Hnrnpl (heterogeneous nuclear ribonucleoprotein L) - Rat Genome Database

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Gene: Hnrnpl (heterogeneous nuclear ribonucleoprotein L) Rattus norvegicus
Analyze
Symbol: Hnrnpl
Name: heterogeneous nuclear ribonucleoprotein L
RGD ID: 71059
Description: Enables mRNA 3'-UTR binding activity and mRNA CDS binding activity. Involved in several processes, including cellular response to amino acid starvation; circadian rhythm; and regulation of gene expression. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and systemic scleroderma. Orthologous to human HNRNPL (heterogeneous nuclear ribonucleoprotein L); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: heterogenous nuclear ribonucleoprotein L; hnrnp-L; Hnrpl
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,226,373 - 93,239,084 (+)NCBIGRCr8
mRatBN7.2184,098,558 - 84,111,568 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,100,879 - 84,111,553 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,510,654 - 89,521,604 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,969,995 - 97,980,674 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,266,512 - 91,277,462 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0186,994,090 - 87,006,776 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,996,093 - 87,006,776 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,174,400 - 88,187,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,919,015 - 83,929,698 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1184,005,781 - 84,007,795 (+)NCBI
Celera178,491,204 - 78,501,887 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic UMP  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (EXP)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
CU-O LINKAGE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
hydrogen sulfide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
methotrexate  (ISO)
morphine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nicotine  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
piroxicam  (ISO)
quinoline  (ISO)
rac-lactic acid  (ISO)
saxitoxin  (ISO)
SB 431542  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA,ISO,ISS)
cytoplasm  (IEA,ISO)
nucleoplasm  (IEA,ISO,ISS)
nucleus  (IBA,IEA,ISO)
perinuclear region of cytoplasm  (IDA)
pronucleus  (ISO)
ribonucleoprotein complex  (IEA,ISO,ISS)
ribonucleoprotein granule  (IEA,ISO,ISS)
synapse  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of new autoantibody specificities directed at proteins involved in the transforming growth factor beta pathway in patients with systemic sclerosis. Bussone G, etal., Arthritis Res Ther. 2011 May 13;13(3):R74. doi: 10.1186/ar3336.
2. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
3. PLG regulates hnRNP-L expression in the rat striatum and pre-frontal cortex: identification by ddPCR. Costain WJ and Mishra RK, Peptides 2003 Jan;24(1):137-46.
4. Lymphoid gene expression as a predictor of risk of secondary brain tumors. Edick MJ, etal., Genes Chromosomes Cancer. 2005 Feb;42(2):107-16.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing. Goehe RW, etal., J Clin Invest. 2010 Nov;120(11):3923-39. doi: 10.1172/JCI43552. Epub 2010 Oct 25.
8. hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo. Hamilton BJ, etal., Biochem Biophys Res Commun. 1999 Aug 11;261(3):646-51.
9. Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation. Kim TD, etal., Mol Cell Biol. 2005 Apr;25(8):3232-46.
10. HnRNPL as a key factor in spermatogenesis: Lesson from functional proteomic studies of azoospermia patients with sertoli cell only syndrome. Li J, etal., J Proteomics. 2012 Jun 6;75(10):2879-91. doi: 10.1016/j.jprot.2011.12.040. Epub 2012 Jan 10.
11. A conserved serine of heterogeneous nuclear ribonucleoprotein L (hnRNP L) mediates depolarization-regulated alternative splicing of potassium channels. Liu G, etal., J Biol Chem. 2012 Jun 29;287(27):22709-16. doi: 10.1074/jbc.M112.357343. Epub 2012 May 8.
12. The hnRNA-binding proteins hnRNP L and PTB are required for efficient translation of the Cat-1 arginine/lysine transporter mRNA during amino acid starvation. Majumder M, etal., Mol Cell Biol. 2009 May;29(10):2899-912. doi: 10.1128/MCB.01774-08. Epub 2009 Mar 9.
13. Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes. Matsui K, etal., Hepatology. 2008 Feb;47(2):686-97.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. An exonic splicing silencer is involved in the regulated splicing of glucose 6-phosphate dehydrogenase mRNA. Szeszel-Fedorowicz W, etal., J Biol Chem. 2006 Nov 10;281(45):34146-58. Epub 2006 Sep 15.
20. Autoantibody recognition of an N-terminal epitope of hnRNP L marks the risk for developing HBV-related hepatocellular carcinoma. Yau WY, etal., J Proteomics. 2013 Dec 6;94:346-58. doi: 10.1016/j.jprot.2013.10.003. Epub 2013 Oct 11.
Additional References at PubMed
PMID:2687284   PMID:7768196   PMID:11809897   PMID:12477932   PMID:15798186   PMID:17289661   PMID:19056867   PMID:19946888   PMID:22082260   PMID:22215678   PMID:22523384   PMID:22658674  
PMID:22681889   PMID:24625528   PMID:25623890   PMID:27315481   PMID:35352799  


Genomics

Comparative Map Data
Hnrnpl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,226,373 - 93,239,084 (+)NCBIGRCr8
mRatBN7.2184,098,558 - 84,111,568 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,100,879 - 84,111,553 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,510,654 - 89,521,604 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,969,995 - 97,980,674 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,266,512 - 91,277,462 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0186,994,090 - 87,006,776 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,996,093 - 87,006,776 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,174,400 - 88,187,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,919,015 - 83,929,698 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1184,005,781 - 84,007,795 (+)NCBI
Celera178,491,204 - 78,501,887 (+)NCBICelera
Cytogenetic Map1q21NCBI
HNRNPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,836,370 - 38,852,347 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,836,370 - 38,852,347 (-)EnsemblGRCh38hg38GRCh38
GRCh371939,327,010 - 39,342,987 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,018,868 - 44,034,819 (-)NCBINCBI36Build 36hg18NCBI36
Build 341944,018,868 - 44,032,457NCBI
Celera1936,129,470 - 36,145,420 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,773,794 - 35,789,557 (-)NCBIHuRef
CHM1_11939,327,480 - 39,343,450 (-)NCBICHM1_1
T2T-CHM13v2.01941,640,403 - 41,656,404 (-)NCBIT2T-CHM13v2.0
Hnrnpl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,507,971 - 28,521,693 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,507,966 - 28,521,691 (+)EnsemblGRCm39 Ensembl
GRCm38728,808,546 - 28,822,268 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,808,541 - 28,822,266 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,595,909 - 29,607,285 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,519,673 - 28,531,004 (+)NCBIMGSCv36mm8
Celera723,371,763 - 23,383,139 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.93NCBI
Hnrnpl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468670,559 - 683,540 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955468668,177 - 683,540 (+)NCBIChiLan1.0ChiLan1.0
HNRNPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,140,619 - 45,158,142 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,011,145 - 47,027,200 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01935,943,720 - 35,959,795 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11944,493,832 - 44,509,183 (-)NCBIpanpan1.1PanPan1.1panPan2
HNRNPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,267,195 - 114,279,107 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,267,210 - 114,278,837 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,668,694 - 113,682,944 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,867,366 - 114,881,619 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,869,714 - 114,881,615 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,424,849 - 114,439,087 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01114,060,575 - 114,072,464 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01115,054,052 - 115,068,304 (+)NCBIUU_Cfam_GSD_1.0
Hnrnpl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,365,722 - 13,378,495 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366611,793,801 - 1,806,579 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366611,793,791 - 1,806,564 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNRNPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,643,566 - 47,657,833 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,643,561 - 47,655,856 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,180,634 - 43,194,945 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HNRNPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,452,705 - 33,469,070 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,452,852 - 33,466,284 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607311,466,361 - 11,483,112 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hnrnpl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,206,252 - 12,218,173 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479412,206,278 - 12,220,679 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hnrnpl
67 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:377
Count of miRNA genes:189
Interacting mature miRNAs:215
Transcripts:ENSRNOT00000027425, ENSRNOT00000027494, ENSRNOT00000057034
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat

Markers in Region
WI-13808  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2184,105,765 - 84,105,895 (+)MAPPERmRatBN7.2
Rnor_6.0187,000,974 - 87,001,103NCBIRnor6.0
Rnor_5.0188,181,592 - 88,181,721UniSTSRnor5.0
RGSC_v3.4183,923,896 - 83,924,025UniSTSRGSC3.4
Celera178,496,085 - 78,496,214UniSTS
Cytogenetic Map1q21UniSTS
AI599652  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2184,110,800 - 84,111,303 (+)MAPPERmRatBN7.2
mRatBN7.288,601,113 - 8,601,258 (+)MAPPERmRatBN7.2
Rnor_6.089,673,364 - 9,673,508NCBIRnor6.0
Rnor_6.0187,006,009 - 87,006,511NCBIRnor6.0
Rnor_5.089,647,369 - 9,647,513UniSTSRnor5.0
Rnor_5.0188,186,627 - 88,187,129UniSTSRnor5.0
RGSC_v3.4183,928,931 - 83,929,433UniSTSRGSC3.4
RGSC_v3.488,436,039 - 8,436,183UniSTSRGSC3.4
Celera810,109,633 - 10,109,777UniSTS
Celera178,501,120 - 78,501,622UniSTS
RH 3.4 Map1844.0UniSTS
Cytogenetic Map8q11UniSTS
Cytogenetic Map1q21UniSTS
D6S1116E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2184,108,040 - 84,108,299 (+)MAPPERmRatBN7.2
Rnor_6.0187,003,249 - 87,003,507NCBIRnor6.0
Rnor_5.0188,183,867 - 88,184,125UniSTSRnor5.0
RGSC_v3.4183,926,171 - 83,926,429UniSTSRGSC3.4
Celera178,498,360 - 78,498,618UniSTS
Cytogenetic Map1q21UniSTS
UniSTS:479127  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.235,939,834 - 5,940,272 (+)MAPPERmRatBN7.2
Rnor_6.03261,494 - 261,931NCBIRnor6.0
Rnor_5.03257,367 - 257,804UniSTSRnor5.0
RGSC_v3.431,378,472 - 1,378,909UniSTSRGSC3.4
Celera3778,564 - 779,001UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000027425   ⟹   ENSRNOP00000027425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,100,879 - 84,111,553 (+)Ensembl
Rnor_6.0 Ensembl186,996,093 - 87,006,776 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000027494   ⟹   ENSRNOP00000027494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,100,879 - 84,111,553 (+)Ensembl
Rnor_6.0 Ensembl186,996,093 - 87,006,776 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000057034   ⟹   ENSRNOP00000053867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,100,911 - 84,111,549 (+)Ensembl
Rnor_6.0 Ensembl187,000,093 - 87,006,753 (+)Ensembl
RefSeq Acc Id: NM_001134760   ⟹   NP_001128232
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,228,401 - 93,239,084 (+)NCBI
mRatBN7.2184,100,885 - 84,111,568 (+)NCBI
Rnor_6.0186,996,093 - 87,006,776 (+)NCBI
Rnor_5.0188,174,400 - 88,187,394 (+)NCBI
RGSC_v3.4183,919,015 - 83,929,698 (+)RGD
Celera178,491,204 - 78,501,887 (+)RGD
Sequence:
RefSeq Acc Id: NM_032619   ⟹   NP_116008
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,228,401 - 93,239,084 (+)NCBI
mRatBN7.2184,100,885 - 84,111,568 (+)NCBI
Rnor_6.0186,996,093 - 87,006,776 (+)NCBI
Rnor_5.0188,174,400 - 88,187,394 (+)NCBI
RGSC_v3.4183,919,015 - 83,929,698 (+)RGD
Celera178,491,204 - 78,501,887 (+)RGD
Sequence:
RefSeq Acc Id: XM_006228691   ⟹   XP_006228753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,226,373 - 93,239,070 (+)NCBI
mRatBN7.2184,098,558 - 84,111,557 (+)NCBI
Rnor_6.0186,994,090 - 87,006,765 (+)NCBI
Rnor_5.0188,174,400 - 88,187,394 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006228692   ⟹   XP_006228754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,226,377 - 93,239,070 (+)NCBI
mRatBN7.2184,098,558 - 84,111,554 (+)NCBI
Rnor_6.0186,994,091 - 87,006,765 (+)NCBI
Rnor_5.0188,174,400 - 88,187,394 (+)NCBI
Sequence:
RefSeq Acc Id: NP_116008   ⟸   NM_032619
- Peptide Label: isoform b
- UniProtKB: A6J9L2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001128232   ⟸   NM_001134760
- Peptide Label: isoform a
- UniProtKB: F1LPP9 (UniProtKB/Swiss-Prot),   Q5U1Y5 (UniProtKB/Swiss-Prot),   F1LQ48 (UniProtKB/TrEMBL),   A0A8L2QEL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228753   ⟸   XM_006228691
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006228754   ⟸   XM_006228692
- Peptide Label: isoform X2
- UniProtKB: A6J9L3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053867   ⟸   ENSRNOT00000057034
Ensembl Acc Id: ENSRNOP00000027494   ⟸   ENSRNOT00000027494
Ensembl Acc Id: ENSRNOP00000027425   ⟸   ENSRNOT00000027425
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LQ48-F1-model_v2 AlphaFold F1LQ48 1-623 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689886
Promoter ID:EPDNEW_R410
Type:initiation region
Name:Hnrnpl_1
Description:heterogeneous nuclear ribonucleoprotein L
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0186,996,119 - 86,996,179EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71059 AgrOrtholog
BioCyc Gene G2FUF-60214 BioCyc
Ensembl Genes ENSRNOG00000020235 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027425.8 UniProtKB/TrEMBL
  ENSRNOT00000027494.8 UniProtKB/TrEMBL
  ENSRNOT00000057034.4 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HnRNP-L/PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hnRNP-L_RRM3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hnRNPL_RRM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hnRNPL_RRM2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hnRNPL_RRM4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTBP1_RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:80846 UniProtKB/Swiss-Prot
NCBI Gene 80846 ENTREZGENE
PANTHER HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MATRIN 3/NUCLEAR PROTEIN 220-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hnrnpl PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020235 RatGTEx
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QEL3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QQ13_RAT UniProtKB/TrEMBL
  A6J9L2 ENTREZGENE, UniProtKB/TrEMBL
  A6J9L3 ENTREZGENE, UniProtKB/TrEMBL
  B5DFG2_RAT UniProtKB/TrEMBL
  F1LPP9 ENTREZGENE
  F1LQ48 ENTREZGENE
  F2Z3R2_RAT UniProtKB/TrEMBL
  HNRPL_RAT UniProtKB/Swiss-Prot
  Q5U1Y5 ENTREZGENE
UniProt Secondary F1LPP9 UniProtKB/Swiss-Prot
  Q5U1Y5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Hnrnpl  heterogeneous nuclear ribonucleoprotein L  Hnrpl  heterogeneous nuclear ribonucleoprotein L  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Hnrpl  heterogeneous nuclear ribonucleoprotein L      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference