse the term
Definition:The concentration of N-acetyl-aspartyl-glutamate (NAAG) in the cerebrospinal fluid (CSF) is below the lower limit of normal.
Comment:N-acetyl-aspartyl-glutamate (NAAG) is the most abundant dipeptide in the brain, where it acts as a neuromodulator of glutamatergic synapses by activating presynaptic metabotropic glutamate receptor 3 (mGluR3).

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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of metabolism/homeostasis 0
        Abnormal CSF protein concentration 0
          Decreased CSF N-acetyl-aspartyl-glutamate concentration 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the nervous system 0
        Abnormal nervous system morphology 0
          Morphological central nervous system abnormality 0
            Abnormal cerebrospinal fluid morphology 0
              Abnormal CSF protein concentration 0
                Decreased CSF N-acetyl-aspartyl-glutamate concentration 0
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