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elacestrant - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:elacestrant
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Accession:CHEBI:229213 term browser browse the term
Definition:A member of the class of tetralins that is 1,2,3,4-tetrahydronaphthalene which is substituted by hydroxy group at position 2 and by a 2-(ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl group at position 6R. It is a is an estrogen receptor degrader indicated for the treatment of postmenopausal women or adult men, with ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer with disease progression following at least one line of endocrine therapy.
Synonyms:exact_synonym: (6R)-6-[2-(ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol
 related_synonym: (R)-6-(2-(ethyl(4-(2-(ethylamino)ethyl)benzyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol;   ER-306323;   Formula=C30H38N2O2;   InChI=1S/C30H38N2O2/c1-4-31-17-16-22-6-8-23(9-7-22)21-32(5-2)30-20-28(34-3)14-15-29(30)26-11-10-25-19-27(33)13-12-24(25)18-26/h6-9,12-15,19-20,26,31,33H,4-5,10-11,16-18,21H2,1-3H3/t26-/m1/s1;   InChIKey=SIFNOOUKXBRGGB-AREMUKBSSA-N;   Orserdu;   RAD 1901;   RAD1901;   SMILES=[H][C@]1(CCC2=C(C1)C=CC(O)=C2)C1=C(C=C(OC)C=C1)N(CC)CC1=CC=C(CCNCC)C=C1;   elacestrantum
 xref: CAS:722533-56-4;   DrugBank:DB06374;   KEGG:D11671;   PDBeChem:I0V;   PMCID:PMC10554897;   PMID:28473534;   PMID:31426673;   PMID:31852484;   PMID:32912274;   PMID:33513026;   PMID:33589422;   PMID:34798371;   PMID:35348779;   PMID:35584336;   PMID:35621343;   PMID:35737918;   PMID:36446866;   PMID:36813113;   PMID:36877283;   PMID:36960661;   PMID:36993871;   PMID:37060385;   PMID:37143269;   PMID:37191763;   PMID:37314500;   PMID:37318638;   PMID:37364222;   PMID:37485921;   PMID:37580832;   PMID:37594177;   PMID:37888769;   PMID:38006464;   PMID:38039056;   PMID:38169749;   PMID:38381994;   Wikipedia:Elacestrant

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  CHEBI ontology 19887
    role 19858
      application 19697
        pharmaceutical 19534
          drug 19534
            antineoplastic agent 17832
              elacestrant 0
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  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    main group molecular entity 19824
                      s-block molecular entity 19658
                        hydrogen molecular entity 19640
                          hydrides 19145
                            inorganic hydride 18162
                              pnictogen hydride 18152
                                nitrogen hydride 18059
                                  azane 17869
                                    ammonia 17868
                                      organic amino compound 17868
                                        aromatic amine 15481
                                          anilines 14421
                                            substituted aniline 14052
                                              elacestrant 0
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