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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA-binding transcription factor activity
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Accession:GO:0003700 term browser browse the term
Definition:A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
Comment:Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions.
Synonyms:exact_synonym: gene-specific transcription factor activity;   sequence-specific DNA binding transcription factor activity
 narrow_synonym: bacterial-type DNA binding transcription factor activity;   bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity;   bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity;   metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity;   metal ion regulated sequence-specific DNA binding transcription factor activity;   nucleic acid binding transcription factor activity;   sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity;   transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding;   transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding;   transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding
 broad_synonym: transcription factor activity
 alt_id: GO:0000130;   GO:0001071;   GO:0001130;   GO:0001131;   GO:0001151;   GO:0001199;   GO:0001204
 xref: Reactome:R-HSA-163666 "Formation of ChREBP:MLX heterodimer"

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      molecular_function 200960
        transcription regulator activity 16514
          DNA-binding transcription factor activity 12011
            DNA-binding transcription activator activity + 4954
            DNA-binding transcription factor activity, RNA polymerase II-specific + 11316
            DNA-binding transcription repressor activity + 2931
            ligand-modulated transcription factor activity + 560
            sigma factor activity 0
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