Mbtps1 (membrane-bound transcription factor peptidase, site 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mbtps1 (membrane-bound transcription factor peptidase, site 1) Rattus norvegicus
Analyze
Symbol: Mbtps1
Name: membrane-bound transcription factor peptidase, site 1
RGD ID: 70935
Description: Enables serine-type endopeptidase activity. Predicted to be involved in lysosome organization; proteolysis; and regulation of vesicle-mediated transport. Predicted to act upstream of or within several processes, including NLS-bearing protein import into nucleus; mitotic G2 DNA damage checkpoint signaling; and positive regulation of cholesterol biosynthetic process. Predicted to be located in Golgi stack. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in spondyloepiphyseal dysplasia Kondo-Fu type. Orthologous to human MBTPS1 (membrane bound transcription factor peptidase, site 1); PARTICIPATES IN sterol regulatory element-binding protein signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: endopeptidase S1P; membrane-bound transcription factor protease, site 1; membrane-bound transcription factor site-1 protease; S1p; S1P endopeptidase; site-1 protease; Ski-1; subtilisin/kexin isozyme 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,470,245 - 64,521,438 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1964,470,545 - 64,521,342 (-)EnsemblGRCr8
mRatBN7.21947,561,598 - 47,612,769 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,561,598 - 47,612,791 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1954,356,280 - 54,407,076 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01955,037,157 - 55,087,952 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,250,566 - 57,301,596 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01952,146,507 - 52,206,310 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,146,808 - 52,206,310 (-)Ensemblrn6Rnor6.0
Rnor_5.01962,894,989 - 62,954,792 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41949,751,424 - 49,802,700 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1946,820,963 - 46,871,847 (-)NCBICelera
RGSC_v3.11949,756,304 - 49,807,581 (-)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Gene Data Set MGD Curation, June 12, 2002
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been. Osborne TF and Espenshade PJ, Genes Dev. 2009 Nov 15;23(22):2578-91.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization. Seidah NG, etal., Proc Natl Acad Sci U S A 1999 Feb 16;96(4):1321-6.
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11069896   PMID:11163209   PMID:11717426   PMID:15938716   PMID:17643267   PMID:21719679   PMID:30046013   PMID:33738762   PMID:37358010  


Genomics

Comparative Map Data
Mbtps1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,470,245 - 64,521,438 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1964,470,545 - 64,521,342 (-)EnsemblGRCr8
mRatBN7.21947,561,598 - 47,612,769 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,561,598 - 47,612,791 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1954,356,280 - 54,407,076 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01955,037,157 - 55,087,952 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,250,566 - 57,301,596 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01952,146,507 - 52,206,310 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,146,808 - 52,206,310 (-)Ensemblrn6Rnor6.0
Rnor_5.01962,894,989 - 62,954,792 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41949,751,424 - 49,802,700 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1946,820,963 - 46,871,847 (-)NCBICelera
RGSC_v3.11949,756,304 - 49,807,581 (-)NCBI
Cytogenetic Map19q12NCBI
MBTPS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381684,053,763 - 84,116,942 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1684,053,761 - 84,116,942 (-)Ensemblhg38GRCh38
GRCh371684,087,368 - 84,150,547 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361682,644,869 - 82,708,018 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341682,644,871 - 82,708,018NCBI
Celera1668,389,268 - 68,452,435 (-)NCBICelera
Cytogenetic Map16q23.3-q24.1NCBI
HuRef1669,841,352 - 69,904,502 (-)NCBIHuRef
CHM1_11685,498,381 - 85,561,902 (-)NCBICHM1_1
T2T-CHM13v2.01690,119,889 - 90,190,524 (-)NCBIT2T-CHM13v2.0
Mbtps1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398120,234,890 - 120,285,603 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8120,234,895 - 120,285,474 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388119,508,151 - 119,558,864 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8119,508,156 - 119,558,735 (-)Ensemblmm10GRCm38
MGSCv378122,032,051 - 122,082,661 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368122,394,132 - 122,444,704 (-)NCBIMGSCv36mm8
Celera8123,725,569 - 123,776,209 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map867.85NCBI
Mbtps1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955564176,230 - 228,587 (+)Ensembl
ChiLan1.0NW_004955564176,230 - 226,555 (+)NCBIChiLan1.0ChiLan1.0
MBTPS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21893,800,904 - 93,863,994 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11699,718,041 - 99,781,111 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01664,719,971 - 64,783,119 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11684,063,508 - 84,126,000 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1684,063,508 - 84,126,000 (-)EnsemblpanPan2panpan1.1
MBTPS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1568,228,176 - 68,281,175 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl568,228,238 - 68,280,515 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha568,242,379 - 68,295,248 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0568,526,299 - 68,579,190 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl568,526,329 - 68,579,190 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1568,474,058 - 68,526,939 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0568,310,640 - 68,363,509 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0568,726,354 - 68,779,243 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mbtps1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934927,942,920 - 27,998,011 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366413,696,536 - 3,751,598 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366413,696,506 - 3,751,558 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MBTPS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl64,503,565 - 4,558,609 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.164,503,530 - 4,558,601 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.265,085,217 - 5,140,266 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MBTPS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1569,464,064 - 69,527,588 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl569,463,920 - 69,527,541 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660476,231,679 - 6,295,208 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mbtps1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247463,455,995 - 3,523,262 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247463,466,723 - 3,521,830 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mbtps1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11739,154,366 - 39,203,560 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:214
Count of miRNA genes:151
Interacting mature miRNAs:173
Transcripts:ENSRNOT00000020838
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
RH127834  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,561,709 - 47,561,912 (+)MAPPERmRatBN7.2
Rnor_6.01952,146,617 - 52,146,819NCBIRnor6.0
Rnor_5.01962,895,099 - 62,895,301UniSTSRnor5.0
RGSC_v3.41949,751,233 - 49,751,435UniSTSRGSC3.4
Celera1946,820,772 - 46,820,974UniSTS
RH 3.4 Map19653.0UniSTS
Cytogenetic Map19q12UniSTS
RH129347  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,561,672 - 47,561,857 (+)MAPPERmRatBN7.2
Rnor_6.01952,146,580 - 52,146,764NCBIRnor6.0
Rnor_5.01962,895,062 - 62,895,246UniSTSRnor5.0
RGSC_v3.41949,751,196 - 49,751,380UniSTSRGSC3.4
Celera1946,820,735 - 46,820,919UniSTS
RH 3.4 Map19652.8UniSTS
Cytogenetic Map19q12UniSTS
UniSTS:225106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,601,467 - 47,601,642 (+)MAPPERmRatBN7.2
Rnor_6.01952,195,075 - 52,195,249NCBIRnor6.0
Rnor_6.01952,186,247 - 52,186,421NCBIRnor6.0
Rnor_5.01962,934,729 - 62,934,903UniSTSRnor5.0
Rnor_5.01962,943,557 - 62,943,731UniSTSRnor5.0
RGSC_v3.41949,791,465 - 49,791,639UniSTSRGSC3.4
Celera1946,860,612 - 46,860,786UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020838   ⟹   ENSRNOP00000020838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1964,470,545 - 64,521,342 (-)Ensembl
mRatBN7.2 Ensembl1947,561,601 - 47,612,791 (-)Ensembl
Rnor_6.0 Ensembl1952,147,127 - 52,186,260 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087886   ⟹   ENSRNOP00000071317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1964,470,545 - 64,521,342 (-)Ensembl
mRatBN7.2 Ensembl1947,561,598 - 47,612,723 (-)Ensembl
Rnor_6.0 Ensembl1952,146,808 - 52,206,310 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108847   ⟹   ENSRNOP00000077523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1964,470,545 - 64,521,342 (-)Ensembl
mRatBN7.2 Ensembl1947,561,606 - 47,612,703 (-)Ensembl
RefSeq Acc Id: NM_053569   ⟹   NP_446021
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,470,545 - 64,521,342 (-)NCBI
mRatBN7.21947,561,901 - 47,612,703 (-)NCBI
Rnor_6.01952,146,808 - 52,206,310 (-)NCBI
Rnor_5.01962,894,989 - 62,954,792 (-)NCBI
RGSC_v3.41949,751,424 - 49,802,700 (-)RGD
Celera1946,820,963 - 46,871,847 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772651   ⟹   XP_008770873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,477,978 - 64,521,438 (-)NCBI
mRatBN7.21947,569,334 - 47,612,769 (-)NCBI
Rnor_6.01952,154,222 - 52,187,411 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098049   ⟹   XP_038953977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,470,245 - 64,521,403 (-)NCBI
mRatBN7.21947,561,598 - 47,612,766 (-)NCBI
RefSeq Acc Id: XM_039098051   ⟹   XP_038953979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,470,245 - 64,490,421 (-)NCBI
mRatBN7.21947,561,598 - 47,581,939 (-)NCBI
RefSeq Acc Id: NP_446021   ⟸   NM_053569
- Peptide Label: precursor
- UniProtKB: Q9WTZ3 (UniProtKB/Swiss-Prot),   G3V7Z2 (UniProtKB/Swiss-Prot),   A0A8L2R475 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770873   ⟸   XM_008772651
- Peptide Label: isoform X1
- UniProtKB: A0A8I5XW81 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071317   ⟸   ENSRNOT00000087886
Ensembl Acc Id: ENSRNOP00000020838   ⟸   ENSRNOT00000020838
RefSeq Acc Id: XP_038953977   ⟸   XM_039098049
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038953979   ⟸   XM_039098051
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000077523   ⟸   ENSRNOT00000108847
Protein Domains
Peptidase S8

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTZ3-F1-model_v2 AlphaFold Q9WTZ3 1-1052 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701181
Promoter ID:EPDNEW_R11703
Type:initiation region
Name:Mbtps1_1
Description:membrane-bound transcription factor peptidase, site 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01952,206,316 - 52,206,376EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70935 AgrOrtholog
BioCyc Gene G2FUF-5515 BioCyc
Ensembl Genes ENSRNOG00000015173 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020838 ENTREZGENE
  ENSRNOT00000020838.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.200 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623811 IMAGE-MGC_LOAD
InterPro MBTP1_N UniProtKB/Swiss-Prot
  MBTPS1_3rd UniProtKB/Swiss-Prot
  MBTPS1_4th UniProtKB/Swiss-Prot
  Peptidase_S8/S53_dom UniProtKB/Swiss-Prot
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot
  Peptidase_S8_His-AS UniProtKB/Swiss-Prot
  Peptidase_S8_Ser-AS UniProtKB/Swiss-Prot
  Peptidase_S8_subtilisin-like UniProtKB/Swiss-Prot
  Peptidase_S8_subtilisin-rel UniProtKB/Swiss-Prot
  Site-1_peptidase_cat_dom UniProtKB/Swiss-Prot
KEGG Report rno:89842 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72356 IMAGE-MGC_LOAD
NCBI Gene 89842 ENTREZGENE
PANTHER MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE UniProtKB/Swiss-Prot
  PEPTIDASE S8 UniProtKB/Swiss-Prot
Pfam MBTP1_N UniProtKB/Swiss-Prot
  MBTPS1_3rd UniProtKB/Swiss-Prot
  MBTPS1_4th UniProtKB/Swiss-Prot
  Peptidase_S8 UniProtKB/Swiss-Prot
PhenoGen Mbtps1 PhenoGen
PRINTS SUBTILISIN UniProtKB/Swiss-Prot
PROSITE SUBTILASE UniProtKB/Swiss-Prot
  SUBTILASE_HIS UniProtKB/Swiss-Prot
  SUBTILASE_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015173 RatGTEx
Superfamily-SCOP SSF52743 UniProtKB/Swiss-Prot
UniProt A0A8I5XW81 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R475 ENTREZGENE, UniProtKB/TrEMBL
  G3V7Z2 ENTREZGENE
  MBTP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V7Z2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Mbtps1  membrane-bound transcription factor peptidase, site 1    membrane-bound transcription factor protease, site 1  Name updated 1299863 APPROVED
2002-07-09 Mbtps1  membrane-bound transcription factor protease, site 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization appears in the Golgi apparatus and within small punctate structures reminiscent of endosomes 70790