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L-778,123 hydrochloride - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-778,123 hydrochloride
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Accession:CHEBI:177371 term browser browse the term
Definition:The hydrochloride salt of L-778,123. It is a dual inhibitor of FPTase and GGPTase-I (IC50 of 2nM and 98nm, respectively) and exhibits anti-cancer properties.
Synonyms:exact_synonym: 4-[(5-{[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl}-1H-imidazol-1-yl)methyl]benzonitrile hydrochloride
 related_synonym: Formula=C22H20ClN5O.ClH;   InChI=1S/C22H20ClN5O.ClH/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18;/h1-7,10,12,16H,8-9,13-15H2;1H;   InChIKey=YNBSQYGTJLIPJS-UHFFFAOYSA-N;   L 778,123;   L-778,123 HCl;   L-778123;   L-778123 HCl;   L-778123 hydrochloride;   L778123;   SMILES=Cl.ClC1=CC(=CC=C1)N1CCN(CC2=CN=CN2CC2=CC=C(C=C2)C#N)CC1=O
 xref: CAS:253863-00-2;   Chemspider:187600;   PMID:11180946;   PMID:11751480;   PMID:12006520;   PMID:12479371;   PMID:12691158;   PMID:15217969;   PMID:15248757;   PMID:15328183;   PMID:15528977;   PMID:20103566;   PMID:21498540;   PMID:21915711;   PMID:24312815;   PMID:27688185;   PMID:32665901

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