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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:midodrine
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Accession:CHEBI:6933 term browser browse the term
Definition:An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
Synonyms:exact_synonym: rac-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]glycinamide
 related_synonym: (+-)-2-amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide;   1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol;   2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamide;   DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamid;   Formula=C12H18N2O4;   InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);   InChIKey=PTKSEFOSCHHMPD-UHFFFAOYSA-N;   SMILES=COc1ccc(OC)c(c1)C(O)CNC(=O)CN;   midodrina;   midodrinum
 xref: Beilstein:2384653;   CAS:42794-76-3;   DrugBank:DB00211;   Drug_Central:1803;   HMDB:HMDB0014356;   KEGG:C07890;   KEGG:D08220;   LINCS:LSM-1815
 xref_mesh: MESH:D008879
 xref: PMID:11096750;   PMID:15273244;   PMID:16676655;   PMID:17901021;   PMID:18410283;   PMID:18840368;   PMID:19522958;   PMID:20376815;   PMID:20844343;   PMID:21343575;   PMID:21801220;   PMID:22436941;   PMID:23051063;   Patent:GB1003659;   Patent:US3340298;   Reaxys:2384653;   Wikipedia:Midodrine
 cyclic_relationship: is_conjugate_base_of CHEBI:73243


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Term Annotations click to browse term
  CHEBI ontology 497
    role 497
      application 457
        pro-agent 17
          prodrug 17
            midodrine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 497
    subatomic particle 497
      composite particle 497
        hadron 497
          baryon 497
            nucleon 501
              atomic nucleus 501
                atom 497
                  main group element atom 490
                    main group molecular entity 494
                      s-block molecular entity 436
                        hydrogen molecular entity 439
                          hydrides 369
                            inorganic hydride 328
                              pnictogen hydride 327
                                nitrogen hydride 329
                                  azane 324
                                    ammonia 324
                                      organic amino compound 324
                                        amino acid 39
                                          alpha-amino acid 21
                                            L-alpha-amino acid 18
                                              serine family amino acid 5
                                                glycine 0
                                                  glycine derivative 0
                                                    glycinamide 0
                                                      midodrine 0
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