Bmpr2 (bone morphogenetic protein receptor type 2) - Rat Genome Database

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Gene: Bmpr2 (bone morphogenetic protein receptor type 2) Rattus norvegicus
Analyze
Symbol: Bmpr2
Name: bone morphogenetic protein receptor type 2
RGD ID: 71082
Description: Enables growth factor binding activity. Involved in retina development in camera-type eye. Located in several cellular components, including apical plasma membrane; basal plasma membrane; and caveola. Used to study pulmonary hypertension. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease 1. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; cytokine mediated signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Bmpr-II; bone morphogenetic protein receptor type II; bone morphogenetic protein receptor type II (serine/threonine kinase); bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Bmpr2em1Sage ; Bmpr2em2Sage ; Bmpr2em1Ang
Genetic Models: SD-Bmpr2em1Ang+/- ; F344-Bmpr2em2Sage+/- ; F344-Bmpr2em1Sage+/-
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8968,685,942 - 68,801,353 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl968,685,988 - 68,801,350 (+)EnsemblGRCr8
mRatBN7.2961,192,718 - 61,307,280 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl961,190,566 - 61,301,809 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx969,692,580 - 69,800,850 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0974,808,556 - 74,916,402 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0973,126,851 - 73,235,117 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0966,568,074 - 66,683,019 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl966,568,074 - 66,676,494 (+)Ensemblrn6Rnor6.0
Rnor_5.0966,371,542 - 66,486,121 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4958,327,587 - 58,436,057 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera958,627,253 - 58,735,336 (+)NCBICelera
RGSC_v3.1958,524,438 - 58,554,549 (+)NCBI
Cytogenetic Map9q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methylcholine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGS 15943  (ISO)
chloroprene  (EXP)
choline  (ISO)
chrysene  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
coumestrol  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenfluramine  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
fosinopril  (EXP)
hydrogen cyanide  (ISO)
iloprost  (ISO)
kenpaullone  (ISO)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methacholine chloride  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
monocrotaline  (EXP)
nitrofen  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
resveratrol  (ISO)
Rutecarpine  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
taurine  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetraphene  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (IEA)
angiogenesis  (ISO)
anterior/posterior pattern specification  (ISO)
aortic valve development  (IEA,ISO)
artery development  (IEA,ISO)
atrial septum morphogenesis  (IEA,ISO)
atrioventricular valve morphogenesis  (ISO)
blood vessel development  (IBA)
blood vessel remodeling  (IEA,ISO)
BMP signaling pathway  (IBA,IEA,ISO)
cardiac muscle tissue development  (ISO)
cell differentiation  (IEA,ISO)
cell fate specification  (ISO)
cell surface receptor protein serine/threonine kinase signaling pathway  (IEA,ISO)
cellular response to BMP stimulus  (IEA,ISO)
cellular response to growth factor stimulus  (IBA)
cellular response to starvation  (IEA,ISO)
chondrocyte development  (IEA,ISO)
endocardial cushion development  (IEA,ISO)
endochondral bone morphogenesis  (ISS)
endothelial cell apoptotic process  (IEA,ISO)
endothelial cell proliferation  (IEA,ISO)
limb development  (ISO)
lung alveolus development  (IEA,ISO)
lung vasculature development  (IEA,ISO)
lymphangiogenesis  (IEA,ISO)
lymphatic endothelial cell differentiation  (IEA,ISO)
maternal placenta development  (ISO)
mesoderm formation  (ISO)
mitral valve morphogenesis  (ISO)
negative regulation of cell growth  (IEA,ISO)
negative regulation of cell proliferation involved in heart valve morphogenesis  (IEA,ISO)
negative regulation of chondrocyte proliferation  (IEA,ISO)
negative regulation of smooth muscle cell proliferation  (IEA,ISO)
negative regulation of systemic arterial blood pressure  (IEA,ISO)
negative regulation of vasoconstriction  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
outflow tract morphogenesis  (IEA,ISO)
outflow tract septum morphogenesis  (ISO)
pharyngeal arch artery morphogenesis  (ISO)
positive regulation of axon extension involved in axon guidance  (IEA,ISO)
positive regulation of bone mineralization  (IEA,ISO)
positive regulation of cartilage development  (ISS)
positive regulation of epithelial cell migration  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of ossification  (IEA,ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of SMAD protein signal transduction  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
proteoglycan biosynthetic process  (ISS)
pulmonary valve development  (IEA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of lung blood pressure  (IEA,ISO)
retina development in camera-type eye  (IEP)
retina vasculature development in camera-type eye  (IEA,ISO)
semi-lunar valve development  (IEA,ISO)
tricuspid valve morphogenesis  (ISO)
venous blood vessel development  (IEA,ISO)
ventricular septum morphogenesis  (IEA,ISO)

Cellular Component
adherens junction  (IEA,ISO)
apical plasma membrane  (IDA)
axon  (IEA,ISO)
basal plasma membrane  (IDA)
caveola  (IDA,IEA,ISO)
cell body  (IEA,ISO)
cell surface  (IEA,ISO)
clathrin-coated pit  (IEA,ISO)
dendrite  (IDA,IEA,ISO)
membrane  (IEA)
neuronal cell body  (IDA)
plasma membrane  (IBA,IEA,ISO)
postsynaptic density  (IEA,ISO)
receptor complex  (IBA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension. Austin ED, etal., Respir Res. 2009 Sep 28;10:87.
2. Characterization of receptors for osteogenic protein-1/bone morphogenetic protein-7 (OP-1/BMP-7) in rat kidneys. Bosukonda D, etal., Kidney Int. 2000 Nov;58(5):1902-11.
3. Distribution of bone morphogenetic protein and bone morphogenetic protein receptor transcripts in the rodent nervous system and up-regulation of bone morphogenetic protein receptor type II in hippocampal dentate gyrus in a rat model of global cerebral ischemia. Charytoniuk DA, etal., Neuroscience. 2000;100(1):33-43.
4. Gross BMPR2 gene rearrangements constitute a new cause for primary pulmonary hypertension. Cogan JD, etal., Genet Med. 2005 Mar;7(3):169-74.
5. Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension. Dewachter L, etal., Eur Respir J. 2009 Nov;34(5):1100-10. Epub 2009 Mar 26.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Absence of influence of gender and BMPR2 mutation type on clinical phenotypes of pulmonary arterial hypertension. Girerd B, etal., Respir Res. 2010 Jun 10;11:73.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension. Hong KH, etal., Circulation. 2008 Aug 12;118(7):722-30. Epub 2008 Jul 28.
10. Basal expression of bone morphogenetic protein receptor is reduced in mild asthma. Kariyawasam HH, etal., Am J Respir Crit Care Med. 2008 May 15;177(10):1074-81. Epub 2008 Feb 21.
11. Expression of serine/threonine kinase receptors in traumatic brain injury. Lewen A, etal., Neuroreport. 1997 Jan 20;8(2):475-9.
12. Type 1 Diabetes-Induced Hyper-Responsiveness to 5-Hydroxytryptamine in Rat Pulmonary Arteries via Oxidative Stress and Induction of Cyclooxygenase-2. Lopez-Lopez JG, etal., J Pharmacol Exp Ther. 2011 Jul;338(1):400-7. Epub 2011 Apr 26.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Bone morphogenetic protein receptor expressions in the adult rat brain. Miyagi M, etal., Neuroscience. 2011 Mar 10;176:93-109. Epub 2010 Dec 23.
15. A novel BMPR2 gene mutation associated with exercise-induced pulmonary hypertension in septal defects. Moller T, etal., Scand Cardiovasc J. 2010 Dec;44(6):331-6. Epub 2010 Nov 11.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats. Onishi T, etal., Bone. 1998 Jun;22(6):605-12.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. The BMP type II receptor is located in lipid rafts, including caveolae, of pulmonary endothelium in vivo and in vitro. Ramos M, etal., Vascul Pharmacol. 2006 Jan;44(1):50-9. Epub 2005 Nov 3.
22. Endothelial-to-mesenchymal transition in pulmonary hypertension. Ranchoux B, etal., Circulation. 2015 Mar 17;131(11):1006-18. doi: 10.1161/CIRCULATIONAHA.114.008750. Epub 2015 Jan 15.
23. Targeted gene delivery of BMPR2 attenuates pulmonary hypertension. Reynolds AM, etal., Eur Respir J. 2012 Feb;39(2):329-43. doi: 10.1183/09031936.00187310. Epub 2011 Jul 7.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Expression of serine/threonine kinase receptors including the bone morphogenetic factor type II receptor in the developing and adult rat brain. Soderstrom S, etal., Cell Tissue Res. 1996 Nov;286(2):269-79.
29. FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. Spiekerkoetter E, etal., J Clin Invest. 2013 Aug;123(8):3600-13. doi: 10.1172/JCI65592. Epub 2013 Jul 15.
30. Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension. Takahashi H, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L450-8. Epub 2005 Dec 16.
31. Phenotypically-Silent Bone Morphogenetic Protein Receptor 2 (Bmpr2) Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing The Risk for Neointimal Transformation. Tian W, etal., Circulation. 2019 Aug 29. doi: 10.1161/CIRCULATIONAHA.119.040629.
32. Identities and frequencies of BMPR2 mutations in Chinese patients with idiopathic pulmonary arterial hypertension. Wang H, etal., Clin Genet. 2010 Feb;77(2):189-92. Epub 2009 Dec 10.
33. Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions. West J, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L744-55. Epub 2008 Aug 22.
34. Expression of transforming growth factor-beta superfamily receptors in developing rat eyes. Yamada H, etal., Jpn J Ophthalmol. 1999 Jul-Aug;43(4):290-4.
Additional References at PubMed
PMID:9442116   PMID:10772805   PMID:11502704   PMID:12045205   PMID:12117821   PMID:12441304   PMID:12819188   PMID:15542835   PMID:15657086   PMID:17114649   PMID:17472960   PMID:17992660  
PMID:18063682   PMID:18326817   PMID:18364108   PMID:18367643   PMID:18436533   PMID:18552156   PMID:19153267   PMID:19366699   PMID:19409885   PMID:19440953   PMID:19669850   PMID:19903896  
PMID:21619414   PMID:21976273   PMID:22664934   PMID:23079343   PMID:23446737   PMID:23610558   PMID:23676498   PMID:23780850   PMID:24052814   PMID:25187962   PMID:25461595   PMID:25468996  
PMID:26076038   PMID:26535780   PMID:26598555   PMID:26774823   PMID:27177866   PMID:27622883   PMID:28187784   PMID:29478969   PMID:30575923   PMID:30586714   PMID:30610955   PMID:31850803  
PMID:32521690   PMID:34857612   PMID:35037801   PMID:35848848   PMID:36917778   PMID:38979789  


Genomics

Comparative Map Data
Bmpr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8968,685,942 - 68,801,353 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl968,685,988 - 68,801,350 (+)EnsemblGRCr8
mRatBN7.2961,192,718 - 61,307,280 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl961,190,566 - 61,301,809 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx969,692,580 - 69,800,850 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0974,808,556 - 74,916,402 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0973,126,851 - 73,235,117 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0966,568,074 - 66,683,019 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl966,568,074 - 66,676,494 (+)Ensemblrn6Rnor6.0
Rnor_5.0966,371,542 - 66,486,121 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4958,327,587 - 58,436,057 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera958,627,253 - 58,735,336 (+)NCBICelera
RGSC_v3.1958,524,438 - 58,554,549 (+)NCBI
Cytogenetic Map9q31NCBI
BMPR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382202,376,327 - 202,567,749 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2202,376,327 - 202,567,751 (+)Ensemblhg38GRCh38
GRCh372203,241,050 - 203,432,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362202,949,916 - 203,140,719 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342203,067,104 - 203,257,979NCBI
Celera2196,992,827 - 197,184,404 (+)NCBICelera
Cytogenetic Map2q33.1-q33.2NCBI
HuRef2195,088,272 - 195,279,312 (+)NCBIHuRef
CHM1_12203,247,530 - 203,439,226 (+)NCBICHM1_1
T2T-CHM13v2.02202,857,368 - 203,049,014 (+)NCBIT2T-CHM13v2.0
Bmpr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39159,802,721 - 59,917,240 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl159,802,559 - 59,918,173 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38159,764,279 - 59,878,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl159,763,400 - 59,879,014 (+)Ensemblmm10GRCm38
MGSCv37159,821,481 - 59,927,703 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36159,709,183 - 59,815,405 (+)NCBIMGSCv36mm8
Celera160,279,442 - 60,385,822 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.44NCBI
Bmpr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545712,235,780 - 12,316,727 (-)Ensembl
ChiLan1.0NW_00495545712,235,780 - 12,315,680 (-)NCBIChiLan1.0ChiLan1.0
BMPR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213105,000,755 - 105,192,826 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B105,008,761 - 105,207,823 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B89,631,622 - 89,823,438 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B207,780,568 - 207,968,900 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B207,780,741 - 207,961,072 (+)EnsemblpanPan2panpan1.1
BMPR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13711,342,292 - 11,540,199 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3711,342,384 - 11,533,024 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3712,225,170 - 12,423,716 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03711,278,198 - 11,476,750 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3711,278,288 - 11,476,741 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13711,228,404 - 11,433,107 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03711,207,452 - 11,404,742 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03711,200,863 - 11,398,681 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bmpr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303159,573,093 - 159,741,130 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367261,543,245 - 1,704,541 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367261,543,263 - 1,711,422 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMPR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15105,970,428 - 106,135,730 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115105,971,577 - 106,132,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215117,426,776 - 117,589,050 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMPR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11088,103,442 - 88,302,578 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1088,106,072 - 88,303,734 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040111,076,327 - 111,285,567 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmpr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476513,857,062 - 13,947,683 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476513,849,689 - 13,950,839 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Bmpr2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v156,478,453 - 6,586,665 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bmpr2
615 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:35
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000035238
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)95746049778547958Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
RH134140  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2961,301,504 - 61,301,688 (+)MAPPERmRatBN7.2
Rnor_6.0966,677,246 - 66,677,429NCBIRnor6.0
Rnor_5.0966,480,348 - 66,480,531UniSTSRnor5.0
RGSC_v3.4958,436,817 - 58,437,000UniSTSRGSC3.4
Celera958,736,088 - 58,736,271UniSTS
RH 3.4 Map9514.9UniSTS
Cytogenetic Map9q31UniSTS
BF403103  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2961,306,281 - 61,306,435 (+)MAPPERmRatBN7.2
Rnor_6.0966,682,023 - 66,682,176NCBIRnor6.0
Rnor_5.0966,485,125 - 66,485,278UniSTSRnor5.0
RGSC_v3.4958,441,597 - 58,441,750UniSTSRGSC3.4
Celera958,740,884 - 58,741,037UniSTS
RH 3.4 Map9496.5UniSTS
Cytogenetic Map9q31UniSTS
AW536011  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2961,306,490 - 61,306,649 (+)MAPPERmRatBN7.2
Rnor_6.0966,682,232 - 66,682,390NCBIRnor6.0
Rnor_5.0966,485,334 - 66,485,492UniSTSRnor5.0
RGSC_v3.4958,441,806 - 58,441,964UniSTSRGSC3.4
Celera958,741,093 - 58,741,251UniSTS
RH 3.4 Map9495.8UniSTS
Cytogenetic Map9q31UniSTS
RH141266  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2961,300,764 - 61,300,945 (+)MAPPERmRatBN7.2
Rnor_6.0966,676,506 - 66,676,686NCBIRnor6.0
Rnor_5.0966,479,608 - 66,479,788UniSTSRnor5.0
RGSC_v3.4958,436,069 - 58,436,249UniSTSRGSC3.4
Celera958,735,348 - 58,735,528UniSTS
RH 3.4 Map9495.8UniSTS
Cytogenetic Map9q31UniSTS
AI009781  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2961,304,981 - 61,305,197 (+)MAPPERmRatBN7.2
Rnor_6.0966,680,723 - 66,680,938NCBIRnor6.0
Rnor_5.0966,483,825 - 66,484,040UniSTSRnor5.0
RGSC_v3.4958,440,297 - 58,440,512UniSTSRGSC3.4
Celera958,739,565 - 58,739,780UniSTS
RH 3.4 Map9515.3UniSTS
Cytogenetic Map9q31UniSTS


Genetic Models
This gene Bmpr2 is modified in the following models/strains:
SD-Bmpr2em1Ang+/-     F344-Bmpr2em2Sage+/-     F344-Bmpr2em1Sage+/-    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000035238   ⟹   ENSRNOP00000037011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl968,686,016 - 68,794,840 (+)Ensembl
mRatBN7.2 Ensembl961,192,718 - 61,301,809 (+)Ensembl
Rnor_6.0 Ensembl966,568,074 - 66,676,494 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100349   ⟹   ENSRNOP00000095162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl968,685,988 - 68,801,350 (+)Ensembl
mRatBN7.2 Ensembl961,190,566 - 61,300,753 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110365   ⟹   ENSRNOP00000111245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl968,707,586 - 68,801,350 (+)Ensembl
RefSeq Acc Id: NM_080407   ⟹   NP_536332
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8968,686,816 - 68,794,828 (+)NCBI
mRatBN7.2961,192,718 - 61,300,753 (+)NCBI
Rnor_6.0966,568,074 - 66,676,494 (+)NCBI
Rnor_5.0966,371,542 - 66,486,121 (+)NCBI
RGSC_v3.4958,327,587 - 58,436,057 (+)RGD
Celera958,627,253 - 58,735,336 (+)RGD
Sequence:
RefSeq Acc Id: XM_006244951   ⟹   XP_006245013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8968,685,942 - 68,801,353 (+)NCBI
mRatBN7.2961,193,040 - 61,307,280 (+)NCBI
Rnor_6.0966,568,427 - 66,683,019 (+)NCBI
Rnor_5.0966,371,542 - 66,486,121 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244952   ⟹   XP_006245014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8968,685,959 - 68,801,353 (+)NCBI
mRatBN7.2961,193,040 - 61,307,280 (+)NCBI
Rnor_6.0966,568,427 - 66,683,019 (+)NCBI
Rnor_5.0966,371,542 - 66,486,121 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063266598   ⟹   XP_063122668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8968,685,951 - 68,801,353 (+)NCBI
RefSeq Acc Id: NP_536332   ⟸   NM_080407
- Peptide Label: precursor
- UniProtKB: A6IPB4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245013   ⟸   XM_006244951
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AM39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245014   ⟸   XM_006244952
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000037011   ⟸   ENSRNOT00000035238
Ensembl Acc Id: ENSRNOP00000095162   ⟸   ENSRNOT00000100349
RefSeq Acc Id: XP_063122668   ⟸   XM_063266598
- Peptide Label: isoform X3
- UniProtKB: F1LQC5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111245   ⟸   ENSRNOT00000110365
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LQC5-F1-model_v2 AlphaFold F1LQC5 1-1038 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71082 AgrOrtholog
BioCyc Gene G2FUF-27392 BioCyc
Ensembl Genes ENSRNOG00000022196 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035238 ENTREZGENE
  ENSRNOT00000035238.6 UniProtKB/TrEMBL
  ENSRNOT00000100349 ENTREZGENE
  ENSRNOT00000100349.2 UniProtKB/TrEMBL
  ENSRNOT00000110365 ENTREZGENE
  ENSRNOT00000110365.2 UniProtKB/TrEMBL
Gene3D-CATH 2.10.60.10 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Activin_rcpt UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Snake_toxin-like_sf UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/TrEMBL
KEGG Report rno:140590 UniProtKB/TrEMBL
NCBI Gene 140590 ENTREZGENE
PANTHER BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2 UniProtKB/TrEMBL
  PTHR23255 UniProtKB/TrEMBL
Pfam Activin_recp UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Bmpr2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022196 RatGTEx
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF57302 UniProtKB/TrEMBL
UniProt A0A8I6AM39 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M2H6_RAT UniProtKB/TrEMBL
  A6IPB4 ENTREZGENE, UniProtKB/TrEMBL
  F1LQC5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Bmpr2  bone morphogenetic protein receptor type 2  Bmpr2  bone morphogenetic protein receptor type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-09 Bmpr2  bone morphogenetic protein receptor type II  Bmpr2  bone morphogenetic protein receptor, type II (serine/threonine kinase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Bmpr2  bone morphogenetic protein receptor, type II (serine/threonine kinase)  Bmpr2  bone morphogenic protein receptor, type II (serine/threonine kinase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Bmpr2  bone morphogenic protein receptor, type II (serine/threonine kinase)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference