CTC-RG2024 Meeting Agenda

October 3 (Thursday)

Registration and Introduction

• 8:00 AM to 9:00 AM - Registration
• 9:00 AM to 9:15 AM - Intro

Session 1 - Genome Biology I

• 9:15 AM to 9:30 AM - Pangenome mapping enhances genotype-phenotype associations in BXD mouse family by Flavia Villani. (Download Abstract)
• 9:30 AM to 9:45 AM - Haplotype-based analyses of phylogeny and regional genome diversity in laboratory rats by Yanchao Pan. (Download Abstract)
• 9:45 AM to 10:00 AM - Genomics and Genetics of Immunoglobulin in the Rat by Peter Doris. (Download Abstract)
• 10:00 AM to 10:15 AM - Y and mitochondrial chromosomes in the heterogeneous stock rat population by Faith Okamoto. (Download Abstract)
• 10:15 AM to 10:30 AM - Discussion

Session 2 - Obesity and Metabolism

• 10:45 AM to 11:00 AM - Genome-wide association of adiposity in heterogeneous stock rats by Apurva Chitre. (Download Abstract)
• 11:00 AM to 11:15 AM - Identification of genes that link obesity and stress/emotional behaviors using outbred rats by Leah Solberg-Woods. (Download Abstract)
• 11:15 AM to 11:30 AM - Complex metabolic traits are mediated by genes with distal heritability by Greg Carter. (Download Abstract)
• 11:30 AM to 11:45 AM - Health Outcomes of PFAS Exposure Through Genetics and Environmental Interactions in Heterogenous Stock Founder Rats by Katie Holl. (Download Abstract)
• 11:45 AM to 12:00 PM - Discussion

Keynote 1

• 1:00 PM to 2:00 PM - Sex chromosome-modified mice and rats to identify factors causing sex differences in physiology and disease by Arthur Arnold. (Download Abstract)

Session 3 - Data Science and Resources

• 2:00 PM to 2:15 PM - ClassifyGxT: Probabilistic classification of gene-by-treatment effects in molecular count phenotypes by William Valdar. (Download Abstract)
• 2:15 PM to 2:30 PM - PipeRat: A high-throughput python package to perform and visualize large-scale genetic association analysis by Thiago Missfeldt Sanches. (Download Abstract)
• 2:30 PM to 2:45 PM - 2024 Update on GeneNetwork.org by Pjotr Prins. (Download Abstract)
• 2:45 PM to 3:00 PM - MoTrPAC Data Hub: Multi-omic, Multi-tissue Collection of Exercise Molecular Responses in Young Adult Rats by Christopher Jin. (Download Abstract)

• 3:30 PM to 3:45 PM - Introducing the center for genetics, genomics, and epigenetics of substance use disorders in outbred rats by Abraham Palmer. (Download Abstract)
• 3:45 PM to 4:00 PM - HRDP Update by Melinda Dwinell. (Download Abstract)
• 4:00 PM to 4:45 PM - Panel Discussion: Expanding the use of biological and data resources.

Lunch supported by generous sponsors:

October 4 (Friday)

Session 4 - Workshop

• 8:30 AM to 9:30 AM - Use case 1: Navigating the public resources for quantitative genetics, phenotypes and omics data for my research.
• 9:30 AM to 10:30 AM - Use case 2: Using online resources to find a model for my disease of interest (in this case, obesity).

Session 5 - Virtual Session

• 10:45 AM to 11:00 AM - Hemodynamic abnormalities and tissue electrolyte accumulation during initiation of salt-induced hypertension in a rat model of primary aldosteronism by Michal Pravenec. (Download Abstract)
• 11:00 AM to 11:15 AM - From rats to humans: revealing conserved molecular networks of addiction through gene expression and GWAS integration by Yanning Zuo. (Download Abstract)

Session 6 - The Microbiome

• 11:15 AM to 11:30 AM - Differences in gut microbiota significantly modulate colon cancer susceptibility in the rat genetic model of familial colon cancer by James Amos-Landgraf. (Download Abstract)
• 11:30 AM to 11:45 AM - Multi-cohort analysis identifies robust host genetic effects on the rat gut microbiome by Amelie Baud. (Download Abstract)
• 11:45 AM to 12:00 PM - Discussion

Poster Session

• 1:00 PM to 2:15 PM - Posters

Session 7 - Disease Models I

• 2:15 PM to 2:30 PM - Developmental systems genomics identifies expression quantitative trait loci underlying strain differences in skeletal differentiation and developmental pace by Ian Welsh. (Download Abstract)
• 2:30 PM to 2:45 PM - Machine learning reveals genetic modifiers of the immune microenvironment of cancer by Michael Flister. (Download Abstract)
• 2:45 PM to 3:00 PM - Linking brain cell types with predisposition to alcohol consumption in rats by Laura Saba. (Download Abstract)

Session 8 - Genome Biology II

• 3:00 PM to 3:15 PM - Multi-platform genome assembly of an SHR/OlaIpcv X BN-Lx/Cub F1 rat trio by Andrea Guarracino. (Download Abstract)
• 3:15 PM to 3:30 PM - Telomere-to-Telomere Assembly of the SHRSP/BbbUtx (SHR-A3) Rat by Kai Li. (Download Abstract)

Keynote 2

• 4:00 PM to 5:00 PM - The Serengeti Rules: The Regulation and Restoration of Biodiversity by Sean Carrol.

Lunch supported by generous sponsors:

October 5 (Saturday)

Session 9 - Substance Use Disorders and Behavior

• 9:15 AM to 9:30 AM - Genome-wide association study of cocaine use in Heterogeneous Stock rats by Montana Lara. (Download Abstract)
• 9:30 AM to 9:45 AM - Identifying the shared genetic signal from genome-wide association studies of externalizing and locomotor activity by Brittany Leger. (Download Abstract)
• 9:45 AM to 10:00 AM - Improved representation of behavior data in the Rat Genome Database's PhenoMiner tool by Jennifer Smith. (Download Abstract)

Session 10 - Disease Models II

• 10:30 AM to 10:45 AM - Oxidative stress induced suppression of metabolism pathways in Dahl Salt-Sensitive rat by Satoshi Shimada. (Download Abstract)
• 10:45 AM to 11:00 AM - Meta-analysis of hundreds of seizure-related traits reveals putative modifiers of epilepsy resilience and susceptibility by Matt Mahoney. (Download Abstract)
• 11:00 AM to 11:15 AM - Genome-wide association study for age-related hearing loss in CFW mice by Oksana Polesskaya. (Download Abstract)
• 11:15 AM to 11:30 PM - The dark matter of the genome and blood pressure regulation – modeling non-coding genetic mechanisms in cellular models and rats by Aron Geurts. (Download Abstract)
• 11:30 AM to Noon - Parting comments