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4-hydroxyphenyl retinamide - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-hydroxyphenyl retinamide
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Accession:CHEBI:42588 term browser browse the term
Definition:A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
Synonyms:exact_synonym: 15-[(4-hydroxyphenyl)amino]retinal
 related_synonym: 4-HPR;   4-hydroxy(phenyl)retinamide;   Formula=C26H33NO2;   InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+;   InChIKey=AKJHMTWEGVYYSE-FXILSDISSA-N;   N-(4-Hydroxyphenyl)retinamide;   N-(4-hydroxyphenyl)all-trans retinamide;   SMILES=CC(\\C=C\\C1=C(C)CCCC1(C)C)=C/C=C/C(C)=C/C(=O)Nc1ccc(O)cc1;   all-trans-4'-Hydroxyretinanilide;   fenretinida;   fenretinide;   fenretinidum
 xref: CAS:65646-68-6;   DrugBank:DB05076;   KEGG:D04162
 xref_mesh: MESH:D017313
 xref: PDBeChem:FEN;   PMID:20878269;   PMID:20978709;   PMID:21241664;   PMID:21319187;   PMID:21674264;   PMID:21964808;   PMID:22094120;   PMID:22162577;   PMID:22183330;   PMID:22221098;   PMID:22280430;   PMID:22323082;   PMID:22350416;   PMID:22382323;   PMID:22387538;   Reaxys:5769490


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      CHEBI ontology 22327
        role 22313
          chemical role 21560
            antioxidant 16461
              4-hydroxyphenyl retinamide 4089
    Path 2
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      CHEBI ontology 22327
        subatomic particle 22322
          composite particle 22322
            hadron 22322
              baryon 22322
                nucleon 22322
                  atomic nucleus 22322
                    atom 22322
                      main group element atom 22209
                        p-block element atom 22209
                          carbon group element atom 22015
                            carbon atom 21958
                              organic molecular entity 21958
                                heteroorganic entity 21604
                                  organochalcogen compound 21109
                                    organooxygen compound 20946
                                      carbon oxoacid 19736
                                        carboxylic acid 19732
                                          carboacyl group 18298
                                            univalent carboacyl group 18298
                                              carbamoyl group 18112
                                                carboxamide 18112
                                                  monocarboxylic acid amide 15891
                                                    4-hydroxyphenyl retinamide 4089
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