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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of AACS mRNA | CTD | PMID:18295293 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:708522 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of AACS mRNA | CTD | PMID:21215274 | 2,4-dinitrotoluene | affects expression | ISO | RGD:708522 | 6480464 | 2,4-dinitrotoluene affects the expression of AACS mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | ISO | RGD:708522 | 6480464 | 2,6-dinitrotoluene affects the expression of AACS mRNA | CTD | PMID:21346803 | 2-amino-2-deoxy-D-glucopyranose | increases expression | EXP | | 6480464 | Glucosamine results in increased expression of AACS mRNA | CTD | PMID:17178593 | 2-methoxyethanol | increases expression | ISO | RGD:708522 | 6480464 | methyl cellosolve results in increased expression of AACS mRNA | CTD | PMID:21061450 | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of AACS mRNA | CTD | PMID:18648102 | aldehydo-D-glucosamine | increases expression | EXP | | 6480464 | Glucosamine results in increased expression of AACS mRNA | CTD | PMID:17178593 | ammonium chloride | affects expression | ISO | RGD:708522 | 6480464 | Ammonium Chloride affects the expression of AACS mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of AACS mRNA | CTD | PMID:21715664 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of AACS mRNA | CTD | PMID:19770486 more ... | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of AACS mRNA] | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of AACS mRNA | CTD | PMID:19770486 PMID:21715664 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of AACS mRNA | CTD | PMID:21715664 PMID:19770486 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of AACS mRNA | CTD | PMID:21715664 | beta-D-glucosamine | increases expression | EXP | | 6480464 | Glucosamine results in increased expression of AACS mRNA | CTD | PMID:17178593 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of AACS mRNA | CTD | PMID:21932408 | cocaine | affects expression | ISO | RGD:708522 | 6480464 | Cocaine affects the expression of AACS mRNA | CTD | PMID:20187946 | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of AACS mRNA | CTD | PMID:17205981 | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of AACS mRNA | CTD | PMID:17205981 | cyclosporin A | increases expression | ISO | RGD:732340 | 6480464 | Cyclosporine results in increased expression of AACS mRNA | CTD | PMID:20106945 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of AACS mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of AACS mRNA | CTD | PMID:17361019 PMID:21266533 | dibutyl phthalate | decreases expression | ISO | RGD:708522 | 6480464 | Dibutyl Phthalate results in decreased expression of AACS mRNA | CTD | PMID:21266533 | isotretinoin | decreases expression | ISO | RGD:732340 | 6480464 | Isotretinoin results in decreased expression of AACS mRNA | CTD | PMID:20436886 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of AACS mRNA | CTD | PMID:17562736 | phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of AACS mRNA | CTD | PMID:19270015 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of AACS mRNA | CTD | PMID:23091169 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of AACS mRNA | CTD | PMID:18445702 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of AACS mRNA | CTD | PMID:18301758 | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of AACS mRNA | CTD | PMID:22698814 | pregnenolone 16alpha-carbonitrile | multiple interactions | EXP | | 6480464 | NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of AACS mRNA] | CTD | PMID:22698814 | tamoxifen | affects expression | EXP | | 6480464 | Tamoxifen affects the expression of AACS mRNA | CTD | PMID:20937368 | testosterone | increases expression | EXP | | 6480464 | Testosterone results in increased expression of AACS mRNA | CTD | PMID:16579987 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of AACS mRNA | CTD | PMID:17292431 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of AACS mRNA | CTD | PMID:21427059 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Butanoate metabolism |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Butanoate metabolism |
References - curated| 1. |
Kawai J, etal., Nature 2001 Feb 8;409(6821):685-90. |
| 2. |
MGD and Homologene mouse data transfer |
| 3. |
MGD data from the GO Consortium |
| 4. |
Morris AA J Inherit Metab Dis. 2005;28(2):109-21. |
| 5. |
Narishima R, etal., Obesity (Silver Spring). 2009 Mar;17(3):611-5. Epub 2008 Dec 11. |
| 6. |
Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. |
| 7. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 8. |
RGD automated import pipeline for gene-chemical interactions |
| 9. |
Sato H, etal., Biochem Pharmacol. 2002 May 15;63(10):1851-5. |
References - uncurated| PubMed | 10349636 |
| 10922068 | |
| 11042159 | |
| 11076861 | |
| 12477932 | |
| 12623130 | |
| 14681479 | |
| 15782199 | |
| 16141072 | |
| 16141073 | |
| 16969126 | |
| 18514076 | |
| 18554416 | |
| 18799693 | |
| 21267068 | |
| 22985732 | |
| 23000407 | |
| 23123469 | |
| 8889548 | |
| 9671465 |
RGD Disease Portals| Aacs has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Aacs (Mus musculus) |
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| AACS (Homo sapiens) |
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| Aacs (Rattus norvegicus) |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_030210 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01049260 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01049261 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01049262 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB054122 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB056114 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC119268 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC140286 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK019063 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK034184 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK043848 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK044017 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK147189 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK150266 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK165418 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK165457 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK170120 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK170653 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK170856 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK177420 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK179654 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK183229 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK186190 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK187132 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK187562 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK192407 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK192468 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK192777 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK192874 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK195042 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK197980 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK201057 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK204214 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK204662 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK205663 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK205708 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK206129 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK206715 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK209375 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK209476 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK218938 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK219028 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY091469 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC026817 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466529 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_030210 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_084486 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_084486 | (Get FASTA) |
| GenBank Protein | AAH26817 | (Get FASTA) |
| AAM44125 | (Get FASTA) | |
| BAB31530 | (Get FASTA) | |
| BAB63403 | (Get FASTA) | |
| BAC28621 | (Get FASTA) | |
| BAC31680 | (Get FASTA) | |
| BAC31740 | (Get FASTA) | |
| BAE27749 | (Get FASTA) | |
| BAE29423 | (Get FASTA) | |
| BAE38173 | (Get FASTA) | |
| BAE38197 | (Get FASTA) | |
| BAE41577 | (Get FASTA) | |
| BAE41938 | (Get FASTA) | |
| BAE42076 | (Get FASTA) | |
| BAF44057 | (Get FASTA) | |
| EDL19553 | (Get FASTA) | |
| EDL19554 | (Get FASTA) | |
| EDL19555 | (Get FASTA) | |
| Q9D2R0 | (Get FASTA) |
Promoters| RGD ID: | 6836828 | ||||||||||
| Promoter ID: | MM_KWN:44151 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, 3T3L1_Day6, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen | ||||||||||
| Transcripts: | OTTMUST00000057367 | ||||||||||
| Position: |
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| RGD ID: | 6848804 | ||||||||||
| Promoter ID: | MM_TRO:7819 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Kidney, Liver | ||||||||||
| Transcripts: | MTR001343.5.2403.1 | ||||||||||
| Position: |
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| RGD ID: | 6836830 | ||||||||||
| Promoter ID: | MM_KWN:44152 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Liver | ||||||||||
| Transcripts: | OTTMUST00000057369 | ||||||||||
| Position: |
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| RGD ID: | 6836829 | ||||||||||
| Promoter ID: | MM_KWN:44153 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Kidney, Liver | ||||||||||
| Transcripts: | OTTMUST00000057368 | ||||||||||
| Position: |
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| RGD ID: | 6847871 | ||||||||||
| Promoter ID: | MM_ACW:39544 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Kidney | ||||||||||
| Transcripts: | AACS.FSEP07 | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000029482 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000031445 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000031445 | ENTREZGENE |
| Entrez Gene | 78894 | ENTREZGENE |
| HomoloGene Group ID | 11322 | ENTREZGENE |
| InterPro | Acac_CoA_synth | UniProtKB/Swiss-Prot |
| Acyl-CoA_synth_DUF3448 | UniProtKB/Swiss-Prot | |
| AMP-binding_CS | UniProtKB/Swiss-Prot | |
| AMP-dep_Synth/Lig | UniProtKB/Swiss-Prot | |
| IPI | IPI00135189 | UniProtKB/Swiss-Prot |
| KEGG Report | mmu:78894 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:1926144 | ENTREZGENE |
| Pfam | AMP-binding | UniProtKB/Swiss-Prot |
| DUF3448 | UniProtKB/Swiss-Prot | |
| PROSITE | AMP_BINDING | UniProtKB/Swiss-Prot |
| TIGRFAMs | Ac_ac_CoA_syn | UniProtKB/Swiss-Prot |
| UniGene | Mm.431573 | ENTREZGENE |
| UniProt | AACS_MOUSE | UniProtKB/Swiss-Prot |
| Q8K3J7_MOUSE | UniProtKB/TrEMBL |
| More on Aacs | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1332110 |
| Created: | 2005-02-01 |
| Species: | Mus musculus |
| Last Modified: | 2013-04-09 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




