Cbx7 (chromobox 7) - Rat Genome Database

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Gene: Cbx7 (chromobox 7) Rattus norvegicus
Analyze
Symbol: Cbx7
Name: chromobox 7
RGD ID: 735027
Description: Predicted to enable chromatin binding activity; histone H3K9me2/3 reader activity; and single-stranded RNA binding activity. Involved in developmental process involved in reproduction; positive regulation of transcription elongation by RNA polymerase II; and response to xenobiotic stimulus. Predicted to be located in heterochromatin and nucleus. Predicted to be part of PRC1 complex. Human ortholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX7 (chromobox 7); PARTICIPATES IN histone modification pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chromobox homolog 7; chromobox protein homolog 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,341,030 - 113,358,716 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7113,341,030 - 113,358,346 (-)EnsemblGRCr8
mRatBN7.27111,460,656 - 111,479,231 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,460,656 - 111,477,973 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7113,208,676 - 113,225,978 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,432,223 - 115,449,524 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,401,568 - 115,418,871 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,136,067 - 121,153,503 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,136,058 - 121,153,383 (-)Ensemblrn6Rnor6.0
Rnor_5.07121,126,405 - 121,144,401 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47118,148,413 - 118,165,701 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7107,790,484 - 107,807,779 (-)NCBICelera
RGSC_v3.17118,182,643 - 118,199,931 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
aripiprazole  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethyl methanesulfonate  (ISO)
fenoldopam  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
ketamine  (EXP)
ketoconazole  (EXP)
lead diacetate  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (EXP)
methylseleninic acid  (ISO)
N(4)-hydroxycytidine  (ISO)
nickel atom  (ISO)
nitrates  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA,ISO)
chromosome  (IEA)
cytosol  (IEA,ISO)
heterochromatin  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
PcG protein complex  (IEA,ISO,ISS)
PRC1 complex  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Chronic treatment with aripiprazole induces differential gene expression in the rat frontal cortex. Cheng MC, etal., Int J Neuropsychopharmacol. 2007 Sep 17;:1-10.
2. Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Chubb D, etal., Nat Genet. 2013 Oct;45(10):1221-5. doi: 10.1038/ng.2733. Epub 2013 Aug 18.
3. Polycomb genes are associated with response to imatinib in chronic myeloid leukemia. Crea F, etal., Epigenomics. 2015 Aug;7(5):757-65. doi: 10.2217/epi.15.35. Epub 2015 Sep 7.
4. Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. Federico A, etal., Cancer Res. 2009 Sep 1;69(17):7079-87. doi: 10.1158/0008-5472.CAN-09-1542. Epub 2009 Aug 25.
5. CBX7 is a tumor suppressor in mice and humans. Forzati F, etal., J Clin Invest. 2012 Feb 1;122(2):612-23. doi: 10.1172/JCI58620. Epub 2012 Jan 3.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. PRC1 complex diversity: where is it taking us? Gil J and O'Loghlen A, Trends Cell Biol. 2014 Jul 22. pii: S0962-8924(14)00102-0. doi: 10.1016/j.tcb.2014.06.005.
8. Polycomb CBX7 has a unifying role in cellular lifespan. Gil J, etal., Nat Cell Biol 2004 Jan;6(1):67-72. Epub 2003 Nov 30.
9. [Downregulation of chromobox protein homolog 7 expression in multiple human cancer tissues] Guan ZP, etal., Zhonghua Yu Fang Yi Xue Za Zhi. 2011 Jul;45(7):597-600.
10. Expression parameters of the polycomb group proteins BMI1, SUZ12, RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance. Hinz S, etal., Tumour Biol. 2008;29(5):323-9. doi: 10.1159/000170879. Epub 2008 Nov 5.
11. Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer. Karamitopoulou E, etal., Eur J Cancer. 2010 May;46(8):1438-44. doi: 10.1016/j.ejca.2010.01.033. Epub 2010 Feb 23.
12. CBX7 inhibits breast tumorigenicity through DKK-1-mediated suppression of the Wnt/beta-catenin pathway. Kim HY, etal., FASEB J. 2015 Jan;29(1):300-13. doi: 10.1096/fj.14-253997. Epub 2014 Oct 28.
13. Tracing dynamics and clonal heterogeneity of Cbx7-induced leukemic stem cells by cellular barcoding. Klauke K, etal., Stem Cell Reports. 2015 Jan 13;4(1):74-89. doi: 10.1016/j.stemcr.2014.10.012. Epub 2014 Nov 26.
14. Altered expression of polycomb group genes in glioblastoma multiforme. Li G, etal., PLoS One. 2013 Nov 15;8(11):e80970. doi: 10.1371/journal.pone.0080970. eCollection 2013.
15. Epigenetic control of female puberty. Lomniczi A, etal., Nat Neurosci. 2013 Mar;16(3):281-9. doi: 10.1038/nn.3319. Epub 2013 Jan 27.
16. Identification of a New Pathway for Tumor Progression: MicroRNA-181b Up-Regulation and CBX7 Down-Regulation by HMGA1 Protein. Mansueto G, etal., Genes Cancer. 2010 Mar;1(3):210-24. doi: 10.1177/1947601910366860.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. CBX7 Expression in Oncocytic Thyroid Neoplastic Lesions (Hurthle Cell Adenomas and Carcinomas). Monaco M, etal., Eur Thyroid J. 2014 Dec;3(4):211-6. doi: 10.1159/000367989. Epub 2014 Oct 15.
19. Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer. Pallante P, etal., Cancer Res. 2008 Aug 15;68(16):6770-8. doi: 10.1158/0008-5472.CAN-08-0695.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. Role of the chromobox protein CBX7 in lymphomagenesis. Scott CL, etal., Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5389-94. Epub 2007 Mar 20.
25. Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation. Shinjo K, etal., Int J Cancer. 2014 Jul 15;135(2):308-18. doi: 10.1002/ijc.28692. Epub 2014 Jan 10.
26. Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Simon JA and Kingston RE, Mol Cell. 2013 Mar 7;49(5):808-24. doi: 10.1016/j.molcel.2013.02.013.
27. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
28. Oncogenic role of the chromobox protein CBX7 in gastric cancer. Zhang XW, etal., J Exp Clin Cancer Res. 2010 Aug 19;29:114. doi: 10.1186/1756-9966-29-114.
Additional References at PubMed
PMID:15489334   PMID:16537902   PMID:19636380   PMID:21282530   PMID:22056776   PMID:23870131   PMID:36222130   PMID:38809351  


Genomics

Comparative Map Data
Cbx7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,341,030 - 113,358,716 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7113,341,030 - 113,358,346 (-)EnsemblGRCr8
mRatBN7.27111,460,656 - 111,479,231 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,460,656 - 111,477,973 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7113,208,676 - 113,225,978 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,432,223 - 115,449,524 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,401,568 - 115,418,871 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,136,067 - 121,153,503 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,136,058 - 121,153,383 (-)Ensemblrn6Rnor6.0
Rnor_5.07121,126,405 - 121,144,401 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47118,148,413 - 118,165,701 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7107,790,484 - 107,807,779 (-)NCBICelera
RGSC_v3.17118,182,643 - 118,199,931 (-)NCBI
Cytogenetic Map7q34NCBI
CBX7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,130,772 - 39,152,680 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2239,120,167 - 39,152,719 (-)Ensemblhg38GRCh38
GRCh372239,526,777 - 39,548,685 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362237,856,723 - 37,878,484 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342237,851,280 - 37,873,038NCBI
Celera2223,328,820 - 23,350,581 (-)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2222,493,890 - 22,515,575 (-)NCBIHuRef
CHM1_12239,485,611 - 39,507,403 (-)NCBICHM1_1
T2T-CHM13v2.02239,601,155 - 39,623,071 (-)NCBIT2T-CHM13v2.0
Cbx7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,800,005 - 79,855,344 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,800,008 - 79,855,320 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381579,915,804 - 79,971,143 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,915,807 - 79,971,119 (-)Ensemblmm10GRCm38
MGSCv371579,746,237 - 79,763,076 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361579,740,244 - 79,759,866 (-)NCBIMGSCv36mm8
Celera1582,033,986 - 82,050,640 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
Cbx7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,086,186 - 25,100,039 (-)Ensembl
ChiLan1.0NW_00495541325,079,627 - 25,100,039 (-)NCBIChiLan1.0ChiLan1.0
CBX7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22348,978,435 - 49,000,373 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12251,669,911 - 51,691,852 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02220,037,529 - 20,059,459 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12237,854,049 - 37,876,861 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2237,854,056 - 37,876,084 (-)EnsemblpanPan2panpan1.1
CBX7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,876,022 - 25,896,284 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,876,016 - 25,893,501 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1025,810,682 - 25,832,138 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01026,627,291 - 26,648,764 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1026,627,343 - 26,648,764 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11026,340,710 - 26,362,175 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01026,661,555 - 26,681,886 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01026,836,680 - 26,858,133 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cbx7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,400,883 - 9,418,070 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364922,410,308 - 2,428,682 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364922,411,171 - 2,428,484 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBX7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl59,070,353 - 9,087,634 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.159,070,312 - 9,090,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,355,114 - 6,372,426 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CBX7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11921,776,618 - 21,798,525 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1921,775,931 - 21,798,309 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045103,958,387 - 103,980,295 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cbx7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247529,133,569 - 9,151,934 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247529,133,587 - 9,151,216 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Cbx7
36 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:298
Count of miRNA genes:198
Interacting mature miRNAs:222
Transcripts:ENSRNOT00000022631
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022631   ⟹   ENSRNOP00000022631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7113,341,030 - 113,358,346 (-)Ensembl
mRatBN7.2 Ensembl7111,460,656 - 111,477,973 (-)Ensembl
Rnor_6.0 Ensembl7121,136,067 - 121,153,383 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077731   ⟹   ENSRNOP00000074584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7113,342,061 - 113,358,346 (-)Ensembl
mRatBN7.2 Ensembl7111,461,688 - 111,477,973 (-)Ensembl
Rnor_6.0 Ensembl7121,136,058 - 121,153,231 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115396   ⟹   ENSRNOP00000076579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7113,343,540 - 113,358,346 (-)Ensembl
mRatBN7.2 Ensembl7111,463,166 - 111,477,973 (-)Ensembl
RefSeq Acc Id: NM_199117   ⟹   NP_954548
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,341,030 - 113,358,346 (-)NCBI
mRatBN7.27111,460,656 - 111,477,973 (-)NCBI
Rnor_6.07121,136,067 - 121,153,383 (-)NCBI
Rnor_5.07121,126,405 - 121,144,401 (-)NCBI
RGSC_v3.47118,148,413 - 118,165,701 (-)RGD
Celera7107,790,484 - 107,807,779 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242020   ⟹   XP_006242082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,341,030 - 113,358,716 (-)NCBI
mRatBN7.27111,460,656 - 111,478,046 (-)NCBI
Rnor_6.07121,136,067 - 121,153,489 (-)NCBI
Rnor_5.07121,126,405 - 121,144,401 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242021   ⟹   XP_006242083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,343,133 - 113,358,716 (-)NCBI
mRatBN7.27111,462,756 - 111,478,053 (-)NCBI
Rnor_6.07121,138,216 - 121,153,490 (-)NCBI
Rnor_5.07121,126,405 - 121,144,401 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242022   ⟹   XP_006242084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,341,030 - 113,358,716 (-)NCBI
mRatBN7.27111,462,754 - 111,479,231 (-)NCBI
Rnor_6.07121,138,485 - 121,153,503 (-)NCBI
Rnor_5.07121,126,405 - 121,144,401 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079590   ⟹   XP_038935518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,341,030 - 113,358,025 (-)NCBI
mRatBN7.27111,460,656 - 111,477,674 (-)NCBI
RefSeq Acc Id: XM_039079591   ⟹   XP_038935519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,341,030 - 113,358,716 (-)NCBI
mRatBN7.27111,460,656 - 111,478,036 (-)NCBI
RefSeq Acc Id: XM_039079592   ⟹   XP_038935520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,341,030 - 113,358,716 (-)NCBI
mRatBN7.27111,462,754 - 111,478,036 (-)NCBI
RefSeq Acc Id: XM_039079593   ⟹   XP_038935521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,341,030 - 113,358,716 (-)NCBI
mRatBN7.27111,460,656 - 111,478,034 (-)NCBI
RefSeq Acc Id: XM_063263925   ⟹   XP_063119995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,341,030 - 113,356,299 (-)NCBI
RefSeq Acc Id: NP_954548   ⟸   NM_199117
- UniProtKB: P60889 (UniProtKB/Swiss-Prot),   A6HSV0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242082   ⟸   XM_006242020
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QCQ7 (UniProtKB/TrEMBL),   A6HSV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242083   ⟸   XM_006242021
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QCQ7 (UniProtKB/TrEMBL),   A6HSV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242084   ⟸   XM_006242022
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000074584   ⟸   ENSRNOT00000077731
Ensembl Acc Id: ENSRNOP00000022631   ⟸   ENSRNOT00000022631
RefSeq Acc Id: XP_038935519   ⟸   XM_039079591
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038935521   ⟸   XM_039079593
- Peptide Label: isoform X7
- UniProtKB: A0A8L2UR72 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935518   ⟸   XM_039079590
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038935520   ⟸   XM_039079592
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000076579   ⟸   ENSRNOT00000115396
RefSeq Acc Id: XP_063119995   ⟸   XM_063263925
- Peptide Label: isoform X5
Protein Domains
Chromo

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P60889-F1-model_v2 AlphaFold P60889 1-158 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695491
Promoter ID:EPDNEW_R6016
Type:single initiation site
Name:Cbx7_1
Description:chromobox 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07121,153,391 - 121,153,451EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735027 AgrOrtholog
BioCyc Gene G2FUF-32731 BioCyc
Ensembl Genes ENSRNOG00000016875 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000022631 ENTREZGENE
  ENSRNOT00000077731 ENTREZGENE
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5621139 IMAGE-MGC_LOAD
InterPro CBX7 UniProtKB/Swiss-Prot
  CBX7_C UniProtKB/Swiss-Prot
  Chromo-like_dom_sf UniProtKB/Swiss-Prot
  Chromo/chromo_shadow_dom UniProtKB/Swiss-Prot
  Chromo_dom_subgr UniProtKB/Swiss-Prot
  Chromo_domain UniProtKB/Swiss-Prot
  Chromodomain_CS UniProtKB/Swiss-Prot
KEGG Report rno:362962 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72633 IMAGE-MGC_LOAD
NCBI Gene 362962 ENTREZGENE
PANTHER CHROMOBOX PROTEIN HOMOLOG 7 UniProtKB/Swiss-Prot
  PTHR47277 UniProtKB/Swiss-Prot
Pfam CBX7_C UniProtKB/Swiss-Prot
  Chromo UniProtKB/Swiss-Prot
PhenoGen Cbx7 PhenoGen
PRINTS CHROMODOMAIN UniProtKB/Swiss-Prot
PROSITE CHROMO_1 UniProtKB/Swiss-Prot
  CHROMO_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016875 RatGTEx
SMART CHROMO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54160 UniProtKB/Swiss-Prot
UniProt A0A8I5Y0I1_RAT UniProtKB/TrEMBL
  A0A8L2QCQ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UR72 ENTREZGENE, UniProtKB/TrEMBL
  A6HSV0 ENTREZGENE, UniProtKB/TrEMBL
  A6HSV1 ENTREZGENE, UniProtKB/TrEMBL
  CBX7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Cbx7  chromobox 7  Cbx7  chromobox homolog 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cbx7  chromobox homolog 7    chromobox 7  Name updated 1299863 APPROVED