Term: | actinomycin X2 |
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Accession: | CHEBI:180658
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Definition: | Actinomycin X2, is a chemotherapy medication used to treat a number of types of cancer and has strong antimicrobial activity against Gram-positive bacteria, including MRSA and non-MRSA. It is given by injection into a vein. Most people develop side effects. Common side effects include bone marrow suppression, vomiting, mouth ulcers, hair loss, liver problems, infections, and muscle pains. Other serious side effects include future cancers, allergic reactions, and tissue death at the site of injection. Use in pregnancy may harm the baby. It is in the cytotoxic antibiotic family of medications. It is believed to work on DNA and Isoleucyl-tRNA synthetase (IleRS). |
Synonyms: | related_synonym: | Formula=C62H84N12O17; InChI=1S/C62H84N12O17/c1-26(2)42-59(85)73-21-17-18-36(73)57(83)69(13)24-38(76)71(15)49(29(7)8)62(88)90-33(12)45(56(82)65-42)68-54(80)40-41(63)50(78)31(10)52-47(40)64-46-35(20-19-30(9)51(46)91-52)53(79)67-44-32(11)89-61(87)48(28(5)6)72(16)39(77)25-70(14)58(84)37-22-34(75)23-74(37)60(86)43(27(3)4)66-55(44)81/h19-20,26-29,32-33,36-37,42-45,48-49H,17-18,21-25,63H2,1-16H3,(H,65,82)(H,66,81)(H,67,79)(H,68,80)/t32-,33-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1; InChIKey=ZGROOAYIFKLEPE-IRFLANFNSA-N; SMILES=[H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)C1=C(N)C(=O)C(C)=C3Oc4c(C)ccc(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@]6([H])CC(=O)CN6C(=O)[C@H](NC5=O)C(C)C)c4N=C13)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C |
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