Ap2a2 (adaptor related protein complex 2 subunit alpha 2) - Rat Genome Database

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Gene: Ap2a2 (adaptor related protein complex 2 subunit alpha 2) Rattus norvegicus
Analyze
Symbol: Ap2a2
Name: adaptor related protein complex 2 subunit alpha 2
RGD ID: 71015
Description: Enables phosphatidylinositol binding activity and protein serine/threonine kinase binding activity. Predicted to be involved in clathrin-dependent endocytosis and synaptic vesicle endocytosis. Part of AP-2 adaptor complex. Is active in synaptic vesicle. Orthologous to human AP2A2 (adaptor related protein complex 2 subunit alpha 2); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; endocytosis pathway; Huntington's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 100 kDa coated vesicle protein C; adapter-related protein complex 2 alpha-2 subunit; adapter-related protein complex 2 subunit alpha-2; adaptor protein complex AP-2 subunit alpha-2; adaptor protein complex AP-2, alpha 2 subunit; adaptor-related protein complex 2 subunit alpha-2; adaptor-related protein complex 2, alpha 2 subunit; alpha-adaptin C; alpha-c large chain of the protein complex AP-2 associated with clathrin; alpha2-adaptin; AP-2 complex subunit alpha-2; clathrin assembly protein complex 2 alpha-C large chain; MGC93391; plasma membrane adaptor HA2/AP2 adaptin alpha C subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,081,856 - 206,155,146 (+)NCBIGRCr8
mRatBN7.21196,652,315 - 196,725,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,652,337 - 196,725,603 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,997,575 - 205,069,879 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,126,225 - 212,198,337 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,800,374 - 204,872,485 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,534,217 - 214,607,497 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,534,284 - 214,606,169 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,451,352 - 221,524,612 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,741,585 - 201,813,472 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,894,982 - 201,967,871 (+)NCBI
Celera1194,285,764 - 194,357,691 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Accessory protein recruitment motifs in clathrin-mediated endocytosis. Brett TJ, etal., Structure. 2002 Jun;10(6):797-809.
2. Aftiphilin is a component of the clathrin machinery in neurons. Burman JL, etal., FEBS Lett. 2005 Apr 11;579(10):2177-84.
3. A novel synaptic vesicle-associated phosphoprotein: SVAPP-120. Bähler M, etal., J Neurochem. 1991 Aug;57(2):423-30.
4. Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin. Chapman ER, etal., J Biol Chem. 1998 Dec 4;273(49):32966-72.
5. Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo. Chen CY and Brodsky FM, J Biol Chem. 2005 Feb 18;280(7):6109-17. Epub 2004 Nov 8.
6. The interaction of epsin and Eps15 with the clathrin adaptor AP-2 is inhibited by mitotic phosphorylation and enhanced by stimulation-dependent dephosphorylation in nerve terminals. Chen H, etal., J Biol Chem. 1999 Feb 5;274(6):3257-60.
7. Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. Chen H, etal., Nature 1998 Aug 20;394(6695):793-7.
8. Molecular architecture and functional model of the endocytic AP2 complex. Collins BM, etal., Cell. 2002 May 17;109(4):523-35.
9. Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites. Drake MT, etal., J Biol Chem. 2000 Mar 3;275(9):6479-89.
10. Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells. Duncker SV, etal., J Neurosci. 2013 May 29;33(22):9508-19. doi: 10.1523/JNEUROSCI.5689-12.2013.
11. Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Evers DM, etal., Nat Neurosci. 2010 Oct;13(10):1199-207. doi: 10.1038/nn.2624. Epub 2010 Aug 29.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function. Hayashi H, etal., Hepatology. 2012 Jun;55(6):1889-900. doi: 10.1002/hep.25591.
15. The AP2 binding site of synaptotagmin 1 is not an internalization signal but a regulator of endocytosis. Jarousse N and Kelly RB, J Cell Biol. 2001 Aug 20;154(4):857-66. Epub 2001 Aug 13.
16. Gene Data Set MGD Curation, June 12, 2002
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. Page LJ, etal., J Cell Biol 1999 Sep 6;146(5):993-1004.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. Synaptic vesicle endocytosis. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
25. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
26. The synaptic vesicle cycle: a single vesicle budding step involving clathrin and dynamin. Takei K, etal., J Cell Biol. 1996 Jun;133(6):1237-50. doi: 10.1083/jcb.133.6.1237.
27. Hidden proteome of synaptic vesicles in the mammalian brain. Taoufiq Z, etal., Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33586-33596. doi: 10.1073/pnas.2011870117. Epub 2020 Dec 21.
28. Phosphorylation of Numb regulates its interaction with the clathrin-associated adaptor AP-2. Tokumitsu H, etal., FEBS Lett. 2006 Oct 16;580(24):5797-801. Epub 2006 Sep 27.
29. Sequence of the rat alpha c large chain of the clathrin associated protein complex AP-2. Tucker KL, etal., Nucleic Acids Res 1990 Sep 11;18(17):5306.
Additional References at PubMed
PMID:1325787   PMID:2495531   PMID:8552632   PMID:10908605   PMID:11756460   PMID:11879655   PMID:12234931   PMID:12732633   PMID:14529712   PMID:14726597   PMID:16025302   PMID:17762867  
PMID:20351096   PMID:21307259   PMID:21700703   PMID:22120110   PMID:22174158   PMID:22396422   PMID:22871113   PMID:23676497   PMID:29476059   PMID:30053369   PMID:32357304   PMID:37127089  


Genomics

Comparative Map Data
Ap2a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,081,856 - 206,155,146 (+)NCBIGRCr8
mRatBN7.21196,652,315 - 196,725,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,652,337 - 196,725,603 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,997,575 - 205,069,879 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,126,225 - 212,198,337 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,800,374 - 204,872,485 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,534,217 - 214,607,497 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,534,284 - 214,606,169 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,451,352 - 221,524,612 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,741,585 - 201,813,472 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,894,982 - 201,967,871 (+)NCBI
Celera1194,285,764 - 194,357,691 (+)NCBICelera
Cytogenetic Map1q41NCBI
AP2A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811925,870 - 1,012,240 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11924,881 - 1,012,245 (+)EnsemblGRCh38hg38GRCh38
GRCh3711925,870 - 1,012,240 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611915,841 - 1,002,240 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411915,880 - 1,000,919NCBI
Celera11993,301 - 1,080,635 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11740,785 - 828,407 (+)NCBIHuRef
CHM1_111924,861 - 1,011,169 (+)NCBICHM1_1
T2T-CHM13v2.011977,298 - 1,071,157 (+)NCBIT2T-CHM13v2.0
Ap2a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,142,093 - 141,212,924 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,142,086 - 141,212,924 (+)EnsemblGRCm39 Ensembl
GRCm387141,562,180 - 141,633,011 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,562,173 - 141,633,011 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,748,079 - 148,818,910 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,413,558 - 141,484,331 (+)NCBIMGSCv36mm8
Celera7141,382,192 - 141,426,917 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.94NCBI
Ap2a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,185,223 - 11,229,409 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,184,944 - 11,229,385 (-)NCBIChiLan1.0ChiLan1.0
AP2A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,325,303 - 3,415,227 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,535,446 - 2,626,050 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011945,170 - 1,034,860 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,005,473 - 1,076,652 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,005,473 - 1,076,652 (+)Ensemblpanpan1.1panPan2
AP2A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,269,962 - 45,358,020 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1845,253,772 - 45,358,018 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1843,928,814 - 44,025,349 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01845,927,072 - 46,023,324 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1845,927,078 - 46,023,539 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11845,391,389 - 45,487,393 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01844,956,103 - 45,052,452 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,694,999 - 45,791,022 (+)NCBIUU_Cfam_GSD_1.0
Ap2a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947671,479 - 735,119 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936888689,727 - 733,541 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936888689,673 - 735,119 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AP2A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2580,182 - 628,087 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12580,169 - 628,098 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2249,080 - 94,085 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AP2A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11731,616 - 820,191 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1731,645 - 818,642 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603897,821,900 - 97,912,108 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ap2a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,567,050 - 21,616,392 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476621,568,217 - 21,616,389 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ap2a2
360 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:102
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000064254
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1192485903199050587Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1189607473200611765Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat

Markers in Region
X14972  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,724,038 - 196,724,200 (+)MAPPERmRatBN7.2
Rnor_6.01214,605,933 - 214,606,094NCBIRnor6.0
Rnor_5.01221,523,048 - 221,523,209UniSTSRnor5.0
RGSC_v3.41201,813,234 - 201,813,395UniSTSRGSC3.4
Celera1194,357,453 - 194,357,614UniSTS
Cytogenetic Map1q41UniSTS
RH128084  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,723,977 - 196,724,194 (+)MAPPERmRatBN7.2
Rnor_6.01214,605,872 - 214,606,088NCBIRnor6.0
Rnor_5.01221,522,987 - 221,523,203UniSTSRnor5.0
RGSC_v3.41201,813,173 - 201,813,389UniSTSRGSC3.4
Celera1194,357,392 - 194,357,608UniSTS
RH 3.4 Map11438.7UniSTS
Cytogenetic Map1q41UniSTS
AA800186  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,701,417 - 196,701,608 (+)MAPPERmRatBN7.2
Rnor_6.01214,583,320 - 214,583,510NCBIRnor6.0
Rnor_5.01221,500,432 - 221,500,622UniSTSRnor5.0
RGSC_v3.41201,790,621 - 201,790,811UniSTSRGSC3.4
Celera1194,334,706 - 194,334,896UniSTS
RH 3.4 Map11438.4UniSTS
Cytogenetic Map1q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000064254   ⟹   ENSRNOP00000060992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1196,652,337 - 196,725,603 (+)Ensembl
Rnor_6.0 Ensembl1214,534,284 - 214,606,169 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085125   ⟹   ENSRNOP00000074852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1196,652,337 - 196,725,603 (+)Ensembl
Rnor_6.0 Ensembl1214,562,897 - 214,605,841 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116549   ⟹   ENSRNOP00000087451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1196,652,337 - 196,725,603 (+)Ensembl
RefSeq Acc Id: NM_031008   ⟹   NP_112270
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81206,081,929 - 206,153,820 (+)NCBI
mRatBN7.21196,652,380 - 196,724,277 (+)NCBI
Rnor_6.01214,534,284 - 214,606,171 (+)NCBI
Rnor_5.01221,451,352 - 221,524,612 (+)NCBI
RGSC_v3.41201,741,585 - 201,813,472 (+)RGD
Celera1194,285,764 - 194,357,691 (+)RGD
Sequence:
RefSeq Acc Id: XM_008760010   ⟹   XP_008758232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81206,081,856 - 206,155,146 (+)NCBI
mRatBN7.21196,652,315 - 196,725,609 (+)NCBI
Rnor_6.01214,534,217 - 214,607,497 (+)NCBI
Sequence:
RefSeq Acc Id: NP_112270   ⟸   NM_031008
- UniProtKB: P18484 (UniProtKB/Swiss-Prot),   Q66HM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758232   ⟸   XM_008760010
- Peptide Label: isoform X1
- UniProtKB: P18484 (UniProtKB/Swiss-Prot),   F7F1Y0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074852   ⟸   ENSRNOT00000085125
Ensembl Acc Id: ENSRNOP00000060992   ⟸   ENSRNOT00000064254
Ensembl Acc Id: ENSRNOP00000087451   ⟸   ENSRNOT00000116549
Protein Domains
Clathrin adaptor alpha/beta/gamma-adaptin appendage   Clathrin/coatomer adaptor adaptin-like N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18484-F1-model_v2 AlphaFold P18484 1-938 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690551
Promoter ID:EPDNEW_R1076
Type:initiation region
Name:Ap2a2_1
Description:adaptor-related protein complex 2, alpha 2 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01214,534,241 - 214,534,301EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71015 AgrOrtholog
BioCyc Gene G2FUF-56939 BioCyc
Ensembl Genes ENSRNOG00000019534 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064254.3 UniProtKB/TrEMBL
  ENSRNOT00000085125.2 UniProtKB/TrEMBL
  ENSRNOT00000116549.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.310.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126468 IMAGE-MGC_LOAD
InterPro Adaptor_Complx_Large_Subunit UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AP2_complex_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin/coatomer_adapt-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin_a-adaptin_app_sub_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin_a/b/g-adaptin_app_Ig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin_app_Ig-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Coatomer/calthrin_app_sub_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBP_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81637 UniProtKB/TrEMBL
MGC_CLONE MGC:93391 IMAGE-MGC_LOAD
NCBI Gene 81637 ENTREZGENE
PANTHER ADAPTIN, ALPHA/GAMMA/EPSILON UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AP-2 COMPLEX SUBUNIT ALPHA-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Adaptin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha_adaptin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha_adaptinC2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ap2a2 PhenoGen
PIRSF AP2_complex_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019534 RatGTEx
SMART Alpha_adaptinC2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49348 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55711 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K943_RAT UniProtKB/TrEMBL
  A0A8I6AGL2_RAT UniProtKB/TrEMBL
  A6HY15_RAT UniProtKB/TrEMBL
  A6HY16_RAT UniProtKB/TrEMBL
  A6HY17_RAT UniProtKB/TrEMBL
  AP2A2_RAT UniProtKB/Swiss-Prot
  F7F1Y0 ENTREZGENE, UniProtKB/TrEMBL
  P18484 ENTREZGENE
  Q66HM2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-03 Ap2a2  adaptor related protein complex 2 subunit alpha 2  Ap2a2  adaptor-related protein complex 2, alpha 2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Ap2a2  adaptor-related protein complex 2, alpha 2 subunit  Ap2a2  adaptor protein complex AP-2, alpha 2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Ap2a2  adaptor protein complex AP-2, alpha 2 subunit      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function components of the adaptor complexes which link clathrin to receptors in coated vesicles; clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration 724707