MBTPS1 (membrane bound transcription factor peptidase, site 1) - Rat Genome Database

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Gene: MBTPS1 (membrane bound transcription factor peptidase, site 1) Sus scrofa
Analyze
Symbol: MBTPS1
Name: membrane bound transcription factor peptidase, site 1
RGD ID: 14120458
Description: ENCODES a protein that exhibits serine-type endopeptidase activity (ortholog); INVOLVED IN lipid metabolic process (ortholog); PARTICIPATES IN sterol regulatory element-binding protein signaling pathway; ASSOCIATED WITH Craniofacial Abnormalities (ortholog); genetic disease (ortholog); hepatocellular carcinoma (ortholog); FOUND IN Golgi membrane (ortholog); INTERACTS WITH resveratrol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: membrane-bound transcription factor site-1 protease
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl64,503,565 - 4,558,609 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.164,503,530 - 4,558,601 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.265,085,217 - 5,140,266 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
resveratrol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Golgi apparatus  (IBA,IEA)
Golgi membrane  (IEA,ISO)
Golgi stack  (IEA)
membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MBTPS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl64,503,565 - 4,558,609 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.164,503,530 - 4,558,601 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.265,085,217 - 5,140,266 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MBTPS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381684,053,763 - 84,116,942 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1684,053,761 - 84,116,942 (-)EnsemblGRCh38hg38GRCh38
GRCh371684,087,368 - 84,150,547 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361682,644,869 - 82,708,018 (-)NCBINCBI36Build 36hg18NCBI36
Build 341682,644,871 - 82,708,018NCBI
Celera1668,389,268 - 68,452,435 (-)NCBICelera
Cytogenetic Map16q23.3-q24.1NCBI
HuRef1669,841,352 - 69,904,502 (-)NCBIHuRef
CHM1_11685,498,381 - 85,561,902 (-)NCBICHM1_1
T2T-CHM13v2.01690,119,889 - 90,190,524 (-)NCBIT2T-CHM13v2.0
Mbtps1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398120,234,890 - 120,285,603 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8120,234,895 - 120,285,474 (-)EnsemblGRCm39 Ensembl
GRCm388119,508,151 - 119,558,864 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8119,508,156 - 119,558,735 (-)EnsemblGRCm38mm10GRCm38
MGSCv378122,032,051 - 122,082,661 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368122,394,132 - 122,444,704 (-)NCBIMGSCv36mm8
Celera8123,725,569 - 123,776,209 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map867.85NCBI
Mbtps1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,470,245 - 64,521,438 (-)NCBIGRCr8
mRatBN7.21947,561,598 - 47,612,769 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,561,598 - 47,612,791 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1954,356,280 - 54,407,076 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01955,037,157 - 55,087,952 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,250,566 - 57,301,596 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01952,146,507 - 52,206,310 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,146,808 - 52,206,310 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01962,894,989 - 62,954,792 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41949,751,424 - 49,802,700 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11949,756,304 - 49,807,581 (-)NCBI
Celera1946,820,963 - 46,871,847 (-)NCBICelera
Cytogenetic Map19q12NCBI
Mbtps1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955564176,230 - 228,587 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955564176,230 - 226,555 (+)NCBIChiLan1.0ChiLan1.0
MBTPS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21893,800,904 - 93,863,994 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11699,718,041 - 99,781,111 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01664,719,971 - 64,783,119 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11684,063,508 - 84,126,000 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1684,063,508 - 84,126,000 (-)Ensemblpanpan1.1panPan2
MBTPS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1568,228,176 - 68,281,175 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl568,228,238 - 68,280,515 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha568,242,379 - 68,295,248 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0568,526,299 - 68,579,190 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl568,526,329 - 68,579,190 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1568,474,058 - 68,526,939 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0568,310,640 - 68,363,509 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0568,726,354 - 68,779,243 (+)NCBIUU_Cfam_GSD_1.0
Mbtps1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934927,942,920 - 27,998,011 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366413,696,536 - 3,751,598 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366413,696,506 - 3,751,558 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MBTPS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1569,464,064 - 69,527,588 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl569,463,920 - 69,527,541 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660476,231,679 - 6,295,208 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mbtps1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247463,455,995 - 3,523,262 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247463,466,723 - 3,521,830 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MBTPS1
2255 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 3 3 4 2 9 2 3
Low 7 1 1 14 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000002975   ⟹   ENSSSCP00000002896
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl64,503,565 - 4,558,599 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000055329   ⟹   ENSSSCP00000032957
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl64,503,573 - 4,558,609 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000057875   ⟹   ENSSSCP00000036900
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl64,503,574 - 4,558,609 (+)Ensembl
RefSeq Acc Id: XM_005664321   ⟹   XP_005664378
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.164,503,530 - 4,558,601 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021093728   ⟹   XP_020949387
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.164,503,548 - 4,558,601 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005664378   ⟸   XM_005664321
- UniProtKB: A0A286ZZH4 (UniProtKB/TrEMBL),   A0A8D1MCH9 (UniProtKB/TrEMBL),   A0A4X1T2D2 (UniProtKB/TrEMBL),   A0A8D0S8G6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949387   ⟸   XM_021093728
- UniProtKB: A0A286ZZH4 (UniProtKB/TrEMBL),   A0A8D1MCH9 (UniProtKB/TrEMBL),   A0A4X1T2D2 (UniProtKB/TrEMBL),   A0A8D0S8G6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000002896   ⟸   ENSSSCT00000002975
RefSeq Acc Id: ENSSSCP00000032957   ⟸   ENSSSCT00000055329
RefSeq Acc Id: ENSSSCP00000036900   ⟸   ENSSSCT00000057875
Protein Domains
Peptidase S8/S53


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002682 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015030319 UniProtKB/TrEMBL
  ENSSSCG00025047122 UniProtKB/TrEMBL
  ENSSSCG00030062799 UniProtKB/TrEMBL
  ENSSSCG00035043513 UniProtKB/TrEMBL
  ENSSSCG00045027665 UniProtKB/TrEMBL
  ENSSSCG00050036976 UniProtKB/TrEMBL
  ENSSSCG00055026161 UniProtKB/TrEMBL
  ENSSSCG00060032602 UniProtKB/TrEMBL
  ENSSSCG00065039186 UniProtKB/TrEMBL
  ENSSSCG00070005991 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000002975.5 UniProtKB/TrEMBL
  ENSSSCT00000057875 ENTREZGENE
  ENSSSCT00000057875.3 UniProtKB/TrEMBL
  ENSSSCT00015040408.1 UniProtKB/TrEMBL
  ENSSSCT00015040987.1 UniProtKB/TrEMBL
  ENSSSCT00025064097.1 UniProtKB/TrEMBL
  ENSSSCT00025064543.1 UniProtKB/TrEMBL
  ENSSSCT00025064840.1 UniProtKB/TrEMBL
  ENSSSCT00025065184.1 UniProtKB/TrEMBL
  ENSSSCT00030087875.1 UniProtKB/TrEMBL
  ENSSSCT00030087917.1 UniProtKB/TrEMBL
  ENSSSCT00035057799.1 UniProtKB/TrEMBL
  ENSSSCT00035057823.1 UniProtKB/TrEMBL
  ENSSSCT00035057828.1 UniProtKB/TrEMBL
  ENSSSCT00035057855.1 UniProtKB/TrEMBL
  ENSSSCT00045047129.1 UniProtKB/TrEMBL
  ENSSSCT00045047318.1 UniProtKB/TrEMBL
  ENSSSCT00045047511.1 UniProtKB/TrEMBL
  ENSSSCT00045047689.1 UniProtKB/TrEMBL
  ENSSSCT00050049792.1 UniProtKB/TrEMBL
  ENSSSCT00050049797.1 UniProtKB/TrEMBL
  ENSSSCT00055051674.1 UniProtKB/TrEMBL
  ENSSSCT00055051782.1 UniProtKB/TrEMBL
  ENSSSCT00060044174.1 UniProtKB/TrEMBL
  ENSSSCT00060044203.1 UniProtKB/TrEMBL
  ENSSSCT00065053554.1 UniProtKB/TrEMBL
  ENSSSCT00070011461.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.200 UniProtKB/TrEMBL
InterPro Peptidase_S8/S53_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/TrEMBL
  Peptidase_S8_His-AS UniProtKB/TrEMBL
  Peptidase_S8_Ser-AS UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/TrEMBL
  Site-1_peptidase_cat_dom UniProtKB/TrEMBL
KEGG Report ssc:100516674 UniProtKB/TrEMBL
NCBI Gene MBTPS1 ENTREZGENE
PANTHER MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE UniProtKB/TrEMBL
  PEPTIDASE S8 UniProtKB/TrEMBL
Pfam Peptidase_S8 UniProtKB/TrEMBL
PRINTS SUBTILISIN UniProtKB/TrEMBL
PROSITE SUBTILASE UniProtKB/TrEMBL
  SUBTILASE_HIS UniProtKB/TrEMBL
  SUBTILASE_SER UniProtKB/TrEMBL
Superfamily-SCOP SSF52743 UniProtKB/TrEMBL
UniProt A0A286ZZH4 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T2D2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0S6Q6_PIG UniProtKB/TrEMBL
  A0A8D0S8G6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0XRS9_PIG UniProtKB/TrEMBL
  A0A8D1A0D4_PIG UniProtKB/TrEMBL
  A0A8D1A0E4_PIG UniProtKB/TrEMBL
  A0A8D1IEX3_PIG UniProtKB/TrEMBL
  A0A8D1IFX8_PIG UniProtKB/TrEMBL
  A0A8D1IG93_PIG UniProtKB/TrEMBL
  A0A8D1IKG4_PIG UniProtKB/TrEMBL
  A0A8D1MCH9 ENTREZGENE, UniProtKB/TrEMBL
  C3W342_PIG UniProtKB/TrEMBL
  F1S5S6_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90061 ENTREZGENE