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ONTOLOGY REPORT - ANNOTATIONS

Term:hydroxymethylglutaryl-CoA reductase (NADH) activity
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Accession:GO:0140643 term browser browse the term
Definition:Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH.
Comment:Note that this activity is not present in eukaryotes, see PMID:29224355.
Synonyms:broad_synonym: 3-hydroxy-3-methylglutaryl coenzyme A reductase activity;   HMG-CoA reductase activity;   beta-hydroxy-beta-methylglutaryl CoA-reductase activity;   beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity;   hydroxymethylglutaryl coenzyme A reductase activity
 xref: EC:1.1.1.88;   KEGG_REACTION:R02081;   MetaCyc:HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN;   RHEA:14833
 never_in_taxon: NCBITaxon:2759 ! Eukaryota


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  molecular_function 19551
    catalytic activity 6024
      oxidoreductase activity 769
        oxidoreductase activity, acting on CH-OH group of donors 136
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 126
            hydroxymethylglutaryl-CoA reductase (NADH) activity 0
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