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ONTOLOGY REPORT - ANNOTATIONS

Term:N-acetyllactosaminide alpha-2,3-sialyltransferase activity
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Accession:GO:0008118 term browser browse the term
Definition:Catalysis of the reaction: a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H+.
Comment:The substrate for this reaction is a beta-D-galactosyl-(1->4)-N-acetyl- D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids.
Synonyms:broad_synonym: N-acetyllactosaminide alpha-2,3-sialyltransferase
 related_synonym: alpha2->3 sialyltransferase activity;   cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity;   neolactotetraosylceramide alpha-2,3-sialyltransferase activity
 xref: EC:2.4.3.6;   MetaCyc:2.4.99.6-RXN;   RHEA:52316


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N-acetyllactosaminide alpha-2,3-sialyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 TAS RGD PMID:1400416 RGD:68308 NCBI chr 5:131,470,348...131,670,794
Ensembl chr 5:131,470,348...131,670,810 		JBrowse link
G St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 enables ISS
ISO		 GO_REF:0000024
(PMID:25498912), (PMID:8611500)
(PMID:12097641)		 UniProt
RGD		 PMID:8611500 PMID:12097641 PMID:25498912 GO_REF:0000024 NCBI chr 8:33,415,666...33,465,319
Ensembl chr 8:33,415,671...33,524,389 		JBrowse link
G St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 enables IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:10206952)		 Ensembl
UniProt
RGD		 PMID:10206952 GO_REF:0000024 GO_REF:0000107 NCBI chr11:42,061,282...42,121,801
Ensembl chr11:42,077,621...42,121,776 		JBrowse link
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Term Annotations click to browse term
  molecular_function 20626
    catalytic activity 6028
      transferase activity 2396
        glycosyltransferase activity 284
          sialyltransferase activity 22
            N-acetyllactosaminide alpha-2,3-sialyltransferase activity 3
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