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Gene: Il1rapl1 (interleukin 1 receptor accessory protein-like 1) Rattus norvegicus

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Symbol:

Il1rapl1

Name:

interleukin 1 receptor accessory protein-like 1

RGD ID:

727891

Description:

Predicted to enable signaling receptor binding activity. Involved in negative regulation of exocytosis and regulation of neuron projection development. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 21. Orthologous to human IL1RAPL1 (interleukin 1 receptor accessory protein like 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; androgen antagonist.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

IL-1-RAPL-1; IL-1RAPL-1; Il1rapl; IL1RAPL-1; interleukin-1 receptor accessory protein-like 1; X-linked interleukin-1 receptor accessory protein-like 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	55,322,779 - 56,827,486 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	55,328,964 - 56,826,613 (-)	Ensembl				GRCr8
mRatBN7.2	X	51,371,969 - 52,876,726 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	51,378,215 - 52,876,772 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	52,707,855 - 53,966,904 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	56,208,265 - 57,467,346 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	53,839,259 - 55,092,392 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	55,439,388 - 57,004,865 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	55,439,578 - 56,765,893 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	55,629,811 - 55,687,317 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	X	56,557,676 - 57,548,519 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	73,692,262 - 74,993,367 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	51,905,428 - 53,154,707 (-)	NCBI		Celera
RGSC_v3.1	X	73,765,553 - 74,546,358 (-)	NCBI
Cytogenetic Map	X	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

autistic disorder (ISO)

Developmental Disease (ISO)

genetic disease (ISO)

intellectual disability (ISO)

melanoma (ISO)

non-syndromic X-linked intellectual disability (ISO)

non-syndromic X-linked intellectual disability 21 (ISO)

schizophrenia (ISO)

X-Linked Intellectual Developmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,4'-trichlorobiphenyl (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

androgen antagonist (EXP)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

Butylparaben (EXP)

cadmium atom (ISO)

DDE (EXP)

dibutyl phthalate (EXP)

dorsomorphin (ISO)

doxorubicin (EXP)

entinostat (ISO)

enzacamene (EXP)

epoxiconazole (EXP)

ethanol (ISO)

ethylbenzene (ISO)

folic acid (ISO)

fulvestrant (ISO)

linuron (EXP)

methapyrilene (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

paracetamol (EXP)

PCB138 (ISO)

PD 0325901 (ISO)

phenylmercury acetate (ISO)

prochloraz (EXP)

procymidone (EXP)

SB 431542 (ISO)

sotorasib (ISO)

sunitinib (ISO)

temozolomide (ISO)

titanium dioxide (ISO)

toluene (ISO)

topotecan (ISO)

trametinib (ISO)

trichostatin A (ISO)

valproic acid (EXP,ISO)

venlafaxine hydrochloride (EXP)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell surface receptor signaling pathway (IBA)

cytokine-mediated signaling pathway (IEA)

heterophilic cell-cell adhesion (ISO)

negative regulation of exocytosis (IBA,IDA,IEA,ISO)

neuron differentiation (ISO)

positive regulation of dendrite morphogenesis (ISO)

positive regulation of dendritic spine morphogenesis (ISO)

positive regulation of synapse assembly (ISO,ISS)

presynaptic membrane assembly (ISO)

regulation of neuron projection development (IDA)

regulation of postsynapse organization (IEA,ISO)

regulation of presynapse assembly (IEA,ISO)

signal transduction (IEA)

synaptic membrane adhesion (ISO)

trans-synaptic signaling by trans-synaptic complex (IEA,ISO)

Cellular Component

axon (IEA)

cell surface (IBA,ISO)

cytoplasm (IEA)

dendrite (IEA,ISO)

glutamatergic synapse (IDA,IEA,ISO)

plasma membrane (IBA,IEA,ISO,ISS)

postsynaptic density membrane (IDA)

Molecular Function

hydrolase activity (IEA)

interleukin-1 binding (ISO,ISS)

interleukin-1 receptor activity (IEA)

NAD+ nucleosidase activity, cyclic ADP-ribose generating (IEA)

protein binding (ISO)

signaling receptor binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation.	Carrie A, etal., Nat Genet 1999 Sep;23(1):25-31.
2.	IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation.	Gambino F, etal., Proc Natl Acad Sci U S A. 2007 May 22;104(21):9063-8. Epub 2007 May 14.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	NCBI rat LocusLink and RefSeq merged data October 15, 2003	NCBI rat LocusLink and RefSeq merged data October 15, 2003
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	A postsynaptic signaling pathway that may account for the cognitive defect due to IL1RAPL1 mutation.	Pavlowsky A, etal., Curr Biol. 2010 Jan 26;20(2):103-15. doi: 10.1016/j.cub.2009.12.030. Epub 2010 Jan 21.
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation
12.	A truncating mutation in the IL1RAPL1 gene is responsible for X-linked mental retardation in the MRX21 family.	Tabolacci E, etal., Am J Med Genet A. 2006 Mar 1;140(5):482-7.

Additional References at PubMed

PMID:12783849	PMID:21926414	PMID:21940441	PMID:25908590

Genomics

Comparative Map Data

Il1rapl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	55,322,779 - 56,827,486 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	55,328,964 - 56,826,613 (-)	Ensembl				GRCr8
mRatBN7.2	X	51,371,969 - 52,876,726 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	51,378,215 - 52,876,772 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	52,707,855 - 53,966,904 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	56,208,265 - 57,467,346 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	53,839,259 - 55,092,392 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	55,439,388 - 57,004,865 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	55,439,578 - 56,765,893 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	55,629,811 - 55,687,317 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	X	56,557,676 - 57,548,519 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	73,692,262 - 74,993,367 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	51,905,428 - 53,154,707 (-)	NCBI		Celera
RGSC_v3.1	X	73,765,553 - 74,546,358 (-)	NCBI
Cytogenetic Map	X	q21	NCBI

IL1RAPL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	28,587,446 - 29,956,718 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	28,587,446 - 29,956,718 (+)	Ensembl			hg38	GRCh38
GRCh37	X	28,605,563 - 29,974,835 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	28,515,480 - 29,884,761 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	X	28,365,215 - 29,734,493	NCBI
Celera	X	32,732,824 - 34,100,946 (+)	NCBI		Celera
Cytogenetic Map	X	p21.3-p21.2	NCBI
HuRef	X	26,346,333 - 27,710,305 (+)	NCBI		HuRef
CHM1_1	X	28,636,125 - 30,004,681 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	28,179,409 - 29,548,899 (+)	NCBI		T2T-CHM13v2.0

Il1rapl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	85,784,543 - 87,159,554 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	85,784,476 - 87,159,251 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	X	86,740,937 - 88,115,948 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	86,740,870 - 88,115,645 (-)	Ensembl			mm10	GRCm38
MGSCv37	X	83,992,581 - 85,360,962 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	X	82,999,961 - 83,673,259 (-)	NCBI		MGSCv36	mm8
Celera	X	55,555,320 - 55,782,072 (-)	NCBI		Celera
Cytogenetic Map	X	C1	NCBI
cM Map	X	39.89	NCBI

IL1RAPL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	30,377,318 - 31,749,055 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	30,380,692 - 31,756,778 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	21,180,693 - 22,548,122 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	28,743,801 - 30,110,177 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	28,950,521 - 30,109,286 (+)	Ensembl			panPan2	panpan1.1

IL1RAPL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	23,747,689 - 25,105,606 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	23,943,871 - 25,099,377 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	28,716,786 - 30,072,066 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	23,768,977 - 25,120,119 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	23,963,965 - 25,119,603 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	23,811,147 - 25,168,166 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	23,817,557 - 25,165,880 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	23,913,009 - 25,261,426 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Il1rapl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	16,779,973 - 18,009,042 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936553	6,055,179 - 6,099,514 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936553	5,063,042 - 5,824,427 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IL1RAPL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	24,409,327 - 25,806,680 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	X	24,408,092 - 25,811,129 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	28,021,764 - 28,070,970 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IL1RAPL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	27,014,769 - 28,388,176 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666056	28,985,163 - 30,376,870 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Il1rapl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624787	268,829 - 1,291,144 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624787	266,027 - 1,489,032 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Il1rapl1
4043 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	44
Count of miRNA genes:	43
Interacting mature miRNAs:	44
Transcripts:	ENSRNOT00000068350
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738035	Stresp1	Stress response QTL 1	4.96	0.000011	stress-related behavior trait (VT:0010451)	defensive burying - coping	X	45182909	117740458	Rat
1598837	Memor13	Memory QTL 13	3.2		exploratory behavior trait (VT:0010471)	difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	44930883	89930883	Rat

Markers in Region

DXRat29

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	X	55,964,826 - 55,964,989 (+)	Marker Load Pipeline
mRatBN7.2	X	52,014,107 - 52,014,270 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	56,098,146 - 56,098,308	NCBI	Rnor6.0
Rnor_5.0	X	56,889,442 - 56,889,604	UniSTS	Rnor5.0
RGSC_v3.4	X	74,354,271 - 74,354,434	RGD	RGSC3.4
RGSC_v3.4	X	74,354,272 - 74,354,434	UniSTS	RGSC3.4
Celera	X	52,536,855 - 52,537,017	UniSTS
RGSC_v3.1	X	74,427,563 - 74,427,726	RGD
FHH x ACI Map	X	22.26	UniSTS
FHH x ACI Map	X	22.26	RGD
Cytogenetic Map	X	q22	UniSTS

DXGot60

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	51,966,031 - 51,966,177 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	56,049,703 - 56,049,848	NCBI	Rnor6.0
Rnor_5.0	X	56,840,999 - 56,841,144	UniSTS	Rnor5.0
RGSC_v3.4	X	74,306,188 - 74,306,334	RGD	RGSC3.4
RGSC_v3.4	X	74,306,189 - 74,306,334	UniSTS	RGSC3.4
Celera	X	52,488,868 - 52,489,013	UniSTS
RGSC_v3.1	X	74,379,481 - 74,379,626	RGD
RH 3.4 Map	X	657.6	UniSTS
RH 3.4 Map	X	657.6	RGD
RH 2.0 Map	21	526.4	RGD
Cytogenetic Map	X	q22	UniSTS

DXGot176

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	51,721,120 - 51,721,287 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	55,787,223 - 55,787,389	NCBI	Rnor6.0
Rnor_5.0	X	56,578,182 - 56,578,348	UniSTS	Rnor5.0
Celera	X	52,244,818 - 52,244,984	UniSTS
Cytogenetic Map	X	q22	UniSTS

RH143953

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	52,588,405 - 52,588,599 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	56,716,092 - 56,716,285	NCBI	Rnor6.0
Rnor_5.0	X	57,498,436 - 57,498,629	UniSTS	Rnor5.0
RGSC_v3.4	X	74,943,960 - 74,944,153	UniSTS	RGSC3.4
Celera	X	53,105,474 - 53,105,667	UniSTS
Cytogenetic Map	X	q22	UniSTS

BF390962

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	51,447,653 - 51,447,816 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	55,508,965 - 55,509,127	NCBI	Rnor6.0
Rnor_5.0	X	55,699,198 - 55,699,360	UniSTS	Rnor5.0
RGSC_v3.4	X	73,765,664 - 73,765,826	UniSTS	RGSC3.4
Celera	X	51,973,377 - 51,973,539	UniSTS
RH 3.4 Map	5	163.62	UniSTS
Cytogenetic Map	X	q22	UniSTS

IL1RAPL1_153

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	51,378,149 - 51,378,920 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	55,439,513 - 55,440,283	NCBI	Rnor6.0
Rnor_5.0	X	55,629,746 - 55,630,516	UniSTS	Rnor5.0
RGSC_v3.4	X	73,692,197 - 73,692,967	UniSTS	RGSC3.4
Celera	X	51,905,363 - 51,906,133	UniSTS
Cytogenetic Map	X	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
5	6	14	141	31	33	10	47	10	1	124	73	6	132	31	54	23	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_177935	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY216593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473966	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000076283 ⟹ ENSRNOP00000068289

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	55,328,964 - 56,698,627 (-)	Ensembl
mRatBN7.2 Ensembl	X	51,378,215 - 52,876,772 (-)	Ensembl
Rnor_6.0 Ensembl	X	55,439,578 - 56,765,893 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000129594 ⟹ ENSRNOP00000112327

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	55,328,964 - 56,826,613 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000154975 ⟹ ENSRNOP00000109625

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	55,328,964 - 56,826,583 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000167055 ⟹ ENSRNOP00000111792

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	55,328,964 - 56,826,496 (-)	Ensembl

RefSeq Acc Id:

NM_177935 ⟹ NP_808796

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	55,328,964 - 56,588,340 (-)	NCBI
mRatBN7.2	X	51,378,215 - 52,637,650 (-)	NCBI
Rnor_6.0	X	55,439,578 - 56,765,893 (-)	NCBI
Rnor_5.0	X	55,629,811 - 55,687,317 (-)	NCBI
Rnor_5.0	X	56,557,676 - 57,548,519 (-)	NCBI
RGSC_v3.4	X	73,692,262 - 74,993,367 (-)	RGD
Celera	X	51,905,428 - 53,154,707 (-)	RGD

Sequence:

show sequence

CTGGAAGATGAAAGCTCCGATTCCACATTTGATTCTCTTATATGCTACTTTCACTCAGAGTCTG
AAGGTTGTGACCAAAAGAGGTTCTGCTGATGGATGCACTGATTGGTCTGTTGATATCAAGAAGT
ACCAAGTATTGGTGGGAGAGCCTGTTAGAATCAAGTGTGCGCTCTTTTATGGTTATATCAGAAC
AAACTACACTCTCGCCCAAAGTGCTGGACTCAGCCTAATGTGGTATAAAAGCTCTGGTCCAGGA
GATTTTGAAGAACCCATTGCGTTTGATGGAAGTAGAATGAGCAAAGAGGAAGACTCCATTTGGT
TCAGACCAACATTACTACAGGACAGTGGGCTTTATGCCTGTGTCATCAGGAACTCCACATACTG
TATGAAAGTATCCATCTCACTGACAGTAGGAGAAAATGACACTGGACTTTGCTACAATTCCAAG
ATGAAATACTTTGAAAAAGCTGAACTTAGCAAAAGCAAGGAAATTTCATGCCGTGACATAGAAG
ACTTTTTATTACCAACCAGGGAACCTGAAATCCTTTGGTACAAGGAATGTAGAACAAAAACATG
GCGACCGAGTATTGTATTCAAAAGAGATACCTTGCTTATAAAAGAAGTCAAAGAAGATGACATT
GGAAACTATACCTGTGAATTAAAATATGGAGGCTTTGTTGTGAGAAGAACCACTGAGTTAACGG
TTACAGCTCCTCTGACTGATAAGCCACCTAAACTTTTGTATCCCATGGAAAGTAAACTGACAAT
TCAGGAGACTCAACTAGGTGGTTCAGCTAACCTTACCTGCAGAGCCTTCTTTGGGTACAGTGGA
GACGTCAGTCCTTTAATTTACTGGATGAAAGGAGAGAAATTTATTGAAGATCTGGATGAAAATA
GAGTTTGGGAAAGTGACATTAGAATCCTTAAGGAACATCTTGGAGAACAGGAAGTTTCTATCTC
ATTAATTGTTGACTCTGTGGAAGAAGGTGACCTGGGGAATTATTCTTGTTATGTTGAAAATGGG
AATGGACGTCGGCATGCCAGTGTTCTCCTTCATAAACGAGAGTTGATGTACACTGTTGAACTTG
CTGGAGGGCTTGGCGCTATTCTCTTGCTGCTCGTCTGCTCGGTGACCATATATAAATGTTACAA
GATAGAAATCATGCTCTTCTACAGGAATCATTTTGGAGCTGAGGAACTGGACGGAGATAACAAA
GATTATGATGCCTATCTGTCATATACCAAAGTGGATCCTGACCAGTGGAATCAAGAGACTGGGG
AAGAAGAACGTTTTGCCCTTGAAATCCTCCCTGATATGCTTGAAAAGCATTATGGATATAAGTT
GTTTATACCAGATAGAGATTTGATCCCAACTGGAACATACATTGAAGATGTGGCTAGATGCGTA
GATCAAAGTAAGCGGCTGATTATTGTCATGACCCCAAATTATGTAGTCCGAAGGGGCTGGAGCA
TCTTTGAGCTGGAAACGAGACTTCGAAACATGCTTGTGACTGGAGAAATCAAAGTGATACTGAT
CGAATGCAGCGAACTCCGAGGAATTATGAACTACCAGGAGGTGGAGGCCCTCAAGCATACCATC
AAGCTTCTGACCGTTATTAAATGGCATGGACCAAAATGCAACAAGTTGAACTCGAAGTTCTGGA
AGCGTTTACAGTACGAAATGCCTTTTAAGAGGATAGAACCCATTACACATGAGCAGGCGTTAGA
TGTTAGTGAGCAGGGGCCTTTTGGGGAGCTGCAGACTGTCTCGGCCATTTCAATGGCTGCGGCC
ACCTCCACAGCTCTAGCCACTGCCCATCCAGATCTCCGTTCTACCTTTCACAACACCTACCATT
CACAAATGCGTCAGAAACACTACTATCGAAGCTATGAGTACGACGTACCTCCTACGGGCACCCT
GCCACTTACCTCCATAGGAAATCAGCATACCTACTGTAACATCCCTATGACACTCATCAATGGG
CAGCGGCCACAGACAAAGTCAAGCAGGGAGCCGAATCCAGATGAAGCCCACACAAACAGTGCCA
TCCTGCCGTTGTTGGCAAGGGAAACCAGTATATCCAGTGTGATTTGGTAACAGAAAAGCAAAGG
ACATCCCGTTCCTGGGAGTTTGAAAGGAATCTGCAGTCCAGTGCCTGGAACTC

hide sequence

RefSeq Acc Id:

XM_017602087 ⟹ XP_017457576

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	55,322,779 - 56,827,486 (-)	NCBI
mRatBN7.2	X	51,371,969 - 52,876,726 (-)	NCBI
Rnor_6.0	X	55,439,388 - 57,004,865 (-)	NCBI

Sequence:

show sequence

TGTGGATTGGCTAGTACTAAAATATCCATTGGGTGGCAGTAATACTATCCTCTTTATGACTTGC
TGCAAACCAGAGAATGCATTCAATCAAATGAACCGATCTTGTAGAAACACTGGAATCATTTATG
CATTGCAGTTTCTCTTTCTTGTTTTCGCTTCTTCTTCCCTGGGATATTTTGAGTGGATTCTGGC
TATTAATCAAGATCTCGTGCTGTTCGTGGTTTGCTTGTCGTTTTCGCTCAGGATTAGCATCATT
CAAGATAAACGCAAAGCTGCTTCCCCCCACCCACTCTCTTTTGAAAAATCATTTTTGGGGTCTG
CTGAAGAGAGCTAGGACCCAGGAGACACCTTCCCAAACAGCAGGGGTTGTGTGCTTTCACATAG
CAGTACTGTACAAGGAAAACCCCGTCGGATCTGTTATTGCGGGATACTTGTGAAATACACATAG
GATTCTTTCTTATGGCTGCATCCCGGATCTGGAAATTTTACTTGGGGACAAGGAAGATTTGAAA
GGCTACATGTATCCAGAAGATTTGCAAGCAAGACTCCGATTCTTGTCATAGAGCTCACAGACTT
ATTCACTTATCGTCCGATTTCCTTCCTTCTTAAAACAAAACAAAACAAAACAAAACACATTTTA
AAATTTTCTCCCTCTTTTTCTTCAGTCTTTCATTTTTTATTCTGCCTCTTCTATTTTTTTCTTC
CTAGTCTTTTTTTCCCCTTCCCTGCTCTGCACCTGGATTGTATCGTCACTAAACAATCGGGCAC
TTTGAGAACTAACTGGCGACAGTCTTGTAGGAAAGATCTGTATGGAATTATCTGCTTTTATGGT
GAACTTGGCGTTTGTGAATGGGTACCTTGTTCACAACATTAATTGCTAGCAAAAACAAGAAAAA
GAACACAGGAGTAAAAAACGTGGATTTTTCTGAATACGCATTGTGATGACCAGCAATTACCTTA
CCGGCTGATATCCAGAGGAGAATAATTTGGAAGACTGTTGTGGGAACAGCAAGAACTGGAAGAT
GAAAGCTCCGATTCCACATTTGATTCTCTTATATGCTACTTTCACTCAGAGTCTGAAGGTTGTG
ACCAAAAGAGGTTCTGCTGATGGATGCACTGATTGGTCTGTTGATATCAAGAAGTACCAAGTAT
TGGTGGGAGAGCCTGTTAGAATCAAGTGTGCGCTCTTTTATGGTTATATCAGAACAAACTACAC
TCTCGCCCAAAGTGCTGGACTCAGCCTAATGTGGTATAAAAGCTCTGGTCCAGGAGATTTTGAA
GAACCCATTGCGTTTGATGGAAGTAGAATGAGCAAAGAGGAAGACTCCATTTGGTTCAGACCAA
CATTACTACAGGACAGTGGGCTTTATGCCTGTGTCATCAGGAACTCCACATACTGTATGAAAGT
ATCCATCTCACTGACAGTAGGAGAAAATGACACTGGACTTTGCTACAATTCCAAGATGAAATAC
TTTGAAAAAGCTGAACTTAGCAAAAGCAAGGAAATTTCATGCCGTGACATAGAAGACTTTTTAT
TACCAACCAGGGAACCTGAAATCCTTTGGTACAAGGAATGTAGAACAAAAACATGGCGACCGAG
TATTGTATTCAAAAGAGATACCTTGCTTATAAAAGAAGTCAAAGAAGATGACATTGGAAACTAT
ACCTGTGAATTAAAATATGGAGGCTTTGTTGTGAGAAGAACCACTGAGTTAACGGTTACAGCTC
CTCTGACTGATAAGCCACCTAAACTTTTGTATCCCATGGAAAGTAAACTGACAATTCAGGAGAC
TCAACTAGGTGGTTCAGCTAACCTTACCTGCAGAGCCTTCTTTGGGTACAGTGGAGACGTCAGT
CCTTTAATTTACTGGATGAAAGGAGAGAAATTTATTGAAGATCTGGATGAAAATAGAGTTTGGG
AAAGTGACATTAGAATCCTTAAGGAACATCTTGGAGAACAGGAAGTTTCTATCTCATTAATTGT
TGACTCTGTGGAAGAAGGTGACCTGGGGAATTATTCTTGTTATGTTGAAAATGGGAATGGACGT
CGGCATGCCAGTGTTCTCCTTCATAAACGAGAGTTGATGTACACTGTTGAACTTGCTGGAGGGC
TTGGCGCTATTCTCTTGCTGCTCGTCTGCTCGGTGACCATATATAAATGTTACAAGATAGAAAT
CATGCTCTTCTACAGGAATCATTTTGGAGCTGAGGAACTGGACGGAGATAACAAAGATTATGAT
GCCTATCTGTCATATACCAAAGTGGATCCTGACCAGTGGAATCAAGAGACTGGGGAAGAAGAAC
GTTTTGCCCTTGAAATCCTCCCTGATATGCTTGAAAAGCATTATGGATATAAGTTGTTTATACC
AGATAGAGATTTGATCCCAACTGGAACATACATTGAAGATGTGGCTAGATGCGTAGATCAAAGT
AAGCGGCTGATTATTGTCATGACCCCAAATTATGTAGTCCGAAGGGGCTGGAGCATCTTTGAGC
TGGAAACGAGACTTCGAAACATGCTTGTGACTGGAGAAATCAAAGTGATACTGATCGAATGCAG
CGAACTCCGAGGAATTATGAACTACCAGGAGGTGGAGGCCCTCAAGCATACCATCAAGCTTCTG
ACCGTTATTAAATGGCATGGACCAAAATGCAACAAGTTGAACTCGAAGTTCTGGAAGCGTTTAC
AGTACGAAATGCCTTTTAAGAGGATAGAACCCATTACACATGAGCAGGCGTTAGATGTTAGTGA
GCAGGGGCCTTTTGGGGAGCTGCAGACTGTCTCGGCCATTTCAATGGCTGCGGCCACCTCCACA
GCTCTAGCCACTGCCCATCCAGATCTCCGTTCTACCTTTCACAACACCTACCATTCACAAATGC
GTCAGAAACACTACTATCGAAGCTATGAGTACGACGTACCTCCTACGGGCACCCTGCCACTTAC
CTCCATAGGAAATCAGCATACCTACTGTAACATCCCTATGACACTCATCAATGGGCAGCGGCCA
CAGACAAAGTCAAGCAGGGAGCCGAATCCAGATGAAGCCCACACAAACAGTGCCATCCTGCCGT
TGTTGCCAAGGGAAACCAGTATATCCAGTGTGATTTGGTAACAGAAAAGCAAAGGACATCCCGT
TCCTGGGAGTTTGAAAGGAATCTGCAGTCCAGTGCCTGGAACTCAATCCTCGACTGCTGCTGTT
AAAAACATGCATTACAATCTCTAGAACACGAGGAAAAACAGGGTCTTGTACATATATTTTTTGG
AATTTCTTTGTAGCATCAGTGTTTTCCTGTTTTACCATGTCTCTTACCATTACATCTTTTTGAC
TTTGTTTTGTATGTCATTGGATTTGTAAATTTACATTTTTTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_808796	(Get FASTA)	NCBI Sequence Viewer
	XP_017457576	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAO62634	(Get FASTA)	NCBI Sequence Viewer
	EDL96039	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000068289
GenBank Protein	P59824	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_808796 ⟸ NM_177935
- Peptide Label:	precursor
- UniProtKB:	P59824 (UniProtKB/Swiss-Prot), A0A096MJW6 (UniProtKB/TrEMBL), A6IPX4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSVDIKKYQVLVGEPVRIKCALFYGYIRTNY TLAQSAGLSLMWYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMK VSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKTWRP SIVFKRDTLLIKEVKEDDIGNYTCELKYGGFVVRRTTELTVTAPLTDKPPKLLYPMESKLTIQE TQLGGSANLTCRAFFGYSGDVSPLIYWMKGEKFIEDLDENRVWESDIRILKEHLGEQEVSISLI VDSVEEGDLGNYSCYVENGNGRRHASVLLHKRELMYTVELAGGLGAILLLLVCSVTIYKCYKIE IMLFYRNHFGAEELDGDNKDYDAYLSYTKVDPDQWNQETGEEERFALEILPDMLEKHYGYKLFI PDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYVVRRGWSIFELETRLRNMLVTGEIKVILIEC SELRGIMNYQEVEALKHTIKLLTVIKWHGPKCNKLNSKFWKRLQYEMPFKRIEPITHEQALDVS EQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNTYHSQMRQKHYYRSYEYDVPPTGTLPL TSIGNQHTYCNIPMTLINGQRPQTKSSREPNPDEAHTNSAILPLLARETSISSVIW hide sequence

RefSeq Acc Id:

XP_017457576 ⟸ XM_017602087

- Peptide Label:

isoform X1

- Sequence:

show sequence

MKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSVDIKKYQVLVGEPVRIKCALFYGYIRTNY
TLAQSAGLSLMWYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMK
VSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKTWRP
SIVFKRDTLLIKEVKEDDIGNYTCELKYGGFVVRRTTELTVTAPLTDKPPKLLYPMESKLTIQE
TQLGGSANLTCRAFFGYSGDVSPLIYWMKGEKFIEDLDENRVWESDIRILKEHLGEQEVSISLI
VDSVEEGDLGNYSCYVENGNGRRHASVLLHKRELMYTVELAGGLGAILLLLVCSVTIYKCYKIE
IMLFYRNHFGAEELDGDNKDYDAYLSYTKVDPDQWNQETGEEERFALEILPDMLEKHYGYKLFI
PDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYVVRRGWSIFELETRLRNMLVTGEIKVILIEC
SELRGIMNYQEVEALKHTIKLLTVIKWHGPKCNKLNSKFWKRLQYEMPFKRIEPITHEQALDVS
EQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNTYHSQMRQKHYYRSYEYDVPPTGTLPL
TSIGNQHTYCNIPMTLINGQRPQTKSSREPNPDEAHTNSAILPLLPRETSISSVIW

hide sequence

Ensembl Acc Id:

ENSRNOP00000068289 ⟸ ENSRNOT00000076283

Ensembl Acc Id:

ENSRNOP00000112327 ⟸ ENSRNOT00000129594

Ensembl Acc Id:

ENSRNOP00000109625 ⟸ ENSRNOT00000154975

Ensembl Acc Id:

ENSRNOP00000111792 ⟸ ENSRNOT00000167055

Protein Domains

Ig-like Ig-like C2-type TIR

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P59824-F1-model_v2	AlphaFold	P59824	1-696	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:727891	AgrOrtholog
BioCyc Gene	G2FUF-2331	BioCyc
Ensembl Genes	ENSRNOG00000029663	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000076283	ENTREZGENE
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot
	3.40.50.10140	UniProtKB/Swiss-Prot
InterPro	Ig-like_dom	UniProtKB/Swiss-Prot
	Ig-like_dom_sf	UniProtKB/Swiss-Prot
	Ig-like_fold	UniProtKB/Swiss-Prot
	Ig_6	UniProtKB/Swiss-Prot
	Ig_sub	UniProtKB/Swiss-Prot
	Ig_sub2	UniProtKB/Swiss-Prot
	IL-1_rcpt_fam	UniProtKB/Swiss-Prot
	Immunoglobulin	UniProtKB/Swiss-Prot
	TIR_dom	UniProtKB/Swiss-Prot
	Toll_tir_struct_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:317553	UniProtKB/Swiss-Prot
NCBI Gene	317553	ENTREZGENE
PANTHER	INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 1	UniProtKB/Swiss-Prot
	PTHR11890	UniProtKB/Swiss-Prot
Pfam	Ig_6	UniProtKB/Swiss-Prot
	PF00047	UniProtKB/Swiss-Prot
	TIR	UniProtKB/Swiss-Prot
PhenoGen	Il1rapl1	PhenoGen
PRINTS	INTRLKN1R1F	UniProtKB/Swiss-Prot
PROSITE	IG_LIKE	UniProtKB/Swiss-Prot
	TIR	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000029663	RatGTEx
SMART	IGc2	UniProtKB/Swiss-Prot
	SM00409	UniProtKB/Swiss-Prot
	TIR	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48726	UniProtKB/Swiss-Prot
	SSF52200	UniProtKB/Swiss-Prot
UniProt	A0A096MJW6	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LYS3_RAT	UniProtKB/TrEMBL
	A0ABK0M3E3_RAT	UniProtKB/TrEMBL
	A0ABK0M6B4_RAT	UniProtKB/TrEMBL
	A6IPX4	ENTREZGENE, UniProtKB/TrEMBL
	IRPL1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-11	Il1rapl1	glucose-6-phosphatase catalytic subunit 3	Il1rapl	interleukin 1 receptor accessory protein-like 1	Symbol updated to reflect Human and Mouse nomenclature	625702	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

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