Aacs (acetoacetyl-CoA synthetase) - Rat Genome Database

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Gene: Aacs (acetoacetyl-CoA synthetase) Rattus norvegicus
Analyze
Symbol: Aacs
Name: acetoacetyl-CoA synthetase
RGD ID: 708522
Description: Enables acetoacetate-CoA ligase activity and short-chain fatty acid-CoA ligase activity. Involved in several processes, including cellular response to cholesterol; cellular response to testosterone stimulus; and positive regulation of insulin secretion. Predicted to be located in cytosol. Biomarker of obesity. Orthologous to human AACS (acetoacetyl-CoA synthetase); PARTICIPATES IN ketone bodies metabolic pathway; butanoate metabolic pathway; INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AcAc-CoA ligase; acetoacetate-CoA ligase; acetoacetyl-CoA ligase; LOC65984
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,774,471 - 36,817,835 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1236,774,471 - 36,822,543 (-)EnsemblGRCr8
mRatBN7.21231,113,098 - 31,156,411 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,113,098 - 31,160,954 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1232,283,912 - 32,327,181 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01232,895,349 - 32,938,612 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01231,947,268 - 31,990,536 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,512,393 - 36,555,694 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,512,393 - 36,555,694 (-)Ensemblrn6Rnor6.0
Rnor_5.01238,381,585 - 38,425,026 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41232,206,863 - 32,250,583 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1232,807,686 - 32,851,029 (-)NCBICelera
RGSC_v3.11232,070,250 - 32,113,971 (-)NCBI
Cytogenetic Map12q14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aldehydo-D-glucosamine  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
chlordecone  (ISO)
cholesterol  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
doxorubicin  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fluoranthene  (ISO)
flusilazole  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
GSK-J4  (ISO)
indometacin  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (EXP)
methylarsonic acid  (ISO)
mevastatin  (EXP)
miconazole  (ISO)
nickel atom  (ISO)
nicotine  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
resveratrol  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The regulation of acetoacetyl-CoA synthetase activity by modulators of cholesterol synthesis in vivo and the utilization of acetoacetate for cholesterogenesis. Bergstrom JD, etal., J Biol Chem. 1984 Dec 10;259(23):14548-53.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Purification and characterization of acetoacetyl-CoA synthetase from rat liver. Ito M, etal., Biochim Biophys Acta. 1984 Jul 6;794(2):183-93.
4. Acetoacetyl-CoA synthetase specific activity and concentration in rat tissues. Ito M, etal., Biochim Biophys Acta. 1986 Apr 15;876(2):280-7.
5. cDNA-derived amino acid sequence of acetoacetyl-CoA synthetase from rat liver. Iwahori A, etal., FEBS Lett 2000 Jan 28;466(2-3):239-43.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Utilization of ketone bodies by the rat liver, brain and heart in chronic alcohol intoxication. Lukivskaya OYa and Buko VU, Alcohol Alcohol. 1993 Jul;28(4):431-6.
8. Feasibility of pathways for transfer of acyl groups from mitochondria to the cytosol to form short chain acyl-CoAs in the pancreatic beta cell. MacDonald MJ, etal., J Biol Chem. 2007 Oct 19;282(42):30596-606. Epub 2007 Aug 27.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Cerebral ketone body metabolism. Morris AA J Inherit Metab Dis. 2005;28(2):109-21.
11. Effects of development on acetoacetyl-CoA synthetase biosynthesis in rat liver. Nakamoto M, etal., Biol Pharm Bull. 1999 Sep;22(9):981-3.
12. Genetic obesity affects neural ketone body utilization in the rat brain. Narishima R, etal., Obesity (Silver Spring). 2009 Mar;17(3):611-5. Epub 2008 Dec 11.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Utlization of D-3-hydroxy[3-14C]butyrate for lipogenesis in vivo in lactating rat mammary gland. Robinson AM and Williamson DH, Biochem J. 1978 Nov 15;176(2):635-8.
18. Stimulation of hepatic cholesterol biosynthesis by fatty acids. Effects of oleate on cytoplasmic acetoacetyl-CoA thiolase, acetoacetyl-CoA synthetase and hydroxymethylglutaryl-CoA synthase. Salam WH, etal., Biochem J. 1989 Mar 1;258(2):563-8.
19. Effects of streptozotocin-induced diabetes on acetoacetyl-CoA synthetase activity in rats. Sato H, etal., Biochem Pharmacol. 2002 May 15;63(10):1851-5.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Acetoacetyl-CoA ligase activity in the isolated rat hepatocyte: effects of 25-hydroxycholesterol and high density lipoprotein. Wong GA, etal., Biosci Rep. 1987 Mar;7(3):217-24.
22. Acetoacetyl-CoA synthetase gene is abundant in rat adipose, and related with fatty acid synthesis in mature adipocytes. Yamasaki M, etal., Biochem Biophys Res Commun. 2005 Sep 16;335(1):215-9.
23. Ketone body utilization is regulated by male-specific factors in rat subcutaneous adipocytes. Yamasaki M, etal., Exp Clin Endocrinol Diabetes. 2009 Apr;117(4):170-4. Epub 2008 Oct 1.
Additional References at PubMed
PMID:26776438  


Genomics

Comparative Map Data
Aacs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,774,471 - 36,817,835 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1236,774,471 - 36,822,543 (-)EnsemblGRCr8
mRatBN7.21231,113,098 - 31,156,411 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,113,098 - 31,160,954 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1232,283,912 - 32,327,181 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01232,895,349 - 32,938,612 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01231,947,268 - 31,990,536 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,512,393 - 36,555,694 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,512,393 - 36,555,694 (-)Ensemblrn6Rnor6.0
Rnor_5.01238,381,585 - 38,425,026 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41232,206,863 - 32,250,583 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1232,807,686 - 32,851,029 (-)NCBICelera
RGSC_v3.11232,070,250 - 32,113,971 (-)NCBI
Cytogenetic Map12q14NCBI
AACS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812125,065,435 - 125,143,316 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12125,065,364 - 125,143,333 (+)Ensemblhg38GRCh38
GRCh3712125,549,981 - 125,627,862 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612124,115,878 - 124,193,824 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3412124,074,886 - 124,152,745NCBI
Celera12125,154,148 - 125,231,815 (+)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12122,513,724 - 122,591,469 (+)NCBIHuRef
CHM1_112125,371,190 - 125,449,292 (+)NCBICHM1_1
T2T-CHM13v2.012125,073,284 - 125,151,299 (+)NCBIT2T-CHM13v2.0
Aacs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395125,552,937 - 125,594,469 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5125,552,878 - 125,594,474 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385125,475,873 - 125,517,405 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5125,475,814 - 125,517,410 (+)Ensemblmm10GRCm38
MGSCv375125,956,243 - 125,997,773 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365125,765,334 - 125,806,864 (+)NCBIMGSCv36mm8
Celera5122,498,146 - 122,541,335 (+)NCBICelera
Cytogenetic Map5G1.1NCBI
cM Map564.24NCBI
Aacs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554824,666,615 - 4,694,021 (-)Ensembl
ChiLan1.0NW_0049554824,663,818 - 4,694,170 (-)NCBIChiLan1.0ChiLan1.0
AACS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210133,153,932 - 133,230,750 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112133,150,310 - 133,227,128 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012122,660,621 - 122,737,421 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112126,942,340 - 127,019,374 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12126,942,340 - 127,019,372 (+)EnsemblpanPan2panpan1.1
AACS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1264,852,582 - 4,903,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl264,452,371 - 4,961,436 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha265,012,574 - 5,070,383 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0265,095,131 - 5,152,920 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl264,689,932 - 5,152,920 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,033,494 - 5,091,252 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0265,122,600 - 5,180,458 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0265,076,523 - 5,134,395 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aacs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118159,105,954 - 159,147,676 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936558327,407 - 373,683 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936558327,822 - 373,474 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AACS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1428,109,869 - 28,169,253 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11428,109,845 - 28,169,261 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21429,816,562 - 29,871,927 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AACS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111120,422,138 - 120,502,200 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11120,422,232 - 120,502,271 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037124,780,182 - 124,860,163 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aacs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474724,108,968 - 24,145,836 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474724,108,770 - 24,145,836 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Aacs
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11628,396,929 - 28,439,905 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aacs
406 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:119
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000001292
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122977552242298555Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)123424347543352593Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)122963663737764351Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat

Markers in Region
RH129160  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81236,774,478 - 36,774,676 (+)Marker Load Pipeline
mRatBN7.21231,113,105 - 31,113,303 (+)MAPPERmRatBN7.2
Rnor_6.01236,512,401 - 36,512,598NCBIRnor6.0
Rnor_5.01238,381,593 - 38,381,790UniSTSRnor5.0
RGSC_v3.41232,206,871 - 32,207,068UniSTSRGSC3.4
Celera1232,807,694 - 32,807,891UniSTS
RH 3.4 Map12566.2UniSTS
Cytogenetic Map12q14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001292   ⟹   ENSRNOP00000001292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1231,113,102 - 31,156,452 (-)Ensembl
Rnor_6.0 Ensembl1236,512,393 - 36,555,694 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102410   ⟹   ENSRNOP00000081188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1236,774,471 - 36,822,543 (-)Ensembl
mRatBN7.2 Ensembl1231,113,098 - 31,160,954 (-)Ensembl
RefSeq Acc Id: NM_023104   ⟹   NP_075592
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81236,774,471 - 36,817,774 (-)NCBI
mRatBN7.21231,113,098 - 31,156,411 (-)NCBI
Rnor_6.01236,512,393 - 36,555,694 (-)NCBI
Rnor_5.01238,381,585 - 38,425,026 (-)NCBI
RGSC_v3.41232,206,863 - 32,250,583 (-)RGD
Celera1232,807,686 - 32,851,029 (-)RGD
Sequence:
RefSeq Acc Id: XM_039089741   ⟹   XP_038945669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81236,774,474 - 36,807,033 (-)NCBI
mRatBN7.21231,113,099 - 31,145,659 (-)NCBI
RefSeq Acc Id: XM_063271646   ⟹   XP_063127716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81236,774,474 - 36,817,835 (-)NCBI
RefSeq Acc Id: NP_075592   ⟸   NM_023104
- UniProtKB: Q9JMI1 (UniProtKB/Swiss-Prot),   A6J0W1 (UniProtKB/TrEMBL),   A0A8I5ZR35 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001292   ⟸   ENSRNOT00000001292
RefSeq Acc Id: XP_038945669   ⟸   XM_039089741
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000081188   ⟸   ENSRNOT00000102410
RefSeq Acc Id: XP_063127716   ⟸   XM_063271646
- Peptide Label: isoform X2
Protein Domains
Acetyl-coenzyme A synthetase N-terminal   AMP-dependent synthetase/ligase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JMI1-F1-model_v2 AlphaFold Q9JMI1 1-672 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698599
Promoter ID:EPDNEW_R9123
Type:multiple initiation site
Name:Aacs_1
Description:acetoacetyl-CoA synthetase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01236,555,696 - 36,555,756EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708522 AgrOrtholog
BioCyc Gene G2FUF-19389 BioCyc
Ensembl Genes ENSRNOG00000000967 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001292.6 UniProtKB/Swiss-Prot
  ENSRNOT00000102410 ENTREZGENE
Gene3D-CATH 3.30.300.30 UniProtKB/Swiss-Prot
  3.40.50.12780 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598532 IMAGE-MGC_LOAD
InterPro Acac_CoA_synth UniProtKB/Swiss-Prot
  ACAS_N UniProtKB/Swiss-Prot
  AMP-bd_C_sf UniProtKB/Swiss-Prot
  AMP-binding_CS UniProtKB/Swiss-Prot
  AMP-dep_Synth/Lig UniProtKB/Swiss-Prot
  AMP-dep_Synthh-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:65984 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72432 IMAGE-MGC_LOAD
NCBI Gene 65984 ENTREZGENE
PANTHER ACETOACETYL-COA SYNTHETASE UniProtKB/Swiss-Prot
  ACETOACETYL-COA SYNTHETASE UniProtKB/Swiss-Prot
Pfam ACAS_N UniProtKB/Swiss-Prot
  AMP-binding UniProtKB/Swiss-Prot
PhenoGen Aacs PhenoGen
PROSITE AMP_BINDING UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000967 RatGTEx
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/Swiss-Prot
UniProt A0A8I5ZR35 ENTREZGENE, UniProtKB/TrEMBL
  A6J0V9_RAT UniProtKB/TrEMBL
  A6J0W0_RAT UniProtKB/TrEMBL
  A6J0W1 ENTREZGENE, UniProtKB/TrEMBL
  A6J0W2_RAT UniProtKB/TrEMBL
  AACS_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Aacs  acetoacetyl-CoA synthetase  LOC65984    Symbol updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference