Hnrnpl (heterogeneous nuclear ribonucleoprotein L) - Rat Genome Database

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Gene: Hnrnpl (heterogeneous nuclear ribonucleoprotein L) Rattus norvegicus
Analyze
Symbol: Hnrnpl
Name: heterogeneous nuclear ribonucleoprotein L
RGD ID: 71059
Description: Enables mRNA 3'-UTR binding activity and mRNA CDS binding activity. Involved in several processes, including cellular response to amino acid starvation; circadian rhythm; and regulation of gene expression. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and systemic scleroderma. Orthologous to human HNRNPL (heterogeneous nuclear ribonucleoprotein L); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: heterogenous nuclear ribonucleoprotein L; hnrnp-L; Hnrpl
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,226,373 - 93,239,084 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl193,235,729 - 93,239,061 (+)EnsemblGRCr8
mRatBN7.2184,098,558 - 84,111,568 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,100,879 - 84,111,553 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx189,510,654 - 89,521,604 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,969,995 - 97,980,674 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,266,512 - 91,277,462 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd191,844,779 - 91,855,458 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive196,985,153 - 96,995,836 (+)NCBILyon_Normotensive
Lyon_Hypertensive193,518,359 - 93,529,038 (+)NCBILyon_Hypertensive
F344_StmMcwi191,972,588 - 91,983,271 (+)NCBIF344_StmMcwi
Rnor_6.0186,994,090 - 87,006,776 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,996,093 - 87,006,776 (+)Ensemblrn6Rnor6.0
Rnor_5.0188,174,400 - 88,187,394 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,919,015 - 83,929,698 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera178,491,204 - 78,501,887 (+)NCBICelera
RGSC_v3.1184,005,781 - 84,007,795 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic UMP  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
CU-O LINKAGE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
hydrogen sulfide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
methotrexate  (ISO)
morphine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nicotine  (ISO)
nobiletin  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
piroxicam  (ISO)
quinoline  (ISO)
rac-lactic acid  (ISO)
saxitoxin  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium chloride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISO,ISS)
cytoplasm  (IEA,ISO)
nucleoplasm  (IEA,ISO,ISS)
nucleus  (IBA,IEA,ISO)
perinuclear region of cytoplasm  (IDA)
pronucleus  (ISO)
ribonucleoprotein complex  (IEA,ISO,ISS)
ribonucleoprotein granule  (ISO,ISS)
synapse  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of new autoantibody specificities directed at proteins involved in the transforming growth factor beta pathway in patients with systemic sclerosis. Bussone G, etal., Arthritis Res Ther. 2011 May 13;13(3):R74. doi: 10.1186/ar3336.
2. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
3. PLG regulates hnRNP-L expression in the rat striatum and pre-frontal cortex: identification by ddPCR. Costain WJ and Mishra RK, Peptides 2003 Jan;24(1):137-46.
4. Lymphoid gene expression as a predictor of risk of secondary brain tumors. Edick MJ, etal., Genes Chromosomes Cancer. 2005 Feb;42(2):107-16.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing. Goehe RW, etal., J Clin Invest. 2010 Nov;120(11):3923-39. doi: 10.1172/JCI43552. Epub 2010 Oct 25.
8. hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo. Hamilton BJ, etal., Biochem Biophys Res Commun. 1999 Aug 11;261(3):646-51.
9. Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation. Kim TD, etal., Mol Cell Biol. 2005 Apr;25(8):3232-46.
10. HnRNPL as a key factor in spermatogenesis: Lesson from functional proteomic studies of azoospermia patients with sertoli cell only syndrome. Li J, etal., J Proteomics. 2012 Jun 6;75(10):2879-91. doi: 10.1016/j.jprot.2011.12.040. Epub 2012 Jan 10.
11. A conserved serine of heterogeneous nuclear ribonucleoprotein L (hnRNP L) mediates depolarization-regulated alternative splicing of potassium channels. Liu G, etal., J Biol Chem. 2012 Jun 29;287(27):22709-16. doi: 10.1074/jbc.M112.357343. Epub 2012 May 8.
12. The hnRNA-binding proteins hnRNP L and PTB are required for efficient translation of the Cat-1 arginine/lysine transporter mRNA during amino acid starvation. Majumder M, etal., Mol Cell Biol. 2009 May;29(10):2899-912. doi: 10.1128/MCB.01774-08. Epub 2009 Mar 9.
13. Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes. Matsui K, etal., Hepatology. 2008 Feb;47(2):686-97.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. An exonic splicing silencer is involved in the regulated splicing of glucose 6-phosphate dehydrogenase mRNA. Szeszel-Fedorowicz W, etal., J Biol Chem. 2006 Nov 10;281(45):34146-58. Epub 2006 Sep 15.
20. Autoantibody recognition of an N-terminal epitope of hnRNP L marks the risk for developing HBV-related hepatocellular carcinoma. Yau WY, etal., J Proteomics. 2013 Dec 6;94:346-58. doi: 10.1016/j.jprot.2013.10.003. Epub 2013 Oct 11.
Additional References at PubMed
PMID:2687284   PMID:7768196   PMID:11809897   PMID:12477932   PMID:15798186   PMID:17289661   PMID:19056867   PMID:19946888   PMID:22082260   PMID:22215678   PMID:22523384   PMID:22658674  
PMID:22681889   PMID:24625528   PMID:25623890   PMID:27315481   PMID:35352799  


Genomics

Comparative Map Data
Hnrnpl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,226,373 - 93,239,084 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl193,235,729 - 93,239,061 (+)EnsemblGRCr8
mRatBN7.2184,098,558 - 84,111,568 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,100,879 - 84,111,553 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx189,510,654 - 89,521,604 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,969,995 - 97,980,674 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,266,512 - 91,277,462 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd191,844,779 - 91,855,458 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive196,985,153 - 96,995,836 (+)NCBILyon_Normotensive
Lyon_Hypertensive193,518,359 - 93,529,038 (+)NCBILyon_Hypertensive
F344_StmMcwi191,972,588 - 91,983,271 (+)NCBIF344_StmMcwi
Rnor_6.0186,994,090 - 87,006,776 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,996,093 - 87,006,776 (+)Ensemblrn6Rnor6.0
Rnor_5.0188,174,400 - 88,187,394 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,919,015 - 83,929,698 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera178,491,204 - 78,501,887 (+)NCBICelera
RGSC_v3.1184,005,781 - 84,007,795 (+)NCBI
Cytogenetic Map1q21NCBI
HNRNPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,836,370 - 38,852,347 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,836,370 - 38,852,347 (-)Ensemblhg38GRCh38
GRCh371939,327,010 - 39,342,987 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,018,868 - 44,034,819 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341944,018,868 - 44,032,457NCBI
Celera1936,129,470 - 36,145,420 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,773,794 - 35,789,557 (-)NCBIHuRef
CHM1_11939,327,480 - 39,343,450 (-)NCBICHM1_1
T2T-CHM13v2.01941,640,403 - 41,656,404 (-)NCBIT2T-CHM13v2.0
Hnrnpl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,507,971 - 28,521,693 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,507,966 - 28,521,691 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38728,808,546 - 28,822,268 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,808,541 - 28,822,266 (+)Ensemblmm10GRCm38
MGSCv37729,595,909 - 29,607,285 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36728,519,673 - 28,531,004 (+)NCBIMGSCv36mm8
Celera723,371,763 - 23,383,139 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.93NCBI
Hnrnpl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468670,559 - 683,540 (+)Ensembl
ChiLan1.0NW_004955468668,177 - 683,540 (+)NCBIChiLan1.0ChiLan1.0
HNRNPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,140,619 - 45,158,142 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,011,145 - 47,027,200 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01935,943,720 - 35,959,795 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11944,493,832 - 44,509,183 (-)NCBIPanPan1.1PanPan1.1panPan2
HNRNPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,267,195 - 114,279,107 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,267,210 - 114,278,837 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1113,668,694 - 113,682,944 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01114,867,366 - 114,881,619 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,869,714 - 114,881,615 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,424,849 - 114,439,087 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01114,060,575 - 114,072,464 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01115,054,052 - 115,068,304 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hnrnpl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,365,722 - 13,378,495 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366611,793,801 - 1,806,579 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366611,793,791 - 1,806,564 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNRNPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,643,566 - 47,657,833 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1647,643,561 - 47,655,856 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,180,634 - 43,194,945 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HNRNPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,452,705 - 33,469,070 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,452,852 - 33,466,284 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607311,466,361 - 11,483,112 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hnrnpl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,206,252 - 12,218,173 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479412,206,278 - 12,220,679 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hnrnpl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12167,180,433 - 167,193,397 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hnrnpl
217 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:377
Count of miRNA genes:189
Interacting mature miRNAs:215
Transcripts:ENSRNOT00000027425, ENSRNOT00000027494, ENSRNOT00000057034
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat

Markers in Region
WI-13808  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2184,105,765 - 84,105,895 (+)MAPPERmRatBN7.2
Rnor_6.0187,000,974 - 87,001,103NCBIRnor6.0
Rnor_5.0188,181,592 - 88,181,721UniSTSRnor5.0
RGSC_v3.4183,923,896 - 83,924,025UniSTSRGSC3.4
Celera178,496,085 - 78,496,214UniSTS
Cytogenetic Map1q21UniSTS
AI599652  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8193,238,316 - 93,238,819 (+)Marker Load Pipeline
mRatBN7.288,601,113 - 8,601,258 (+)MAPPERmRatBN7.2
mRatBN7.2184,110,800 - 84,111,303 (+)MAPPERmRatBN7.2
Rnor_6.089,673,364 - 9,673,508NCBIRnor6.0
Rnor_6.0187,006,009 - 87,006,511NCBIRnor6.0
Rnor_5.089,647,369 - 9,647,513UniSTSRnor5.0
Rnor_5.0188,186,627 - 88,187,129UniSTSRnor5.0
RGSC_v3.4183,928,931 - 83,929,433UniSTSRGSC3.4
RGSC_v3.488,436,039 - 8,436,183UniSTSRGSC3.4
Celera810,109,633 - 10,109,777UniSTS
Celera178,501,120 - 78,501,622UniSTS
RH 3.4 Map1844.0UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map8q11UniSTS
D6S1116E  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8193,235,556 - 93,235,815 (+)Marker Load Pipeline
mRatBN7.2184,108,040 - 84,108,299 (+)MAPPERmRatBN7.2
Rnor_6.0187,003,249 - 87,003,507NCBIRnor6.0
Rnor_5.0188,183,867 - 88,184,125UniSTSRnor5.0
RGSC_v3.4183,926,171 - 83,926,429UniSTSRGSC3.4
Celera178,498,360 - 78,498,618UniSTS
Cytogenetic Map1q21UniSTS
UniSTS:479127  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.235,939,834 - 5,940,272 (+)MAPPERmRatBN7.2
Rnor_6.03261,494 - 261,931NCBIRnor6.0
Rnor_5.03257,367 - 257,804UniSTSRnor5.0
RGSC_v3.431,378,472 - 1,378,909UniSTSRGSC3.4
Celera3778,564 - 779,001UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027425   ⟹   ENSRNOP00000027425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,100,879 - 84,111,553 (+)Ensembl
Rnor_6.0 Ensembl186,996,093 - 87,006,776 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000027494   ⟹   ENSRNOP00000027494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl193,235,729 - 93,239,061 (+)Ensembl
mRatBN7.2 Ensembl184,100,879 - 84,111,553 (+)Ensembl
Rnor_6.0 Ensembl186,996,093 - 87,006,776 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000057034   ⟹   ENSRNOP00000053867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,100,911 - 84,111,549 (+)Ensembl
Rnor_6.0 Ensembl187,000,093 - 87,006,753 (+)Ensembl
RefSeq Acc Id: NM_001134760   ⟹   NP_001128232
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,228,401 - 93,239,084 (+)NCBI
mRatBN7.2184,100,885 - 84,111,568 (+)NCBI
Dahl_SR_JrHsd191,844,779 - 91,855,458 (+)NCBI
Lyon_Normotensive196,985,153 - 96,995,836 (+)NCBI
Lyon_Hypertensive193,518,359 - 93,529,038 (+)NCBI
F344_StmMcwi191,972,588 - 91,983,271 (+)NCBI
Rnor_6.0186,996,093 - 87,006,776 (+)NCBI
Rnor_5.0188,174,400 - 88,187,394 (+)NCBI
RGSC_v3.4183,919,015 - 83,929,698 (+)RGD
Celera178,491,204 - 78,501,887 (+)RGD
Sequence:
RefSeq Acc Id: NM_032619   ⟹   NP_116008
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,228,401 - 93,239,084 (+)NCBI
mRatBN7.2184,100,885 - 84,111,568 (+)NCBI
Dahl_SR_JrHsd191,844,779 - 91,855,458 (+)NCBI
Lyon_Normotensive196,985,153 - 96,995,836 (+)NCBI
Lyon_Hypertensive193,518,359 - 93,529,038 (+)NCBI
F344_StmMcwi191,972,588 - 91,983,271 (+)NCBI
Rnor_6.0186,996,093 - 87,006,776 (+)NCBI
Rnor_5.0188,174,400 - 88,187,394 (+)NCBI
RGSC_v3.4183,919,015 - 83,929,698 (+)RGD
Celera178,491,204 - 78,501,887 (+)RGD
Sequence:
RefSeq Acc Id: XM_006228691   ⟹   XP_006228753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,226,373 - 93,239,070 (+)NCBI
mRatBN7.2184,098,558 - 84,111,557 (+)NCBI
Rnor_6.0186,994,090 - 87,006,765 (+)NCBI
Rnor_5.0188,174,400 - 88,187,394 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006228692   ⟹   XP_006228754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,226,377 - 93,239,070 (+)NCBI
mRatBN7.2184,098,558 - 84,111,554 (+)NCBI
Rnor_6.0186,994,091 - 87,006,765 (+)NCBI
Rnor_5.0188,174,400 - 88,187,394 (+)NCBI
Sequence:
RefSeq Acc Id: NP_116008   ⟸   NM_032619
- Peptide Label: isoform b
- UniProtKB: A6J9L2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001128232   ⟸   NM_001134760
- Peptide Label: isoform a
- UniProtKB: F1LPP9 (UniProtKB/Swiss-Prot),   Q5U1Y5 (UniProtKB/Swiss-Prot),   F1LQ48 (UniProtKB/TrEMBL),   A0A8L2QEL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228753   ⟸   XM_006228691
- Peptide Label: isoform X1
- UniProtKB: A6J9L2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228754   ⟸   XM_006228692
- Peptide Label: isoform X2
- UniProtKB: A6J9L3 (UniProtKB/TrEMBL),   A6J9L2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053867   ⟸   ENSRNOT00000057034
Ensembl Acc Id: ENSRNOP00000027494   ⟸   ENSRNOT00000027494
Ensembl Acc Id: ENSRNOP00000027425   ⟸   ENSRNOT00000027425
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LQ48-F1-model_v2 AlphaFold F1LQ48 1-623 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689886
Promoter ID:EPDNEW_R410
Type:initiation region
Name:Hnrnpl_1
Description:heterogeneous nuclear ribonucleoprotein L
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0186,996,119 - 86,996,179EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71059 AgrOrtholog
BioCyc Gene G2FUF-60214 BioCyc
Ensembl Genes ENSRNOG00000020235 Ensembl
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
InterPro HnRNP-L/PTB UniProtKB/Swiss-Prot
  hnRNP-L_RRM3 UniProtKB/Swiss-Prot
  HNRNPL_RRM UniProtKB/Swiss-Prot
  hnRNPL_RRM1 UniProtKB/Swiss-Prot
  hnRNPL_RRM2 UniProtKB/Swiss-Prot
  hnRNPL_RRM4 UniProtKB/Swiss-Prot
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  PTBP1_RRM UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report rno:80846 UniProtKB/Swiss-Prot
NCBI Gene 80846 ENTREZGENE
PANTHER MATRIN 3/NUCLEAR PROTEIN 220-RELATED UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
  RRM_10 UniProtKB/Swiss-Prot
  RRM_5 UniProtKB/Swiss-Prot
  RRM_8 UniProtKB/Swiss-Prot
PhenoGen Hnrnpl PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020235 RatGTEx
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A8L2QEL3 ENTREZGENE
  A0A8L2QQ13_RAT UniProtKB/TrEMBL
  A6J9L2 ENTREZGENE, UniProtKB/TrEMBL
  A6J9L3 ENTREZGENE, UniProtKB/TrEMBL
  B5DFG2_RAT UniProtKB/TrEMBL
  F1LPP9 ENTREZGENE
  F1LQ48 ENTREZGENE
  F2Z3R2_RAT UniProtKB/TrEMBL
  HNRPL_RAT UniProtKB/Swiss-Prot
  Q5U1Y5 ENTREZGENE
UniProt Secondary F1LPP9 UniProtKB/Swiss-Prot
  Q5U1Y5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Hnrnpl  heterogeneous nuclear ribonucleoprotein L  Hnrpl  heterogeneous nuclear ribonucleoprotein L  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Hnrpl  heterogeneous nuclear ribonucleoprotein L      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference