Smad9 (SMAD family member 9) - Rat Genome Database

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Gene: Smad9 (SMAD family member 9) Rattus norvegicus
Analyze
Symbol: Smad9
Name: SMAD family member 9
RGD ID: 71004
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including Mullerian duct regression; positive regulation of DNA-templated transcription; and response to hypoxia. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human SMAD9 (SMAD family member 9); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103691556; MAD homolog 9; MAD homolog 9 (Drosophila); Madh9; mothers against decapentaplegic homolog 9; mothers against DPP homolog 9; SMAD 9; Smad8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82141,106,668 - 141,156,477 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2141,106,668 - 141,156,477 (+)EnsemblGRCr8
mRatBN7.22138,956,326 - 139,006,315 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2138,986,471 - 139,006,307 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2145,530,752 - 145,581,180 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02143,642,776 - 143,692,620 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02138,274,611 - 138,325,053 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02143,951,725 - 144,002,025 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2143,951,838 - 143,998,205 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl2144,191,846 - 144,212,138 (+)Ensemblrn6Rnor6.0
Rnor_5.02163,609,377 - 163,629,230 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42144,014,436 - 144,030,672 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2133,441,288 - 133,491,482 (+)NCBICelera
RGSC_v3.12143,964,398 - 143,980,635 (+)NCBI
RH 3.4 Map2858.9RGD
Cytogenetic Map2q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-naphthylamine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxypsoralen  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
aucubin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
furan  (ISO)
gentamycin  (EXP)
glycerol 2-phosphate  (ISO)
GW 4064  (ISO)
imperatorin  (ISO)
inulin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
neomycin  (ISO)
nicotine  (ISO)
okadaic acid  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
Salidroside  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
simvastatin  (ISO)
sirtinol  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Smad8 mediates the signaling of the ALK-2 receptor serine kinase. Chen Y, etal., Proc Natl Acad Sci U S A 1997 Nov 25;94(24):12938-43.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Neotendon formation induced by manipulation of the Smad8 signalling pathway in mesenchymal stem cells. Hoffmann A, etal., J Clin Invest. 2006 Apr;116(4):940-52.
5. Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. Horvath LG, etal., Prostate. 2004 May 15;59(3):234-42.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Gene Data Set MGD Curation, June 12, 2002
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension. Morty RE, etal., Arterioscler Thromb Vasc Biol. 2007 May;27(5):1072-8. Epub 2007 Mar 8.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Altered expression of Smad family members in injured motor neurons of rat. Okuyama N, etal., Brain Res. 2007 Feb 9;1132(1):36-41. Epub 2006 Dec 12.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension. Takahashi H, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L450-8. Epub 2005 Dec 16.
20. Hypoxia induces alteration of bone morphogenetic protein receptor signaling in pulmonary artery endothelial cell. Takahashi K, etal., Pediatr Res. 2007 Apr;61(4):392-7.
21. Mullerian inhibiting substance regulates its receptor/SMAD signaling and causes mesenchymal transition of the coelomic epithelial cells early in Mullerian duct regression. Zhan Y, etal., Development. 2006 Jun;133(12):2359-69. Epub 2006 May 10.
Additional References at PubMed
PMID:12714599   PMID:14656760   PMID:15899870   PMID:18590716   PMID:18776146   PMID:19103752   PMID:19224984   PMID:19252488   PMID:19793887   PMID:21515935   PMID:26687945   PMID:27035233  


Genomics

Comparative Map Data
Smad9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82141,106,668 - 141,156,477 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2141,106,668 - 141,156,477 (+)EnsemblGRCr8
mRatBN7.22138,956,326 - 139,006,315 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2138,986,471 - 139,006,307 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2145,530,752 - 145,581,180 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02143,642,776 - 143,692,620 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02138,274,611 - 138,325,053 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02143,951,725 - 144,002,025 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2143,951,838 - 143,998,205 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl2144,191,846 - 144,212,138 (+)Ensemblrn6Rnor6.0
Rnor_5.02163,609,377 - 163,629,230 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42144,014,436 - 144,030,672 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2133,441,288 - 133,491,482 (+)NCBICelera
RGSC_v3.12143,964,398 - 143,980,635 (+)NCBI
RH 3.4 Map2858.9RGD
Cytogenetic Map2q26NCBI
SMAD9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381336,844,831 - 36,920,854 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1336,844,831 - 36,920,887 (-)Ensemblhg38GRCh38
GRCh371337,418,968 - 37,494,375 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361336,320,321 - 36,351,966 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341336,320,320 - 36,351,966NCBI
Celera1318,486,256 - 18,561,694 (-)NCBICelera
Cytogenetic Map13q13.3NCBI
HuRef1318,230,428 - 18,265,347 (-)NCBIHuRef
CHM1_11337,386,514 - 37,421,563 (-)NCBICHM1_1
T2T-CHM13v2.01336,064,076 - 36,139,427 (-)NCBIT2T-CHM13v2.0
Smad9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39354,662,873 - 54,709,162 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl354,663,003 - 54,708,678 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38354,755,455 - 54,801,662 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl354,755,582 - 54,801,257 (+)Ensemblmm10GRCm38
MGSCv37354,559,504 - 54,605,179 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36354,843,511 - 54,889,186 (+)NCBIMGSCv36mm8
Celera354,477,243 - 54,523,151 (+)NCBICelera
Cytogenetic Map3CNCBI
cM Map325.62NCBI
Smad9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554319,153,353 - 9,185,475 (+)Ensembl
ChiLan1.0NW_0049554319,117,616 - 9,184,920 (+)NCBIChiLan1.0ChiLan1.0
SMAD9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21436,367,970 - 36,443,118 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11327,474,138 - 27,549,239 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01318,055,427 - 18,130,571 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11336,486,595 - 36,521,646 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1336,486,597 - 36,521,646 (-)EnsemblpanPan2panpan1.1
SMAD9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1253,768,851 - 3,844,645 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl253,779,197 - 3,841,321 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha253,798,972 - 3,874,799 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0253,867,196 - 3,943,051 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl253,867,166 - 3,943,035 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1253,817,322 - 3,845,450 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0253,767,514 - 3,842,931 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0253,833,387 - 3,909,198 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Smad9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945164,902,130 - 164,971,217 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647230,980,928 - 31,049,618 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647230,980,850 - 31,050,138 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1112,705,368 - 12,763,008 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11112,705,652 - 12,727,981 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21112,653,062 - 12,675,499 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1315,369,119 - 15,444,599 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl315,372,933 - 15,405,836 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605728,840,614 - 28,916,197 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smad9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624776332,591 - 378,199 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Smad9
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1399,602,011 - 99,621,695 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Smad9
240 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:31
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000000102
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2124103798154505346Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
RH143177  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22138,991,502 - 138,991,613 (+)MAPPERmRatBN7.2
Rnor_6.02144,196,866 - 144,196,976NCBIRnor6.0
Rnor_6.02143,986,905 - 143,987,015NCBIRnor6.0
Rnor_5.02163,614,419 - 163,614,529UniSTSRnor5.0
RGSC_v3.42144,019,412 - 144,019,522UniSTSRGSC3.4
Celera2133,476,642 - 133,476,752UniSTS
RH 3.4 Map2860.2UniSTS
Cytogenetic Map2q26UniSTS
RH94763  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22139,002,602 - 139,002,762 (+)MAPPERmRatBN7.2
Rnor_6.02144,207,965 - 144,208,124NCBIRnor6.0
Rnor_6.02143,998,004 - 143,998,163NCBIRnor6.0
Rnor_5.02163,625,518 - 163,625,677UniSTSRnor5.0
RGSC_v3.42144,030,511 - 144,030,670UniSTSRGSC3.4
Celera2133,487,461 - 133,487,620UniSTS
RH 3.4 Map2858.9UniSTS
Cytogenetic Map2q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
24 11 100 215 123 124 70 87 70 12 428 236 11 177 90 129 54 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000000102   ⟹   ENSRNOP00000000102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2141,106,668 - 141,156,477 (+)Ensembl
mRatBN7.2 Ensembl2138,986,471 - 139,006,307 (+)Ensembl
Rnor_6.0 Ensembl2144,191,846 - 144,212,138 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079544   ⟹   ENSRNOP00000070480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2141,136,738 - 141,156,477 (+)Ensembl
mRatBN7.2 Ensembl2138,986,575 - 139,006,307 (+)Ensembl
Rnor_6.0 Ensembl2143,951,838 - 143,998,205 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000170599   ⟹   ENSRNOP00000106853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2141,106,713 - 141,155,014 (+)Ensembl
RefSeq Acc Id: NM_138872   ⟹   NP_620227
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,106,668 - 141,156,477 (+)NCBI
mRatBN7.22138,956,505 - 139,006,315 (+)NCBI
Rnor_6.02143,981,929 - 143,998,165 (+)NCBI
Rnor_5.02163,609,377 - 163,629,230 (+)NCBI
RGSC_v3.42144,014,436 - 144,030,672 (+)RGD
Sequence:
RefSeq Acc Id: XM_063282646   ⟹   XP_063138716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,124,586 - 141,156,477 (+)NCBI
Protein Sequences
Protein RefSeqs NP_620227 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138716 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53515 (Get FASTA)   NCBI Sequence Viewer  
  EDM14913 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000102
GenBank Protein O54835 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620227   ⟸   NM_138872
- UniProtKB: O54835 (UniProtKB/Swiss-Prot),   G3V603 (UniProtKB/TrEMBL),   A6JVE0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070480   ⟸   ENSRNOT00000079544
Ensembl Acc Id: ENSRNOP00000000102   ⟸   ENSRNOT00000000102
RefSeq Acc Id: XP_063138716   ⟸   XM_063282646
- Peptide Label: isoform X1
- UniProtKB: O54835 (UniProtKB/Swiss-Prot),   A6JVE0 (UniProtKB/TrEMBL),   G3V603 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000106853   ⟸   ENSRNOT00000170599
Protein Domains
MH1   MH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54835-F1-model_v2 AlphaFold O54835 1-434 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691329
Promoter ID:EPDNEW_R1854
Type:single initiation site
Name:LOC103691556_1
Description:mothers against decapentaplegic homolog 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02143,951,779 - 143,951,839EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71004 AgrOrtholog
BioCyc Gene G2FUF-53074 BioCyc
Ensembl Genes ENSRNOG00000000091 Ensembl, ENTREZGENE
  ENSRNOG00000058416 Ensembl
Ensembl Transcript ENSRNOT00000000102 ENTREZGENE
Gene3D-CATH 2.60.200.10 UniProtKB/Swiss-Prot
  3.90.520.10 UniProtKB/Swiss-Prot
InterPro Dwarfin UniProtKB/Swiss-Prot
  MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot
  MAD_homology_MH1 UniProtKB/Swiss-Prot
  SMAD-like_dom_sf UniProtKB/Swiss-Prot
  SMAD_dom_Dwarfin-type UniProtKB/Swiss-Prot
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot
  SMAD_MH1_sf UniProtKB/Swiss-Prot
KEGG Report rno:85435 UniProtKB/Swiss-Prot
NCBI Gene 85435 ENTREZGENE
PANTHER MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9 UniProtKB/Swiss-Prot
  PTHR13703 UniProtKB/Swiss-Prot
Pfam MH1 UniProtKB/Swiss-Prot
  MH2 UniProtKB/Swiss-Prot
PhenoGen Smad9 PhenoGen
PROSITE MH1 UniProtKB/Swiss-Prot
  MH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000091 RatGTEx
  ENSRNOG00000058416 RatGTEx
SMART DWA UniProtKB/Swiss-Prot
  DWB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot
  SSF56366 UniProtKB/Swiss-Prot
UniProt A0A0G2JY15_RAT UniProtKB/TrEMBL
  A0ABK0LPP7_RAT UniProtKB/TrEMBL
  A6JVE0 ENTREZGENE, UniProtKB/TrEMBL
  G3V603 ENTREZGENE, UniProtKB/TrEMBL
  O54835 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Smad9  SMAD family member 9  LOC103691556  mothers against decapentaplegic homolog 9  Data merged from RGD:9309512 737654 PROVISIONAL
2014-08-25 LOC103691556  mothers against decapentaplegic homolog 9      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-10-23 Smad9  SMAD family member 9  Smad9  MAD homolog 9 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Smad9  MAD homolog 9 (Drosophila)  Madh9    Symbol updated 1299863 APPROVED
2002-07-09 Madh9  MAD homolog 9 (Drosophila)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction associates with Smad4 70780
gene_process activates gene transcription when associated with Smad4 70780
gene_regulation phosphorylated by a constitutively active activin receptor-like kinase (ALK-2) 70780