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EXPERIMENTAL FACTOR ONTOLOGY - ANNOTATIONS

Term:infantile hypertrophic pyloric stenosis
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Accession:EFO:0004707 term browser browse the term
Definition:An abnormality characterized by thickening of the muscle in the wall of the pylorus. It results in the narrowing of the pyloric channel. The overlying mucosa may appear hypertrophic as well. Clinical signs and symptoms appear early in life and include projectile vomiting and dehydration. This condition is caused by diffuse hypertrophy and hyperplasia of the smooth muscle of the antrum of the stomach and pylorus. It usually occurs in infants aged 2-8 weeks. The pyloric muscle hypertrophy results in narrowing of the pyloric canal, which can then become easily obstructed. Genetic studies have identified susceptibility loci for infantile hypertrophic pyloric stenosis (IHPS) and molecular studies have concluded that smooth muscle cells are not properly innervated in this condition.
Comment:"Panteli C; New insights into the pathogenesis of infantile pyloric stenosis. Pediatr Surg Int. 2009 Dec;25(12):1043-52. Epub 2009 Sep 16. [abstract]"
Synonyms:exact_synonym: IHPS;   congenital Hypertrophy of the pylorus;   congenital constriction of the pylorus;   congenital hypertrophic pyloric stenosis;   congenital or infantile stricture of pylorus;   congenital pyloric stenosis;   congenital stricture of the pylorus;   hypertrophic pyloric stenosis;   infantile Hypertrophy of the pylorus;   infantile constriction of the pylorus;   infantile pyloric stenosis;   infantile stricture of the pylorus
 xref: DOID:12638;   HP:0002021;   ICD10CM:Q40.0;   ICD9:750.5;   MESH:D046248;   MONDO:0001560;   MP:0003307;   NCI:C98952;   SCTID:48644003


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Term Annotations click to browse term
  experimental factor 0
    material property 0
      disposition 0
        disease 0
          digestive system disease 0
            intestinal disease 0
              infantile hypertrophic pyloric stenosis 0
                acquired hypertrophic pyloric stenosis 0
                inherited hypertrophic pyloric stenosis + 0
Path 2
Term Annotations click to browse term
  experimental factor 0
    material property 0
      disposition 0
        disease 0
          digestive system disease 0
            gastrointestinal disease 0
              stomach disease 0
                pyloric stenosis 0
                  infantile hypertrophic pyloric stenosis 0
                    acquired hypertrophic pyloric stenosis 0
                    inherited hypertrophic pyloric stenosis + 0
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