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quisinostat - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:quisinostat
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Accession:CHEBI:94771 term browser browse the term
Definition:A member of the class of methylindoles that is 1H-indole substituted by methyl and [({1-[5-(hydroxycarbamoyl)pyrimidin-2-yl]piperidin-4-yl}methyl)amino]methyl groups at positions 1 and 3, respectively. It is an orally bioavailable pan-HDAC inhibitor that exhibits antineoplastic activity.
Synonyms:exact_synonym: N-hydroxy-2-[4-({[(1-methyl-1H-indol-3-yl)methyl]amino}methyl)piperidin-1-yl]pyrimidine-5-carboxamide
 related_synonym: Formula=C21H26N6O2;   InChI=1S/C21H26N6O2/c1-26-14-17(18-4-2-3-5-19(18)26)11-22-10-15-6-8-27(9-7-15)21-23-12-16(13-24-21)20(28)25-29/h2-5,12-15,22,29H,6-11H2,1H3,(H,25,28);   InChIKey=PAWIYAYFNXQGAP-UHFFFAOYSA-N;   JNJ 26481585;   JNJ26481585;   SMILES=CN1C=C(CNCC2CCN(CC2)C2=NC=C(C=N2)C(=O)NO)C2=CC=CC=C12;   quisinostatum
 xref: CAS:875320-29-9;   DrugBank:DB12985;   KEGG:D10321;   LINCS:LSM-5900;   PDBeChem:GOK;   PMID:19322073;   PMID:19494837;   PMID:19531653;   PMID:19682743;   PMID:19861438;   PMID:20331455;   PMID:23073311;   PMID:23741066;   PMID:24038993;   PMID:25085711;   PMID:26473375;   PMID:26616861;   PMID:28617441;   PMID:29709701;   PMID:30012418;   PMID:30347148;   PMID:30443188;   PMID:31082457;   PMID:32146648;   PMID:32286289;   PMID:33290780;   PMID:33690666;   PMID:33913071;   PMID:33974136;   PMID:34004213;   PMID:34125328;   PMID:34834249;   PMID:34936867;   PMID:35175762;   PMID:35636521;   PMID:35681564;   PMID:37603953;   PMID:37991020;   PMID:38338691;   PMID:38693852;   Wikipedia:Quisinostat

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  CHEBI ontology 19887
    role 19858
      biological role 19856
        biochemical role 19566
          autophagy inducer 2098
            quisinostat 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  carbon oxoacid 18676
                                    carboxylic acid 18673
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17545
                                            carboxamide 17545
                                              hydroxamic acid 6342
                                                quisinostat 0
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