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EXPERIMENTAL FACTOR ONTOLOGY - ANNOTATIONS

Term:Tourette syndrome
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Accession:EFO:0004895 term browser browse the term
Definition:A neurologic disorder caused by defective metabolism of the neurotransmitters in the brain. It is characterized by repeated involuntary movements (motor tics) and uncontrollable vocal sounds (vocal tics). The symptoms are usually manifested before the age of eighteen. A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or a general medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
Synonyms:exact_synonym: Guinon's disease;   Tourette disease;   Tourette's syndrome;   motor-verbal tic disorder;   psychogenic tics
 related_synonym: GTS;   Gilles DE LA TOURETTE syndrome;   Gilles De 50A Tourette syndrome;   Tourette disorder;   chronic motor tics
 xref: DOID:11119;   ICD9:307.23;   MEDGEN:21219;   MESH:D005879;   MIM:137580;   MONDO:0007661;   MedDRA:10044125;   NCI:C35078;   ORDO:856;   SCTID:5158005;   UMLS:C0040517


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