Gene: Ap2a1 (adaptor-related protein complex 2, alpha 1 subunit)
Rattus norvegicus
Symbol:
Ap2a1
Name:
adaptor-related protein complex 2, alpha 1 subunit
Description:
ENCODES a protein that exhibits protein C-terminus binding; INVOLVED IN intracellular protein transport (inferred); vesicle-mediated transport (inferred); PARTICIPATES IN Arf family mediated signaling pathway; endocytosis pathway; Huntington disease pathway; FOUND IN apical plasma membrane; basolateral plasma membrane; protein complex; INTERACTS WITH 2,6-dinitrotoluene; bis(2-ethylhexyl) phthalate; bisphenol A
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
adaptor protein complex AP-2, alpha 1 subunit; adaptor protein complex AP-2, alpha 1 subunit ; adaptor protein complex AP-2, alpha 1 subunit (predicted); adaptor-related protein complex 2, alpha 1 subunit; AP-2 complex subunit alpha-1; Ap2a1_predicted; LOC308578
Orthologs:
Homo sapiens : AP2A1
(adaptor-related protein complex 2, alpha 1 subunit)
HGNC
Ap2a1
(adaptor-related protein complex 2, alpha 1 subunit)
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 1 q22 NCBI RGSC Genome Assembly v5.0 1 101,961,565 - 101,990,733 - NCBI RGSC Genome Assembly v3.4 1 95,373,135 - 95,403,376 - NCBI Rat Celera Assembly 1 89,646,459 - 89,675,632 - NCBI Genome Assembly 3.1 1 95,451,977 - 95,481,455 - NCBI
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol decreases expression ISO RGD:1314770 6480464 Ethinyl Estradiol results in decreased expression of AP2A1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression ISO RGD:1314770 6480464 Ethinyl Estradiol affects the expression of AP2A1 mRNA CTD PMID:17555576 17alpha-ethynylestradiol multiple interactions ISO RGD:1314770 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of AP2A1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1314770 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of AP2A1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases methylation ISO RGD:1314770 6480464 Tetrachlorodibenzodioxin results in decreased methylation of AP2A1 gene CTD PMID:21212295 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1314770 6480464 Tetrachlorodibenzodioxin results in decreased expression of AP2A1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1314770 6480464 [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of AP2A1 gene CTD PMID:21212295 2,6-dinitrotoluene affects expression EXP 6480464 2,6-dinitrotoluene affects the expression of AP2A1 mRNA CTD PMID:21346803 4,4'-diaminodiphenylmethane increases expression ISO RGD:1314770 6480464 4,4'-diaminodiphenylmethane results in increased expression of AP2A1 mRNA CTD PMID:18648102 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of AP2A1 promoter CTD PMID:23359474 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of AP2A1 promoter CTD PMID:23359474 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of AP2A1 mRNA CTD PMID:19167457 dibutyl phthalate multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of AP2A1 promoter CTD PMID:23359474 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:1314770 6480464 Ethylnitrosourea results in increased mutagenesis of AP2A1 exon CTD PMID:16300676 paracetamol increases expression ISO RGD:1314769 6480464 Acetaminophen results in increased expression of AP2A1 mRNA CTD PMID:22230336 tamoxifen affects expression ISO RGD:1314770 6480464 Tamoxifen affects the expression of AP2A1 mRNA CTD PMID:17555576
Gene Ontology Annotations
Biological Process biological_process ND 1598407 06/2010: no relevant rat data RGD intracellular protein transport IEA InterPro:IPR002553|InterPro:IPR003164|InterPro:IPR008152|InterPro:IPR009028|InterPro:IPR013038|InterPro:IPR015873 1600115 GO_REF:0000002 InterPro GO_REF:0000002 vesicle-mediated transport IEA InterPro:IPR002553|InterPro:IPR003164|InterPro:IPR008152|InterPro:IPR009028|InterPro:IPR013038|InterPro:IPR015873 1600115 GO_REF:0000002 InterPro GO_REF:0000002
631688 Hcas2 Hepatocarcinoma susceptibility QTL 2 3 .0001 Liver tumor susceptibility nodule number 1 6253946 116153262 Rat 631495 Bp96 Blood pressure QTL 96 4.52 Blood pressure systolic 1 22842898 102532417 Rat 1358359 Sradr1 Stress Responsive Adrenal Weight QTL 1 4.74 Hypothalamic-pituitary-adrenal axis adrenal gland weight 1 28716493 124749065 Rat 2313051 Bss57 Bone structure and strength QTL 57 3.7 .0001 Bone strength 1 37646940 119780561 Rat 2313059 Bss55 Bone structure and strength QTL 55 3.2 .0001 Bone structure 1 37646940 119780561 Rat 2313072 Bss53 Bone structure and strength QTL 53 4.3 .0001 Bone structure 1 37646940 119780561 Rat 2313078 Bss54 Bone structure and strength QTL 54 3.5 .0001 Bone structure 1 37646940 119780561 Rat 2313094 Bss58 Bone structure and strength QTL 58 3.7 .0001 Bone strength 1 37646940 119780561 Rat 2313098 Bmd70 Bone mineral density QTL 70 3.6 .0001 Bone mineral density 1 37646940 119780561 Rat 2313099 Bss56 Bone structure and strength QTL 56 2.4 .0001 Bone structure 1 37646940 119780561 Rat 2313402 Anxrr24 Anxiety related response QTL 24 Anxiety response domestication 1 43426139 146971983 Rat 1578654 Bss10 Bone structure and strength QTL 10 4 Bone structure femoral neck cortical area 1 43872710 162735928 Rat 634314 Niddm44 Non-insulin dependent diabetes mellitus QTL 44 Glucose level 1 43872827 204280278 Rat 2298545 Neuinf8 Neuroinflammation QTL 8 2.9 Neuroinflammation 1 55083934 154002647 Rat 2300324 Fetw1 Fetal weight QTL 1 12.1 .005 Fetal weight 1 55540384 100540384 Rat 2300164 Bmd44 Bone mineral density QTL 44 5.4 .0001 Bone mineral density 1 56601368 101601368 Rat 1300121 Hrtrt1 Heart rate QTL 1 3.7 Heart rate salt-loaded 1 64744882 116153262 Rat 1549903 Bp267 Blood pressure QTL 267 Blood pressure systolic, nighttime 1 77541583 106445306 Rat 1582234 Gluco18 Glucose level QTL 18 3.4 .0003 Glucose level uptake 1 79749065 124749065 Rat 4889494 Scort2 Serum corticosterone level QTL 2 4.2 Hormone level corticosterone 1 80851478 125851478 Rat 1578780 Cm52 Cardiac mass QTL 52 3.3 .0001 Cardiac mass 1 81342810 225814178 Rat 2313083 Bmd74 Bone mineral density QTL 74 4 .0001 Bone mineral density 1 81947770 119780561 Rat 631519 Pia11 Pristane induced arthritis QTL 11 5.3 Joint/bone inflammation arthritis severity 1 83489176 186472032 Rat 738022 Anxrr13 Anxiety related response QTL 13 4.6 .00039 Anxiety response open field inner locomotion 1 83945235 128945235 Rat 724529 Cm16 Cardiac mass QTL 16 2.7 Cardiac mass 1 87465281 153578547 Rat 1358902 Bw47 Body weight QTL 47 1.67 Body weight 1 90282040 184857893 Rat 724521 Uae1 Urinary albumin excretion QTL 1 3.8 .0001 Renal function urine albumin level 1 90282040 185923619 Rat 1302788 Scl19 Serum cholesterol QTL 19 4.6 .001 Lipid level cholesterol level 1 90306033 124749065 Rat 1300153 Bp171 Blood pressure QTL 171 3.37 Blood pressure salt-loaded diastolic 1 90448902 145865373 Rat 724567 Tcas6 Tongue tumor susceptibility QTL 6 6.85 Tongue tumor susceptibility 1 92101613 146971983 Rat 2293142 Bp314 Blood pressure QTL 314 Blood pressure systolic 1 94471673 139471673 Rat 1331800 Scl25 Serum cholesterol level QTL 25 3.013 Lipid level cholesterol 1 94473940 134980682 Rat 1331793 Bp200 Blood pressure QTL 200 3.71601 Blood pressure systolic 1 94473940 176855135 Rat 1331751 Bp199 Blood pressure QTL 199 3.60022 Blood pressure diastolic 1 94473940 186472032 Rat 1331749 Hrtrt11 Heart rate QTL 11 2.973 Heart rate 1 94473940 203303100 Rat 70209 Niddm23 Non-insulin dependent diabetes mellitus QTL 23 2.82 Glucose level fasting 1 94473940 203416143 Rat 731168 Bp154 Blood pressure QTL 154 3.4 Blood pressure systolic 1 94624828 220639653 Rat
Gene Ontology Annotations
