Nedd4l (NEDD4 like E3 ubiquitin protein ligase) - Rat Genome Database

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Gene: Nedd4l (NEDD4 like E3 ubiquitin protein ligase) Rattus norvegicus
Analyze
Symbol: Nedd4l
Name: NEDD4 like E3 ubiquitin protein ligase
RGD ID: 735047
Description: Enables ubiquitin-protein transferase activity. Involved in positive regulation of protein catabolic process and protein monoubiquitination. Predicted to be located in plasma membrane. Predicted to be active in apical plasma membrane; cytoplasm; and glutamatergic synapse. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human NEDD4L (NEDD4 like E3 ubiquitin protein ligase); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; aldosterone signaling pathway; endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase NEDD4-like; MGC105877; Nedd4-2; neural precursor cell expressed, developmentally down-regulated 4-like; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down-regulated gene 4-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81860,663,918 - 60,996,824 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1860,663,970 - 60,996,824 (+)EnsemblGRCr8
mRatBN7.21858,393,759 - 58,726,709 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1858,393,509 - 58,723,137 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1860,487,918 - 60,820,828 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01861,186,393 - 61,519,168 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01859,015,711 - 59,343,901 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01860,392,376 - 60,719,720 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1860,392,376 - 60,719,720 (+)Ensemblrn6Rnor6.0
Rnor_5.01859,595,643 - 59,921,504 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41861,134,242 - 61,477,040 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1856,529,040 - 56,853,871 (+)NCBICelera
RGSC_v3.11861,528,414 - 61,549,290 (+)NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP)
aldosterone  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
deoxynivalenol  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glucose  (EXP)
glyphosate  (EXP)
graphite  (EXP)
hydroquinone  (ISO)
inulin  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese(II) chloride  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methacrylate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
WIN 55212-2  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IEA)
monoatomic ion transport  (IEA)
negative regulation of potassium ion export across plasma membrane  (IEA,ISO)
negative regulation of potassium ion transmembrane transport  (IEA,IMP,ISO)
negative regulation of protein localization to cell surface  (IEA,ISO)
negative regulation of sodium ion import across plasma membrane  (IEA,ISO)
negative regulation of sodium ion transmembrane transport  (IEA,ISO)
negative regulation of sodium ion transport  (IEA,ISO)
negative regulation of systemic arterial blood pressure  (ISO)
positive regulation of cation channel activity  (ISO)
positive regulation of caveolin-mediated endocytosis  (IMP)
positive regulation of dendrite extension  (IEA,ISO)
positive regulation of protein catabolic process  (IMP)
positive regulation of sodium ion transport  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA,ISO)
protein K48-linked ubiquitination  (IEA,ISO)
protein monoubiquitination  (IMP)
protein ubiquitination  (IEA,ISO)
proteolysis involved in protein catabolic process  (IEA)
regulation of bicellular tight junction assembly  (ISO)
regulation of dendrite morphogenesis  (IBA)
regulation of membrane depolarization  (IEA,ISO)
regulation of membrane potential  (IEA,ISO)
regulation of membrane repolarization  (IEA,ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of protein stability  (IEA,ISO)
regulation of sodium ion transmembrane transport  (IEA,ISO)
regulation of sodium ion transport  (ISO)
regulation of transport  (IEA)
regulation protein catabolic process at postsynapse  (ISO)
response to salt stress  (ISO)
ubiquitin-dependent protein catabolic process  (IBA,IEA,ISO)
ventricular cardiac muscle cell action potential  (IMP)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2. Ekberg J, etal., J Biol Chem. 2007 Apr 20;282(16):12135-42. Epub 2007 Feb 23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Ubiquitination of TrkA by Nedd4-2 regulates receptor lysosomal targeting and mediates receptor signaling. Georgieva MV, etal., J Neurochem. 2011 May;117(3):479-93. doi: 10.1111/j.1471-4159.2011.07218.x. Epub 2011 Mar 15.
4. Cell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2. Guo J, etal., J Biol Chem. 2012 Sep 28;287(40):33132-41. Epub 2012 Aug 9.
5. Nedd4-2 induces endocytosis and degradation of proteolytically cleaved epithelial Na+ channels. Kabra R, etal., J Biol Chem. 2008 Mar 7;283(10):6033-9. Epub 2008 Jan 3.
6. A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel. Kamynina E, etal., FASEB J 2001 Jan;15(1):204-214.
7. Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke. Lackovic J, etal., Exp Neurol. 2012 May;235(1):326-35. Epub 2012 Mar 5.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Persaud A, etal., Mol Syst Biol. 2009;5:333. Epub 2009 Dec 1.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Downregulation of MicroRNA-494 inhibits the TGF-β1/Smads signaling pathway and prevents the development of hypospadias through upregulating Nedd4L. Tian RH, etal., Exp Mol Pathol. 2020 Aug;115:104452. doi: 10.1016/j.yexmp.2020.104452. Epub 2020 May 13.
17. Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels. Wilkars W, etal., FASEB J. 2014 May;28(5):2177-90. doi: 10.1096/fj.13-242032. Epub 2014 Jan 22.
Additional References at PubMed
PMID:11244092   PMID:12477932   PMID:15217910   PMID:15958725   PMID:16338225   PMID:17289006   PMID:17693485   PMID:17715136   PMID:18524855   PMID:18981174   PMID:19028597   PMID:19144635  
PMID:19381069   PMID:20504882   PMID:21300902   PMID:21463633   PMID:23022218   PMID:23376485   PMID:23533145   PMID:23589291   PMID:23999003   PMID:24093724   PMID:25631046   PMID:26651153  
PMID:27445338   PMID:33063281   PMID:37768316  


Genomics

Comparative Map Data
Nedd4l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81860,663,918 - 60,996,824 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1860,663,970 - 60,996,824 (+)EnsemblGRCr8
mRatBN7.21858,393,759 - 58,726,709 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1858,393,509 - 58,723,137 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1860,487,918 - 60,820,828 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01861,186,393 - 61,519,168 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01859,015,711 - 59,343,901 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01860,392,376 - 60,719,720 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1860,392,376 - 60,719,720 (+)Ensemblrn6Rnor6.0
Rnor_5.01859,595,643 - 59,921,504 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41861,134,242 - 61,477,040 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1856,529,040 - 56,853,871 (+)NCBICelera
RGSC_v3.11861,528,414 - 61,549,290 (+)NCBI
Cytogenetic Map18q12.1NCBI
NEDD4L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381858,044,226 - 58,401,540 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1858,044,050 - 58,401,540 (+)Ensemblhg38GRCh38
GRCh371855,711,458 - 56,068,772 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361853,862,778 - 54,216,369 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341853,862,777 - 54,216,369NCBI
Celera1852,429,273 - 52,785,147 (+)NCBICelera
Cytogenetic Map18q21.31NCBI
HuRef1852,421,551 - 52,777,135 (+)NCBIHuRef
CHM1_11855,707,037 - 56,063,999 (+)NCBICHM1_1
T2T-CHM13v2.01858,244,126 - 58,602,300 (+)NCBIT2T-CHM13v2.0
Nedd4l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391865,017,551 - 65,350,888 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1865,020,776 - 65,350,899 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381864,884,480 - 65,217,826 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1864,887,705 - 65,217,828 (+)Ensemblmm10GRCm38
MGSCv371865,047,410 - 65,377,480 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361865,149,263 - 65,338,676 (+)NCBIMGSCv36mm8
Celera1866,271,347 - 66,493,213 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1837.57NCBI
Nedd4l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540242,339,380 - 42,688,714 (+)Ensembl
ChiLan1.0NW_00495540242,339,380 - 42,688,661 (+)NCBIChiLan1.0ChiLan1.0
NEDD4L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21775,577,762 - 75,942,886 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11861,270,375 - 61,635,499 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01851,428,077 - 51,792,995 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11854,762,516 - 55,122,236 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1854,867,149 - 55,123,423 (+)EnsemblpanPan2panpan1.1
NEDD4L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1117,629,163 - 17,858,471 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl117,633,591 - 17,950,072 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha118,613,069 - 18,951,799 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0117,509,482 - 17,848,443 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl117,509,487 - 17,849,053 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1117,567,699 - 17,905,982 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0117,465,765 - 17,804,137 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0117,733,960 - 18,072,781 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nedd4l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494430,867,247 - 31,171,348 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364976,106,268 - 6,318,354 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364976,106,284 - 6,318,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEDD4L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1162,364,057 - 162,513,718 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11162,364,053 - 162,736,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NEDD4L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11821,326,276 - 21,683,817 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1821,327,567 - 21,683,905 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660603,882,156 - 4,244,040 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nedd4l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247923,553,004 - 3,902,468 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247923,553,185 - 3,903,288 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nedd4l
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11566,057,102 - 66,380,876 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nedd4l
2981 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:348
Count of miRNA genes:189
Interacting mature miRNAs:229
Transcripts:ENSRNOT00000023890
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185384517561982387Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184918722662647720Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185782524385493247Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat

Markers in Region
D18Rat52  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81860,806,253 - 60,806,448 (+)Marker Load Pipeline
mRatBN7.21858,536,116 - 58,536,311 (+)MAPPERmRatBN7.2
Rnor_6.01860,531,893 - 60,532,087NCBIRnor6.0
Rnor_5.01859,735,224 - 59,735,418UniSTSRnor5.0
RGSC_v3.41861,290,684 - 61,290,878UniSTSRGSC3.4
RGSC_v3.41861,290,683 - 61,290,878RGDRGSC3.4
Celera1856,668,317 - 56,668,511UniSTS
RGSC_v3.11861,363,848 - 61,364,185RGD
SHRSP x BN Map1830.9799RGD
SHRSP x BN Map1830.9799UniSTS
Cytogenetic Map18q12.1UniSTS
D18Rat91  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81860,735,395 - 60,735,506 (+)Marker Load Pipeline
mRatBN7.21858,465,253 - 58,465,364 (+)MAPPERmRatBN7.2
Rnor_6.01860,462,846 - 60,462,956NCBIRnor6.0
Rnor_5.01859,665,486 - 59,665,596UniSTSRnor5.0
RGSC_v3.41861,205,326 - 61,205,436UniSTSRGSC3.4
RGSC_v3.41861,205,325 - 61,205,436RGDRGSC3.4
Celera1856,598,319 - 56,598,429UniSTS
RGSC_v3.11861,278,527 - 61,278,637RGD
RH 3.4 Map18595.5RGD
RH 3.4 Map18595.5UniSTS
SHRSP x BN Map1833.2299UniSTS
SHRSP x BN Map1833.2299RGD
Cytogenetic Map18q12.1UniSTS
D18Chm95  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21858,441,223 - 58,441,462 (+)MAPPERmRatBN7.2
Rnor_6.01860,438,621 - 60,438,859NCBIRnor6.0
Rnor_5.01859,641,836 - 59,642,074UniSTSRnor5.0
RGSC_v3.41861,181,902 - 61,182,140UniSTSRGSC3.4
Celera1856,574,993 - 56,575,231UniSTS
Cytogenetic Map18q12.1UniSTS
RH132932  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21858,716,691 - 58,716,872 (+)MAPPERmRatBN7.2
Rnor_6.01860,713,143 - 60,713,323NCBIRnor6.0
Rnor_5.01859,915,830 - 59,916,010UniSTSRnor5.0
RGSC_v3.41861,471,061 - 61,471,241UniSTSRGSC3.4
Celera1856,847,600 - 56,847,780UniSTS
RH 3.4 Map18573.5UniSTS
Cytogenetic Map18q12.1UniSTS
BF411259  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21858,418,373 - 58,418,505 (+)MAPPERmRatBN7.2
Rnor_6.01860,415,773 - 60,415,904NCBIRnor6.0
Rnor_5.01859,618,988 - 59,619,119UniSTSRnor5.0
RGSC_v3.41861,159,052 - 61,159,183UniSTSRGSC3.4
Celera1856,552,262 - 56,552,393UniSTS
RH 3.4 Map18573.3UniSTS
Cytogenetic Map18q12.1UniSTS
AU046785  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21858,422,220 - 58,422,323 (+)MAPPERmRatBN7.2
Rnor_6.01860,419,620 - 60,419,722NCBIRnor6.0
Rnor_5.01859,622,835 - 59,622,937UniSTSRnor5.0
RGSC_v3.41861,162,899 - 61,163,001UniSTSRGSC3.4
Celera1856,556,107 - 56,556,209UniSTS
Cytogenetic Map18q12.1UniSTS
RH140712  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21858,721,766 - 58,721,897 (+)MAPPERmRatBN7.2
Rnor_6.01860,718,350 - 60,718,480NCBIRnor6.0
Rnor_5.01859,920,134 - 59,920,264UniSTSRnor5.0
RGSC_v3.41861,475,670 - 61,475,800UniSTSRGSC3.4
Celera1856,852,501 - 56,852,631UniSTS
RH 3.4 Map18572.6UniSTS
Cytogenetic Map18q12.1UniSTS
AU048729  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21858,488,685 - 58,488,808 (+)MAPPERmRatBN7.2
Rnor_6.01860,485,065 - 60,485,189NCBIRnor6.0
Celera1856,620,962 - 56,621,084UniSTS
Cytogenetic Map18q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001401320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC061798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ160815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ160816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000023890   ⟹   ENSRNOP00000023890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1860,663,970 - 60,996,824 (+)Ensembl
mRatBN7.2 Ensembl1858,394,977 - 58,723,137 (+)Ensembl
Rnor_6.0 Ensembl1860,392,376 - 60,719,720 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083363   ⟹   ENSRNOP00000069274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1860,855,262 - 60,994,170 (+)Ensembl
mRatBN7.2 Ensembl1858,576,355 - 58,723,137 (+)Ensembl
Rnor_6.0 Ensembl1860,639,860 - 60,718,474 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088624   ⟹   ENSRNOP00000070352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1860,767,993 - 60,992,521 (+)Ensembl
mRatBN7.2 Ensembl1858,497,852 - 58,722,406 (+)Ensembl
Rnor_6.0 Ensembl1860,496,778 - 60,718,471 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094594   ⟹   ENSRNOP00000088199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1860,663,970 - 60,996,824 (+)Ensembl
mRatBN7.2 Ensembl1858,393,509 - 58,723,137 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095391   ⟹   ENSRNOP00000095085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1860,663,970 - 60,996,824 (+)Ensembl
mRatBN7.2 Ensembl1858,393,509 - 58,723,137 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098803   ⟹   ENSRNOP00000096933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1860,665,189 - 60,992,428 (+)Ensembl
mRatBN7.2 Ensembl1858,393,509 - 58,723,137 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099820   ⟹   ENSRNOP00000095025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1860,829,767 - 60,996,820 (+)Ensembl
mRatBN7.2 Ensembl1858,393,509 - 58,723,137 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101899   ⟹   ENSRNOP00000090808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1860,855,262 - 60,994,170 (+)Ensembl
mRatBN7.2 Ensembl1858,585,009 - 58,723,137 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111699   ⟹   ENSRNOP00000086606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1860,846,489 - 60,996,824 (+)Ensembl
mRatBN7.2 Ensembl1858,576,472 - 58,723,137 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114166   ⟹   ENSRNOP00000094503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1860,770,617 - 60,996,824 (+)Ensembl
mRatBN7.2 Ensembl1858,500,476 - 58,723,137 (+)Ensembl
RefSeq Acc Id: NM_001401320   ⟹   NP_001388249
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,663,970 - 60,996,824 (+)NCBI
mRatBN7.21858,393,813 - 58,726,709 (+)NCBI
RefSeq Acc Id: XM_039096672   ⟹   XP_038952600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,852,753 - 60,996,824 (+)NCBI
mRatBN7.21858,582,621 - 58,726,709 (+)NCBI
RefSeq Acc Id: XM_039096674   ⟹   XP_038952602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,852,756 - 60,996,824 (+)NCBI
mRatBN7.21858,582,624 - 58,726,709 (+)NCBI
RefSeq Acc Id: XM_039096675   ⟹   XP_038952603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,852,758 - 60,996,824 (+)NCBI
mRatBN7.21858,582,626 - 58,726,709 (+)NCBI
RefSeq Acc Id: XM_039096679   ⟹   XP_038952607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,663,920 - 60,996,824 (+)NCBI
mRatBN7.21858,393,761 - 58,726,709 (+)NCBI
RefSeq Acc Id: XM_063277195   ⟹   XP_063133265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,852,755 - 60,996,824 (+)NCBI
RefSeq Acc Id: XM_063277196   ⟹   XP_063133266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,852,754 - 60,996,824 (+)NCBI
RefSeq Acc Id: XM_063277197   ⟹   XP_063133267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,852,752 - 60,996,824 (+)NCBI
RefSeq Acc Id: XM_063277198   ⟹   XP_063133268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,852,755 - 60,996,824 (+)NCBI
RefSeq Acc Id: XM_063277199   ⟹   XP_063133269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,663,918 - 60,996,824 (+)NCBI
RefSeq Acc Id: XM_063277200   ⟹   XP_063133270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,663,918 - 60,996,824 (+)NCBI
RefSeq Acc Id: XM_063277201   ⟹   XP_063133271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,663,919 - 60,996,824 (+)NCBI
RefSeq Acc Id: XM_063277202   ⟹   XP_063133272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,823,271 - 60,996,824 (+)NCBI
RefSeq Acc Id: XM_063277203   ⟹   XP_063133273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,797,347 - 60,996,824 (+)NCBI
RefSeq Acc Id: XM_063277204   ⟹   XP_063133274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,797,347 - 60,996,824 (+)NCBI
RefSeq Acc Id: XM_063277205   ⟹   XP_063133275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,848,746 - 60,996,824 (+)NCBI
RefSeq Acc Id: XM_063277206   ⟹   XP_063133276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,665,174 - 60,996,824 (+)NCBI
RefSeq Acc Id: XM_063277207   ⟹   XP_063133277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,797,595 - 60,996,824 (+)NCBI
RefSeq Acc Id: XM_063277208   ⟹   XP_063133278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,823,893 - 60,996,824 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001388249 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952600 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952602 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952603 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952607 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133265 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133266 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133267 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133268 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133269 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133270 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133271 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133272 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133273 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133274 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133275 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133276 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133277 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133278 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61798 (Get FASTA)   NCBI Sequence Viewer  
  AAH86371 (Get FASTA)   NCBI Sequence Viewer  
  ADD16471 (Get FASTA)   NCBI Sequence Viewer  
  ADD16472 (Get FASTA)   NCBI Sequence Viewer  
  EDM14676 (Get FASTA)   NCBI Sequence Viewer  
  EDM14677 (Get FASTA)   NCBI Sequence Viewer  
  EDM14678 (Get FASTA)   NCBI Sequence Viewer  
  EDM14679 (Get FASTA)   NCBI Sequence Viewer  
  EDM14680 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023890.9
  ENSRNOP00000069274
  ENSRNOP00000069274.3
  ENSRNOP00000070352.2
  ENSRNOP00000086606
  ENSRNOP00000086606.2
  ENSRNOP00000088199
  ENSRNOP00000088199.1
  ENSRNOP00000090808
  ENSRNOP00000090808.1
  ENSRNOP00000094503.1
  ENSRNOP00000095025.2
  ENSRNOP00000095085
  ENSRNOP00000095085.2
  ENSRNOP00000096933.2
Ensembl Acc Id: ENSRNOP00000023890   ⟸   ENSRNOT00000023890
Ensembl Acc Id: ENSRNOP00000069274   ⟸   ENSRNOT00000083363
Ensembl Acc Id: ENSRNOP00000070352   ⟸   ENSRNOT00000088624
RefSeq Acc Id: XP_038952607   ⟸   XM_039096679
- Peptide Label: isoform X11
- UniProtKB: A0A8I6GLU0 (UniProtKB/TrEMBL),   A6IXP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952600   ⟸   XM_039096672
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952602   ⟸   XM_039096674
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038952603   ⟸   XM_039096675
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000095085   ⟸   ENSRNOT00000095391
Ensembl Acc Id: ENSRNOP00000094503   ⟸   ENSRNOT00000114166
Ensembl Acc Id: ENSRNOP00000095025   ⟸   ENSRNOT00000099820
Ensembl Acc Id: ENSRNOP00000090808   ⟸   ENSRNOT00000101899
Ensembl Acc Id: ENSRNOP00000088199   ⟸   ENSRNOT00000094594
Ensembl Acc Id: ENSRNOP00000086606   ⟸   ENSRNOT00000111699
Ensembl Acc Id: ENSRNOP00000096933   ⟸   ENSRNOT00000098803
RefSeq Acc Id: NP_001388249   ⟸   NM_001401320
- UniProtKB: A6IXP5 (UniProtKB/TrEMBL),   A0A8I6A4L5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133269   ⟸   XM_063277199
- Peptide Label: isoform X8
- UniProtKB: A6IXP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133270   ⟸   XM_063277200
- Peptide Label: isoform X9
- UniProtKB: A6IXP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133271   ⟸   XM_063277201
- Peptide Label: isoform X10
- UniProtKB: A6IXP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133276   ⟸   XM_063277206
- Peptide Label: isoform X14
- UniProtKB: A6IXP7 (UniProtKB/TrEMBL),   A6IXP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133274   ⟸   XM_063277204
- Peptide Label: isoform X12
- UniProtKB: A6IXP7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133273   ⟸   XM_063277203
- Peptide Label: isoform X12
- UniProtKB: A6IXP7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133277   ⟸   XM_063277207
- Peptide Label: isoform X14
- UniProtKB: A6IXP7 (UniProtKB/TrEMBL),   A6IXP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133272   ⟸   XM_063277202
- Peptide Label: isoform X12
- UniProtKB: A6IXP7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133278   ⟸   XM_063277208
- Peptide Label: isoform X14
- UniProtKB: A6IXP7 (UniProtKB/TrEMBL),   A6IXP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133275   ⟸   XM_063277205
- Peptide Label: isoform X13
- UniProtKB: A6IXP7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133267   ⟸   XM_063277197
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063133266   ⟸   XM_063277196
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063133265   ⟸   XM_063277195
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063133268   ⟸   XM_063277198
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AEH7 (UniProtKB/TrEMBL)
Protein Domains
C2   HECT   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JXP3-F1-model_v2 AlphaFold A0A0G2JXP3 1-961 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735047 AgrOrtholog
BioCyc Gene G2FUF-7244 BioCyc
BioCyc Pathway PWY-7511 [protein ubiquitination] BioCyc
BioCyc Pathway Image PWY-7511 BioCyc
Ensembl Genes ENSRNOG00000017610 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023890.9 UniProtKB/TrEMBL
  ENSRNOT00000083363 ENTREZGENE
  ENSRNOT00000083363.3 UniProtKB/TrEMBL
  ENSRNOT00000088624.3 UniProtKB/TrEMBL
  ENSRNOT00000094594 ENTREZGENE
  ENSRNOT00000094594.2 UniProtKB/TrEMBL
  ENSRNOT00000095391 ENTREZGENE
  ENSRNOT00000095391.2 UniProtKB/TrEMBL
  ENSRNOT00000098803.2 UniProtKB/TrEMBL
  ENSRNOT00000099820.2 UniProtKB/TrEMBL
  ENSRNOT00000101899 ENTREZGENE
  ENSRNOT00000101899.2 UniProtKB/TrEMBL
  ENSRNOT00000111699 ENTREZGENE
  ENSRNOT00000111699.2 UniProtKB/TrEMBL
  ENSRNOT00000114166.2 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598079 IMAGE-MGC_LOAD
InterPro C2_Ca-dep UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
  E3_ubiq-protein_ligase UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
MGC_CLONE MGC:72524 IMAGE-MGC_LOAD
NCBI Gene 291553 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE NEDD-4 UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE NEDD4-LIKE UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
  HECT-TYPE E3 UBIQUITIN TRANSFERASE UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PhenoGen Nedd4l PhenoGen
PIRSF E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
PRINTS C2DOMAIN UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017610 RatGTEx
SMART HECTc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP HECT UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
UniProt A0A0G2JUY1_RAT UniProtKB/TrEMBL
  A0A8I6A4L5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A6J7_RAT UniProtKB/TrEMBL
  A0A8I6AEH7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIV5_RAT UniProtKB/TrEMBL
  A0A8I6GKS9_RAT UniProtKB/TrEMBL
  A0A8I6GL04_RAT UniProtKB/TrEMBL
  A0A8I6GLU0 ENTREZGENE, UniProtKB/TrEMBL
  A6IXP5 ENTREZGENE, UniProtKB/TrEMBL
  A6IXP7 ENTREZGENE, UniProtKB/TrEMBL
  A6IXP8 ENTREZGENE, UniProtKB/TrEMBL
  A6IXP9_RAT UniProtKB/TrEMBL
  D7NIW0_RAT UniProtKB/TrEMBL
  F1LRN8_RAT UniProtKB/TrEMBL
  Q5U1Z5_RAT UniProtKB/TrEMBL
  Q6P778_RAT UniProtKB/TrEMBL
UniProt Secondary A0A0G2JXP3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Nedd4l  NEDD4 like E3 ubiquitin protein ligase  Nedd4l  neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-05 Nedd4l  neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase  Nedd4l  neural precursor cell expressed, developmentally down-regulated 4-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Nedd4l  neural precursor cell expressed, developmentally down-regulated 4-like  Nedd4l  neural precursor cell expressed, developmentally down-regulated gene 4-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Nedd4l  neural precursor cell expressed, developmentally down-regulated gene 4-like  Nedd4l  neural precursor cell expressed, developmentally down-regulated 4-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Nedd4l  neural precursor cell expressed, developmentally down-regulated 4-like      Symbol and Name status set to approved 1299863 APPROVED