Several downstream targets of AMPK have been identified and the list is growing. For information on target genes, check references PMIDs 16054041, 16879084 and 22137581 (also available from the diagram page). Selected primary targets of AMPK are listed with aliases in parentheses, full names and links to gene report pages:
Acaca (ACC-alpha, ACC1) – acetyl-CoA carboxylase alpha
Acacb (Acc2, Accb) – acetyl-CoA carboxylase beta
Hmgcr (3H3M) – 3-hydroxy-3-methylglutaryl-CoA reductase
Gys1 – glycogen synthase 1
Tsc2 (tuberous sclerosis 2) – TSC complex subunit 2
Rptor (Raptor) – regulatory associated protein of MTOR, complex 1
Pfkfb2 – 6- phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Lipe (Lhs, Hsl) – lipase E, hormone-sensitive type
Foxo3 (Fkhrl1, Foxo3a) – forkhead box O3
Tbc1d1 – TBC1 domain family member 1
Ppargc1a (PGC-1alpha, Ppargc1) – PPARG coactivator 1 alpha
Ppp1r12c (LENG3, MBS85) – protein phosphatase 1, regulatory subunit 12C
Baiap2 (BAP2, IRS-58, FLAF3) – BAI1-associated protein 2
Cdc27 (ANAPC3, APC3) – cell division cycle 27
Pak2 (gamma-PAK, PAK65) – p21 (RAC1) activated kinase 2