Fabp5 (fatty acid binding protein 5) - Rat Genome Database

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Gene: Fabp5 (fatty acid binding protein 5) Rattus norvegicus
Analyze
Symbol: Fabp5
Name: fatty acid binding protein 5
RGD ID: 70997
Description: Enables fatty acid binding activity. Predicted to be involved in several processes, including lipid transport across blood-brain barrier; positive regulation of cold-induced thermogenesis; and positive regulation of peroxisome proliferator activated receptor signaling pathway. Predicted to act upstream of or within several processes, including glucose homeostasis; negative regulation of D-glucose transmembrane transport; and phosphatidylcholine biosynthetic process. Predicted to be located in cytoplasm; extracellular space; and postsynaptic density. Predicted to be active in several cellular components, including glutamatergic synapse; postsynaptic cytosol; and postsynaptic density, intracellular component. Orthologous to several human genes including FABP5 (fatty acid binding protein 5); PARTICIPATES IN retinoic acid metabolic pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-FABP; cutaneous fatty acid-binding protein; DA11; E-FABP; epidermal-type fatty acid-binding protein; fatty acid binding protein 5, epidermal; fatty acid-binding protein 5; fatty acid-binding protein, epidermal
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8293,672,451 - 93,676,186 (-)NCBIGRCr8
mRatBN7.2291,765,056 - 91,768,716 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl291,765,056 - 91,853,773 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx298,262,009 - 98,265,679 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0296,383,007 - 96,386,677 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0291,439,871 - 91,443,541 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0293,981,662 - 93,985,322 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl293,981,656 - 93,985,378 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02113,735,156 - 113,738,856 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera287,366,175 - 87,369,839 (-)NCBICelera
Cytogenetic Map2q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
Alisol B  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
buspirone  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
choline  (EXP,ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyanocob(III)alamin  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
difenoconazole  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP,ISO)
dioxygen  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
fonofos  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glycine betaine  (ISO)
graphene oxide  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
itraconazole  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP,ISO)
L-methionine  (EXP,ISO)
lead(0)  (ISO)
melphalan  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
methcathinone  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin RR  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorobutyric acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenacetin  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylhydrazine  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
sarin  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
tributylstannane  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Fatty acid binding protein is induced in neurons of the dorsal root ganglia after peripheral nerve injury. De Leon M, etal., J Neurosci Res 1996 May 1;44(3):283-92.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Gene expression profiling of Japanese psoriatic skin reveals an increased activity in molecular stress and immune response signals. Kulski JK, etal., J Mol Med. 2005 Dec;83(12):964-75. Epub 2005 Nov 11.
5. Gene Data Set MGD Curation, June 12, 2002
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Fatty acid binding protein 4 and 5 play a crucial role in thermogenesis under the conditions of fasting and cold stress. Syamsunarno MR, etal., PLoS One. 2014 Mar 6;9(6):e90825. doi: 10.1371/journal.pone.0090825. eCollection 2014.
13. PDLIM4 repression by hypermethylation as a potential biomarker for prostate cancer. Vanaja DK, etal., Clin Cancer Res. 2006 Feb 15;12(4):1128-36.
14. Molecular cloning of a cDNA encoding a novel fatty acid-binding protein from rat skin. Watanabe R, etal., Biochem Biophys Res Commun 1994 Apr 15;200(1):253-9.
15. Lens epithelial cell mRNA, II. Expression of a mRNA encoding a lipid-binding protein in rat lens epithelial cells. Wen Y, etal., Gene 1995 Jun 9;158(2):269-74.
Additional References at PubMed
PMID:8092987   PMID:10965032   PMID:12540600   PMID:14676186   PMID:15164767   PMID:17512406   PMID:17898460   PMID:18513372   PMID:20211260   PMID:20458337   PMID:20854474   PMID:21099311  
PMID:21395585   PMID:23376485   PMID:23533145   PMID:24531463   PMID:24692551   PMID:29440395   PMID:29531087   PMID:30485159   PMID:35650684   PMID:37747506   PMID:38035977  


Genomics

Comparative Map Data
Fabp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8293,672,451 - 93,676,186 (-)NCBIGRCr8
mRatBN7.2291,765,056 - 91,768,716 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl291,765,056 - 91,853,773 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx298,262,009 - 98,265,679 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0296,383,007 - 96,386,677 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0291,439,871 - 91,443,541 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0293,981,662 - 93,985,322 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl293,981,656 - 93,985,378 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02113,735,156 - 113,738,856 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera287,366,175 - 87,369,839 (-)NCBICelera
Cytogenetic Map2q23NCBI
FABP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38881,280,536 - 81,284,775 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl881,280,536 - 81,284,777 (+)EnsemblGRCh38hg38GRCh38
GRCh37882,192,771 - 82,197,010 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36882,355,340 - 82,359,563 (+)NCBINCBI36Build 36hg18NCBI36
Build 34882,355,339 - 82,359,563NCBI
Celera878,197,737 - 78,201,964 (+)NCBICelera
Cytogenetic Map8q21.13NCBI
HuRef877,682,447 - 77,686,745 (+)NCBIHuRef
CHM1_1882,244,290 - 82,248,584 (+)NCBICHM1_1
T2T-CHM13v2.0881,712,114 - 81,716,359 (+)NCBIT2T-CHM13v2.0
Fabp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39310,077,645 - 10,081,670 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl310,077,608 - 10,081,667 (+)EnsemblGRCm39 Ensembl
GRCm38310,012,585 - 10,016,610 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl310,012,548 - 10,016,607 (+)EnsemblGRCm38mm10GRCm38
MGSCv37310,012,606 - 10,016,610 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3639,995,138 - 9,999,142 (+)NCBIMGSCv36mm8
Celera310,036,283 - 10,040,303 (+)NCBICelera
Cytogenetic Map3A1NCBI
cM Map32.47NCBI
Fabp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955444325,515 - 331,516 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955444325,515 - 329,248 (-)NCBIChiLan1.0ChiLan1.0
FABP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2797,018,311 - 97,022,694 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1872,646,170 - 72,650,553 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0877,803,369 - 77,807,630 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1879,426,678 - 79,430,879 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl879,426,684 - 79,430,879 (+)Ensemblpanpan1.1panPan2
LOC102155424
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X35,086,820 - 35,087,968 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX22,435,088 - 22,436,224 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X35,135,219 - 35,136,355 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X35,214,287 - 35,215,423 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X35,186,976 - 35,188,112 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X35,229,782 - 35,230,918 (+)NCBIUU_Cfam_GSD_1.0
Fabp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530350,691,127 - 50,695,573 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366562,881,552 - 2,886,192 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FABP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl455,275,205 - 55,282,908 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1455,277,831 - 55,282,585 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2460,306,428 - 60,311,182 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FABP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1876,696,899 - 76,701,459 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603964,492,525 - 64,497,788 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fabp5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474410,129,515 - 10,133,700 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fabp5
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:19
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000075493
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)276539322102785628Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)27478666494359546Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)264366971109366971Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
RH128775  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2291,765,101 - 91,765,310 (+)MAPPERmRatBN7.2
Rnor_6.0293,981,708 - 93,981,916NCBIRnor6.0
Rnor_5.02113,735,205 - 113,735,413UniSTSRnor5.0
Celera287,366,221 - 87,366,429UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000075493   ⟹   ENSRNOP00000064809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl291,765,056 - 91,853,773 (-)Ensembl
Rnor_6.0 Ensembl293,981,656 - 93,985,378 (-)Ensembl
RefSeq Acc Id: NM_145878   ⟹   NP_665885
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8293,672,451 - 93,676,111 (-)NCBI
mRatBN7.2291,765,056 - 91,768,716 (-)NCBI
Rnor_6.0293,981,662 - 93,985,322 (-)NCBI
Rnor_5.02113,735,156 - 113,738,856 (-)NCBI
Celera287,366,175 - 87,369,839 (-)RGD
Sequence:
RefSeq Acc Id: XM_063281209   ⟹   XP_063137279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8293,672,455 - 93,676,186 (-)NCBI
RefSeq Acc Id: NP_665885   ⟸   NM_145878
- UniProtKB: P55053 (UniProtKB/Swiss-Prot),   P97757 (UniProtKB/Swiss-Prot),   A6IH50 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064809   ⟸   ENSRNOT00000075493
RefSeq Acc Id: XP_063137279   ⟸   XM_063281209
- Peptide Label: isoform X1
Protein Domains
Cytosolic fatty-acid binding proteins   Lipocalin/cytosolic fatty-acid binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55053-F1-model_v2 AlphaFold P55053 1-135 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691239
Promoter ID:EPDNEW_R1763
Type:multiple initiation site
Name:Fabp5_1
Description:fatty acid binding protein 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0293,985,336 - 93,985,396EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70997 AgrOrtholog
BioCyc Gene G2FUF-53742 BioCyc
BioCyc Pathway PWY-6318 [L-phenylalanine degradation IV (mammalian, via side chain)] BioCyc
BioCyc Pathway Image PWY-6318 BioCyc
Ensembl Genes ENSRNOG00000049075 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055001808 UniProtKB/Swiss-Prot
  ENSRNOG00060001912 UniProtKB/Swiss-Prot
  ENSRNOG00065013312 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000075493.3 UniProtKB/TrEMBL
  ENSRNOT00055002924 UniProtKB/Swiss-Prot
  ENSRNOT00060002960 UniProtKB/Swiss-Prot
  ENSRNOT00065021881 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Calycin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fatty_acid-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ILBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140868 UniProtKB/Swiss-Prot
NCBI Gene 140868 ENTREZGENE
PANTHER FATTY ACID-BINDING PROTEIN 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11955 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fabp5 PhenoGen
PRINTS FATTYACIDBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FABP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049075 RatGTEx
  ENSRNOG00055001808 RatGTEx
  ENSRNOG00060001912 RatGTEx
  ENSRNOG00065013312 RatGTEx
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QXH8_RAT UniProtKB/TrEMBL
  A6IH50 ENTREZGENE, UniProtKB/TrEMBL
  FABP5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P97757 ENTREZGENE
  Q2XTA4_RAT UniProtKB/TrEMBL
UniProt Secondary P97757 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-18 Fabp5  fatty acid binding protein 5  Fabp5  fatty acid binding protein 5, epidermal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Fabp5  fatty acid binding protein 5, epidermal      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression in the dorsal root ganglia increases following nerve crush injury 728625