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Pathways

calcium buffers

Ca2+ Buffers – unlike sensors, they do not undergo conformational changes upon Ca2+ binding; their role is to chelate the metal ion, thus controlling its free concentration. Cytosolic and organellar buffers are listed; for more information check main text and PMIDs 20943758 and 21421925. Genes are listed with aliases in parentheses, full names and links to gene report pages:

Cytosolic:
Pvalb (parvalbumin alpha) – parvalbumin
Ocm2 (parvalbumin beta) – oncomodulin 2
Calb1 (D-28K, D28) – calbindin 1
S100g (calbindin-D9K, Cabp) – S100 calcium binding protein G
Calb2 (29kDa, calretinin) – calbindin 2

Organellar:
Calr (CRP55, grp60) – calreticulin
Casq1 (calmitin) – calsequestrin 1
Casq2 (PDIB2) – calsequestrin 2


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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.