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SU4312 - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:SU4312
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Accession:CHEBI:92369 term browser browse the term
Definition:A member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group. SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.
Synonyms:exact_synonym: 3-[4-(dimethylamino)benzylidene]-1,3-dihydro-2H-indol-2-one
 related_synonym: 3-(4-dimethylamino-benzylidenyl)-2-indolinone;   3-[[4-(dimethylamino)phenyl]methylidene]-1H-indol-2-one;   DMBI;   Formula=C17H16N2O;   InChI=1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20);   InChIKey=UAKWLVYMKBWHMX-UHFFFAOYSA-N;   SMILES=N1C(C(C2=C1C=CC=C2)=CC=3C=CC(=CC3)N(C)C)=O;   SU 4312
 xref: CAS:5812-07-7;   LINCS:LSM-2454;   PMID:19235725;   PMID:23062100;   PMID:24134630;   PMID:26327470;   PMID:26820057;   PMID:28807675;   Reaxys:28935825

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  CHEBI ontology 5223
    role 5190
      application 978
        pharmaceutical 811
          drug 811
            antineoplastic agent 247
              SU4312 0
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  CHEBI ontology 5223
    subatomic particle 5213
      composite particle 5213
        hadron 5213
          baryon 5213
            nucleon 5213
              atomic nucleus 5213
                atom 5213
                  main group element atom 5185
                    p-block element atom 5182
                      carbon group element atom 5099
                        carbon atom 5098
                          organic molecular entity 5098
                            heteroorganic entity 4943
                              organochalcogen compound 4896
                                organooxygen compound 4862
                                  carbon oxoacid 411
                                    carboxylic acid 406
                                      carboacyl group 228
                                        univalent carboacyl group 228
                                          carbamoyl group 225
                                            carboxamide 225
                                              lactam 49
                                                gamma-lactam 9
                                                  oxindoles 2
                                                    SU4312 0
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