AP2A2 (adaptor related protein complex 2 subunit alpha 2) - Rat Genome Database

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Gene: AP2A2 (adaptor related protein complex 2 subunit alpha 2) Pan paniscus
Analyze
Symbol: AP2A2
Name: adaptor related protein complex 2 subunit alpha 2
RGD ID: 11716206
Description: ENCODES a protein that exhibits phosphatidylinositol binding (ortholog); protein serine/threonine kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN synaptic vesicle endocytosis (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ASSOCIATED WITH delta beta-thalassemia (ortholog); developmental and epileptic encephalopathy (ortholog); early infantile epileptic encephalopathy (ortholog); FOUND IN synaptic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adaptor related protein complex 2 alpha 2 subunit; AP-2 complex subunit alpha-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,325,303 - 3,415,227 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,535,446 - 2,626,050 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011945,170 - 1,034,860 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,005,473 - 1,076,652 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,005,473 - 1,076,652 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AP2A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,325,303 - 3,415,227 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,535,446 - 2,626,050 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011945,170 - 1,034,860 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,005,473 - 1,076,652 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,005,473 - 1,076,652 (+)Ensemblpanpan1.1panPan2
AP2A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811925,870 - 1,012,240 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11924,881 - 1,012,245 (+)EnsemblGRCh38hg38GRCh38
GRCh3711925,870 - 1,012,240 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611915,841 - 1,002,240 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411915,880 - 1,000,919NCBI
Celera11993,301 - 1,080,635 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11740,785 - 828,407 (+)NCBIHuRef
CHM1_111924,861 - 1,011,169 (+)NCBICHM1_1
T2T-CHM13v2.011977,298 - 1,071,157 (+)NCBIT2T-CHM13v2.0
Ap2a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,142,093 - 141,212,924 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,142,086 - 141,212,924 (+)EnsemblGRCm39 Ensembl
GRCm387141,562,180 - 141,633,011 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,562,173 - 141,633,011 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,748,079 - 148,818,910 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,413,558 - 141,484,331 (+)NCBIMGSCv36mm8
Celera7141,382,192 - 141,426,917 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.94NCBI
Ap2a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,081,856 - 206,155,146 (+)NCBIGRCr8
mRatBN7.21196,652,315 - 196,725,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,652,337 - 196,725,603 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,997,575 - 205,069,879 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,126,225 - 212,198,337 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,800,374 - 204,872,485 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,534,217 - 214,607,497 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,534,284 - 214,606,169 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,451,352 - 221,524,612 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,741,585 - 201,813,472 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,894,982 - 201,967,871 (+)NCBI
Celera1194,285,764 - 194,357,691 (+)NCBICelera
Cytogenetic Map1q41NCBI
Ap2a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,185,223 - 11,229,409 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,184,944 - 11,229,385 (-)NCBIChiLan1.0ChiLan1.0
AP2A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,269,962 - 45,358,020 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1845,253,772 - 45,358,018 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1843,928,814 - 44,025,349 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01845,927,072 - 46,023,324 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1845,927,078 - 46,023,539 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11845,391,389 - 45,487,393 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01844,956,103 - 45,052,452 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,694,999 - 45,791,022 (+)NCBIUU_Cfam_GSD_1.0
Ap2a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947671,479 - 735,119 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936888689,727 - 733,541 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936888689,673 - 735,119 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AP2A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2580,182 - 628,087 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12580,169 - 628,098 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2249,080 - 94,085 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AP2A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11731,616 - 820,191 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1731,645 - 818,642 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603897,821,900 - 97,912,108 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ap2a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,567,050 - 21,616,392 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476621,568,217 - 21,616,389 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000037316   ⟹   ENSPPAP00000014629
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,005,473 - 1,076,652 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000037335   ⟹   ENSPPAP00000014648
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,019,941 - 1,075,034 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000037354   ⟹   ENSPPAP00000014667
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,022,378 - 1,075,116 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000037357   ⟹   ENSPPAP00000014671
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,022,378 - 1,075,034 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000037370   ⟹   ENSPPAP00000014683
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,022,495 - 1,075,034 (+)Ensembl
RefSeq Acc Id: XM_034931893   ⟹   XP_034787784
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v293,325,316 - 3,415,227 (+)NCBI
NHGRI_mPanPan1112,535,446 - 2,626,050 (+)NCBI
Mhudiblu_PPA_v011945,170 - 1,034,860 (+)NCBI
RefSeq Acc Id: XM_034931894   ⟹   XP_034787785
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v293,325,303 - 3,415,227 (+)NCBI
NHGRI_mPanPan1112,535,461 - 2,626,050 (+)NCBI
Mhudiblu_PPA_v011945,218 - 1,034,860 (+)NCBI
RefSeq Acc Id: XM_055093945   ⟹   XP_054949920
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v293,325,384 - 3,415,227 (+)NCBI
NHGRI_mPanPan1112,535,521 - 2,626,050 (+)NCBI
RefSeq Acc Id: XM_055093946   ⟹   XP_054949921
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v293,325,385 - 3,415,227 (+)NCBI
NHGRI_mPanPan1112,535,521 - 2,626,050 (+)NCBI
RefSeq Acc Id: XM_055093947   ⟹   XP_054949922
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v293,346,260 - 3,415,227 (+)NCBI
NHGRI_mPanPan1112,556,386 - 2,626,050 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_034787784   ⟸   XM_034931893
- Peptide Label: isoform X1
- UniProtKB: A0A2R9ABI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034787785   ⟸   XM_034931894
- Peptide Label: isoform X2
- UniProtKB: A0A2R9ABI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000014648   ⟸   ENSPPAT00000037335
RefSeq Acc Id: ENSPPAP00000014629   ⟸   ENSPPAT00000037316
RefSeq Acc Id: ENSPPAP00000014683   ⟸   ENSPPAT00000037370
RefSeq Acc Id: ENSPPAP00000014671   ⟸   ENSPPAT00000037357
RefSeq Acc Id: ENSPPAP00000014667   ⟸   ENSPPAT00000037354
RefSeq Acc Id: XP_054949920   ⟸   XM_055093945
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054949921   ⟸   XM_055093946
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054949922   ⟸   XM_055093947
- Peptide Label: isoform X4
Protein Domains
Clathrin adaptor alpha/beta/gamma-adaptin appendage   Clathrin/coatomer adaptor adaptin-like N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030265 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000037316.1 UniProtKB/TrEMBL
  ENSPPAT00000037335.1 UniProtKB/TrEMBL
  ENSPPAT00000037354.1 UniProtKB/TrEMBL
  ENSPPAT00000037357.1 UniProtKB/TrEMBL
  ENSPPAT00000037370.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
  2.60.40.1230 UniProtKB/TrEMBL
  3.30.310.10 UniProtKB/TrEMBL
InterPro AP2_complex_asu UniProtKB/TrEMBL
  ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Clathrin/coatomer_adapt-like_N UniProtKB/TrEMBL
  Clathrin_a-adaptin_app_sub_C UniProtKB/TrEMBL
  Clathrin_a/b/g-adaptin_app_Ig UniProtKB/TrEMBL
  Clathrin_app_Ig-like_sf UniProtKB/TrEMBL
  Coatomer/calthrin_app_sub_C UniProtKB/TrEMBL
  TBP_dom_sf UniProtKB/TrEMBL
NCBI Gene AP2A2 ENTREZGENE
PANTHER ADAPTIN, ALPHA/GAMMA/EPSILON UniProtKB/TrEMBL
  AP-2 COMPLEX SUBUNIT ALPHA-2 UniProtKB/TrEMBL
Pfam Adaptin_N UniProtKB/TrEMBL
  Alpha_adaptin_C UniProtKB/TrEMBL
  Alpha_adaptinC2 UniProtKB/TrEMBL
PIRSF AP2_complex_alpha UniProtKB/TrEMBL
SMART Alpha_adaptinC2 UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF49348 UniProtKB/TrEMBL
  SSF55711 UniProtKB/TrEMBL
UniProt A0A2R9ABI9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ACN2_PANPA UniProtKB/TrEMBL
  A0A2R9AGI7_PANPA UniProtKB/TrEMBL
  A0A2R9AGM4_PANPA UniProtKB/TrEMBL
  A0A2R9AHE9_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 AP2A2  adaptor related protein complex 2 subunit alpha 2    adaptor related protein complex 2 alpha 2 subunit  Symbol and/or name change 5135510 APPROVED