Ugt1a8 (UDP glucuronosyltransferase family 1 member A8) - Rat Genome Database

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Gene: Ugt1a8 (UDP glucuronosyltransferase family 1 member A8) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ugt1a8 (Ensembl: Ugt1a5)
Name: UDP glucuronosyltransferase family 1 member A8 (Ensembl:UDP glucuronosyltransferase family 1 member A5)
RGD ID: 708474
Description: Enables glucuronosyltransferase activity. Involved in cellular response to 3-methylcholanthrene and coumarin catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in alcoholic pancreatitis and pancreatic cancer. Orthologous to several human genes including UGT1A10 (UDP glucuronosyltransferase family 1 member A10); UGT1A7 (UDP glucuronosyltransferase family 1 member A7); and UGT1A8 (UDP glucuronosyltransferase family 1 member A8); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; mycophenolic acid pharmacokinetics pathway; .
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A3; UDP glycosyltransferase 1 family, polypeptide A8; UDP-glucuronosyltransferase 1-8; UDP-glucuronosyltransferase 1A8; UDPGT; UDPGT 1-8; Ugt1; UGT1*8; UGT1-08; UGT1.8; Ugt1a9
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8996,174,899 - 96,256,264 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl996,144,786 - 96,256,264 (+)EnsemblGRCr8
mRatBN7.2988,727,094 - 88,808,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx997,151,117 - 97,232,360 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09102,287,309 - 102,368,552 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09100,655,294 - 100,736,659 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0995,221,474 - 95,302,822 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)Ensemblrn6Rnor6.0
Rnor_5.0994,910,377 - 94,990,037 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4987,017,029 - 87,098,362 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera986,288,443 - 86,369,556 (+)NCBICelera
RGSC_v3.1987,202,433 - 87,284,226 (+)NCBI
Cytogenetic Map9q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases. Kessler FK, etal., Drug Metab Dispos 2002 Mar;30(3):324-30.
3. Induction of UDP-glucuronosyltransferase 1A8 mRNA by 3-methylcholanthene in rat hepatoma cells. Leung YK and Ho JW, Biochem Pharmacol. 2002 Feb 15;63(4):767-75.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Analysis of substrate specificities and tissue expression of rat UDP-glucuronosyltransferases UGT1A7 and UGT1A8. Webb LJ, etal., Drug Metab Dispos. 2005 Jan;33(1):77-82. Epub 2004 Oct 22.
10. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, etal., Genome Res 2004 Jan;14(1):79-89. Epub 2003 Dec 12.
Additional References at PubMed
PMID:2112380   PMID:7608130   PMID:16141793   PMID:17179145   PMID:18052087   PMID:19996319   PMID:20056724   PMID:20308471   PMID:20610558  


Genomics

Variants

.
Variants in Ugt1a8
890 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1403
Count of miRNA genes:204
Interacting mature miRNAs:226
Transcripts:ENSRNOT00000025045, ENSRNOT00000025291, ENSRNOT00000025652, ENSRNOT00000032634, ENSRNOT00000045163, ENSRNOT00000063853, ENSRNOT00000066839
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat

Markers in Region
D9Mco15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,786,718 - 88,787,007 (+)MAPPERmRatBN7.2
Rnor_6.0995,281,097 - 95,281,383NCBIRnor6.0
Rnor_5.0994,968,312 - 94,968,598UniSTSRnor5.0
RGSC_v3.4987,076,637 - 87,076,923UniSTSRGSC3.4
Celera986,348,016 - 86,348,299UniSTS
Cytogenetic Map9q35UniSTS
D9Wox40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,786,755 - 88,786,956 (+)MAPPERmRatBN7.2
Rnor_6.0995,281,134 - 95,281,332NCBIRnor6.0
Rnor_5.0994,968,349 - 94,968,547UniSTSRnor5.0
RGSC_v3.4987,076,674 - 87,076,872UniSTSRGSC3.4
Celera986,348,053 - 86,348,248UniSTS
Cytogenetic Map9q35UniSTS
RH130767  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,795,599 - 88,795,779 (+)MAPPERmRatBN7.2
Rnor_6.0995,289,976 - 95,290,155NCBIRnor6.0
Rnor_5.0994,977,191 - 94,977,370UniSTSRnor5.0
RGSC_v3.4987,085,516 - 87,085,695UniSTSRGSC3.4
Celera986,356,892 - 86,357,071UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map9q35-q36UniSTS
RH94830  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8996,255,939 - 96,256,140 (+)Marker Load Pipeline
mRatBN7.2988,808,140 - 88,808,341 (+)MAPPERmRatBN7.2
Rnor_6.0995,302,498 - 95,302,698NCBIRnor6.0
Rnor_5.0994,989,713 - 94,989,913UniSTSRnor5.0
RGSC_v3.4987,098,038 - 87,098,238UniSTSRGSC3.4
Celera986,369,232 - 86,369,432UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map9q35-q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
5 12 51 100 57 60 41 29 41 202 92 2 100 56 70 19 6 6

Sequence


RefSeq Acc Id: NM_175846   ⟹   NP_787040
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8996,174,899 - 96,256,264 (+)NCBI
mRatBN7.2988,727,094 - 88,808,465 (+)NCBI
Rnor_6.0995,221,474 - 95,302,822 (+)NCBI
Rnor_5.0994,910,377 - 94,990,037 (+)NCBI
RGSC_v3.4987,017,029 - 87,098,362 (+)RGD
Celera986,288,443 - 86,369,556 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_787040 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL67851 (Get FASTA)   NCBI Sequence Viewer  
  AAR95636 (Get FASTA)   NCBI Sequence Viewer  
  BAA07259 (Get FASTA)   NCBI Sequence Viewer  
  EDL92107 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066773
GenBank Protein Q64634 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_787040   ⟸   NM_175846
- Peptide Label: precursor
- UniProtKB: Q6T5E7 (UniProtKB/TrEMBL),   A6JQH6 (UniProtKB/TrEMBL),   Q8VD44 (UniProtKB/TrEMBL),   M0RB50 (UniProtKB/TrEMBL)
- Sequence:

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64634-F1-model_v2 AlphaFold Q64634 1-530 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708474 AgrOrtholog
BioCyc Gene G2FUF-26827 BioCyc
BioCyc Pathway PWY-6261 [thyroid hormone metabolism II (via conjugation and/or degradation)] BioCyc
BioCyc Pathway Image PWY-6261 BioCyc
Ensembl Genes ENSRNOG00000018740 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000071200 ENTREZGENE
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot
InterPro UDP-glycosyltransferase UniProtKB/Swiss-Prot
  UDP_glucos_trans UniProtKB/Swiss-Prot
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot
NCBI Gene 301595 ENTREZGENE
PANTHER EG:EG0003.4 PROTEIN-RELATED UniProtKB/Swiss-Prot
  UDP GLUCURONOSYLTRANSFERASE FAMILY 1 MEMBER A1 UniProtKB/Swiss-Prot
Pfam UDPGT UniProtKB/Swiss-Prot
PhenoGen Ugt1a8 PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018740 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot
UniProt A6JQH6 ENTREZGENE, UniProtKB/TrEMBL
  F7EKA4_RAT UniProtKB/TrEMBL
  M0RB50 ENTREZGENE, UniProtKB/TrEMBL
  Q64634 ENTREZGENE
  Q6T5E7 ENTREZGENE
  Q8VD44 ENTREZGENE, UniProtKB/TrEMBL
  UD18_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-18 Ugt1a8  UDP glucuronosyltransferase family 1 member A8  Ugt1a8  UDP glycosyltransferase 1 family, polypeptide A8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Slc1a7  UDP glycosyltransferase 1 family, polypeptide A8  Ugt1a8  UDP-glucuronosyltransferase 1A8  Name updated to reflect Human and Mouse nomenclature 625702 APPROVED